5-lipoxygenase activating protein (FLAP) dependent leukotriene biosynthesis inhibition (MK591) attenuates lipid a endotoxin-induced inflammation

PLoS ONE

Volumn 9, Issue 7, 2014, Pages

  Fang, Wen Feng ^a,b   Douglas, Ivor S ^c   Wang, Chin Chou ^a,b   Kao, Hsu Ching ^a   Chang, Ya Ting ^a   Tseng, Chia Cheng ^a   Huang, Kuo Tung ^a   Chang, Huang Chih ^a   Lin, Meng Chih ^a,b  

^a CHANG GUNG MEMORIAL HOSPITAL   (Taiwan)

^b CHANG GUNG UNIVERSITY OF SCIENCE AND TECHNOLOGY   (Taiwan)

^c UNIVERSITY OF COLORADO SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ARACHIDONATE 5 LIPOXYGENASE; ARACHIDONATE 5 LIPOXYGENASE ACTIVATING PROTEIN; CYCLOOXYGENASE 2; ESCHERICHIA COLI LIPOPOLYSACCHARIDE; LEUKOTRIENE; LIPID A; MITOGEN ACTIVATED PROTEIN KINASE; QUIFLAPON; TOLL LIKE RECEPTOR 2; TOLL LIKE RECEPTOR 4; ALOX5AP PROTEIN, MOUSE; ARACHIDONATE 5 LIPOXYGENASE ACTIVATING PROTEIN INHIBITOR; CXCL2 CHEMOKINE; CXCL2 PROTEIN, MOUSE; INDOLE DERIVATIVE; QUINOLINE DERIVATIVE; TLR2 PROTEIN, MOUSE; TLR4 PROTEIN, MOUSE;

ANIMAL CELL; ANTIINFLAMMATORY ACTIVITY; ANTIPROLIFERATIVE ACTIVITY; APOPTOSIS; ARTICLE; BACTERIAL STRAIN; CELL PROLIFERATION; CELL SURFACE; CONTROLLED STUDY; ENZYME ACTIVATION; ESCHERICHIA COLI; INFLAMMATION; MACROPHAGE ACTIVATION; MOUSE; NONHUMAN; PROSTAGLANDIN SYNTHESIS INHIBITION; PROTEIN EXPRESSION; SEPSIS; ANIMAL; BIOSYNTHESIS; CELL LINE; CELL SURVIVAL; DRUG EFFECTS; IMMUNOLOGY; MACROPHAGE; METABOLISM; PHYSIOLOGY; SECRETION (PROCESS);

5-LIPOXYGENASE-ACTIVATING PROTEIN INHIBITORS; 5-LIPOXYGENASE-ACTIVATING PROTEINS; ANIMALS; APOPTOSIS; ARACHIDONATE 5-LIPOXYGENASE; CELL LINE; CELL PROLIFERATION; CELL SURVIVAL; CHEMOKINE CXCL2; INDOLES; LEUKOTRIENES; LIPID A; MACROPHAGES; MICE; QUINOLINES; TOLL-LIKE RECEPTOR 2; TOLL-LIKE RECEPTOR 4;

EID: 84904248710     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0102622     Document Type: Article

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