Long noncoding RNA-EBIC promotes tumor cell invasion by binding to EZH2 and repressing E-cadherin in cervical cancer

PLoS ONE

Volumn 9, Issue 7, 2014, Pages

  Sun, Ning Xia ^a   Ye, Chen ^a   Zhao, Qian ^a   Zhang, Qing ^a   Xu, Chen ^a   Wang, Shao Bing ^b   Jin, Zhi Jun ^a   Sun, Shuhan ^b   Wang, Fang ^b   Li, Wen ^a  

^a SECOND MILITARY MEDICAL UNIVERSITY   (China)

^b SECOND MILITARY MEDICAL UNIVERSITY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

LONG NONCODING RNA EBIC; LONG UNTRANSLATED RNA; SMALL INTERFERING RNA; TRANSCRIPTION FACTOR EZH2; TRANSCRIPTOME; UNCLASSIFIED DRUG; UVOMORULIN; CADHERIN; CDH1 PROTEIN, HUMAN; EZH2 PROTEIN, HUMAN; POLYCOMB REPRESSIVE COMPLEX 2;

ARTICLE; ASSAY; CANCER CELL; CANCER CONTROL; CELL INVASION; CELL MIGRATION; CONTROLLED STUDY; DOWN REGULATION; ENHANCER REGION; GENE EXPRESSION; GENE FUNCTION; GENE SILENCING; HISTOPATHOLOGY; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOPRECIPITATION; MATRIGEL INVASION ASSAY; METASTASIS; MICROARRAY ANALYSIS; MOLECULAR PROBE; NUCLEOTIDE SEQUENCE; PROTEIN RNA BINDING; QUANTITATIVE ANALYSIS; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; UPREGULATION; UTERINE CERVIX CANCER; VALIDATION STUDY; WOUND HEALING ASSAY; CELL MOTION; FEMALE; GENE EXPRESSION REGULATION; GENETICS; HELA CELL LINE; METABOLISM; PATHOLOGY; PHYSIOLOGY; TUMOR INVASION; UTERINE CERVIX TUMOR;

CADHERINS; CELL MOVEMENT; FEMALE; GENE EXPRESSION REGULATION, NEOPLASTIC; HELA CELLS; HUMANS; NEOPLASM INVASIVENESS; POLYCOMB REPRESSIVE COMPLEX 2; RNA, LONG NONCODING; TRANSCRIPTOME; UTERINE CERVICAL NEOPLASMS;

EID: 84904116554     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0100340     Document Type: Article

References (32)

1. Jemal A, Bray F, Center MM, Ferlay J, Ward E, et al. (2011) Global cancer statistics. CA Cancer J Clin 61: 69-90.
2. Chang SC, Woo JS, Yau V, Gorzalka BB, Brotto LA (2013) Cervical cancer screening and chinese women:insights from focus groups. Front Psychol, 4: 48.
3. Krieger N, Bassett MT, Gomez SL (2012) Breast and cervical cancer in 187 countries between 1980 and 2010. Lancet 379: 1391-1392.
4. Egger G, Liang G, Aparicio A, Jones PA (2004) Epigenetics in human disease and prospects for epigenetic therapy. Nature 429: 457-463. (Pubitemid 38715140)
5. Jones PA, Baylin SB (2002) The fundamental role of epigenetic events in cancer. Nat Rev Genet 3: 415-428. (Pubitemid 34587077)
6. Krol J, Loedige I, Filipowicz W (2010) The widespread regulation of micro-RNA biogenesis,function and decay. Nat Rev Genet 11: 597-610.
7. Qin W, Dong P, Ma C (2012) MicroRNA-133b is a key promoter of cervical carcinoma development through the activation of the ERK and AKT1 pathways. Oncogene 31: 4067-75.
8. Huarte M, Rinn JL (2010) Large non-coding RNAs: missing links in cancer? Hum Mol Genet 19: R152-161.
9. Yang F, Zhang L, Huo XS, Yuan JH, Xu D, et al. (2011) Long noncoding RNA high expression in hepatocellular carcinoma facilitates tumor growth through enhancer of zeste homolog 2 in humans. Hepatology 54: 1679-1689.
10. Gibb EA, Becker-Santos DD, Enfield KS, Guillaud M, Niekerk Dv, et al. (2012) Aberrant expression of long noncoding RNAs in cervical intraepithelial neoplasia. Int J Gynecol Cancer 22: 1557-1563.
11. Khalil AM, Guttman M, Huarte M, Garber M, Raj A, et al. (2009) Many human large intergenic noncoding RNAs associate with chromatin-modifying complexes and affect gene expression. Proc Natl Acad. Sci. USA 106: 11667-11672.
12. Sparmann A, van Lohuizen M (2006) Polycomb silencers control cell fate, development and cancer. Nat Rev Cancer 6: 846-856. (Pubitemid 44629896)
13. Simon JA, Lange CA (2008) Roles of the EZH2 histone methyltransferase in cancer epigenetics. Mutant Res 647(1), 21-29.
14. Cao Q, Yu J, Dhanasekaran SM, Kim JH, Mani RS, et al. (2008) Repression of E-cadherin by the polycomb groupprotein EZH2 in cancer. Oncogene 27: 7274-7284.
15. Li H, Cai Q, Godwin AK, Zhang R (2010) Enhancer of zeste homolog 2 promotes the proliferation and invasion of epithelial ovarian cancer cells. Molecular Cancer Research, 8(12), 1610-1618.
16. Lu C, Han HD, Mangala LS, Ali-Fehmi R, Newton CS, et al. (2010) Regulation of tumor angiogenesis by EZH2. Cancer cell, 18(2), 185-197.
17. Luo M, Li Z, Wang W, Zeng Y, Liu Z, et al. (2013) Long non-coding RNA H19 increases bladder cancer metastasis by associating with EZH2 and inhibiting Ecadherin expression. Cancer Letters 333: 213-221.
18. Gupta RA, Shah N, Wang KC, Kim J, Horlings HM, et al. (2010) Long noncoding RNA HOTAIR reprograms chromatin state to promote cancer metastasis. Nature 464: 1071-1076.
19. Wright GW, Simon RM (2003) A random variance model for detection of differential gene expression in small microarray experiments. Bioinformatics 19: 2448-2455. (Pubitemid 38016644)
20. Yang H, Crawford N, Lukes L, Finney R, Lancaster M, et al. (2005) Metastasis predictive signature profiles pre-exist in normal tissues. Clin Exp Metastasis 22: 593-603. (Pubitemid 43234644)
21. Pujana MA, Han JD, Starita LM, Stevens KN, Tewari M, et al. (2007) Network modeling links breast cancer susceptibility and centrosome dysfunction. Nat Genet 39: 1338-1349. (Pubitemid 350035000)
22. Zhang B, Horvath S (2005) A general framework for weighted gene coexpression network analysis. Stat Appl Genet Mol Biol.; 4:Article 17.
23. Holland D, Hoppe-Seyler K, Schuller B, Lohrey C, Maroldt J, et al. (2008) Activation of the enhancer of zeste homologue 2 gene by the human papillomavirus E7 oncoprotein. Cancer research, 68(23), 9964-9972.
24. Fang J, Zhang M, Li Q (2011) Enhancer of zeste homolog 2 expression is associated with tumor cell proliferation and invasion in cervical cancer. The American journal of the medical sciences, 342(3), 198-204.
25. Wang C, Liu X, Chen Z, Huang H, Jin Y, et al. (2013) Polycomb group protein EZH2-mediated E-cadherin repression promotes metastasis of oral tongue squamous cell carcinoma. Molecular carcinogenesis, 52(3), 229-236.
26. Mercer TR, Dinger ME, Mattick JS (2009) Long non-coding RNAs: insights into functions. Nat Rev Genet 10: 155-159.
27. Wilusz JE, Sunwoo H, Spector DL (2009) Long noncoding RNAs: functional surprises from the RNA world. Genes Dev 23: 1494-1504.
28. Nagano T, Fraser P (2011) No-nonsense functions for long noncoding RNAs. Cell, 145(2), 178-181.
29. Cao R, Zhang Y (2004) The functions of E(Z)/Ezh2-mediated methylation of lysine 27 in histone H3.Curr Opin Genet Dev 14: 155-164. (Pubitemid 38520143)
30. Simon JA, Lange CA (2008) Roles of the EZH2 histone methyltransferase in cancer epigenetics. Mutat Res 647: 21-29.
31. Larue L, Bellacosa A (2005) Epithelial-mesenchymal transition in development and cancer: role of phosphatidylinositol 39 kinase/AKT pathways. Oncogene 24: 7443-7454. (Pubitemid 41637984)
32. D'Costa ZJ, Jolly C, Androphy EJ, Mercer A, Matthews CM, et al. (2012) Transcriptional repression of E-cadherin by human papillomavirus type 16 E6.PLOS One 7:e48954.