Post-transcriptional regulation of BCL2 mRNA by the RNA-binding protein ZFP36L1 in malignant B cells

PLoS ONE

Volumn 9, Issue 7, 2014, Pages

  Zekavati, Anna ^a   Nasir, Asghar ^a   Alcaraz, Amor ^b   Aldrovandi, Maceler ^a   Marsh, Phil ^a   Norton, John D ^c   Murphy, John J ^a,b  

^a KING'S COLLEGE LONDON   (United Kingdom)

^b UNIVERSITY OF WESTMINSTER   (United Kingdom)

^c UNIVERSITY OF ESSEX   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

MESSENGER RNA; PROTEIN BCL 2; PROTEIN ZFP36L1; RNA BINDING PROTEIN; UNCLASSIFIED DRUG; 3' UNTRANSLATED REGION; BCL2 PROTEIN, HUMAN; BCL2 PROTEIN, MOUSE; BUTYRATE RESPONSE FACTOR 1; LUCIFERASE; NUCLEAR PROTEIN; PROTEIN BINDING; SMALL INTERFERING RNA; ZFP36L1 PROTEIN, HUMAN; ZFP36L1 PROTEIN, MOUSE;

3' UNTRANSLATED REGION; ANIMAL CELL; APOPTOSIS; ARTICLE; BCL2 GENE; CONTROLLED STUDY; GEL MOBILITY SHIFT ASSAY; GENE EXPRESSION; GENE REGULATORY NETWORK; HEK293 CELL LINE; MOLECULAR INTERACTION; NONHUMAN; PROTEIN FUNCTION; RNA DEGRADATION; TRANSCRIPTION REGULATION; ANIMAL; ANTAGONISTS AND INHIBITORS; B LYMPHOCYTE; DNA RESPONSIVE ELEMENT; GENE EXPRESSION REGULATION; GENE VECTOR; GENETICS; HUMAN; LENTIVIRINAE; METABOLISM; MOUSE; REPORTER GENE; RNA STABILITY; SIGNAL TRANSDUCTION; TUMOR CELL LINE;

3' UNTRANSLATED REGIONS; ANIMALS; B-LYMPHOCYTES; BUTYRATE RESPONSE FACTOR 1; CELL LINE, TUMOR; GENE EXPRESSION REGULATION, NEOPLASTIC; GENES, REPORTER; GENETIC VECTORS; HEK293 CELLS; HUMANS; LENTIVIRUS; LUCIFERASES; MICE; NUCLEAR PROTEINS; PROTEIN BINDING; PROTO-ONCOGENE PROTEINS C-BCL-2; RESPONSE ELEMENTS; RNA STABILITY; RNA, SMALL INTERFERING; RNA-BINDING PROTEINS; SIGNAL TRANSDUCTION;

EID: 84904249893     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0102625     Document Type: Article

References (44)

1. Baou M, Jewell A, Murphy J (2009) TIS11 family proteins and their roles in posttranscriptional gene regulation. J Biomed Biotechnol 2009: 634520.
2. Baou M, Norton JD, Murphy JJ (2011) AU-rich RNA binding proteins in hematopoiesis and leukemogenesis. Blood 118: 5732-5740.
3. Ciais D, Cherradi N, Feige JJ (2013) Multiple functions of tristetraprolin/TIS11 RNA-binding proteins in the regulation of mRNA biogenesis and degradation. Cell Mol Life Sci 70: 2031-2044.
4. Blackshear P, Phillips R, Ghosh S, Ramos S, Ramos S, et al. (2005) Zfp36l3, a rodent X chromosome gene encoding a placenta-specific member of the Tristetraprolin family of CCCH tandem zinc finger proteins. Biol Reprod 73: 297-307. (Pubitemid 41022789)
5. Ma Q, Wadleigh D, Chi T, Herschman H (1994) The Drosophila TIS11 homologue encodes a developmentally controlled gene. Oncogene 9: 3329-3334.
6. Ma Q, Herschman H (1995) The yeast homologue YTIS11, of the mammalian TIS11 gene family is a non-essential, glucose repressible gene. Oncogene 10: 487-494.
7. Tréguer K, Faucheux C, Veschambre P, Fédou S, Thézé N, et al. (2013) Comparative functional analysis of ZFP36 genes during Xenopus development. PLoS One 8: e54550.
8. Vignudelli T, Selmi T, Martello A, Parenti S, Grande A, et al. (2010) ZFP36L1 Negatively Regulates Erythroid Differentiation of CD34+ Hematopoietic Stem Cells by Interfering with the Stat5b Pathway. Molecular Biology of the Cell: 3340-3351.
9. Nasir A, Norton JD, Baou M, Zekavati A, Bijlmakers MJ, et al. (2012) ZFP36L1 negatively regulates plasmacytoid differentiation of BCL1 cells by targeting BLIMP1 mRNA. PLoS One 7: e52187.
10. Ning Z, Norton J, Li J, Murphy J (1996) Distinct mechanisms for rescue from apoptosis in Ramos human B cells by signaling through CD40 and interleukin-4 receptor: role for inhibition of an early response gene, Berg36. Eur J Immunol 26: 2356-2363. (Pubitemid 26340935)
11. Baou M, Jewell A, Muthurania A, Wickremasinghe RG, Yong KL, et al. (2009) Involvement of Tis11b, an AU-rich binding protein, in induction of apoptosis by rituximab in B cell chronic lymphocytic leukemia cells. Leukemia 23: 986-989.
12. Murphy J, Norton J (1990) Cell-type-specific early response gene expression during plasmacytoid differentiation of human B lymphocytic leukemia cells. Biochim Biophys Acta 1049: 261-271. (Pubitemid 20224619)
13. Johnson B, Geha M, Blackwell T (2000) Similar but distinct effects of the tristetraprolin/TIS11 immediate-early proteins on cell survival. Oncogene 19: 1657-1664. (Pubitemid 30200967)
14. Johnson B, Blackwell T (2002) Multiple tristetraprolin sequence domains required to induce apoptosis and modulate responses to TNFalpha through distinct pathways. Oncogene 21: 4237-4246. (Pubitemid 34753830)
15. Reshef DN, Reshef YA, Finucane HK, Grossman SR, McVean G, et al. (2011) Detecting novel associations in large data sets. Science 334: 1518-1524.
16. McCall MN, Bolstad BM, Irizarry RA (2010) Frozen robust multiarray analysis (fRMA). Biostatistics 11: 242-253.
17. McCall MN, Uppal K, Jaffee HA, Zilliox MJ, Irizarry RA (2011) The Gene Expression Barcode: leveraging public data repositories to begin cataloging the human and murine transcriptomes. Nucleic Acids Res 39: D1011-1015.
18. Margolin A, Wang K, Lim W, Kustagi M, Nemenman I, et al. (2006) Reverse engineering cellular networks. Nature Protocols: 663-672.
19. Reich M, Liefeld T, Gould J, Lerner J, Tamayo P, et al. (2006) GenePattern 2.0. Nature Genetics: 500-501.
20. Subramanian A, Tamayo P, Mootha VK, Mukherjee S, Ebert BL, et al. (2005) Gene set enrichment analysis: a knowledge-based approach for interpreting genome-wide expression profiles. Proc Natl Acad Sci U S A 102: 15545-15550. (Pubitemid 41528093)
21. Ishmael F, Fang X, Galdiero M, Atasoy U, Rigby W, et al. (2008) Role of the RNA-binding protein tristetraprolin in glucocorticoid-mediated gene regulation. J Immunol 180: 8342-8353.
22. Lai W, Parker J, Grissom S, Stumpo D, Blackshear P (2006) Novel mRNA targets for tristetraprolin (TTP) identified by global analysis of stabilized transcripts in TTP-deficient fibroblasts. Mol Cell Biol 26: 9196-9208. (Pubitemid 44904416)
23. Conesa A, Nueda MJ, Ferrer A, Talón M (2006) maSigPro: a method to identify significantly differential expression profiles in time-course microarray experiments. Bioinformatics 22: 1096-1102.
24. Bakheet T, Williams B, Khabar K (2003) ARED 2.0: an update of AU-rich element mRNA database. Nucleic Acids Res 31: 421-423. (Pubitemid 36150418)
25. Stoecklin G, Tenenbaum S, Mayo T, Chittur S, George A, et al. (2008) Genome-wide analysis identifies interleukin-10 mRNA as target of tristetraprolin. J Biol Chem 283: 11689-11699.
26. Cook KB, Kazan H, Zuberi K, Morris Q, Hughes TR (2011) RBPDB: a database of RNA-binding specificities. Nucleic Acids Res 39: D301-308.
27. Smoot ME, Ono K, Ruscheinski J, Wang PL, Ideker T (2011) Cytoscape 2.8: new features for data integration and network visualization. Bioinformatics 27: 431-432.
28. Ventura A, Meissner A, Dillon CP, McManus M, Sharp PA, et al. (2004) Cre-lox- regulated conditional RNA interference from transgenes. Proc Natl Acad Sci U S A 101: 10380-10385. (Pubitemid 38924934)
29. Stoecklin G, Colombi M, Raineri I, Leuenberger S, Mallaun M, et al. (2002) Functional cloning of BRF1, a regulator of ARE-dependent mRNA turnover. EMBO J 21: 4709-4718. (Pubitemid 34984358)
30. Lapucci A, Donnini M, Papucci L, Witort E, Tempestini A, et al. (2002) AUF1 Is a bcl-2 A + U-rich element-binding protein involved in bcl-2 mRNA destabilization during apoptosis. J Biol Chem 277: 16139-16146. (Pubitemid 34967900)
31. Livak K, Schmittgen T (2001) Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) Method. Methods 25: 402-408. (Pubitemid 34164012)
32. Ning ZQ, Norton JD, Johnson D, Murphy JJ (1995) Early gene signalling-dependent and -independent induction of apoptosis in Ramos human B cells can be inhibited by over-expression of Bcl-2. Biochem Biophys Res Commun 215: 23-29.
33. Renault TT, Chipuk JE (2013) Getting away with murder: how does the BCL-2 family of proteins kill with immunity? Ann N Y Acad Sci 1285: 59-79.
34. Ishimaru D, Zuraw L, Ramalingam S, Sengupta TK, Bandyopadhyay S, et al. (2010) Mechanism of regulation of bcl-2 mRNA by nucleolin and A+U-rich element-binding factor 1 (AUF1). J Biol Chem 285: 27182-27191.
35. Sengupta TK, Bandyopadhyay S, Fernandes DJ, Spicer EK (2004) Identification of nucleolin as an AU-rich element binding protein involved in bcl-2 mRNA stabilization. J Biol Chem 279: 10855-10863. (Pubitemid 38401575)
36. Otake Y, Soundararajan S, Sengupta TK, Kio EA, Smith JC, et al. (2007) Overexpression of nucleolin in chronic lymphocytic leukemia cells induces stabilization of bcl2 mRNA. Blood 109: 3069-3075. (Pubitemid 46482108)
37. Ishimaru D, Ramalingam S, Sengupta T, Bandyopadhyay S, Dellis S, et al. (2009) Regulation of Bcl-2 expression by HuR in HL60 leukemia cells and A431 carcinoma cells. Mol Cancer Res 7: 1354-1366.
38. Cimmino A, Calin GA, Fabbri M, Iorio MV, Ferracin M, et al. (2005) miR-15 and miR-16 induce apoptosis by targeting BCL2. Proc Natl Acad Sci U S A 102: 13944-13949. (Pubitemid 41377683)
39. Calin GA, Cimmino A, Fabbri M, Ferracin M, Wojcik SE, et al. (2008) MiR-15a and miR-16-1 cluster functions in human leukemia. Proc Natl Acad Sci U S A 105: 5166-5171. (Pubitemid 351738528)
40. Jing Q, Huang S, Guth S, Zarubin T, Motoyama A, et al. (2005) Involvement of microRNA in AU-rich element-mediated mRNA instability. Cell 120: 623-634. (Pubitemid 40343075)
41. Hodson DJ, Janas ML, Galloway A, Bell SE, Andrews S, et al. (2010) Deletion of the RNA-binding proteins ZFP36L1 and ZFP36L2 leads to perturbed thymic development and T lymphoblastic leukemia. Nat Immunol 11: 717-724.
42. Rounbehler RJ, Fallahi M, Yang C, Steeves MA, Li W, et al. (2012) Tristetraprolin impairs myc-induced lymphoma and abolishes the malignant state. Cell 150: 563-574.
43. Pospisilova H, Baens M, Michaux L, Stul M, Van Hummelen P, et al. (2007) Interstitial del(14)(q) involving IGH: a novel recurrent aberration in B-NHL. Leukemia 21: 2079-2083. (Pubitemid 47299996)
44. Chapman MA, Lawrence MS, Keats JJ, Cibulskis K, Sougnez C, et al. (2011) Initial genome sequencing and analysis of multiple myeloma. Nature 471: 467-472.