The σ1 receptor antagonist S1RA is a promising candidate for the treatment of neurogenic pain

Journal of Medicinal Chemistry

Volumn 55, Issue 19, 2012, Pages 8209-8210

  Wünsch, Bernhard ^a  

^a UNIVERSITY OF MÜNSTER   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

OPIATE ANTAGONIST; PREGABALIN; S1RA; SIGMA OPIATE RECEPTOR; SIGMA1 RECEPTOR; UNCLASSIFIED DRUG;

DRUG STRUCTURE; NEUROPATHIC PAIN; NONHUMAN; NOTE;

ANIMALS; FEMALE; HUMANS; MALE; MORPHOLINES; PYRAZOLES; RECEPTORS, SIGMA;

EID: 84867340616     PISSN: 00222623     EISSN: 15204804     Source Type: Journal    
DOI: 10.1021/jm3011993     Document Type: Note

References (4)

1. 1 Receptor Antagonists: Identification of 4-{2-[5-Methyl-1- (naphthalen-2-yl)-1 H -pyrazol-3-yloxy]ethyl}morpholine (S1RA, E-52862). J. Med. Chem. 2012, DOI: 10.1021/jm3007323.
2. 1 Receptor Curr. Pharm. Des. 2012, 18, 930-937
3. 1 Receptor ACS Med. Chem. Lett. 2011, 2, 834-839
4. Entrena, J. M.; Cobos, E. J.; Nieto, F. R.; Cendan, C. M.; Gris, G.; Del Pozo, E.; Zamanillo, D.; Baeyens, M. Sigma-1 Receptors Are Essential for Capsaicin Induced Mechanical Hypersensitivity: Studies with Selective Sigma-1 Ligands and Sigma-1 Knockout Mice Pain 2009, 143, 252-261