Aberrant frequency of IL-10-producing B cells and its association with Treg/Th17 in adult primary immune thrombocytopenia patients

BioMed Research International

Volumn 2014, Issue , 2014, Pages

  Hua, Fanli ^a   Ji, Lili ^a   Zhan, Yanxia ^a   Li, Feng ^a   Zou, Shanhua ^a   Chen, Lihang ^a,b   Gao, Song ^a   Li, Ying ^a   Chen, Hao ^c   Cheng, Yunfeng ^a  

^a FUDAN UNIVERSITY   (China)

^b UNIVERSITY OF HAWAII   (United States)

^c TONGJI UNIVERSITY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

BREFELDIN A; CD19 ANTIGEN; CD4 ANTIGEN; GLUCOCORTICOID; IMMUNOGLOBULIN; INTERLEUKIN 10; INTERLEUKIN 2 RECEPTOR ALPHA; IONOMYCIN; MESSENGER RNA; RETINOID RELATED ORPHAN RECEPTOR GAMMA; TRANSCRIPTION FACTOR FOXP3; CD3 ANTIGEN; IL10 PROTEIN, HUMAN; INTERLEUKIN 17; PHORBOL ESTER; PHORBOL-12-MYRISTATE;

ADULT; AGED; ARTICLE; AUTOIMMUNE THROMBOCYTOPENIA; B LYMPHOCYTE; CLINICAL ARTICLE; CONTROLLED STUDY; CYTOKINE PRODUCTION; FEMALE; FLOW CYTOMETRY; HUMAN; HUMAN CELL; MALE; MIDDLE AGED; PERIPHERAL BLOOD MONONUCLEAR CELL; PROTEIN EXPRESSION; REAL TIME POLYMERASE CHAIN REACTION; REGULATORY T LYMPHOCYTE; YOUNG ADULT; BLOOD; CD4+ T LYMPHOCYTE; CHEMISTRY; CYTOLOGY; IDIOPATHIC THROMBOCYTOPENIC PURPURA; METABOLISM; MONONUCLEAR CELL; POLYMERASE CHAIN REACTION; TH17 CELL; TREATMENT OUTCOME;

ADULT; AGED; ANTIGENS, CD19; ANTIGENS, CD3; B-LYMPHOCYTES; BREFELDIN A; CD4-POSITIVE T-LYMPHOCYTES; FEMALE; FLOW CYTOMETRY; HUMANS; INTERLEUKIN-10; INTERLEUKIN-17; INTERLEUKIN-2 RECEPTOR ALPHA SUBUNIT; IONOMYCIN; LEUKOCYTES, MONONUCLEAR; MALE; MIDDLE AGED; PHORBOL ESTERS; POLYMERASE CHAIN REACTION; PURPURA, THROMBOCYTOPENIC, IDIOPATHIC; TH17 CELLS; TREATMENT OUTCOME; YOUNG ADULT;

EID: 84904099290     PISSN: 23146133     EISSN: 23146141     Source Type: Journal    
DOI: 10.1155/2014/571302     Document Type: Article

References (38)

1. Stasi R., Immune thrombocytopenia: pathophysiologic and clinical update. Seminars in Thrombosis and Hemostasis 2012 38 5 454 462 10.1055/s-0032-1305780 2-s2.0-84863106330
2. Nugent D., McMillan R., Nichol J. L., Slichter S. J., Pathogenesis of chronic immune thrombocytopenia: Increased platelet destruction and/or decreased platelet production. British Journal of Haematology 2009 146 6 585 596 10.1111/j.1365-2141.2009.07717.x 2-s2.0-73249121880
3. Cines D. B., Bussel J. B., Liebman H. A., Luning Prak E. T., The ITP syndrome: pathogenic and clinical diversity. Blood 2009 113 26 6511 6521 10.1182/blood-2009-01-129155 2-s2.0-69249240344
4. He R., Reid D. M., Jones C. E., Shulman N. R., Extracellular epitopes of platelet glycoprotein Ib α reactive with serum antibodies from patients with chronic idiopathic thrombocytopenic purpura. Blood 1995 86 10 3789 3796 2-s2.0-0028884246
5. Woods V. L. Jr., Oh E. H., Mason D., McMillan R., Autoantibodies against the platelet glycoprotein IIb/IIIa complex in patients with chronic ITP. Blood 1984 63 2 368 375 2-s2.0-0021364892 (Pubitemid 14188884)
6. Panitsas F. P., Theodoropoulou M., Kouraklis A., Karakantza M., Theodorou G. L., Zoumbos N. C., Maniatis A., Mouzaki A., Adult chronic idiopathic thrombocytopenic purpura (ITP) is the manifestation of a type-1 polarized immune response. Blood 2004 103 7 2645 2647 10.1182/blood-2003-07-2268 2-s2.0-1642320808 (Pubitemid 38393019)
7. Wang T., Zhao H., Ren H., Guo J., Xu M., Yang R., Han Z. C., Type 1 and type 2 T-cell profiles in idiopathic thrombocytopenic purpura. Haematologica 2005 90 7 914 923 2-s2.0-22544456923 (Pubitemid 41020294)
8. Teke H. U., Gunduz E., Akay O. M., Abnormality of regulatory T-cells in remission and non-remission idiopathic thrombocytopaenic purpura patients. Platelets 2013 24 625 631 10.3109/09537104.2012.748188
9. Yu J., Heck S., Patel V., Levan J., Yu Y., Bussel J. B., Yazdanbakhsh K., Defective circulating CD25 regulatory T cells in patients with chronic immune thrombocytopenic purpura. Blood 2008 112 4 1325 1328 10.1182/blood-2008-01- 135335 2-s2.0-51649127854
10. Ji L., Zhan Y., Hua F., Li F., Zou S., Wang W., Song D., Min Z., Chen H., Cheng Y., The ratio of Treg/Th17 cells correlates with the disease activity of primary immune thrombocytopenia. PLoS ONE 2012 7 12 e50909 10.1371/journal.pone. 0050909 2-s2.0-84870662738
11. Rocha A. M. C., Souza C., Rocha G. A., de Melo F. F., Clementino N. C. D., Marino M. C. A., Bozzi A., Silva M. L., Filho O. A. M., Queiroz D. M. M., The levels of IL-17A and of the cytokines involved in Th17 cell commitment are increased in patients with chronic immune thrombocytopenia. Haematologica 2011 96 10 1560 1564 10.3324/haematol.2011.046417 2-s2.0-80053646104
12. Kuwana M., Kaburaki J., Ikeda Y., Autoreactive T cells to platelet GPIIb-IIIa in immune thrombocytopenic purpura. Role in production of anti-platelet autoantibody. The Journal of Clinical Investigation 1998 102 7 1393 1402 10.1172/JCI4238 2-s2.0-0032190549 (Pubitemid 28467568)
13. Patel V. L., Mahévas M., Lee S. Y., Stasi R., Cunningham-Rundles S., Godeau B., Kanter J., Neufeld E., Taube T., Ramenghi U., Shenoy S., Ward M. J., Mihatov N., Patel V. L., Bierling P., Lesser M., Cooper N., Bussel J. B., Outcomes 5 years after response to rituximab therapy in children and adults with immune thrombocytopenia. Blood 2012 119 25 5989 5995 10.1182/blood-2011-11- 393975 2-s2.0-84862739912
14. Zaja F., Baccarani M., Mazza P., Bocchia M., Gugliotta L., Zaccaria A., Vianelli N., Defina M., Tieghi A., Amadori S., Campagna S., Ferrara F., Angelucci E., Usala E., Cantoni S., Visani G., Fornaro A., Rizzi R., De Stefano V., Casulli F., Battista M. L., Isola M., Soldano F., Gamba E., Fanin R., Dexamethasone plus rituximab yields higher sustained response rates than dexamethasone monotherapy in adults with primary immune thrombocytopenia. Blood 2010 115 14 2755 2762 10.1182/blood-2009-07-229815 2-s2.0-77950974675
15. Stasi R., Cooper N., Poeta G. D., Stipa E., Evangelista M. L., Abruzzese E., Amadori S., Analysis of regulatory T-cell changes in patients with idiopathic thrombocytopenic purpura receiving B cell depleting therapy with rituximab. Blood 2008 112 4 1147 1150 10.1182/blood-2007-12-129262 2-s2.0-51649091745
16. Stasi R., del Poeta G., Stipa E., Evangelista M. L., Trawinska M. M., Cooper N., Amadori S., Response to B-cell-depleting therapy with rituximab reverts the abnormalities of T-cell subsets in patients with idiopathic thrombocytopenic purpura. Blood 2007 110 8 2924 2930 10.1182/blood-2007-02- 068999 2-s2.0-35548960551 (Pubitemid 350006946)
17. + T cell immunity. Nature Reviews Immunology 2010 10 4 236 247 10.1038/nri2729 2-s2.0-77950070632
18. Mann M. K., Ray A., Basu S., Karp C. L., Dittel B. N., Pathogenic and regulatory roles for B cells in experimental autoimmune encephalomyelitis. Autoimmunity 2012 45 5 388 399 10.3109/08916934.2012.665523 2-s2.0-84863480832
19. Salinas G. F., Braza F., Brouard S., Tak P., Baeten D., The role of B lymphocytes in the progression from autoimmunity to autoimmune disease. Clinical Immunology 2013 146 1 34 45 10.1016/j.clim.2012.10.005 2-s2.0-84870372431
20. Dilillo D. J., Matsushita T., Tedder T. F., B10 cells and regulatory B cells balance immune responses during inflammation, autoimmunity, and cancer. Annals of the New York Academy of Sciences 2010 1183 38 57 10.1111/j.1749-6632. 2009.05137.x 2-s2.0-75749087574
21. Kalampokis I., Yoshizaki A., Tedder T. F., IL-10-producing regulatory B cells (B10 cells) in autoimmune disease. Arthritis Research and Therapy 2013 15 1, article 1 10.1186/ar3907 2-s2.0-84873601139
22. Carter N. A., Rosser E. C., Mauri C., Interleukin-10 produced by B cells is crucial for the suppression of Th17/Th1 responses, induction of T regulatory type 1 cells and reduction of collagen-induced arthritis. Arthritis Research and Therapy 2012 14 1, article R32 10.1186/ar3736 2-s2.0-84856616941
23. Carter N. A., Vasconcellos R., Rosser E. C., Tulone C., Muñoz-Suano A., Kamanaka M., Ehrenstein M. R., Flavell R. A., Mauri C., Mice lacking endogenous IL-10-producing regulatory B cells develop exacerbated disease and present with an increased frequency of Th1/Th17 but a decrease in regulatory T cells. The Journal of Immunology 2011 186 10 5569 5579 10.4049/jimmunol.1100284 2-s2.0-79956224216
24. Matsushita T., Yanaba K., Bouaziz J., Fujimoto M., Tedder T. F., Regulatory B cells inhibit EAE initiation in mice while other B cells promote disease progression. Journal of Clinical Investigation 2008 118 10 3420 3430 10.1172/JCI36030 2-s2.0-54949141219
25. Nakken B., Munthe L. A., Konttinen Y. T., Sandberg A. K., Szekanecz Z., Alex P., Szodoray P., B-cells and their targeting in rheumatoid arthritis-current concepts and future perspectives. Autoimmunity Reviews 2011 11 1 28 34 10.1016/j.autrev.2011.06.010 2-s2.0-80855138676
26. Watanabe R., Ishiura N., Nakashima H., Kuwano Y., Okochi H., Tamaki K., Sato S., Tedder T. F., Fujimoto M., Regulatory B cells (B10 cells) have a suppressive role in murine lupus: CD19 and B10 cell deficiency exacerbates systemic autoimmunity. Journal of Immunology 2010 184 9 4801 4809 10.4049/jimmunol.0902385 2-s2.0-77954505663
27. Yang M., Sun L., Wang S., Ko K., Xu H., Zheng B., Cao X., Lu L., Cutting edge: novel function of B cell-activating factor in the induction of IL-10-producing regulatory B cells. Journal of Immunology 2010 184 7 3321 3325 10.4049/jimmunol.0902551 2-s2.0-77951640991
28. Ma L., Liu B., Jiang Z., Jiang Y., Reduced numbers of regulatory B cells are negatively correlated with disease activity in patients with new-onset rheumatoid arthritis. Clinical Rheumatology 2014 33 2 187 195 10.1007/s10067-013-2359-3 2-s2.0-84881350409
29. Das A., Ellis G., Pallant C., Lopes A. R., Khanna P., Peppa D., Chen A., Blair P., Dusheiko G., Gill U., Kennedy P. T., Brunetto M., Lampertico P., Mauri C., Maini M. K., IL-10-producing regulatory B cells in the pathogenesis of chronic hepatitis B virus infection. Journal of Immunology 2012 189 8 3925 3935 10.4049/jimmunol.1103139 2-s2.0-84867308365
30. Rodeghiero F., Stasi R., Gernsheimer T., Michel M., Provan D., Arnold D. M., Bussel J. B., Cines D. B., Chong B. H., Cooper N., Godeau B., Lechner K., Mazzucconi M. G., McMillan R., Sanz M. A., Imbach P., Blanchette V., Kuhne T., Ruggeri M., George J. N., Standardization of terminology, definitions and outcome criteria in immune thrombocytopenic purpura of adults and children: report from an international working group. Blood 2009 113 11 2386 2393 10.1182/blood-2008-07-162503 2-s2.0-64049085194
31. Amel Kashipazl M. R., Huggins M. L., Lanyon P., Robins A., Powell R. J., Todd I., Assessment of Be1 and Be2 cells in systemic lupus erythematosus indicates elevated interleukin-10 producing CD5+ B cells. Lupus 2003 12 5 356 363 10.1191/0961203303lu338oa 2-s2.0-0037903552 (Pubitemid 36596979)
32. Iwata Y., Matsushita T., Horikawa M., DiLillo D. J., Yanaba K., Venturi G. M., Szabolcs P. M., Bernstein S. H., Magro C. M., Williams A. D., Hall R. P., St Clair E. W., Tedder T. F., Characterization of a rare IL-10-competent B-cell subset in humans that parallels mouse regulatory B10 cells. Blood 2011 117 2 530 541 10.1182/blood-2010-07-294249 2-s2.0-78751469622
33. Lemoine S., Morva A., Youinou P., Jamin C., Human T cells induce their own regulation through activation of B cells. Journal of Autoimmunity 2011 36 3-4 228 238 10.1016/j.jaut.2011.01.005 2-s2.0-79954939552
34. Li X., Zhong H., Bao W., Boulad N., Evangelista J., Haider M. A., Bussel J., Yazdanbakhsh K., Defective regulatory B-cell compartment in patients with immune thrombocytopenia. Blood 2012 120 16 3318 3325 10.1182/blood-2012-05- 432575 2-s2.0-84868100092
35. hi B cells exhibit regulatory capacity in healthy individuals but are functionally impaired in systemic Lupus Erythematosus patients. Immunity 2010 32 1 129 140 10.1016/j.immuni.2009.11.009 2-s2.0-74649083783
36. Wilde B., Thewissen M., Damoiseaux J., Knippenberg S., Hilhorst M., Van Paassen P., Witzke O., Cohen Tervaert J. W., Regulatory B cells in ANCA-associated vasculitis. Annals of the Rheumatic Diseases 2013 72 8 1416 1419 10.1136/annrheumdis-2012-202986 2-s2.0-84880135117
37. hi B cells maintain regulatory T cells while limiting TH1 and TH17 differentiation. Science Translational Medicine 2013 5 173 173ra23 10.1126/scitranslmed.3005407 2-s2.0-84881077504
38. + B cells in patients with primary immune thrombocytopenia. Journal of Clinical Immunology 2012 32 6 1233 1242 10.1007/s10875-012-9714-z 2-s2.0-84878227048