Combined linkage and association studies show that HLA class II variants control levels of antibodies against Epstein-Barr virus antigens

PLoS ONE

Volumn 9, Issue 7, 2014, Pages

  Pedergnana, Vincent ^a,b   Syx, Laurène ^a,b   Cobat, Aurélie ^a,b   Guergnon, Julien ^c   Brice, Pauline ^d   Fermé, Christophe ^e   Carde, Patrice ^e   Hermine, Olivier ^f   Le Pendeven, Catherine ^g   Amiel, Corinne ^g   Taoufik, Yassine ^c,h,i   Alcaïs, Alexandre ^a,b   Theodorou, Ioannis ^c   Besson, Caroline ^c,h,i   Abel, Laurent ^a,b,j  

^a IMAGINE INSTITUTE   (France)

^b UNIVERSITÉ PARIS DESCARTES   (France)

^c INSERM   (France)

^d SAINT LOUIS HOSPITAL   (France)

^e INSTITUT GUSTAVE ROUSSY   (France)

^f HÔPITAL NECKER ENFANTS MALADES   (France)

^g ASSISTANCE PUBLIQUE HÔPITAUX DE PARIS   (France)

^h BICÊTRE HOSPITAL   (France)

ⁱ UNIVERSITÉ PARIS SACLAY   (France)

^j ROCKEFELLER UNIVERSITY   (United States)

more..

Author keywords

[No Author keywords available]

Indexed keywords

EPSTEIN BARR VIRUS ANTIGEN; HLA ANTIGEN CLASS 2; IMMUNOGLOBULIN G; VIRUS ANTIBODY; VIRUS CAPSID ANTIGEN;

ADOLESCENT; ADULT; ANTIBODY DETECTION; ANTIBODY TITER; ARTICLE; CONTROLLED STUDY; EPSTEIN BARR VIRUS INFECTION; GENE FREQUENCY; GENE LINKAGE DISEQUILIBRIUM; GENE LOCUS; GENETIC ASSOCIATION; GENETIC LINKAGE; GENETIC PREDISPOSITION; GENOTYPE; HODGKIN DISEASE; HUMAN; IMMUNOGLOBULIN BLOOD LEVEL; MAJOR CLINICAL STUDY; NONHUMAN; SEROPREVALENCE; SINGLE NUCLEOTIDE POLYMORPHISM; ADAPTIVE IMMUNITY; AGED; BIOSYNTHESIS; BLOOD; EPSTEIN BARR VIRUS; FEMALE; GENETICS; IMMUNOLOGY; MALE; MIDDLE AGED; VERY ELDERLY; YOUNG ADULT;

ADAPTIVE IMMUNITY; ADOLESCENT; ADULT; AGED; AGED, 80 AND OVER; ANTIBODIES, VIRAL; EPSTEIN-BARR VIRUS INFECTIONS; FEMALE; GENOME-WIDE ASSOCIATION STUDY; HERPESVIRUS 4, HUMAN; HISTOCOMPATIBILITY ANTIGENS CLASS II; HUMANS; LINKAGE DISEQUILIBRIUM; MALE; MIDDLE AGED; POLYMORPHISM, SINGLE NUCLEOTIDE; YOUNG ADULT;

EID: 84904250917     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0102501     Document Type: Article

References (15)

1. Young LS, Rickinson AB (2004) Epstein-Barr virus: 40 years on. Nat Rev Cancer 4: 757-768. (Pubitemid 39331148)
2. Besson C, Amiel C, Le-Pendeven C, Plancoulaine S, Bonnardel C, et al. (2009) Strong correlations of anti-viral capsid antigen antibody levels in first-degree relatives from families with Epstein-Barr virus-related lymphomas. J Infect Dis 199: 1121-1127.
3. Rubicz R, Yolken R, Drigalenko E, Carless MA, Dyer TD, et al. (2013) A genome-wide integrative genomic study localizes genetic factors influencing antibodies against Epstein-Barr virus nuclear antigen 1 (EBNA-1). PLoS Genet 9: e1003147.
4. Besson C, Roetynck S, Williams F, Orsi L, Amiel C, et al. (2007) Association of Killer Cell Immunoglobulin-Like Receptor Genes with Hodgkin's Lymphoma in a Familial Study. PLoS ONE 2: e406.
5. Besson C, Amiel C, Le-Pendeven C, Brice P, Ferme C, et al. (2006) Positive correlation between Epstein-Barr virus viral load and anti-viral capsid immunoglobulin G titers determined for Hodgkin's lymphoma patients and their relatives. J Clin Microbiol 44: 47-50. (Pubitemid 43100577)
6. Alcais A, Abel L (1999) Maximum-Likelihood-Binomial method for genetic model-free linkage analysis of quantitative traits in sibships. Genet Epidemiol 17: 102-117. (Pubitemid 29318684)
7. Cobat A, Abel L, Alcais A (2011) The Maximum-Likelihood-Binomial method revisited: a robust approach for model-free linkage analysis of quantitative traits in large sibships. Genet Epidemiol 35: 46-56.
8. Lander E, Kruglyak L (1995) Genetic dissection of complex traits: guidelines for interpreting and reporting linkage results. Nat Genet 11: 241-247.
9. Horvath S, Xu X, Laird NM (2001) The family based association test method: strategies for studying general genotype-phenotype associations. Eur J Hum Genet 9: 301-306. (Pubitemid 32366699)
10. Barrett JC, Fry B, Maller J, Daly MJ (2005) Haploview: analysis and visualization of LD and haplotype maps. Bioinformatics 21: 263-265. (Pubitemid 40202029)
11. Delaneau O, Marchini J, Zagury JF (2012) A linear complexity phasing method for thousands of genomes. Nat Methods 9: 179-181.
12. Zheng X, Shen J, Cox C, Wakefield JC, Ehm MG, et al. (2014) HIBAG-HLA genotype imputation with attribute bagging. Pharmacogenomics J 14: 192-200.
13. Cobat A, Abel L, Alcais A, Schurr E (2014) A general efficient and flexible approach for genome-wide association analyses of imputed genotypes in family-based designs. Genet Epidemiol: in press.
14. Urayama KY, Jarrett RF, Hjalgrim H, Diepstra A, Kamatani Y, et al. (2012) Genome-wide association study of classical Hodgkin lymphoma and Epstein-Barr virus status-defined subgroups. J Natl Cancer Inst 104: 240-253.
15. Mueller N, Evans A, Harris NL, Comstock GW, Jellum E, et al. (1989) Hodgkin's disease and Epstein-Barr virus. Altered antibody pattern before diagnosis. N Engl J Med 320: 689-695. (Pubitemid 19072487)