RASAL1 influences the proliferation and invasion of gastric cancer cells by regulating the RAS/ERK signaling pathway

Human Cell

Volumn 27, Issue 3, 2014, Pages 103-110

  Chen, Hong ^a   Cheng, Zheng Yuan ^a   Pan, Ying ^a   Wang, Zhi ^a   Liu, Yang ^a   Zhang, Jin Qi ^b  

^a SOUTHEAST UNIVERSITY   (China)

^b Department of Interventional Radiology   (China)

Author keywords

BGC 823 cells; Gastric cancer; MKN 28 cells; RASAL1

Indexed keywords

LIPOCORTIN 5; MITOGEN ACTIVATED PROTEIN KINASE 1; PLASMID VECTOR; PROPIDIUM IODIDE; RAS PROTEIN; RAS PROTEIN ACTIVATOR LIKE 1; UNCLASSIFIED DRUG; GUANOSINE TRIPHOSPHATASE ACTIVATING PROTEIN; RASAL1 PROTEIN, HUMAN;

ANIMAL CELL; APOPTOSIS; ARTICLE; CANCER CELL; CELL COUNTING; CELL DIFFERENTIATION; CELL INVASION; CELL MIGRATION; CELL PROLIFERATION; CONTROLLED STUDY; DOWN REGULATION; FLOW CYTOMETRY; GASTRIC CANCER CELL LINE; GENETIC TRANSFECTION; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; RNA INTERFERENCE; SIGNAL TRANSDUCTION; STOMACH CANCER; TUMOR INVASION; TUMOR SUPPRESSOR GENE; UPREGULATION; WESTERN BLOTTING; GENETICS; HUMAN; PATHOLOGY; PHYSIOLOGY; STOMACH TUMOR; TUMOR CELL CULTURE;

CELL PROLIFERATION; GTPASE-ACTIVATING PROTEINS; HUMANS; MAP KINASE SIGNALING SYSTEM; NEOPLASM INVASIVENESS; RAS PROTEINS; STOMACH NEOPLASMS; TUMOR CELLS, CULTURED;

EID: 84904174743     PISSN: 09147470     EISSN: 17490774     Source Type: Journal    
DOI: 10.1007/s13577-014-0090-2     Document Type: Article

References (24)

1. Brenner H, Rothenbacher D, Arndt V. Epidemiology of stomach cancer. Meth Mol Biol. 2009;472: 467-77.
2. Nardone G, Compare D. Epigenetic alterations due to diet and helicobacter pylori infection in gastric carcinogenesis. Exp Rev Gastroenterol Hepatol. 2008;2: 243-8.
3. Vogiatzi P, Vindigni C, Roviello F, Renieri A, Giordano A. Deciphering the underlying genetic and epigenetic events leading to gastric carcinogenesis. J Cell Physiol. 2007;211: 287-95.
4. Jin H, Wang X, Ying J, Wong AH, Cui Y, Srivastava G, Shen ZY, Li EM, Zhang Q, Jin J, Kupzig S, Chan AT, Cullen PJ, Tao Q. Epigenetic silencing of a Ca (2+)-regulated RAS GTPase-activating protein RASAL defines a new mechanism of RAS activation in human cancers. Proc Natl Acad Sci USA. 2007;104: 12353-8.
5. Calvisi DF, Ladu Sara, Conner EA, Seo D, Hsieh J-T, Factor VM, Snorri S. Inactivation of Ras GTPase-activating proteins promotes unrestrained activity of wild-type Ras in human liver cancer. J Hepatol. 2011;54: 311-9.
6. Bernards A, Settleman J. GAPs in growth factor signalling. Grow Fact. 2005;23: 143-9.
7. Chen H, Yang XW, Zhang H, Yang Q, Wang Z, Liu Y, Lu FL, Zhou BY, Qiu-Xi CH, Lu SL. In vivo and in vitro expression of the RASAL1 gene in human gastric adenocarcinoma and its clinicopathological significance. Oncol Lett. 2012;3: 535-40.
8. Seto M, Ohta M, Ikenoue T, Sugimoto T, Asaoka Y, Tada M, Mohri D, Kudo Y, Ijichi H, Tateishi K, Otsuka M, Hirata Y, Maeda S, Koike K, Omata M. Reduced expression of RAS protein activator like-1 in gastric cancer. Int J Cancer. 2011;128: 1293-302.
9. Schaich M, Illmei T. Mdrl gene expression and mutations in Ras proto-oncogene in acute myeloid leukemia. Leuk Lymphoma. 2002;43: 1345-54.
10. Karnoub AE, Weinberg RA. Ras oncogenes: split personalities. Nat Rev Mol Cell Biol. 2008;9: 517-31.
11. Ohuchi N, Hand PH, Merlo G, Fujita J, Mariani-Costantini R, Thor A, Nose M, Callahan R, Schlom J. Enhanced expression of c-Ha-ras p21 in the human stomach adenocarcinoma defined by immunoassays using monoclonal antibodies and in situ hybridization. Cancer Res. 1987;47: 1413-20.
12. Kimura K, Nagasaka T, Hoshizima N, Sasamoto H, Notohara K, Takeda M, Kominami K, Iishii T, Tanaka N, Matsubara N. No duplicate KRAS mutation is identified on the same allele in gastric or colorectal cancer cell with multiple KRAS mutations. J Int Med Res. 2007;35: 450-7.
13. Liu ZM, Liu LN, Li M, Zhang QP, Cheng SH, Lu S. Mutation detection of KRAS by high-resolution melting analysis in Chinese with gastric cancer. Oncol Rep. 2009;22: 515-20.
14. Okumura T, Ericksen RE, Takaishi S, Wang SS, Dubeykovskiy Z, Shibata W, Betz KS, Muthupalani S, Rogers AB, Fox JG, Rustgi AK, Wang TC. K-ras mutation targeted to gastric tissue progenitor cell results in chronic inflammation, an altered microenvironment, and progression to intraepithelial neoplasia. Cancer Res. 2010;70: 8435-45.
15. Gyorffy B, Schfer R. Biomarkers downstream of RAS: a search for robust transcriptional targets. Curr Cancer Drug Targ. 2010;10: 858-68.
16. Kong Z, Xie D, Boike T, Raghavan P, Burma S, Chen DJ, Habib AA, Chakraborty A, Hsieh JT, Saha D. Down-regulation of human DAB2IP gene expression in prostate cancer cell results in resistance to ionizing radiation. Cancer Res. 2010;70: 2829-39.
17. Vigil D, Cherfils J, Rossman KL, Der CJ. Ras superfamily GEFs and GAPs: validated and tractable targets for cancer therapy? Nat Rev Cancer. 2010;10: 842-57.
18. Bos JL, Rehmann H, Wittinghofer A. GEFs and GAPs: critical elements in the control of small G proteins. Cell. 2007;129: 865-77.
19. Iwashita S, Song SY. Ras GAPs: a crucial regulator of extracellular stimuli for homeostasis of cellular functions. Mol Bio Syst. 2008;48: 213-22.
20. Hölzel M, Huang S, Koster J, Ora I, Lakeman A, Caron H, Nijkamp W, Xie J, Callens T, Asgharzadeh S, Seeger RC, Messiaen L, Versteeg R, Bernards R. NF1 is a tumor suppressor in neuroblastoma that determines retinoic acid response and disease outcome. Cell. 2010;142: 218-29.
21. O'Neill E, Kolch W. Conferring specificity on the ubiquitous Raf/MEK signaling pathway. Br J Cancer. 2004;90: 283-8.
22. Bernards A, Settleman J. Loss of the Ras regulator RASAL1: another route to Ras activation in colorectal cancer. Gastroenterology. 2009;136: 46-8.
23. Ohta M, Seto M, Ijichi H, Miyabayashi K, Kudo Y, Mohri D, Asaoka Y, Tada M, Tanaka Y, Ikenoue T, Kanai F, Kawabe T, Omata M. Decreased expression of the ras-GTPase activating protein RASAL1 is associated with colorectal tumor progression. Gastroenterology. 2009;136: 206-16.
24. Qiao F, Su X, Qiu X, Qian D, Peng X, Chen H, Zhao Z, Fan H. Enforced expression of RASAL1 suppresses cell proliferation and the transformation ability of gastric cancer cell. Oncol Rep. 2012;28: 1475-81.