Genetically predicted 17β-estradiol and systemic inflammation in women: A separate-sample Mendelian randomisation analysis in the Guangzhou Biobank cohort study

Journal of Epidemiology and Community Health

Volumn 68, Issue 8, 2014, Pages 780-785

  Zhao, J ^a   Jiang, C Q ^b   Lam, T H ^a   Liu, B ^b   Cheng, K K ^c   Kavikondala, S ^a   Zhang, W S ^b   Leung, G M ^a   Schooling, C M ^a,d  

^a UNIVERSITY OF HONG KONG   (Hong Kong)

^b Guangzhou Number 12 Hospital   (China)

^c UNIVERSITY OF BIRMINGHAM   (United Kingdom)

^d CITY UNIVERSITY OF NEW YORK   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

COHORT ANALYSIS; EPIDEMIOLOGY; GENETIC MARKER; IMMUNE RESPONSE; SAMPLING; WOMENS HEALTH;

CHINA; GUANGDONG; GUANGZHOU;

ANIMALIA;

BIOLOGICAL MARKER; ESTRADIOL;

AGED; BLOOD; CONFIDENCE INTERVAL; FEMALE; GENETICS; GRANULOCYTE; HONG KONG; HUMAN; IMMUNOLOGY; INFLAMMATION; LEUKOCYTE COUNT; MENDELIAN RANDOMIZATION ANALYSIS; MIDDLE AGED; VERY ELDERLY;

AGED; AGED, 80 AND OVER; BIOLOGICAL MARKERS; CONFIDENCE INTERVALS; ESTRADIOL; FEMALE; GRANULOCYTES; HONG KONG; HUMANS; INFLAMMATION; LEUKOCYTE COUNT; MENDELIAN RANDOMIZATION ANALYSIS; MIDDLE AGED;

EID: 84904185092     PISSN: 0143005X     EISSN: 14702738     Source Type: Journal    
DOI: 10.1136/jech-2013-203451     Document Type: Article

References (52)

1. Tabas I, Glass CK. Anti-inflammatory therapy in chronic disease: challenges and opportunities. Science 2013;339:166-72.
2. Ansar Ahmed S, Penhale WJ, Talal N. Sex hormones, immune responses, and autoimmune diseases. Mechanisms of sex hormone action. Am J Pathol 1985;121:531-51.
3. Marriott I, Huet-Hudson YM. Sexual dimorphism in innate immune responses to infectious organisms. Immunol Res 2006;34:177-92.
4. Nadkarni S, Cooper D, Brancaleone V, et al. Activation of the annexin A1 pathway underlies the protective effects exerted by estrogen in polymorphonuclear leukocytes. Arterioscler Thromb Vasc Biol 2011;31:2749-59.
5. Abu-Taha M, Rius C, Hermenegildo C, et al. Menopause and ovariectomy cause a low grade of systemic inflammation that may be prevented by chronic treatment with low doses of estrogen or losartan. J Immunol 2009;183:1393-402.
6. Hughes EL, Cover PO, Buckingham JC, et al. Role and interactions of annexin A1 and oestrogens in the manifestation of sexual dimorphisms in cerebral and systemic inflammation. Br J Pharmacol 2013;169:539-53.
7. Molero L, Garcia-Duran M, Diaz-Recasens J, et al. Expression of estrogen receptor subtypes and neuronal nitric oxide synthase in neutrophils from women and men: regulation by estrogen. Cardiovasc Res 2002;56:43-51.
8. Cunningham M, Gilkeson G. Estrogen receptors in immunity and autoimmunity. Clin Rev Allergy Immunol 2011;40:66-73.
9. Fahlman MM, Boardley D, Flynn MG, et al. Effects of hormone replacement therapy on selected indices of immune function in postmenopausal women. Gynecol Obstet Invest 2000;50:189-93.
10. Bergstrom H, Tonstad S. Combined hormone replacement therapy improves lipids but may increase leucocytes. J Intern Med 2006;259:537-8.
11. Meng YX, Jiang HY, Chen AJ, et al. Hemostatic changes in women using a monthly injectable contraceptive for one year. Contraception 1990;42:455-66.
12. Ben-Hur H, Mor G, Insler V, et al. Menopause is associated with a significant increase in blood monocyte number and a relative decrease in the expression of estrogen receptors in human peripheral monocytes. Am J Reprod Immunol 1995;34:363-9.
13. Frohlich M, Muhlberger N, Hanke H, et al. Markers of inflammation in women on different hormone replacement therapies. Ann Med 2003;35:353-61.
14. Folsom AR, Golden SH, Boland LL, et al. Association of endogenous hormones with C-reactive protein, fibrinogen, and white blood count in post-menopausal women. Eur J Epidemiol 2005;20:1015-22.
15. Rossouw JE, Anderson GL, Prentice RL, et al. Risks and benefits of estrogen plus progestin in healthy postmenopausal women: principal results From the Women's Health Initiative randomized controlled trial. JAMA 2002;288:321-33.
16. Straub RH. The complex role of estrogens in inflammation. Endocr Rev 2007;28:521-74.
17. Jiang C, Thomas GN, Lam TH, et al. Cohort profile: the Guangzhou Biobank Cohort Study, a Guangzhou-Hong Kong-Birmingham collaboration. Int J Epidemiol 2006;35:844-52.
18. Tsang S. A modern history of Hong Kong. Hong Kong: Hong Kong University Press, 2004, xi, 340.
19. Au Yeung SL, Jiang CQ, Cheng KK, et al. Evaluation of moderate alcohol use and cognitive function among men using a Mendelian randomization design in the Guangzhou biobank cohort study. Am J Epidemiol 2012;175:1021-8.
20. Breast and Prostate Cancer Cohort Consortium, Cox DG, Bretsky P, et al. Haplotypes of the estrogen receptor beta gene and breast cancer risk. Int J Cancer 2008;122:387-92.
21. Lundin E, Wirgin I, Lukanova A, et al. Selected polymorphisms in sex hormone-related genes, circulating sex hormones and risk of endometrial cancer. Cancer Epidemiol 2012;36:445-52.
22. Udler MS, Azzato EM, Healey CS, et al. Common germline polymorphisms in COMT, CYP19A1, ESR1, PGR, SULT1E1 and STS and survival after a diagnosis of breast cancer. Int J Cancer 2009;125:2687-96.
23. Talbott KE, Gammon MD, Kibriya MG, et al. A CYP19 (aromatase) polymorphism is associated with increased premenopausal breast cancer risk. Breast Cancer Res Treat 2008;111:481-7.
24. National Center for Biotechnology Information, US National Library of Medicine. NCBI Single Nucleotide Polymorphism database. http://www.ncbi.nlm.nih.gov/snp (accessed 10 Dec 2013).
25. Burgess S, Thompson SG, Collaboration CCG. Avoiding bias from weak instruments in Mendelian randomization studies. Int J Epidemiol 2011;40:755-64.
26. Naessen T, Bergquist J, Lind L, et al. Higher endogenous estrogen levels in 70-year-old women and men: an endogenous response to counteract developing atherosclerosis? Menopause 2012;19:1322-8.
27. Ovesen L. Adolescence: a critical period for long-term tracking of risk for coronary heart disease? Ann Nutr Metab 2006;50:317-24.
28. Kadlubar FF, Berkowitz GS, Delongchamp RR, et al. The CYP3A4*1B variant is related to the onset of puberty, a known risk factor for the development of breast cancer. Cancer Epidemiol Biomarkers Prev 2003;12:327-31.
29. MacMahon B, Cole P, Brown JB, et al. Urine oestrogen profiles of Asian and North American women. Int J Cancer 1974;14:161-7.
30. Sheehan NA, Didelez V, Burton PR, et al. Mendelian randomisation and causal inference in observational epidemiology. PLoS Med 2008;5:e177.
31. Cutolo M, Sulli A, Capellino S, et al. Sex hormones influence on the immune system: basic and clinical aspects in autoimmunity. Lupus 2004;13:635-8.
32. Mundy GR. Osteoporosis and inflammation. Nutr Rev 2007;65(12 Pt 2):S147-51.
33. Xia X, Zhang S, Yu Y, et al. Effects of estrogen replacement therapy on estrogen receptor expression and immunoregulatory cytokine secretion in surgically induced menopausal women. J Reprod Immunol 2009;81:89-96.
34. Jain SK, Kannan K, Prouty L, et al. Progesterone, but not 17beta-estradiol, increases TNF-alpha secretion in U937 monocytes. Cytokine 2004;26:102-5.
35. Hou L, Lloyd-Jones DM, Ning H, et al. White blood cell count in young adulthood and coronary artery calcification in early middle age: coronary artery risk development in young adults (CARDIA) study. Eur J Epidemiol 2013;28:735-42.
36. Danesh J, Collins R, Appleby P, et al. Association of fibrinogen, C-reactive protein, albumin, or leukocyte count with coronary heart disease: meta-analyses of prospective studies. JAMA 1998;279:1477-82.
37. Kolaczkowska E, Kubes P. Neutrophil recruitment and function in health and inflammation. Nat Rev Immunol 2013;13:159-75.
38. Li H, Beeghly-Fadiel A, Wen W, et al. Gene-environment interactions for breast cancer risk among Chinese women: a report from the Shanghai Breast Cancer Genetics Study. Am J Epidemiol 2013;177:161-70.
39. Tchetgen Tchetgen EJ, Walter S, Glymour MM. Commentary: building an evidence base for mendelian randomization studies: assessing the validity and strength of proposed genetic instrumental variables. Int J Epidemiol 2013;42:328-31.
40. Dunning AM, Dowsett M, Healey CS, et al. Polymorphisms associated with circulating sex hormone levels in postmenopausal women. J Natl Cancer Inst 2004;96:936-45.
41. Haiman CA, Dossus L, Setiawan VW, et al. Genetic variation at the CYP19A1 locus predicts circulating estrogen levels but not breast cancer risk in postmenopausal women. Cancer Res 2007;67:1893-7.
42. Bennett DA. An introduction to instrumental variables--part 2: mendelian randomisation. Neuroepidemiology 2010;35:307-10.
43. Burgess S, Butterworth A, Thompson SG. Mendelian randomization analysis with multiple genetic variants using summarized data. Genet Epidemiol 2013;37:658-65.
44. Schuit SC, de Jong FH, Stolk L, et al. Estrogen receptor alpha gene polymorphisms are associated with estradiol levels in postmenopausal women. Eur J Endocrinol 2005;153:327-34.
45. Olson SH, Bandera EV, Orlow I. Variants in estrogen biosynthesis genes, sex steroid hormone levels, and endometrial cancer: a HuGE review. Am J Epidemiol 2007;165:235-45.
46. Freeman G, Cowling BJ, Schooling CM. Power and sample size calculations for Mendelian randomization studies using one genetic instrument. Int J Epidemiol 2013;42:1157-63.
47. Schooling CM, Au Yeung SL, Freeman G. Mendelian randomization estimates may be inflated. J Am Coll Cardiol 2013;61:1931.
48. Dai SM, Han XH, Zhao DB, et al. Prevalence of rheumatic symptoms, rheumatoid arthritis, ankylosing spondylitis, and gout in Shanghai, China: a COPCORD study. J Rheumatol 2003;30:2245-51.
49. Key TJ, Chen J, Wang DY, et al. Sex hormones in women in rural China and in Britain. Br J Cancer 1990;62:631-6.
50. Wong IO, Cowling BJ, Leung GM, et al. Trends in mortality from septicaemia and pneumonia with economic development: an age-period-cohort analysis. PLoS ONE 2012;7:e38988.
51. Ridker PM. Closing the loop on inflammation and atherothrombosis: why perform the cirt and cantos trials? Trans Am Clin Climatol Assoc 2013;124:174-90.
52. Goldfine AB, Conlin PR, Halperin F, et al. A randomised trial of salsalate for insulin resistance and cardiovascular risk factors in persons with abnormal glucose tolerance. Diabetologia 2013;56:714-23.