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European League Against Rheumatism recommendations for the management of psoriatic arthritis with pharmacological therapies
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Gossec L, Smolen JS, Gaujoux-Viala C, et al. European League Against Rheumatism recommendations for the management of psoriatic arthritis with pharmacological therapies. Ann Rheum Dis. 2012;71(1):4-12.
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A systematic literature review of drug therapies for the treatment of psoriatic arthritis: Current evidence and meta-analysis informing the EULAR recommendations for the management of psoriatic arthritis
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Ash Z, Gaujoux-Viala C, Gossec L, et al. A systematic literature review of drug therapies for the treatment of psoriatic arthritis: current evidence and meta-analysis informing the EULAR recommendations for the management of psoriatic arthritis. Ann Rheum Dis. 2012;71(3):319-26.
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Ash, Z.1
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84859073115
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Anti-interleukin-17 monoclonal antibody ixekizumab in chronic plaque psoriasis
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Leonardi C, Matheson R, Zachariae C, et al. Anti-interleukin-17 monoclonal antibody ixekizumab in chronic plaque psoriasis. N Engl J Med. 2012;366(13):1190-9.
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Leonardi, C.1
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Brodalumab, an anti-interleukin-17-receptor antibody for psoriasis
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Papp KA, Leonardi C, Menter A, et al. Brodalumab, an anti-interleukin-17- receptor antibody for psoriasis. N Engl J Med. 2012;366(13):1181-9.
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Effects of AIN457, a fully human antibody to interleukin-17A, on psoriasis, rheumatoid arthritis, and uveitis
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Hueber W, Patel DD, Dryja T, et al. Effects of AIN457, a fully human antibody to interleukin-17A, on psoriasis, rheumatoid arthritis, and uveitis. Sci Transl Med. 2010;2(52):52ra72.
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Hueber, W.1
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Efficacy and safety of secukinumab in the treatment of moderate-to-severe plaque psoriasis: A randomized, double-blind, placebo-controlled phase II dose-ranging study
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Papp KA, Langley RG, Sigurgeirsson B, et al. Efficacy and safety of secukinumab in the treatment of moderate-to-severe plaque psoriasis: a randomized, double-blind, placebo-controlled phase II dose-ranging study. Br J Dermatol. 2013;168(2):412-21.
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Papp, K.A.1
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Secukinumab induction and maintenance therapy in moderate-to-severe plaque psoriasis: A randomized, double-blind, placebo-controlled, phase II regimen-finding study
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Rich P, Sigurgeirsson B, Thaci D, et al. Secukinumab induction and maintenance therapy in moderate-to-severe plaque psoriasis: a randomized, double-blind, placebo-controlled, phase II regimen-finding study. Br J Dermatol. 2013;168(2):402-11.
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Rich, P.1
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Abatacept in the treatment of patients with psoriatic arthritis: Results of a six-month, multicenter, randomized, double-blind, placebo-controlled, phase II trial
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Mease P, Genovese MC, Gladstein G, et al. Abatacept in the treatment of patients with psoriatic arthritis: results of a six-month, multicenter, randomized, double-blind, placebo-controlled, phase II trial. Arthritis Rheum. 2011;63(4):939-48.
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Mease, P.1
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Biochemistry and physiology of cyclic nucleotide phosphodiesterases: Essential components in cyclic nucleotide signaling
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Conti M, Beavo J. Biochemistry and physiology of cyclic nucleotide phosphodiesterases: essential components in cyclic nucleotide signaling. Annu Rev Biochem. 2007;76:481-511.
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Conti, M.1
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12
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Apremilast mechanism of action and application to psoriasis and psoriatic arthritis
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A good article providing a thorough description of mechanism of action of PDE4 inhibitor apremilast
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• Schafer P. Apremilast mechanism of action and application to psoriasis and psoriatic arthritis. Biochem Pharmacol. 2012;83(12):1583-90. A good article providing a thorough description of mechanism of action of PDE4 inhibitor apremilast.
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Schafer, P.1
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Keynote review: Phosphodiesterase-4 as a therapeutic target
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DOI 10.1016/S1359-6446(05)03622-6, PII S1359644605036226
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Houslay MD, Schafer P, Zhang KY. Keynote review: phosphodiesterase-4 as a therapeutic target. Drug Discov Today. 2005;10(22):1503-19. (Pubitemid 41527193)
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Drug Discovery Today
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Houslay, M.D.1
Schafer, P.2
Zhang, K.Y.J.3
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14
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Apremilast, a cAMP phosphodiesterase-4 inhibitor, demonstrates anti-inflammatory activity in vitro and in a model of psoriasis
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Schafer PH, Parton A, Gandhi AK, et al. Apremilast, a cAMP phosphodiesterase-4 inhibitor, demonstrates anti-inflammatory activity in vitro and in a model of psoriasis. Br J Pharmacol. 2010;159(4):842-55.
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Schafer, P.H.1
Parton, A.2
Gandhi, A.K.3
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15
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Apremilast, a novel PDE4 inhibitor, inhibits spontaneous production of tumour necrosis factor-alpha from human rheumatoid synovial cells and ameliorates experimental arthritis
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McCann FE, Palfreeman AC, Andrews M, et al. Apremilast, a novel PDE4 inhibitor, inhibits spontaneous production of tumour necrosis factor-alpha from human rheumatoid synovial cells and ameliorates experimental arthritis. Arthritis Res Ther. 2010;12(3):R107.
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McCann, F.E.1
Palfreeman, A.C.2
Andrews, M.3
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16
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Efficacy of apremilast in the treatment of moderate to severe psoriasis: A randomised controlled trial
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Papp K, Cather JC, Rosoph L, et al. Efficacy of apremilast in the treatment of moderate to severe psoriasis: a randomised controlled trial. Lancet. 2012;380(9843):738-46.
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Papp, K.1
Cather, J.C.2
Rosoph, L.3
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17
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84874110064
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Efficacy and safety of apremilast in subjects with moderate to severe plaque psoriasis: Results from a phase II, multicenter, randomized, double-blind, placebo-controlled, parallel-group, dosecomparison study
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Papp KA, Kaufmann R, Thaci D, Hu C, Sutherland D, Rohane P. Efficacy and safety of apremilast in subjects with moderate to severe plaque psoriasis: results from a phase II, multicenter, randomized, double-blind, placebo-controlled, parallel-group, dosecomparison study. J Eur Acad Dermatol Venereol. 2013;27(3):e376-83.
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J Eur Acad Dermatol Venereol
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Papp, K.A.1
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18
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84869014252
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Oral apremilast in the treatment of active psoriatic arthritis: Results of a multicenter, randomized, double-blind, placebo-controlled study
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Important article describing a phase II study showing efficacy of apremilast in joint symptoms in patients with PsA
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• Schett G, Wollenhaupt J, Papp K, et al. Oral apremilast in the treatment of active psoriatic arthritis: results of a multicenter, randomized, double-blind, placebo-controlled study. Arthritis Rheum. 2012;64(10):3156-67. Important article describing a phase II study showing efficacy of apremilast in joint symptoms in patients with PsA.
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Arthritis Rheum
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Schett, G.1
Wollenhaupt, J.2
Papp, K.3
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19
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84879984872
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Patient-reported health-related quality of life with apremilast for psoriatic arthritis: A phase II, randomized, controlled study
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Strand V, Schett G, Hu C, et al. Patient-reported health-related quality of life with apremilast for psoriatic arthritis: a phase II, randomized, controlled study. J Rheumatol. 2013;40(7):1158-65.
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J Rheumatol
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Strand, V.1
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Hu, C.3
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20
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84899981396
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Treatment of psoriatic arthritis in a phase 3 randomised, placebo-controlled trial with apremilast, an oral phosphodiesterase 4 inhibitor
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Important article describing a phase III study on apremilast in 504 patients with PsA. Apremilast demonstrated efficacy in improving skin and joint symptoms, as well as enthesitis and dactylitis
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•• Kavanaugh A, Mease PJ, Gomez-Reino JJ, et al. Treatment of psoriatic arthritis in a phase 3 randomised, placebo-controlled trial with apremilast, an oral phosphodiesterase 4 inhibitor. Ann Rheum Dis. 2014;73:1020-6. Important article describing a phase III study on apremilast in 504 patients with PsA. Apremilast demonstrated efficacy in improving skin and joint symptoms, as well as enthesitis and dactylitis.
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Ann Rheum Dis
, vol.73
, pp. 1020-1026
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Kavanaugh, A.1
Mease, P.J.2
Gomez-Reino, J.J.3
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21
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84901833481
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Long-term (52-week) results of a Phase 3, randomized, controlled trial of apremilast, an oral phosphodiesterase 4 inhibitor, in patients with psoriatic arthritis (PALACE 2)
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abstract This abstract describes efficacy of a apremilast in improving joint symptoms, the Health assessment questionnaire disability index, Medical Outcomes Survey Short form-36 Physical Functioning and skin at 52 weeks of treatment in a phase III study of 484 patients with PsA
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Cutolo M, Myerson GE, Fleischmann RM, et al. Long-term (52-week) results of a Phase 3, randomized, controlled trial of apremilast, an oral phosphodiesterase 4 inhibitor, in patients with psoriatic arthritis (PALACE 2) [abstract]. Arthritis Rheum. 2013;65(Suppl):S346. This abstract describes efficacy of a apremilast in improving joint symptoms, the Health assessment questionnaire disability index, Medical Outcomes Survey Short form-36 Physical Functioning and skin at 52 weeks of treatment in a phase III study of 484 patients with PsA.
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(2013)
Arthritis Rheum
, vol.65
, Issue.SUPPL.
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Cutolo, M.1
Myerson, G.E.2
Fleischmann, R.M.3
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22
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84901833481
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Long-term (52-week) results of a Phase 3, randomized, controlled trial of apremilast, an oral phosphodiesterase 4 inhibitor, in patients with psoriatic arthritis and current skin involvement (PALACE 3)
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abstract
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Edwards CJ, Blanco FJ, Crowley J, et al. Long-term (52-week) results of a Phase 3, randomized, controlled trial of apremilast, an oral phosphodiesterase 4 inhibitor, in patients with psoriatic arthritis and current skin involvement (PALACE 3) [abstract]. Arthritis Rheum. 2013;65(Suppl):S132.
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(2013)
Arthritis Rheum
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Edwards, C.J.1
Blanco, F.J.2
Crowley, J.3
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23
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84896137044
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Apremilast, an oral phosphodiesterase 4 inhibitor, is associated with long-term (52-week) improvements in enthesitis and dactylitis in patients with psoriatic arthritis: Pooled results from three Phase 3, randomized, controlled trials
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abstract This article provides a description of the efficacy of apremilast in improving dactylitis and enthesitis in PsA patients in three phase III studies
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•• Gladman DD, Mease PJ, Kavanaugh A, et al. Apremilast, an oral phosphodiesterase 4 inhibitor, is associated with long-term (52-week) improvements in enthesitis and dactylitis in patients with psoriatic arthritis: pooled results from three Phase 3, randomized, controlled trials [abstract]. Arthritis Rheum. 2013;65(Suppl):S347. This article provides a description of the efficacy of apremilast in improving dactylitis and enthesitis in PsA patients in three phase III studies.
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(2013)
Arthritis Rheum
, vol.65
, Issue.SUPPL.
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Gladman, D.D.1
Mease, P.J.2
Kavanaugh, A.3
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24
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84901841741
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Long-term safety and tolerability of apremilast, an oral phospho- diesterase 4 inhibitor, in patients with psoriatic arthritis: Pooled safety analysis of three Phase 3, randomized, controlled trials
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abstract This article provides a describtion of adverse events of apremilast from three phase III studies
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• Mease PJ, Kavanaugh A, Gladman DD, et al. Long-term safety and tolerability of apremilast, an oral phospho- diesterase 4 inhibitor, in patients with psoriatic arthritis: pooled safety analysis of three Phase 3, randomized, controlled trials [abstract]. Arthritis Rheum. 2013;65(Suppl):S131. This article provides a describtion of adverse events of apremilast from three phase III studies.
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(2013)
Arthritis Rheum
, vol.65
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Mease, P.J.1
Kavanaugh, A.2
Gladman, D.D.3
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25
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84901824985
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Laboratory abnormalities in patients with psoriatic arthritis receiving apremilast, an oral phosphodiesterase 4 inhibitor: Pooled safety analysis of three Phase 3, randomized, controlled trials
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abstract
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Mease PJ, Kavanaugh A, Adebajo AO, et al. Laboratory abnormalities in patients with psoriatic arthritis receiving apremilast, an oral phosphodiesterase 4 inhibitor: pooled safety analysis of three Phase 3, randomized, controlled trials [abstract]. Arthritis Rheum. 2013;65(Suppl):S151.
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Arthritis Rheum
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Mease, P.J.1
Kavanaugh, A.2
Adebajo, A.O.3
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26
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84864994569
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Jakinibs: A new class of kinase inhibitors in cancer and autoimmune disease
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This article describes the mechanism of action of JAK inhibitors
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• Kontzias A, Kotlyar A, Laurence A, Changelian P, O'Shea JJ. Jakinibs: a new class of kinase inhibitors in cancer and autoimmune disease. Curr Opin Pharmacol. 2012;12(4):464-70. This article describes the mechanism of action of JAK inhibitors.
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Curr Opin Pharmacol
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Kontzias, A.1
Kotlyar, A.2
Laurence, A.3
Changelian, P.4
O'Shea, J.J.5
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27
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84898990827
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Molecular pathways: Molecular basis for sensitivity and resistance to JAK kinase inhibitors
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Meyer SC, Levine RL. Molecular pathways: molecular basis for sensitivity and resistance to JAK kinase inhibitors. Clin Cancer Res. 2014;20:2051-9.
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Clin Cancer Res
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Meyer, S.C.1
Levine, R.L.2
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28
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84865592373
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Efficacy and safety of tofacitinib, an oral Janus kinase inhibitor, in the treatment of psoriasis: A Phase 2b randomized placebo-controlled dose-ranging study
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This study describes the efficacy of JAK inhibitor tofacitinib in improving skin symptoms in a phase II study in patients with psoriasis
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• Papp KA, Menter A, Strober B, et al. Efficacy and safety of tofacitinib, an oral Janus kinase inhibitor, in the treatment of psoriasis: a Phase 2b randomized placebo-controlled dose-ranging study. Br J Dermatol. 2012;167(3):668-77. This study describes the efficacy of JAK inhibitor tofacitinib in improving skin symptoms in a phase II study in patients with psoriasis.
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(2012)
Br J Dermatol
, vol.167
, Issue.3
, pp. 668-677
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Papp, K.A.1
Menter, A.2
Strober, B.3
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29
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84892605793
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Tofacitinib (CP-690,550), an oral Janus kinase inhibitor, improves patient-reported outcomes in a phase 2b, randomized, double-blind, placebo-controlled study in patients with moderate-to-severe psoriasis
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doi:10.1111/jdv.12081. This article describes the efficacy of JAK inhibitor tofacitinib in improving patient-reported outcomes in phase II study in patients with psoriasis
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• Mamolo C, Harness J, Tan H, et al. Tofacitinib (CP-690,550), an oral Janus kinase inhibitor, improves patient-reported outcomes in a phase 2b, randomized, double-blind, placebo-controlled study in patients with moderate-to-severe psoriasis. J Eur Acad Dermatol Venereol. 2013.doi:10.1111/ jdv.12081. This article describes the efficacy of JAK inhibitor tofacitinib in improving patient-reported outcomes in phase II study in patients with psoriasis.
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(2013)
J Eur Acad Dermatol Venereol
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Mamolo, C.1
Harness, J.2
Tan, H.3
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30
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84873707288
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Tofacitinib (CP-690,550) in combination with methotrexate in patients with active rheumatoid arthritis with an inadequate response to tumour necrosis factor inhibitors: A randomised phase 3 trial
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Burmester GR, Blanco R, Charles-Schoeman C, et al. Tofacitinib (CP-690,550) in combination with methotrexate in patients with active rheumatoid arthritis with an inadequate response to tumour necrosis factor inhibitors: a randomised phase 3 trial. Lancet. 2013;381(9865):451-60.
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Lancet
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Burmester, G.R.1
Blanco, R.2
Charles-Schoeman, C.3
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31
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84874402383
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Tofacitinib (CP-690,550) in patients with rheumatoid arthritis receiving methotrexate: Twelve-month data from a twenty-four-month phase III randomized radiographic study
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van der Heijde D, Tanaka Y, Fleischmann R, et al. Tofacitinib (CP-690,550) in patients with rheumatoid arthritis receiving methotrexate: twelve-month data from a twenty-four-month phase III randomized radiographic study. Arthritis Rheum. 2013;65(3):559-70.
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(2013)
Arthritis Rheum
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Van Der Heijde, D.1
Tanaka, Y.2
Fleischmann, R.3
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32
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84882266430
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Tofacitinib in combination with nonbiologic disease-modifying antirheumatic drugs in patients with active rheumatoid arthritis: A randomized trial
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Kremer J, Li ZG, Hall S, et al. Tofacitinib in combination with nonbiologic disease-modifying antirheumatic drugs in patients with active rheumatoid arthritis: a randomized trial. Ann Intern Med. 2013;159(4):253-61.
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Ann Intern Med
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Kremer, J.1
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33
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84893738246
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Efficacy of conventional synthetic disease-modifying antirheumatic drugs, glucocorticoids and tofacitinib: A systematic literature review informing the 2013 update of the EULAR recommendations for management of rheumatoid arthritis
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A good review of adverse events of tofacitinib in RA patients
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• Gaujoux-Viala C, Nam J, Ramiro S, et al. Efficacy of conventional synthetic disease-modifying antirheumatic drugs, glucocorticoids and tofacitinib: a systematic literature review informing the 2013 update of the EULAR recommendations for management of rheumatoid arthritis. Ann Rheum Dis. 2014;73(3):510-5. A good review of adverse events of tofacitinib in RA patients.
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(2014)
Ann Rheum Dis
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, pp. 510-515
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Gaujoux-Viala, C.1
Nam, J.2
Ramiro, S.3
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34
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84901248425
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Kinase inhibitors: The next generation of therapies in the treatment of rheumatoid arthritis
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Macfarlane LA, Todd DJ. Kinase inhibitors: the next generation of therapies in the treatment of rheumatoid arthritis. Int J Rheum Dis. 2014;17(4):359-68.
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Int J Rheum Dis
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Macfarlane, L.A.1
Todd, D.J.2
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EULAR recommendations for the management of rheumatoid arthritis with synthetic and biological disease-modifying antirheumatic drugs: 2013 update
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Smolen JS, Landewe R, Breedveld FC, et al. EULAR recommendations for the management of rheumatoid arthritis with synthetic and biological disease-modifying antirheumatic drugs: 2013 update. Ann Rheum Dis. 2014;73(3):492-509.
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Ann Rheum Dis
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Smolen, J.S.1
Landewe, R.2
Breedveld, F.C.3
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36
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84879988459
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A randomized phase 2a efficacy and safety trial of the topical Janus kinase inhibitor tofacitinib in the treatment of chronic plaque psoriasis
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Ports WC, Khan S, Lan S, et al. A randomized phase 2a efficacy and safety trial of the topical Janus kinase inhibitor tofacitinib in the treatment of chronic plaque psoriasis. Br J Dermatol. 2013;169(1):137-45.
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Br J Dermatol
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Ports, W.C.1
Khan, S.2
Lan, S.3
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37
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84904688087
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A Phase 2b trial of baricitinib, an oral JAK inhibitor, in patients with moderate-to-severe psoriasis
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abstract
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Menter A, Papp K, Janes J, et al. A Phase 2b trial of baricitinib, an oral JAK inhibitor, in patients with moderate-to-severe psoriasis [abstract]. J Am Acad Dermatol. 2014;70(5):AB162.
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J Am Acad Dermatol
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Menter, A.1
Papp, K.2
Janes, J.3
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39
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51349152055
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The PKC inhibitor AEB071 may be a therapeutic option for psoriasis
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Skvara H, Dawid M, Kleyn E, et al. The PKC inhibitor AEB071 may be a therapeutic option for psoriasis. J Clin Invest. 2008;118(9):3151-9.
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Skvara, H.1
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