Synthesis and σ receptor affinity of regioisomeric spirocyclic furopyridines

European Journal of Medicinal Chemistry

Volumn 83, Issue , 2014, Pages 709-716

  Miyata, Kengo ^a,b   Schepmann, Dirk ^a   Wünsch, Bernhard ^a  

^a UNIVERSITY OF MÜNSTER   (Germany)

^b NAGOYA UNIVERSITY   (Japan)

Author keywords

Furopyridines; Regioisomers; Spirocyclic piperidines; Structure affinity relationships

Indexed keywords

1' BENZYL 1 METHOXY 7H SPIRO[FURO[3,4 B]PYRIDINE 3,4' PIPERIDINE]; 1' BENZYL 3 METHOXY 7H SPIRO[FURO[3,4 B]PYRIDINE 1,4' PIPERIDINE]; 1' BENZYL 5 METHOXY 7H SPIRO[FURO[3,4 B]PYRIDINE 7,4' PIPERIDINE]; 1' BENZYL 7 METHOXY 7H SPIRO[FURO[3,4 B]PYRIDINE 5,4' PIPERIDINE]; BENZENE; FUROPYRIDINE DERIVATIVE; HALOPERIDOL; PENTAZOCINE; PYRIDINE DERIVATIVE; RADIOLIGAND; SIGMA 1 OPIATE RECEPTOR; SIGMA 2 OPIATE RECEPTOR; UNCLASSIFIED DRUG; PROTEIN BINDING; SIGMA OPIATE RECEPTOR; SPIRO COMPOUND; 1' BENZYL 1 METHOXY 1H SPIRO(FURO[3,4 C]PYRIDINE 3,4' PIPERIDINE); 1' BENZYL 3 METHOXY 3H SPIRO(FURO[3,4 C]PYRIDINE 1,4' PIPERIDINE); 1' BENZYL 5 METHOXY 5H SPIRO(FURO[3,4 B]PYRIDINE 7,4' PIPERIDINE); 1' BENZYL 7 METHOXY 7H SPIRO(FURO[3,4 B]PYRIDINE 5,4' PIPERIDINE); 2 BROMO 3 (DIBROMOMETHYL)PYRIDINE; 2 BROMOPYRIDINE 3 CARBALDEHYDE; 2 BROMOPYRIDINE 3 CARBALDEHYDE DIMETHYL ACETAL; 3 (1 BENZYL 4 HYDROXYPIPERIDIN 4 YL)PYRIDINE 4 CARBALDEHYDE DIMETHYL ACETAL; 3 BROMO 2 (DIBROMOMETHYL)PYRIDINE; 3 BROMOPYRIDINE 2 CARBALDEHYDE; 3 BROMOPYRIDINE 2 CARBALDEHYDE DIMETHYL ACETAL; 3 BROMOPYRIDINE 4 CARBALDEHYDE; 3 BROMOPYRIDINE 4 CARBALDEHYDE DIMETHYL ACETAL; 4 BROMOPYRIDINE 3 CARBALDEHYDE; 4 BROMOPYRIDINE 3 CARBALDEHYDE DIMETHYL ACETAL; ACETAL DERIVATIVE; BROMINE; DI O TOLYGUANIDINE; GUANIDINE DERIVATIVE; LITHIUM; OPIATE ANTAGONIST; SIGMA RECEPTOR LIGAND;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CARBON NUCLEAR MAGNETIC RESONANCE; CYCLIZATION; DRUG RECEPTOR BINDING; DRUG SYNTHESIS; ELECTRON; GUINEA PIG; HYDROGEN BOND; NONHUMAN; PROTON NUCLEAR MAGNETIC RESONANCE; ANIMAL; CHEMISTRY; METABOLISM; RAT; STEREOISOMERISM; STRUCTURE ACTIVITY RELATION; SYNTHESIS; ACETALIZATION; BRAIN HOMOGENATE; BROMINATION; CONTROLLED STUDY; DRUG OXIDATION; HUMAN; ISOMER; LIVER HOMOGENATE; MOLECULAR INTERACTION; RECEPTOR AFFINITY; RECEPTOR BINDING ASSAY;

ANIMALS; CHEMISTRY TECHNIQUES, SYNTHETIC; CYCLIZATION; GUINEA PIGS; HYDROGEN BONDING; PROTEIN BINDING; PYRIDINES; RATS; RECEPTORS, SIGMA; SPIRO COMPOUNDS; STEREOISOMERISM; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 84904195688     PISSN: 02235234     EISSN: 17683254     Source Type: Journal    
DOI: 10.1016/j.ejmech.2014.06.073     Document Type: Article

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