Halogenated diarylacetylenes repress c-myc expression in cancer cells

Bioorganic and Medicinal Chemistry Letters

Volumn 24, Issue 15, 2014, Pages 3638-3640

  Sviripa, Vitaliy M ^a,b   Zhang, Wen ^a,c   Kril, Liliia M ^a,b   Liu, Alice X ^a,b   Yuan, Yaxia ^b   Zhan, Chang Guo ^b   Liu, Chunming ^a,c   Watt, David S ^a,b,c  

^a UNIVERSITY OF KENTUCKY   (United States)

^b University of Kentucky   (United States)

^c UNIVERSITY OF KENTUCKY   (United States)

Author keywords

Antineoplastic agents; c myc; Colon cancer; Diarylacetylenes

Indexed keywords

4 (2',6' DIFLUOROSTYRYL) N,N DIMETHYLANILINE; 4 [(2,6 DIFLUOROPHENYL)ETHYNYL] N,N DIMETHYLANILINE; ACETYLENE DERIVATIVE; ANTINEOPLASTIC AGENT; CHLORINE; CYCLIN DEPENDENT KINASE INHIBITOR 1; DIARYLACETYLENE DERIVATIVE; FLUORINE; MYC PROTEIN; STILBENE DERIVATIVE; UNCLASSIFIED DRUG; ALKYNE; CHLORINATED HYDROCARBON; FLUORINATED HYDROCARBON; (E) 4 (2',6' DIFLUOROSTYRYL) N,N DIMETHYLANILINE; HALIDE; HALOGENATED DIARYLACETYLENE DERIVATIVE;

ARTICLE; CANCER CELL; CELL PROLIFERATION; COLON CANCER; CONTROLLED STUDY; DRUG MECHANISM; GENE REPRESSION; HALOGENATION; PROTEIN EXPRESSION; PROTEIN INDUCTION; ANTAGONISTS AND INHIBITORS; BIOSYNTHESIS; CHEMICAL STRUCTURE; CHEMISTRY; DOSE RESPONSE; DRUG EFFECTS; DRUG SCREENING; HUMAN; STRUCTURE ACTIVITY RELATION; SYNTHESIS; TUMOR CELL LINE; ANTINEOPLASTIC ACTIVITY; CANCER INHIBITION; COMPUTER MODEL; DRUG BINDING; DRUG STRUCTURE;

ALKYNES; ANTINEOPLASTIC AGENTS; CELL LINE, TUMOR; CELL PROLIFERATION; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG SCREENING ASSAYS, ANTITUMOR; HALOGENATION; HUMANS; HYDROCARBONS, CHLORINATED; HYDROCARBONS, FLUORINATED; MODELS, MOLECULAR; MOLECULAR STRUCTURE; PROTO-ONCOGENE PROTEINS C-MYC; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 84904057693     PISSN: 0960894X     EISSN: 14643405     Source Type: Journal    
DOI: 10.1016/j.bmcl.2014.04.113     Document Type: Article

References (12)

1. D.M. Miller, S.D. Thomas, A. Islam, D. Muench, and K. Sedoris Clin. Cancer Res. 18 2012 5546
2. W. Zhang, V. Sviripa, L.M. Kril, X. Chen, T. Yu, J. Shi, P. Rychahou, B.M. Evers, D.S. Watt, and C. Liu J. Med. Chem. 54 2011 1288
3. W. Zhang, V. Sviripa, X. Chen, J. Shi, T. Yu, A. Hamza, N.D. Ward, L.M. Kril, C.W. Vander Kooi, C.-G. Zhan, B.M. Evers, D.S. Watt, and C. Liu ACS Chem. Biol. 8 2013 796
4. Watt, D.; Liu, C.; Sviripa, V. M.; Zhang, W. U.S. Patent 8,664,276 March 4, 2014.
5. J. Cai, W.M. Sun, J.J. Hwang, S.C. Stain, and S.C. Lu Hepatology 1090 1996 24
6. H. Chen, M. Xia, M. Lin, H. Yang, J. Kuhlenkamp, T. Li, N.M. Sodir, Y.H. Chen, H. Josef-Lenz, P.W. Laird, S. Clarke, J.M. Mato, and S.C. Lu Gastroenterology 133 2007 207
7. K. Ito, S. Ikeda, N. Kojima, M. Miura, K. Shimizu-Saito, I. Yamaguchi, I. Katsuyama, K. Sanada, T. Iwai, H. Senoo, and S. Horikawa Surg. Today 30 2000 706
8. Q. Liu, J. Chen, L. Liu, J. Zhang, D. Wang, L. Ma, Y. He, Y. Liu, Z. Liu, and J. Wu J. Biol. Chem. 286 2011 17168
9. V.M. Dembitsky, D.O. Levitsky, T.A. Gloriozova, and V.V. Poroikov Nat. Prod. Commun. 1 2006 773
10. J.A. Hadfield, and A.T. McGown Synth. Commun. 28 1998 1421
11. S. Bhattacharya, and S. Sengupta Tetrahedron Lett. 47 2004 8733
12. K. Okuro, M. Furuune, M. Enna, M. Miura, and M. Nomura J. Org. Chem. 58 1993 4716