Ferutinin dose-dependent effects on uterus and mammary gland in ovariectomized rats

Histology and Histopathology

Volumn 29, Issue 8, 2014, Pages 1027-1037

  Ferretti, Marzia ^a   Cavani, Francesco ^a   Manni, Paola ^a   Carnevale, Gianluca ^a   Bertoni, Laura ^a   Zavatti, Manuela ^a   Palumbo, Carla ^a  

^a UNIVERSITY OF MODENA AND REGGIO EMILIA   (Italy)

Author keywords

Apoptosis; Ferutinin; Mammary gland; Ovariectomized rat; Proliferation; Uterus

Indexed keywords

4-OXY-6-(4-OXYBEZOYLOXY)DAUC-8,9-EN; BENZOIC ACID DERIVATIVE; BICYCLO COMPOUND; CYCLOHEPTANE DERIVATIVE; PHYTOESTROGEN; SESQUITERPENE;

ANIMAL; DOSE RESPONSE; DRUG EFFECTS; FEMALE; OVARIECTOMY; RAT; SPRAGUE DAWLEY RAT; TUNEL ASSAY; UDDER; UTERUS;

ANIMALS; BENZOATES; BICYCLO COMPOUNDS; CYCLOHEPTANES; DOSE-RESPONSE RELATIONSHIP, DRUG; FEMALE; IN SITU NICK-END LABELING; MAMMARY GLANDS, ANIMAL; OVARIECTOMY; PHYTOESTROGENS; RATS; RATS, SPRAGUE-DAWLEY; SESQUITERPENES; UTERUS;

EID: 84904117641     PISSN: 02133911     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (42)

1. Allred C. D., Allred K. F., Ju Y. H., Clausen L. M., Doerge D. R., Schantz S. L., Korol D. L., Wallig M. A. and Helferich W. G. (2004a). Dietary genistein results in larger MNU-induced, estrogen-dependent mammary tumors following ovariectomy of Sprague-Dawley rats. Carcinogenesis 25, 211-218.
2. Allred C. D., Allred K. F., Ju Y. H., Goeppinger T. S., Doerge D. R. and Helferich W. G. (2004b). Soy processing influences growth of estrogen-dependent breast cancer tumors. Carcinogenesis 25, 1649-1657.
3. Appendino G., Spagliardi P., Cravotto G., Pocock V. and Milligan S. (2002). Daucane phytoestrogens: a structure-activity study. J. Nat. Prod. 65, 1612-1615.
4. Barnes S., Peterson T. G. and Coward L. (1995). Rationale for the use of genistein-containing soy matrices in chemoprevention trials for breast and prostate cancer. J. Cell. Biochem. 22 (Suppl.), 181-187.
5. Cavani F., Ferretti M., Carnevale G., Bertoni L., Zavatti M. and Palumbo C. (2012). Effects of different doses of ferutinin on bone formation/resorption in ovariectomized rats. J. Bone Miner. Metab. 30, 619-629.
6. de Lemos M. L. (2001). Effects of soy phytoestrogens genistein and daidzein on breast cancer growth. Ann. Pharmacother. 35, 1118-1121.
7. Duffy C., Perez K. and Partridge A. (2007). Impl icat ions of phytoestrogen intake for breast cancer. CA Cancer J. Clin. 57, 260-277.
8. El Sheikh Saad H., Meduri G., Phrakonkham P., Bergès R., Vacher S., Djallali M., Auger J., Canivenc-Lavier M. C. and Perrot-Applanat M. (2011). Abnormal peripubertal development of the rat mammary gland following exposure in utero and during lactation to a mixture of genistein and the food contaminant vinclozolin. Reprod. Toxicol. 32, 15-25.
9. Fanti P., Monier-Faugere M. C., Geng Z., Schmidt J., Morris P. E., Cohen D. and Malluche H. H. (1998). The phytoestrogen genistein reduces bone loss in short-term ovariectomized rats. Osteoporos. Int. 8, 274-281.
10. Ferretti M., Bertoni L., Cavani F., Zavatti M., Resca E., Carnevale G., Benelli A., Zanoli P. and Palumbo C. (2010). Influence of ferutinin on bone metabolism in ovariectomized rats. II: role in recovering osteoporosis. J. Anat. 217, 48-56.
11. Ferretti M., Bertoni L., Cavani F., Benincasa M., Sena P., Carnevale G., Zavatti M., Di Viesti V., Zanoli P. and Palumbo C. (2012). Structural and histomorphometric evaluations of ferutinin effects on the uterus of ovariectomized rats during osteoporosis treatment. Life Sci. 90, 161-168.
12. Gaete L., Tchernitchin A. N., Bustamante R., Villena J., Lemus I., Gidekel M., Cabrera G. and Astorga P. (2012) J. Daidzein-estrogen interaction in the rat uterus and its effect on human breast cancer cell growth. J. Med. Food. 15, 1081-1090.
13. Hilakivi-Clarke L. and de Assis S. (2006) Fetal origins of breast cancer. Trends Endocrinol. Metab. 17, 340-348.
14. Hirose K., Tajima K., Hamajima N., Inoue M., Takezaki T., Kuroisha T., Yoshida M. and Tokudome S. (1995). A large-scale, hospital-based case-control study of risk factors of breast cancers according to menopausal status. Jpn. J. Cancer Res. 86, 146-154.
15. Hsieh C. Y., Santell R. C., Haslam S. Z. and Helferich W. G. (1998). Estrogenic effects of genistein on the growth of estrogen receptorpositive human breast cancer (MCF-7) cells in vitro and in vivo. Cancer Res. 58, 3833-3838.
16. Ikeda K., Arao Y., Otsuka H., Nomoto S., Horiguchi H., Kato S. and Kayama F. (2002). Terpenoids found in the Umbelliferae family act as agonists/antagonists for ER//and ERß: differential transcription activity between ferutinine-liganded ERaaand ERß. Biochem. Biophys. Res. Commun. 291, 354-360.
17. Ju Y. H., Allred C. D., Allred K. F., Karko K. L., Doerge D. R. and Helferich W. G. (2001). Physiological concentrations of dietary genistein dosedependently stimulate growth of estrogen-dependent human breast cancer (MCF-7) tumors implanted in athymic nude mice. J. Nutr. 131, 2957-2962.
18. Kalu D. N. (1991). The ovariectomized rat model of postmenopausal bone loss. Bone Miner. 15, 175-191.
19. Kennedy A. R. (1995). The evidence for soybean products as cancer preventive agents. J. Nutr. 125, S733-S743.
20. Lee H. P., Gourley L., Duffy S. W., Esteve J. and Day N. E. (1991). Dietary effects on breast-cancer risk in Singapore. Lancet 337, 1197-1200.
21. Lucki N. C. and Sewer M. B. (2011). Genistein stimulates MCF-7 breast cancer cell growth by inducing acid ceramidase (ASAH1) gene expression. J. Biol. Chem. 286, 19399-19409.
22. Martin P. M., Horwitz K. B., Ryan D. S. and McGuire W. L. (1978). Phytoestrogen interaction with estrogen receptors in human breast cancer cells. Endocrinology 103, 1860-1867.
23. Masso-Welch P. A., Darcy K. M., Stangle-Castor N. C. and Ip M. M. (2000). A developmental atlas of rat mammary gland histology. J. Mammary Gland Biol. Neoplasia 5, 165-185.
24. Messina M. J. and Loprinzi C. L. (2001). Soy for breast cancer survivors: a critical review of the literature. J. Nutr. 131, 3095S-3108S.
25. Messina M., McCaskill-Stevens W. and Lampe J. W. (2006). Addressing the soy and breast cancer relationship: review, commentary, and workshop proceedings. J. Natl. Cancer Inst. 98, 1275-1284.
26. Messina M. J., Persky V., Setchell K. D. and Barnes S. (1994). Soy intake and cancer risk: a review of the in vitro and in vivo data. Nutr. Cancer 21, 113-131.
27. Mosquette R., de Mosquette R., de Jesus Simões M., da Silva I. D., Oshima C. T., Oliveira-Filho R. M., Haidar M. A., Simões R. S., Baracat E. C. and Soares Júnior J. M. (2007). The effects of soy extract on the uterus of castrated adult rats. Maturitas 56, 173-183.
28. Palumbo C., Ferretti M., Bertoni L., Cavani F., Resca E., Casolari B., Carnevale G., Zavatti M., Montanari C., Benelli A. and Zanoli P. (2009). Influence of bone metabolism in ovariectomized rats. I: role in preventing osteoporosis. J. Bone. Miner. Metab. 27, 538-545.
29. Rao C. V., Wang C. X., Simi B., Lubet R., Kelloff G., Steele V. and Reddy B. S. (1997). Enhancement of experimental colon cancer by genistein. Cancer Res. 57, 3717-3722.
30. Shimizu H., Ross R. K., Bernstein L., Yatani R., Henderson B. E. and Mack T. M. (1991). Cancers of the prostate and breast among Japanese and white immigrants in Los Angeles County. Br. J. Cancer 63, 963-966.
31. Tan P. H., Bay B. H., Yip G., Selvarajan S., Tan P., Wu J., Lee C. H. and Li K. B. (2005). Immunohistochemical detection of Ki67 in breast cancer correlates with transcriptional regulation of genes related to apoptosis and cell death. Mod. Pathol. 18, 374-381.
32. Wang X. J., Bartolucci-Page E., Fenton S. E. and You L. (2006). Altered mammary gland development in male rats exposed to genistein and methoxychior. Toxicol. Sci. 91, 93-103.
33. Westwood F. R. (2008). The female rat reproductive cycle: a practical histological guide to staging. Toxicol. Pathol. 36, 375-384.
34. Wu A. H., Wan P., Hankin J., Tseng C. C., Yu M. C. and Pike M. C. (2002). Adolescent and adult soy intake and risk of breast cancer in Asian-Americans. Carcinogenesis 23, 1491-1496.
35. Wu A. H., Ziegler R. G., Horn-Ross P. L., Nomura A. M., West D. W., Kolonel L. N., Rosenthal J. F., Hoover R. N. and Pike M. C. (1996). Tofu and risk of breast cancer in Asian-Americans. Cancer Epidemiol. Biomarkers Prev. 5, 901-906.
36. Yamamoto S., Sobue T., Kobayashi M., Sasaki S. and Tsugane S. (2003). Soy, isoflavones and breast cancer risk in Japan. J. Natl. Cancer Inst. 95, 906-913.
37. Yanagihara K., Ito A., Toge T. and Numoto M. (1993). Antiproliferative effects of isoflavones on human cancer cell lines established from the gastrointestinal tract. Cancer Res. 53, 5815-5821.
38. Yang Y., Liu J., Li X. and Li J. C. (2012). PCDH17 gene promoter demethylation and cell cycle arrest by genistein in gastric cancer. Histol Histopathol. 27, 217-224.
39. Yuan J. M., Wang Q. S., Ross R. K., Henderson B. E. and Yu M. C. (1995). Diet and breast cancer in Shanghai and Tianjin, China. Br. J. Cancer 71, 1353-1358.
40. Yuan L., Wagatsuma C., Sun B., Kim J. H. and Surh Y. J. (2003). The role of ß-glucuronidase in induction of apoptosis by genistein combined polysaccharide (GCP) in Xenogeneic mice bearing human mammary cancer cel ls. Ann. N. Y. Acad. Sci. 1010, 347-349.
41. Zanoli P., Rivasi M., Zavatti M., Brusiani F., Vezzalini F. and Baraldi M. (2005). Activity of single components of Ferula hermonis on male rat sexual behavior. Int. J. Impot. Res. 17, 513-518.
42. Zavatti M., Montanari C. and Zanoli P. (2006). Role of ferutinin in the impairment of female sexual function by Ferula hermonis. Physiol. Behav. 89, 656-661.