Curcumin induces apoptosis in breast cancer cells and inhibits tumor growth in vitro and in vivo

International Journal of Clinical and Experimental Pathology

Volumn 7, Issue 6, 2014, Pages 2818-2824

  Lv, Zhi Dong ^a   Liu, Xiang Ping ^b   Zhao, Wei Jun ^c   Dong, Qian ^d   Li, Fu Nian ^a   Wang, Hai Bo ^a   Kong, Bin ^a  

^a Department of Breast Surgery ^*  (China)

^b Central Laboratory of Molecular Biology   (China)

^c Chifeng University   (China)

^d QINGDAO UNIVERSITY   (China)

Author keywords

Apoptosis; Breast carcinoma; Curcumin; Nude mice

Indexed keywords

ANTINEOPLASTIC AGENT; CURCUMIN;

ANIMAL; APOPTOSIS; BAGG ALBINO MOUSE; BREAST TUMOR; CELL PROLIFERATION; CELL SURVIVAL; DRUG EFFECTS; DRUG SCREENING; FEMALE; FLOW CYTOMETRY; HUMAN; IN VITRO STUDY; MOUSE; NUDE MOUSE; PATHOLOGY; TRANSMISSION ELECTRON MICROSCOPY; TUMOR CELL LINE; WESTERN BLOTTING;

ANIMALS; ANTINEOPLASTIC AGENTS; APOPTOSIS; BLOTTING, WESTERN; BREAST NEOPLASMS; CELL LINE, TUMOR; CELL PROLIFERATION; CELL SURVIVAL; CURCUMIN; FEMALE; FLOW CYTOMETRY; HUMANS; IN VITRO TECHNIQUES; MICE; MICE, INBRED BALB C; MICE, NUDE; MICROSCOPY, ELECTRON, TRANSMISSION; XENOGRAFT MODEL ANTITUMOR ASSAYS;

EID: 84904247762     PISSN: None     EISSN: 19362625     Source Type: Journal    
DOI: None     Document Type: Article

References (15)

1. Liu MM, Huang Y and Wang J. Developing phytoestrogens for breast cancer prevention. Anticancer Agents Med Chem 2012; 12: 1306-1313.
2. Conforti F and Menichini F. Phenolic compounds from plants as nitric oxide production inhibitors. Curr Med Chem 2011; 18: 1137-1145.
3. Bright-Gbebry M, Makambi KH, Rohan JP, Llanos AA, Rosenberg L, Palmer JR and Adams-Campbell LL. Use of multivitamins, folic acid and herbal supplements among breast cancer survivors: the black women's health study. BMC Complement Altern Med 2011; 11: 30.
4. Spazzapan S, Crivellari D, Bedard P, Lombardi D, Miolo G, Scalone S and Veronesi A. Therapeutic management of breast cancer in the elderly. Expert Opin Pharmacother 2011; 12: 945-960.
5. Guzman-Villanueva D, El-Sherbiny IM, Herrera-Ruiz D and Smyth HD. Design and in vitro evaluation of a new nano-microparticulate system for enhanced aqueous-phase solubility of curcumin. Biomed Res Int 2013; 2013: 724763.
6. Xu P, Yao Y, Guo P, Wang T, Yang B and Zhang Z. Curcumin protects rat heart mitochondria against anoxia-reoxygenation induced oxidative injury. Can J Physiol Pharmacol 2013; 91: 715-723.
7. Chen CC, Sureshbabul M, Chen HW, Lin YS, Lee JY, Hong QS, Yang YC and Yu SL. Curcumin Suppresses Metastasis via Sp-1, FAK Inhibition, and E-Cadherin Upregulation in Colorectal Cancer. Evid Based Complement Alternat Med 2013; 2013: 541695.
8. Chang Z, Xing J and Yu X. Curcumin induces osteosarcoma MG63 cells apoptosis via ROS/Cyto-C/Caspase-3 pathway. Tumour Biol 2014; 35: 753-758.
9. Temraz S, Mukherji D and Shamseddine A. Potential targets for colorectal cancer prevention. Int J Mol Sci 2013; 14: 17279-17303.
10. Shehzad A, Lee J and Lee YS. Curcumin in various cancers. Biofactors 2013; 39: 56-68.
11. Heath RM, Jayne DG, O'Leary R, Morrison EE and Guillou PJ. Tumour-induced apoptosis in human mesothelial cells: a mechanism of peritoneal invasion by Fas Ligand/Fas interaction. Br J Cancer 2004; 90: 1437-1442.
12. Leard LE and Broaddus VC. Mesothelial cell proliferation and apoptosis. Respirology 2004; 9: 292-299.
13. Amundson SA, Myers TG and Fornace AJ. Roles for p53 in growth arrest and apoptosis: putting on the brakes after genotoxic stress. Oncogene 1998; 17: 3287-3299.
14. Narasimhan SR, Yang L, Gerwin BI and Broaddus VC. Resistance of pleural mesothelioma cell lines to apoptosis: relation to expression of Bcl-2 and Bax. Am J Physiol 1998; 275: L165-L171.
15. Fang CC, Yen CJ, Tsai TJ, Chen RH, Lee PH and Tomino Y. Antibiotics induce apoptosis of human peritoneal mesothelial cells. Nephrology (Carlton) 2003; 8: 142-149.