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Volumn 7, Issue 1, 2014, Pages 137-144

Targeting metastatic colorectal cancer - Present and emerging treatment options

Author keywords

Aflibercept; Bevacizumab; Biomarker; Cetuximab; Panitumumab; Regorafenib

Indexed keywords

AFLIBERCEPT; BEVACIZUMAB; BIOLOGICAL PRODUCT; CAPECITABINE; CETUXIMAB; CYTOTOXIC AGENT; EPIDERMAL GROWTH FACTOR RECEPTOR; ERLOTINIB; FLUOROURACIL; FOLINIC ACID; OXALIPLATIN; PANITUMUMAB; PLACENTAL GROWTH FACTOR; PLATELET DERIVED GROWTH FACTOR RECEPTOR; REGORAFENIB; VASCULOTROPIN; VASCULOTROPIN RECEPTOR;

EID: 84904167163     PISSN: None     EISSN: 11787066     Source Type: Journal    
DOI: 10.2147/PGPM.S47582     Document Type: Review
Times cited : (20)

References (46)
  • 2
    • 0036701049 scopus 로고    scopus 로고
    • The genetic pathogenesis of colorectal cancer
    • Lynch JP, Hoops TC. The genetic pathogenesis of colorectal cancer. Hematol Oncol Clin North Am. 2002; 16(4): 775-810.
    • (2002) Hematol Oncol Clin North Am. , vol.16 , Issue.4 , pp. 775-810
    • Lynch, J.P.1    Hoops, T.C.2
  • 3
    • 0025312728 scopus 로고
    • A genetic model for colorectal tumorigenesis
    • Fearon ER, Vogelstein B. A genetic model for colorectal tumorigenesis. Cell. 1990; 61(5): 759-767.
    • (1990) Cell. , vol.61 , Issue.5 , pp. 759-767
    • Fearon, E.R.1    Vogelstein, B.2
  • 4
    • 33745541234 scopus 로고    scopus 로고
    • CpG island methylator phenotype underlies sporadic microsatellite instability and is tightly associated with BRAF mutation in colorectal cancer
    • Weisenberger DJ, Siegmund KD, Campan M, etal. CpG island methylator phenotype underlies sporadic microsatellite instability and is tightly associated with BRAF mutation in colorectal cancer. Nat Genet. 2006; 38(7): 787-793.
    • (2006) Nat Genet. , vol.38 , Issue.7 , pp. 787-793
    • Weisenberger, D.J.1    Siegmund, K.D.2    Campan, M.3
  • 5
    • 66149095468 scopus 로고    scopus 로고
    • Serrated polyps and colorectal cancer: New pathway to malignancy
    • Noffsinger AE. Serrated polyps and colorectal cancer: new pathway to malignancy. Annu Rev Pathol. 2009; 4: 343-364.
    • (2009) Annu Rev Pathol. , vol.4 , pp. 343-364
    • Noffsinger, A.E.1
  • 7
    • 20544437157 scopus 로고    scopus 로고
    • BRAF-V600E is not involved in the colorectal tumorigenesis of HNPCC in patients with functional MLH1 and MSH2 genes
    • Domingo E, Niessen RC, Oliveira C, etal. BRAF-V600E is not involved in the colorectal tumorigenesis of HNPCC in patients with functional MLH1 and MSH2 genes. Oncogene. 2005; 24(24): 3995-3998.
    • (2005) Oncogene. , vol.24 , Issue.24 , pp. 3995-3998
    • Domingo, E.1    Niessen, R.C.2    Oliveira, C.3
  • 8
    • 63849088630 scopus 로고    scopus 로고
    • Cetuximab and chemotherapy as initial treatment for metastatic colorectal cancer
    • Van Cutsem E, Köhne CH, Hitre E, etal. Cetuximab and chemotherapy as initial treatment for metastatic colorectal cancer. N Engl J Med. 2009; 360(14): 1408-1417.
    • (2009) N Engl J Med. , vol.360 , Issue.14 , pp. 1408-1417
    • Van Cutsem, E.1    Köhne, C.H.2    Hitre, E.3
  • 9
    • 79956298812 scopus 로고    scopus 로고
    • Cetuximab plus irinotecan, fluorouracil, and leucovorin as first-line treatment for metastatic colorectal cancer: Updated analysis of overall survival according to tumor KRAS and BRAF mutation status
    • Van Cutsem E, Köhne CH, Láng I, etal. Cetuximab plus irinotecan, fluorouracil, and leucovorin as first-line treatment for metastatic colorectal cancer: updated analysis of overall survival according to tumor KRAS and BRAF mutation status. J Clin Oncol. 2011; 29(15): 2011-2019.
    • (2011) J Clin Oncol. , vol.29 , Issue.15 , pp. 2011-2019
    • Van Cutsem, E.1    Köhne, C.H.2    Láng, I.3
  • 10
    • 44249111440 scopus 로고    scopus 로고
    • EPIC: Phase III trial of cetuximab plus irinotecan after fluoropyrimidine and oxaliplatin failure in patients with metastatic colorectal cancer
    • Sobrero AF, Maurel J, Fehrenbacher L, etal. EPIC: phase III trial of cetuximab plus irinotecan after fluoropyrimidine and oxaliplatin failure in patients with metastatic colorectal cancer. J Clin Oncol. 2008; 26(14): 2311-2319.
    • (2008) J Clin Oncol. , vol.26 , Issue.14 , pp. 2311-2319
    • Sobrero, A.F.1    Maurel, J.2    Fehrenbacher, L.3
  • 11
    • 59949091448 scopus 로고    scopus 로고
    • Fluorouracil, leucovorin, and oxaliplatin with and without cetuximab in the first-line treatment of metastatic colorectal cancer
    • Bokemeyer C, Bondarenko I, Makhson A, etal. Fluorouracil, leucovorin, and oxaliplatin with and without cetuximab in the first-line treatment of metastatic colorectal cancer. J Clin Oncol. 2009; 27(5): 663-671.
    • (2009) J Clin Oncol. , vol.27 , Issue.5 , pp. 663-671
    • Bokemeyer, C.1    Bondarenko, I.2    Makhson, A.3
  • 12
    • 78149250536 scopus 로고    scopus 로고
    • Randomized, phase III trial of panitumumab with infusional fluorouracil, leucovorin, and oxaliplatin (FOLFOX4) versus FOLFOX4 alone as first-line treatment in patients with previously untreated metastatic colorectal cancer: The PRIME study
    • Douillard JY, Siena S, Cassidy J, etal. Randomized, phase III trial of panitumumab with infusional fluorouracil, leucovorin, and oxaliplatin (FOLFOX4) versus FOLFOX4 alone as first-line treatment in patients with previously untreated metastatic colorectal cancer: the PRIME study. J Clin Oncol. 2010; 28(31): 4697-4705.
    • (2010) J Clin Oncol. , vol.28 , Issue.31 , pp. 4697-4705
    • Douillard, J.Y.1    Siena, S.2    Cassidy, J.3
  • 13
    • 84899992093 scopus 로고    scopus 로고
    • Overall survival analysis from PRIME: Randomized phase III study of panitumumab (pmab) with FOLFOX4 for first-line metastatic colorectal cancer (mCRC)
    • abstr
    • Douillard JY, Siena S, Tabernero J, etal. Overall survival analysis from PRIME: randomized phase III study of panitumumab (pmab) with FOLFOX4 for first-line metastatic colorectal cancer (mCRC). J Clin Oncol. 2013; 31 Suppl: abstr 3620.
    • (2013) J Clin Oncol. , vol.31 , Issue.SUPPL. , pp. 3620
    • Douillard, J.Y.1    Siena, S.2    Tabernero, J.3
  • 14
    • 78149239651 scopus 로고    scopus 로고
    • Randomized phase III study of panitumumab with fluorouracil, leucovorin, and irinotecan (FOLFIRI) compared with FOLFIRI alone as second-line treatment in patients with metastatic colorectal cancer
    • Peeters M, Price TJ, Cervantes A, etal. Randomized phase III study of panitumumab with fluorouracil, leucovorin, and irinotecan (FOLFIRI) compared with FOLFIRI alone as second-line treatment in patients with metastatic colorectal cancer. J Clin Oncol. 2010; 28(31): 4706-4713.
    • (2010) J Clin Oncol. , vol.28 , Issue.31 , pp. 4706-4713
    • Peeters, M.1    Price, T.J.2    Cervantes, A.3
  • 15
    • 36148941301 scopus 로고    scopus 로고
    • Cetuximab for the treatment of colorectal cancer
    • Jonker DJ, O'Callaghan CJ, Karapetis CS, etal. Cetuximab for the treatment of colorectal cancer. N Engl J Med. 2007; 357(20): 2040-2048.
    • (2007) N Engl J Med. , vol.357 , Issue.20 , pp. 2040-2048
    • Jonker, D.J.1    O'Callaghan, C.J.2    Karapetis, C.S.3
  • 16
    • 34147103678 scopus 로고    scopus 로고
    • Open-label phase III trial of panitumumab plus best supportive care compared with best supportive care alone in patients with chemotherapy-refractory metastatic colorectal cancer
    • Van Cutsem E, Peeters M, Siena S, etal. Open-label phase III trial of panitumumab plus best supportive care compared with best supportive care alone in patients with chemotherapy-refractory metastatic colorectal cancer. J Clin Oncol. 2007; 25(13): 1658-1664.
    • (2007) J Clin Oncol. , vol.25 , Issue.13 , pp. 1658-1664
    • Van Cutsem, E.1    Peeters, M.2    Siena, S.3
  • 17
    • 84904189112 scopus 로고    scopus 로고
    • ASPECCT: A randomized, multicenter, open-label, phase 3 study of panitumumab (pmab) vs cetuximab (cmab) for previously treated wild-type (WT) KRAS metastatic colorectal cancer (mCRC)
    • Price TJ, Peeters M, Kim TW, etal. ASPECCT: a randomized, multicenter, open-label, phase 3 study of panitumumab (pmab) vs cetuximab (cmab) for previously treated wild-type (WT) KRAS metastatic colorectal cancer (mCRC). Eur J Cancer. 2013; 49 Suppl 3: LBA 18.
    • (2013) Eur J Cancer. , vol.49 , Issue.SUPPL. 3
    • Price, T.J.1    Peeters, M.2    Kim, T.W.3
  • 18
    • 84880736194 scopus 로고    scopus 로고
    • Randomized controlled trial of cetuximab plus chemotherapy for patients with KRAS wild-type unresectable colorectal liver-limited metastases
    • Ye LC, Liu TS, Ren L, etal. Randomized controlled trial of cetuximab plus chemotherapy for patients with KRAS wild-type unresectable colorectal liver-limited metastases. J Clin Oncol. 2013; 31(16): 1931-1938.
    • (2013) J Clin Oncol. , vol.31 , Issue.16 , pp. 1931-1938
    • Ye, L.C.1    Liu, T.S.2    Ren, L.3
  • 19
    • 84882937605 scopus 로고    scopus 로고
    • Randomized comparison of FOLFIRI plus cetuximab versus FOLFIRI plus bevacizumab as first-line treatment of KRAS wild-type metastatic colorectal cancer: German AIO study KRK-0306 (FIRE-3)
    • abstr
    • Heinemann V, von Weikersthal LF, Decker T, etal. Randomized comparison of FOLFIRI plus cetuximab versus FOLFIRI plus bevacizumab as first-line treatment of KRAS wild-type metastatic colorectal cancer: German AIO study KRK-0306 (FIRE-3). J Clin Oncol. 2013; 31 Suppl: abstr LBA3506.
    • (2013) J Clin Oncol. , vol.31 , Issue.SUPPL.
    • Heinemann, V.1    von Weikersthal, L.F.2    Decker, T.3
  • 20
    • 33644836082 scopus 로고    scopus 로고
    • Cancer and Leukemia Group B/Southwest Oncology Group Trial 80405: A phase III trial of chemotherapy and biologic agents for patients with untreated advanced colorectal adenocarcinoma
    • Venook AP, Blanke CD, Niedzwiecki D, etal. Cancer and Leukemia Group B/Southwest Oncology Group Trial 80405: a phase III trial of chemotherapy and biologic agents for patients with untreated advanced colorectal adenocarcinoma. Clin Colorectal Cancer. 2005; 5(4): 292-294.
    • (2005) Clin Colorectal Cancer. , vol.5 , Issue.4 , pp. 292-294
    • Venook, A.P.1    Blanke, C.D.2    Niedzwiecki, D.3
  • 21
    • 34250330400 scopus 로고    scopus 로고
    • Revisiting the Cancer and Leukemia Group B/Southwest Oncology Group 80405 trial: A phase III trial of chemotherapy and biologic agents for patients with untreated advanced colorectal adenocarcinoma
    • Venook AP, Blanke CD, Niedzwiecki D, etal. Revisiting the Cancer and Leukemia Group B/Southwest Oncology Group 80405 trial: a phase III trial of chemotherapy and biologic agents for patients with untreated advanced colorectal adenocarcinoma. Clin Colorectal Cancer. 2007; 6(7): 536-538.
    • (2007) Clin Colorectal Cancer. , vol.6 , Issue.7 , pp. 536-538
    • Venook, A.P.1    Blanke, C.D.2    Niedzwiecki, D.3
  • 22
    • 84883680951 scopus 로고    scopus 로고
    • Panitumumab-FOLFOX4 treatment and RAS mutations in colorectal cancer
    • Douillard JY, Oliner KS, Siena S, etal. Panitumumab-FOLFOX4 treatment and RAS mutations in colorectal cancer. N Engl J Med. 2013; 369(11): 1023-1034.
    • (2013) N Engl J Med. , vol.369 , Issue.11 , pp. 1023-1034
    • Douillard, J.Y.1    Oliner, K.S.2    Siena, S.3
  • 23
    • 84898666033 scopus 로고    scopus 로고
    • Analysis of KRAS/NRAS and BRAF mutations in FIRE-3: A randomized phase III study of FOLFIRI plus cetuximab or bevacizumab as first-line treatment for wild-type KRAS (exon 2) metastatic colorectal cancer patients
    • Stintzing S, Jung A, Rossius L, etal. Analysis of KRAS/NRAS and BRAF mutations in FIRE-3: a randomized phase III study of FOLFIRI plus cetuximab or bevacizumab as first-line treatment for wild-type KRAS (exon 2) metastatic colorectal cancer patients. Eur J Cancer. 2013; 49 Suppl 3: LBA17.
    • (2013) Eur J Cancer. , vol.49 , Issue.SUPPL. 3
    • Stintzing, S.1    Jung, A.2    Rossius, L.3
  • 24
    • 2542561964 scopus 로고    scopus 로고
    • Bevacizumab plus irinotecan, fluorouracil, and leucovorin for metastatic colorectal cancer
    • Hurwitz H, Fehrenbacher L, Novotny W, etal. Bevacizumab plus irinotecan, fluorouracil, and leucovorin for metastatic colorectal cancer. N Engl J Med. 2004; 350(23): 2335-2342.
    • (2004) N Engl J Med. , vol.350 , Issue.23 , pp. 2335-2342
    • Hurwitz, H.1    Fehrenbacher, L.2    Novotny, W.3
  • 25
    • 36048960109 scopus 로고    scopus 로고
    • Randomized, controlled trial of irinotecan plus infusional, bolus, or oral fluoropyrimidines in first-line treatment of metastatic colorectal cancer: Results from the BICC-C Study
    • Fuchs CS, Marshall J, Mitchell E, etal. Randomized, controlled trial of irinotecan plus infusional, bolus, or oral fluoropyrimidines in first-line treatment of metastatic colorectal cancer: results from the BICC-C Study. J Clin Oncol. 2007; 25(30): 4779-4786.
    • (2007) J Clin Oncol. , vol.25 , Issue.30 , pp. 4779-4786
    • Fuchs, C.S.1    Marshall, J.2    Mitchell, E.3
  • 26
    • 49049105525 scopus 로고    scopus 로고
    • Safety and efficacy of oxaliplatin and fluoropyrimidine regimens with or without bevacizumab as first-line treatment of metastatic colorectal cancer: Results of the TREE study
    • Hochster HS, Hart LL, Ramanathan RK, etal. Safety and efficacy of oxaliplatin and fluoropyrimidine regimens with or without bevacizumab as first-line treatment of metastatic colorectal cancer: results of the TREE study. J Clin Oncol. 2008; 26(21): 3523-3529.
    • (2008) J Clin Oncol. , vol.26 , Issue.21 , pp. 3523-3529
    • Hochster, H.S.1    Hart, L.L.2    Ramanathan, R.K.3
  • 27
    • 42949149159 scopus 로고    scopus 로고
    • Bevacizumab in combination with oxaliplatin-based chemotherapy as first-line therapy in metastatic colorectal cancer: A randomized phase III study
    • Saltz LB, Clarke S, Díaz-Rubio E, etal. Bevacizumab in combination with oxaliplatin-based chemotherapy as first-line therapy in metastatic colorectal cancer: a randomized phase III study. J Clin Oncol. 2008; 26(12): 2013-2019.
    • (2008) J Clin Oncol. , vol.26 , Issue.12 , pp. 2013-2019
    • Saltz, L.B.1    Clarke, S.2    Díaz-Rubio, E.3
  • 28
    • 39149108869 scopus 로고    scopus 로고
    • Randomized, controlled trial of irinotecan plus infusional, bolus, or oral fluoropyrimidines in first-line treatment of metastatic colorectal cancer: Updated results from the BICC-C study
    • Fuchs CS, Marshall J, Barrueco J. Randomized, controlled trial of irinotecan plus infusional, bolus, or oral fluoropyrimidines in first-line treatment of metastatic colorectal cancer: updated results from the BICC-C study. J Clin Oncol. 2008; 26(4): 689-690.
    • (2008) J Clin Oncol. , vol.26 , Issue.4 , pp. 689-690
    • Fuchs, C.S.1    Marshall, J.2    Barrueco, J.3
  • 29
    • 34248173883 scopus 로고    scopus 로고
    • Eastern Cooperative Oncology Group Study E3200. Bevacizumab in combination with oxaliplatin, fluorouracil, and leucovorin (FOLFOX4) for previously treated metastatic colorectal cancer: Results from the Eastern Cooperative Oncology Group Study E3200
    • Giantonio BJ, Catalano PJ, Meropol NJ, etal; Eastern Cooperative Oncology Group Study E3200. Bevacizumab in combination with oxaliplatin, fluorouracil, and leucovorin (FOLFOX4) for previously treated metastatic colorectal cancer: results from the Eastern Cooperative Oncology Group Study E3200. J Clin Oncol. 2007; 25(12): 1539-1544.
    • (2007) J Clin Oncol. , vol.25 , Issue.12 , pp. 1539-1544
    • Giantonio, B.J.1    Catalano, P.J.2    Meropol, N.J.3
  • 30
    • 56749169353 scopus 로고    scopus 로고
    • Bevacizumab beyond first progression is associated with prolonged overall survival in metastatic colorectal cancer: Results from a large observational cohort study (BRiTE)
    • Grothey A, Sugrue MM, Purdie DM, etal. Bevacizumab beyond first progression is associated with prolonged overall survival in metastatic colorectal cancer: results from a large observational cohort study (BRiTE). J Clin Oncol. 2008; 26(33): 5326-5334.
    • (2008) J Clin Oncol. , vol.26 , Issue.33 , pp. 5326-5334
    • Grothey, A.1    Sugrue, M.M.2    Purdie, D.M.3
  • 31
    • 77956185692 scopus 로고    scopus 로고
    • Clinical outcomes in bevacizumab(BV)-treated patients (pts) with metastatic colorectal cancer (mCRC): Results from ARIES observational cohort study (OCS) and confirmation of BRiTE data on BV beyond progression (BBP)
    • abstr
    • Cohn AL, Bekaii-Saab TS, Bendell JC, etal. Clinical outcomes in bevacizumab(BV)-treated patients (pts) with metastatic colorectal cancer (mCRC): Results from ARIES observational cohort study (OCS) and confirmation of BRiTE data on BV beyond progression (BBP). J Clin Oncol. 2010; 28(Suppl 15): abstr 3596.
    • (2010) J Clin Oncol. , vol.28 , Issue.SUPPL. 15 , pp. 3596
    • Cohn, A.L.1    Bekaii-Saab, T.S.2    Bendell, J.C.3
  • 32
    • 84871720057 scopus 로고    scopus 로고
    • ML18147 Study Investigators. Continuation of bevacizumab after first progression in metastatic colorectal cancer (ML18147): A randomised phase 3 trial
    • Bennouna J, Sastre J, Arnold D, etal; ML18147 Study Investigators. Continuation of bevacizumab after first progression in metastatic colorectal cancer (ML18147): a randomised phase 3 trial. Lancet Oncol. 2013; 14(1): 29-37.
    • (2013) Lancet Oncol. , vol.14 , Issue.1 , pp. 29-37
    • Bennouna, J.1    Sastre, J.2    Arnold, D.3
  • 33
    • 78651297593 scopus 로고    scopus 로고
    • Randomized trial of two induction chemotherapy regimens in metastatic colorectal cancer: An updated analysis
    • Masi G, Vasile E, Loupakis F, etal. Randomized trial of two induction chemotherapy regimens in metastatic colorectal cancer: an updated analysis. J Natl Cancer Inst. 2011; 103(1): 21-30.
    • (2011) J Natl Cancer Inst. , vol.103 , Issue.1 , pp. 21-30
    • Masi, G.1    Vasile, E.2    Loupakis, F.3
  • 34
    • 34249000361 scopus 로고    scopus 로고
    • Gruppo Oncologico Nord Ovest. Phase III trial of infusional fluorouracil, leucovorin, oxaliplatin, and irinotecan (FOLFOXIRI) compared with infusional fluorouracil, leucovorin, and irinotecan (FOLFIRI) as first-line treatment for metastatic colorectal cancer: The Gruppo Oncologico Nord Ovest
    • Falcone A, Ricci S, Brunetti I, etal; Gruppo Oncologico Nord Ovest. Phase III trial of infusional fluorouracil, leucovorin, oxaliplatin, and irinotecan (FOLFOXIRI) compared with infusional fluorouracil, leucovorin, and irinotecan (FOLFIRI) as first-line treatment for metastatic colorectal cancer: the Gruppo Oncologico Nord Ovest. J Clin Oncol. 2007; 25(13): 1670-1676.
    • (2007) J Clin Oncol. , vol.25 , Issue.13 , pp. 1670-1676
    • Falcone, A.1    Ricci, S.2    Brunetti, I.3
  • 35
    • 33645309877 scopus 로고    scopus 로고
    • FOLFOXIRI (folinic acid, 5-fluorouracil, oxaliplatin and irinotecan) vs FOLFIRI (folinic acid, 5-fluorouracil and irinotecan) as first-line treatment in metastatic colorectal cancer: A multicentre randomised phase III trial from the Hellenic Oncology Research Group (HORG)
    • Souglakos J, Androulakis N, Syrigos K, etal. FOLFOXIRI (folinic acid, 5-fluorouracil, oxaliplatin and irinotecan) vs FOLFIRI (folinic acid, 5-fluorouracil and irinotecan) as first-line treatment in metastatic colorectal cancer: a multicentre randomised phase III trial from the Hellenic Oncology Research Group (HORG). Br J Cancer. 2006; 94(6): 798-805.
    • (2006) Br J Cancer. , vol.94 , Issue.6 , pp. 798-805
    • Souglakos, J.1    Androulakis, N.2    Syrigos, K.3
  • 36
    • 84884674438 scopus 로고    scopus 로고
    • FOLFOXIRI/bevacizumab (bev) versus FOLFIRI/bev as first-line treatment in unresectable metastatic colorectal cancer (mCRC) patients (pts): Results of the phase III TRIBE trial by GONO group
    • abstr
    • Falcone A, Cremolini C, Masi G, etal. FOLFOXIRI/bevacizumab (bev) versus FOLFIRI/bev as first-line treatment in unresectable metastatic colorectal cancer (mCRC) patients (pts): Results of the phase III TRIBE trial by GONO group. J Clin Oncol. 2013; 31 Suppl: abstr 3505.
    • (2013) J Clin Oncol. , vol.31 , Issue.SUPPL. , pp. 3505
    • Falcone, A.1    Cremolini, C.2    Masi, G.3
  • 37
    • 84877586981 scopus 로고    scopus 로고
    • FOLFOXIRI plus bevacizumab (bev) versus FOLFIRI plus bev as first-line treatment of metastatic colorectal cancer (MCRC): Results of the phase III randomized TRIBE trial
    • abstr
    • Loupakis F, Cremolini C, Masi G, etal. FOLFOXIRI plus bevacizumab (bev) versus FOLFIRI plus bev as first-line treatment of metastatic colorectal cancer (MCRC): Results of the phase III randomized TRIBE trial. J Clin Oncol. 2012; 31 Suppl 4: abstr 336.
    • (2012) J Clin Oncol. , vol.31 , Issue.SUPPL. 4 , pp. 336
    • Loupakis, F.1    Cremolini, C.2    Masi, G.3
  • 38
    • 84885366390 scopus 로고    scopus 로고
    • Maintenance treatment with capecitabine and bevacizumab versus observation after induction treatment with chemotherapy and bevacizumab in metastatic colorectal cancer (mCRC): The phase III CAIRO3 study of the Dutch Colorectal Cancer Group
    • abst
    • Koopman M, Simkins LH, Tije AJ, etal. Maintenance treatment with capecitabine and bevacizumab versus observation after induction treatment with chemotherapy and bevacizumab in metastatic colorectal cancer (mCRC): The phase III CAIRO3 study of the Dutch Colorectal Cancer Group. J Clin Oncol. 2013; 31 Suppl: abst 3502.
    • (2013) J Clin Oncol. , vol.31 , Issue.SUPPL. , pp. 3502
    • Koopman, M.1    Simkins, L.H.2    Tije, A.J.3
  • 39
    • 84904157668 scopus 로고    scopus 로고
    • Updated results including quality of life of the phase III CAIRO3 study of the Dutch Colorectal Cancer Group: Maintenance treatment with capecitabine and bevacizumab versus observation after induction treatment with chemotherapy and bevacizumab in metastatic colorectal cancer
    • abstr
    • Punt CJA, Simkens LHJ, May A, etal. Updated results including quality of life of the phase III CAIRO3 study of the Dutch Colorectal Cancer Group: maintenance treatment with capecitabine and bevacizumab versus observation after induction treatment with chemotherapy and bevacizumab in metastatic colorectal cancer. Eur J Cancer. 2013; 49 Suppl 3: abstr 2166.
    • (2013) Eur J Cancer. , vol.49 , Issue.SUPPL. 3 , pp. 2166
    • Punt, C.J.A.1    Simkens, L.H.J.2    May, A.3
  • 40
    • 84883339111 scopus 로고    scopus 로고
    • A randomized phase III trial on maintenance treatment with bevacizumab alone or in combination with erlotinib after chemotherapy and bevacizumab in metastatic colorectal cancer: The Nordic ACT trial
    • Johnsson A, Hagman H, Frödin JE, etal. A randomized phase III trial on maintenance treatment with bevacizumab alone or in combination with erlotinib after chemotherapy and bevacizumab in metastatic colorectal cancer: the Nordic ACT trial. Ann Oncol. 2013; 24(9): 2335-2341.
    • (2013) Ann Oncol. , vol.24 , Issue.9 , pp. 2335-2341
    • Johnsson, A.1    Hagman, H.2    Frödin, J.E.3
  • 41
    • 0037143764 scopus 로고    scopus 로고
    • VEGF-Trap: A VEGF blocker with potent antitumor effects
    • Holash J, Davis S, Papadopoulos N, etal. VEGF-Trap: a VEGF blocker with potent antitumor effects. Proc Natl Acad Sci U S A. 2002; 99(17): 11393-11398.
    • (2002) Proc Natl Acad Sci U S A. , vol.99 , Issue.17 , pp. 11393-11398
    • Holash, J.1    Davis, S.2    Papadopoulos, N.3
  • 42
    • 84867047384 scopus 로고    scopus 로고
    • Addition of aflibercept to fluorouracil, leucovorin, and irinotecan improves survival in a phase III randomized trial in patients with metastatic colorectal cancer previously treated with an oxaliplatin-based regimen
    • Van Cutsem E, Tabernero J, Lakomy R, etal. Addition of aflibercept to fluorouracil, leucovorin, and irinotecan improves survival in a phase III randomized trial in patients with metastatic colorectal cancer previously treated with an oxaliplatin-based regimen. J Clin Oncol. 2012; 30(28): 3499-3506.
    • (2012) J Clin Oncol. , vol.30 , Issue.28 , pp. 3499-3506
    • Van Cutsem, E.1    Tabernero, J.2    Lakomy, R.3
  • 43
    • 84891831211 scopus 로고    scopus 로고
    • Aflibercept versus placebo in combination with fluorouracil, leucovorin and irinotecan in the treatment of previously treated metastatic colorectal cancer: Prespecified subgroup analyses from the VELOUR trial
    • Tabernero J, Van Cutsem E, Lakomý R, etal. Aflibercept versus placebo in combination with fluorouracil, leucovorin and irinotecan in the treatment of previously treated metastatic colorectal cancer: prespecified subgroup analyses from the VELOUR trial. Eur J Cancer. 2014; 50(2): 320-331.
    • (2014) Eur J Cancer. , vol.50 , Issue.2 , pp. 320-331
    • Tabernero, J.1    Van Cutsem, E.2    Lakomý, R.3
  • 44
    • 79954499886 scopus 로고    scopus 로고
    • Regorafenib (BAY 73-4506): A new oral multikinase inhibitor of angiogenic, stromal and oncogenic receptor tyrosine kinases with potent preclinical antitumor activity
    • Wilhelm SM, Dumas J, Adnane L, etal. Regorafenib (BAY 73-4506): a new oral multikinase inhibitor of angiogenic, stromal and oncogenic receptor tyrosine kinases with potent preclinical antitumor activity. Int J Cancer. 2011; 129(1): 245-255.
    • (2011) Int J Cancer. , vol.129 , Issue.1 , pp. 245-255
    • Wilhelm, S.M.1    Dumas, J.2    Adnane, L.3
  • 45
    • 84872921660 scopus 로고    scopus 로고
    • CORRECT Study Group. Regorafenib monotherapy for previously treated metastatic colorectal cancer (CORRECT): An international, multicentre, randomised, placebo-controlled, phase 3 trial
    • Grothey A, Van Cutsem E, Sobrero A, etal; CORRECT Study Group. Regorafenib monotherapy for previously treated metastatic colorectal cancer (CORRECT): an international, multicentre, randomised, placebo-controlled, phase 3 trial. Lancet. 2013; 381(9863): 303-312.
    • (2013) Lancet. , vol.381 , Issue.9863 , pp. 303-312
    • Grothey, A.1    Van Cutsem, E.2    Sobrero, A.3
  • 46
    • 84863922124 scopus 로고    scopus 로고
    • Comprehensive molecular characterization of human colon and rectal cancer
    • Cancer Genome Atlas Network
    • Cancer Genome Atlas Network. Comprehensive molecular characterization of human colon and rectal cancer. Nature. 2012; 487(7407): 330-337.
    • (2012) Nature. , vol.487 , Issue.7407 , pp. 330-337


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