An up-date on newly discovered immunohistochemical biomarkers for the diagnosis of human testicular germ cell tumors

Histology and Histopathology

Volumn 29, Issue 8, 2014, Pages 999-1006

  Chieffi, Paolo ^a   Chieffi, Sergio ^a  

^a UNIVERSITY OF NAPLES FEDERICO II   (Italy)

Author keywords

Aurora B; GPR30; PATZ1; Seminomas; Testicular germ cells tumors

Indexed keywords

TUMOR MARKER;

HUMAN; IMMUNOHISTOCHEMISTRY; MALE; NEOPLASMS, GERM CELL AND EMBRYONAL; TESTICULAR NEOPLASMS;

HUMANS; IMMUNOHISTOCHEMISTRY; MALE; NEOPLASMS, GERM CELL AND EMBRYONAL; TESTICULAR NEOPLASMS; TUMOR MARKERS, BIOLOGICAL;

EID: 84904096331     PISSN: 02133911     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Review

References (58)

1. Almstrup K., Hoei-Hansen C. E., Wirkner U., Blake J., Schwager C., Ansorge W., Nielsen J. E., Skakkebaek N. E., Rajpert-De Meyts E. and Leffers H. (2004). Embryonic stem cell-like features of testicular carcinoma in situ revealed by genome-wide gene expression profiling. Cancer Res. 64, 4736-4743.
2. Atlasi Y., Mowla S. J., Ziaee S. A., Gokhale P. J. and Andrews P. W. (2008). OCT4 spliced variants are differentially expressed in human pluripotent and non-pluripotent cells. Stem Cells 26, 3068-3074.
3. Avilion A. A., Nicolis S. K. Pevny L. H., Perez L., Vivian N. and Lovell Badge R. (2003). Multipotent cell lineages in early mouse development depend on SOX2 function. Genes Dev. 17, 126-140.
4. Barbagallo F., Paronetto M. P., Franco R., Chieffi P., Dolci S., Fry A. M., Geremia R. and Sette C. (2009). Increased expression and nuclear localization of the centrosomal kinase Nek2 in human testicular seminomas. J. Pathol. 217, 431-441.
5. Bernstein E., Kim S. Y., Carmell M. A., Murchison E. P., Alcorn H., Li M. Z., Mills A. A., Elledge S. J., Anderson K. V. and Hannon G. J. (2003). Dicer is essential for mouse development. Nat. Genet. 35, 215-217.
6. Berthelsen J. G., Skakkebaek N. E., von der Maase H., Sorensen B. L. and Mogensen P. (1982). Screening for carcinoma in situ of the contralateral testis in patients with germinal testicular cancer. Br. Med. J. 285, 1683-1686.
7. Bonner M. R., McCann S. E. and Moysich K. B. (2002). Dietary factors and the risk of testicular cancer. Nutr. Cancer 44, 35-43.
8. Chaganti R. S. and Houldsworth J. (2000). Genetics and biology of adult human male germ cell tumors. Cancer Res. 60, 1474-1482.
9. Chieffi P. (2007). Molecular targets for the treatment of testicular germ cell tumors. Mini Rev. Med. Chem. 7, 755-759.
10. Chieffi P. and Chieffi S. (2013). Molecular biomarkers as potential targets for therapeutic strategies in human testicular germ cell tumours: an overview. J. Cell. Physiol. 228, 1641-1646.
11. Chieffi P., Colucci D'Amato G. L., Staibano S., Franco R. and Tramontano D. (2000). Estradiol-induced mitogen-activated protein kinase (extracellular signal-regulated kinase 1 and 2) activity in the frog (Rana esculenta) testis. J. Endocrinol. 167, 77-84.
12. Chieffi P., Battista S., Barchi M., Di Agostino S., Pierantoni G., Fedele M., Chiariotti L., Tramontano D. and Fusco A. (2002). HMGA1 and HMGA2 protein expression in mouse spermatogenesis. Oncogene 21, 3644-3650.
13. Chieffi P., Troncone G., Caleo A., Libertini S., Linardopoulos S., Tramontano D. and Portella G. (2004). Aurora B expression in normal testis and seminomas. J. Endocrinol. 181, 263-270.
14. Chieffi P., Franco R. and Portella G. (2009). Molecular and cell biology of testicular germ cell tumors. Int. Rev. Cell. Mol. Biol. 278, 277-308
15. Chieffi P., Chieffi S., Franco R. and Sinisi A. (2012). Recent advances in the biology of germ cell tumors: implications for the diagnosis and treatment. J. Endocrinol. Invest. 35, 1015-1020.
16. de Jong J. and Looijenga L. H. (2006). Stem cell marker OCT3/4 in tumor biology and germ cell tumor diagnostics: history and future. Crit. Rev. Oncog. 12, 171-203.
17. de Jong J., Stoop H., Gillis A. J., van Gurp R. J., van de Geijn G. J., Boer M., Hersmus R., Saunders P. T., Anderson R. A., Oosterhuis J. W. and Looijenga L. H. (2008). Differential expression of SOX17 and SOX2 in germ cells and stem cells has biological and clinical implications. J. Pathol. 215, 21-30.
18. Di Agostino S., Fedele M., Chieffi P., Fusco A., Rossi P., Geremia R. and Sette C. (2004). Phosphorylation of high mobility group protein A2 by Nek kinase during the first meiotic division in mouse spermatocytes. Mol. Biol. Cell 15, 1224-1232.
19. Dieckmann K. P. and Pichlmeier U. (2002). Is risk of testicular cancer related to body size? Eur. Urol. 42, 564-569.
20. Dieckmann K. P., Endsin G. and Pichlmeier U. (2001). How valid is the prenatal estrogen excess hypothesis of testicular germ cell cancer? A case control study on hormone-related factors. Eur. Urol. 40, 677-683.
21. Dieckmann K. P., Hartmann J. T., Classen J., Diederichs M. and Pichlmeier U. (2009). Is increased body mass index associated with the incidence of testicular germ cell cancer? J. Cancer Res. Clin. Oncol. 135, 731-738.
22. Esposito F., Libertini S., Franco R., Abagnale A., Marra L., Portella G. and Chieffi P. (2009). Aurora B expression in post-puberal testicular germ cell tumours. J. Cell. Physiol. 221, 435-439.
23. Esposito F., Boscia F., Franco R., Tornincasa M., Fusco A., Kitazawa S., Looijenga L. H. and Chieffi P. (2011). Down-regulation of estrogen receptor-ß associates with transcriptional coregulator PATZ1 delocalization in human testicular seminomas. J. Pathol. 224, 110-120.
24. Esposito F., Boscia F., Gigantino V., Tornincasa M., Fusco A., Franco R. and Chieffi P. (2012). The high mobility group A1-oestrogen receptor ' nuclear interaction is impaired in human testicular seminomas J. Cell. Physiol. 227, 3749-3755.
25. Fedele M., Franco R., Salvatore G., Paronetto M. P., Barbagallo F., Pero R., Chiariotti L., Sette C., Tramontano D., Chieffi G., Fusco A. and Chieffi P. (2008). PATZ1 gene has a critical role in the spermatogenesis and testicular tumours. J. Pathol. 215, 39-47.
26. Ferranti F., Muciaccia B., Ricci G., Dovere L., Canipari R., Magliocca F., Stefanini M., Catizone A. and Vicini E. (2012). Glial cell line-derived neurotrophic factor promotes invasive behaviour in testicular seminoma cells. Int. J. Androl. 35, 758-768.
27. Forman D., Oliver R. T., Brett A. R., Marsh S. G., Moses J. H., Bodmer J. G., Chilvers C. E. and Pike, M. C. (1992). Familial testicular cancer: a report of the UK family register, estimation of risk and an HLA class 1 sib-pair analysis. Br. J. Cancer 65, 255-262.
28. Franco R., Esposito F., Fedele M., Liguori G., Pierantoni G., Botti G., Tramontano D., Fusco A. and Chieffi P. (2008). Detection of high mobility group proteins A1 and A2 represents a valid diagnostic marker in post-puberal testicular germ cell tumours. J. Pathol. 214, 58-64.
29. Franco R., Boscia F., Gigantino V., Marra L., Esposito F., Ferrara D., Pariante P., Botti G., Caraglia M., Minucci S. and Chieffi P. (2011). GPR30 is over-expressed in post puberal testicular germ cell tumors. Cancer Biol. Ther. 11, 609-613.
30. Garner M., Turner M. C., Ghadirian P., Krewski D. and Wade M. (2008). Testicular cancer and hormonally active agents. J. Toxicol. Environ. Health B Crit. Rev. 11, 260-275.
31. Hart A. H., Hartley L., Parker K., Ibrahim M,. Looijenga L. H., Pauchnik M., Chow C. W. and Robb L. (2005). The pluripotency homeobox gene NANOG is expressed in human germ cell tumors. Cancer 104, 2092-2098.
32. Hoei-Hansen C. E., Almstrup K., Nielsen J. E., Brask Sonne S., Graem N., Skakkebaek N. E., Leffers H. and Rajpert-De Meyts E. (2005). Stem cell pluripotency factor NANOG is expressed inhuman fetal gonocytes, testicular carcinoma in situ and germ cell tumours. Histopathology 47, 48-56.
33. Jones R. H. and Vasey P. A. (2003). Part II: testicular cancermanagement of advanced disease. Lancet Oncol. 4, 738-747.
34. Kedde M., Strasser M. J., Boldajipour B., Oude Vrielink J. A., Slanchev K., le Sage C., Nagel R., Voorhoeve P. M., van Duijse J., Ørom U. A., Lund A. H., Perrakis A., Raz E. and Agami R. (2007). RNA-binding protein Dnd1 inhibits microRNA access to target mRNA. Cell 131, 1273-1286.
35. Kim I., Saunders T. L. and Morrison S. J. (2007). Sox17 dependence distinguishes the transcriptional regulation of fetal from adult hematopoietic stem cells. Cell 130, 470-483.
36. Ledford H. (2007). Doubts raised over stem-cell marker. Nature (London) 449, 647.
37. Linger R., Dudakia D., Huddart R., Tucker K., Friedlander M., Phillips K. A., Hogg D., Jewett M. A., Lohynska R., Daugaard G., Richard S., Chompret A., Stoppa-Lyonnet D., Bonaïti-Pellié C., Heidenreich A., Albers P., Olah E., Geczi L., Bodrogi I., Daly P. A., Guilford P., Fosså S. D., Heimdal K., Tjulandin S. A., Liubchenko L., Stoll H., Weber W., Einhorn L., McMaster M., Korde L., Greene M. H., Nathanson K. L., Cortessis V., Easton D. F., Bishop D. T., Stratton M. R. and Rapley E. A. (2008). Analysis of the DND1 gene in men with sporadic and familial testicular germ cell tumors. Genes Chromosomes Cancer 47, 247-252.
38. Lutke Holzik M. F., Rapley E. A., Hoekstra H. J., Sleijfer D. T., Nolte, I. M. and Sijmons R. H. (2004). Genetic predisposition to testicular germcell tumours. Lancet Oncol. 5, 363-371.
39. Maatouk D. M., Loveland K. L., McManus M. T., Moore K. and Harfe B. D. (2008). Dicer1 is required for differentiation of the mouse male germline. Biol. Reprod. 79, 696-703.
40. Martin O. V., Shialis T., Lester J. N., Scrimshaw M. D., Boobis A. R. and Voulvoulis N. (2008). Testicular dysgenesis syndrome and the estrogen hypothesis: a quantitative metaanalysis. Environ. Health Perspect. 116, 149-157.
41. McGlynn K. A., Quraishi S. M., Graubard B. I., Weber J. P., Rubertone M. V. and Erickson R. L. (2008). Persistent organochlorine pesticides and risk of testicular germ cell tumors. J. Natl. Cancer Inst. 100, 663-671.
42. Meng X., de Rooij D. G., Westerdahl K., Saarma M. and Sariola H. (2001). Promotion of seminomatous tumors by targeted overexpression of glial cell line-derived neurotrophic factor in mouse testis. Cancer Res. 61, 3267-3271.
43. Muller J., Skakkebaek N. E., Nielsen O. H. and Graem N. (1984). Cryptorchidism and testis cancer. Atypical infantile germ cells followed by carcinoma in situ and invasive carcinoma in adulthood. Cancer 54, 629-634.
44. Nielsen H., Nielsen M. and Skakkebaek N. E. (1974). The fine structure of possible carcinoma in-situ in the seminiferous tubules in the testis of four infertile men. Acta Pathol. Microbiol. Scand. A 82, 235-248.
45. Oosterhuis J. W. and Looijenga L. H. (2005). Testicular germ-cell tumors in a broader perspective. Nat. Rev. Cancer 5, 210-222.
46. Pero R., Lembo F., Di Vizio D., Boccia A., Chieffi P., Fedele M., Pierantoni G., Rossi P., Iuliano R., Santoro M., Viglietto G., Bruni C. B, Fusco A. and Chiariotti L. (2001). RNF4 is a growth inhibitor expressed in germ cells and lost in human testicular tumours. Am. J. Pathol. 159, 1225-1230.
47. Pero R., Lembo F., Chieffi P., Del Pozzo G., Fedele M., Fusco A., Bruni C. B. and Chiariotti L. (2003). Translational regulation of a novel testis-specific RNF4 transcript. Mol. Reprod. Dev. 66, 1-7.
48. Portella G,. Passaro C. and Chieffi P. (2011). Aurora B: a new prognostic marker and therapeutic target in cancer. Curr. Med. Chem. 18, 482-496.
49. Rajpert-De Meyts E. and Skakkebaek N. E. (2011). Pathogenesis of testicular carcinoma in situ and germ cell cancer: still more questions than answers. Int. J. Androl. 34, e2-6.
50. Skakkebaek N. E. (1972). Possible carcinoma-in-situ of the testis. Lancet 2, 516-517.
51. Skakkebaek N. E., Berthelsen J. G., Giwercman A. and Muller J. (1987). Carcinoma-in-situ of the testis: possible origin from gonocytes and precursor of all types of germ cell tumours except spermatocytoma. Int. J. Androl. 10, 19-28.
52. Staibano S., Ilardi G., Leone V., Luise C., Merolla F., Esposito F., Morra F., Siano M., Franco R., Fusco A., Chieffi P. and Celetti A. (2013). Critical role of CCDC6 in the neoplastic growth of testicular germ cell tumors. BMC Cancer 13, 433.
53. Strohsnitte W. C., Noller K. L., Hoover R. N., Robboy S. J., Palmer J. R., Titus-Ernstoff L., Kaufman R. H., Adam E., Herbst A. L. and Hatch E. E. (2001). Cancer risk in men exposed in utero to diethylstilbestrol. J. Natl. Cancer Inst. 93, 545-551.
54. Ulbright T. M. (2005). Germ cell tumors of the gonads: a selective review emphasizing problems in differential diagnosis, newly appreciated, and controversial issues. Modern Pathol. 18, S61-S79.
55. Vicini E., Loiarro M., Di Agostino S., Corallini S., Capolunghi F., Carsetti R., Chieffi P., Geremia R., Stefanini M. and Sette C. (2006). 17-ßestradiol elicits genomic and non-genomic responses in mouse male germ cells. J. Cell. Physiol. 206, 238-245.
56. Voorhoeve P. M., le Sage C., Schrier M., Gillis A. J., Stoop H., Nagel R., Liu Y. P., van Duijse J., Drost J., Griekspoor A., Zlotorynski E., Yabuta N., De Vita G., Nojima H., Looijenga L. H., and Agami R. (2006). A genetic screen implicates miRNA-372 and miRNA-373 as oncogenes in testicular germ cell tumors. Cell 124, 1169-1181.
57. Yamaguchi S., Kimura H., Tada M., Nakatsuji N. and Tada T. (2005). Nanog expression in mouse germ cell development. Gene Expr. Patterns 5, 639-646.
58. Wicha M. S., Liu S. and Dontu G. (2006). Cancer stem cells: an old ideaa paradigm shift. Cancer Res. 66, 1883-1890.