Dimethylthiourea protects against chlorine induced changes in airway function in a murine model of irritant induced asthma

Respiratory Research

Volumn 11, Issue , 2010, Pages

  McGovern, Toby K ^a   Powell, William S ^a   Day, Brian J ^b   White, Carl W ^b   Govindaraju, Karuthapillai ^a   Karmouty Quintana, Harry ^a   Lavoie, Normand ^a   Tan, Ju Jing ^a   Martin, James G ^a  

^a MCGILL UNIVERSITY   (Canada)

^b DEPARTMENT OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

4 HYDROXYNONENAL; CHLORINE; DIMETHYLTHIOUREA; GLUTATHIONE; 1,3-DIMETHYLTHIOUREA; DRUG DERIVATIVE; IRRITANT AGENT; THIOUREA;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; ASTHMA; CELL COUNT; CONTROLLED STUDY; INFLAMMATORY CELL; LIPID PEROXIDATION; LUNG ALVEOLUS EPITHELIUM; LUNG FUNCTION; LUNG LAVAGE; MALE; MOUSE; NONHUMAN; OXIDATIVE STRESS; PROTEIN BLOOD LEVEL; RESPIRATORY TRACT INJURY; ANIMAL; BAGG ALBINO MOUSE; CHEMICALLY INDUCED DISORDER; COMPARATIVE STUDY; DOSE RESPONSE; DRUG ANTAGONISM; DRUG EFFECT; EXPOSURE; LUNG; LUNG FUNCTION TEST; METHODOLOGY; PATHOPHYSIOLOGY; PHYSIOLOGY;

ANIMALS; ASTHMA; CHLORINE; DOSE-RESPONSE RELATIONSHIP, DRUG; INHALATION EXPOSURE; IRRITANTS; LUNG; MALE; MICE; MICE, INBRED BALB C; RESPIRATORY FUNCTION TESTS; THIOUREA;

EID: 77957294106     PISSN: 14659921     EISSN: 1465993X     Source Type: Journal    
DOI: 10.1186/1465-9921-11-138     Document Type: Article

References (28)

1. Henneberger PK, Olin AC, Andersson E, Hagberg S, Toren K. The incidence of respiratory symptoms and diseases among pulp mill workers with peak exposures to ozone and other irritant gases. Chest 2005, 128:3028. 10.1378/chest.128.4.3028, 16236983.
2. Brooks SM, Weiss MA, Bernstein IL. Reactive airways dysfunction syndrome (RADS). Persistent asthma syndrome after high level irritant exposures. Chest 1985, 88:376. 10.1378/chest.88.3.376, 4028848.
3. Deschamps D, Soler P, Rosenberg N, Baud F, Gervais P. Persistent Asthma After Inhalation of A Mixture of Sodium-Hypochlorite and Hydrochloric-Acid. Chest 1994, 105:1895. 10.1378/chest.105.6.1895, 8205904.
4. Van SD, Wenck MA, Belflower A, Drociuk D, Ferdinands J, Holguin F, Svendsen E, Bretous L, Jankelevich S, Gibson JJ, Garbe P, Moolenaar RL. Acute health effects after exposure to chlorine gas released after a train derailment. Am J Emerg Med 2009, 27:1. 10.1016/j.ajem.2007.12.006, 19041527.
5. Lemiere C, Malo JL, Boutet M. Reactive airways dysfunction syndrome due to chlorine: sequential bronchial biopsies and functional assessment. Eur Respir J 1997, 10:241. 10.1183/09031936.97.10010241, 9032521.
6. Jia Y, Xu L, Turner DJ, Martin JG. Endogenous nitric oxide contributes to strain-related differences in airway responsiveness in rats. J Appl Physiol 1996, 80:404.
7. Martin JG, Campbell HR, Iijima H, Gautrin D, Malo JL, Eidelman DH, Hamid Q, Maghni K. Chlorine-induced injury to the airways in mice. Am J Respir Crit Care Med 2003, 168:568. 10.1164/rccm.200201-021OC, 12724121.
8. Cheek JM, Mcdonald RJ, Rapalyea L, Tarkington BK, Hyde DM. Neutrophils Enhance Removal of Ozone-Injured Alveolar Epithelial-Cells In-Vitro. American Journal of Physiology-Lung Cellular and Molecular Physiology 1995, 13:L527-L535.
9. Leustik M, Doran S, Bracher A, Williams S, Squadrito GL, Schoeb TR, Postlethwait E, Matalon S. Mitigation of chlorine-induced lung injury by low-molecular-weight antioxidants. Am J Physiol Lung Cell Mol Physiol 2008, 295:L733-L743. 10.1152/ajplung.90240.2008, 2584876, 18708632.
10. Jackson JH, White CW, Parker NB, Ryan JW, Repine JE. Dimethylthiourea consumption reflects H2O2 concentrations and severity of acute lung injury. J Appl Physiol 1985, 59(6):1995-8.
11. Day BJ, van Heeckeren AM, Min E, Velsor LW. Role for cystic fibrosis transmembrane conductance regulator protein in a glutathione response to bronchopulmonary pseudomonas infection. Infect Immun 2004, 72:2045. 10.1128/IAI.72.4.2045-2051.2004, 375208, 15039325.
12. Hamada K, Goldsmith CA, Kobzik L. Increased airway hyperresponsiveness and inflammation in a juvenile mouse model of asthma exposed to air-pollutant aerosol. Journal of Toxicology and Environmental Health-Part A 1999, 58:129. 10.1080/009841099157340, 10522645.
13. Parmentier C, Leroy P, Wellman M, Nicolas A. Determination of cellular thiols and glutathione-related enzyme activities: versatility of high-performance liquid chromatography-spectrofluorimetric detection. J Chromatogr B Biomed Sci Appl 1998, 719:37. 10.1016/S0378-4347(98)00414-9, 9869362.
14. Pichavant M, Goya S, Meyer EH, Johnston RA, Kim HY, Matangkasombut P, Zhu M, Iwakura Y, Savage PB, Dekruyff RH, Shore SA, Umetsu DT. Ozone exposure in a mouse model induces airway hyperreactivity that requires the presence of natural killer T cells and IL-17. J Exp Med 2008, 205:385. 10.1084/jem.20071507, 2271004, 18250191.
15. Demnati R, Fraser R, Ghezzo H, Martin JG, Plaa G, Malo JL. Time-course of functional and pathological changes after a single high acute inhalation of chlorine in rats. Eur Respir J 1998, 11:922. 10.1183/09031936.98.11040922, 9623698.
16. Koohsari H, Tamaoka M, Campbell HR, Martin JG. The role of gamma delta T cells in airway epithelial injury and bronchial responsiveness after chlorine gas exposure in mice. Respir Res 2007, 8:21. 10.1186/1465-9921-8-21, 1831470, 17343743.
17. Demnati R, Fraser R, Plaa G, Malo JL. Histopathological effects of acute exposure to chlorine gas on Sprague-Dawley rat lungs. J Environ Pathol Toxicol Oncol 1995, 14:15.
18. Jongejan R, De Jongste J, Raatgeep R, Stijnen T, Bonta I, Kerrebijn K. Effect of epithelial denudation, inflammatory mediators and mast cell activation on the sensitivity of isolated human airways to methacholine. Eur J Pharmacol 1991, 203:187. 10.1016/0014-2999(91)90714-2, 1800116.
19. Morrison KJ, Gao Y, Vanhoutte PM. Epithelial modulation of airway smooth muscle. [Review]. Am J Physiol 1990, 258:L254-L262.
20. Xie Z, Hakoda H, Ito Y. Airway epithelial cells regulate membrane potential, neurotransmission and muscle tone of the dog airway smooth muscle. J Physiol (Lond) 1992, 449:619. 1176098, 1326048.
21. Cantin AM, North SL, Hubbard RC, Crystal RG. Normal alveolar epithelial lining fluid contains high levels of glutathione. J Appl Physiol 1987, 63:152.
22. Rahman I, Macnee W. Oxidative stress and regulation of glutathione in lung inflammation. Eur Respir J 2000, 16:534. 10.1034/j.1399-3003.2000.016003534.x, 11028671.
23. Kariya C, Leitner H, Min E, van HC, van HA, Day BJ. A role for CFTR in the elevation of glutathione levels in the lung by oral glutathione administration. Am J Physiol Lung Cell Mol Physiol 2007, 292:L1590-L1597. 10.1152/ajplung.00365.2006, 17369290.
24. Allen GB, Leclair TR, von RJ, Larrabee YC, Cloutier ME, Irvin CG, Bates JHT. Acid aspiration-induced airways hyperresponsiveness in mice. J Appl Physiol 2009, 107:1763-70. 10.1152/japplphysiol.00572.2009, 19797689.
25. Fox RB. Prevention of granulocyte-mediated oxidant lung injury in rats by a hydroxyl radical scavenger, dimethylthiourea. J Clin Invest 1984, 74:1456. 10.1172/JCI111558, 425315, 6090504.
26. Wang SZ, Xu H, Wraith A, Bowden JJ, Alpers JH, Forsyth KD. Neutrophils induce damage to respiratory epithelial cells infected with respiratory syncytial virus. Eur Respir J 1998, 12:612. 10.1183/09031936.98.12030612, 9762789.
27. Nadeem A, Chhabra SK, Masood A, Raj HG. Increased oxidative stress and altered levels of antioxidants in asthma. J Allergy Clin Immunol 2003, 111:72. 10.1067/mai.2003.17, 12532099.
28. Sackesen C, Ercan H, Dizdar E, Soyer O, Gumus P, Tosun BN, Buyuktuncer Z, Karabulut E, Besler T, Kalayci O. A comprehensive evaluation of the enzymatic and nonenzymatic antioxidant systems in childhood asthma. J Allergy Clin Immunol 2008, 122(1):78-85. 10.1016/j.jaci.2008.03.035, 18485467.