Genetic variation in the Vitamin D receptor, plasma 25-Hydroxyvitamin D, and biomarkers of cardiometabolic disease in caucasian young adults

Journal of Nutrigenetics and Nutrigenomics

Volumn 6, Issue 4-5, 2013, Pages 256-267

  García Bailo, Bibiana ^a,b   Jamnik, Joseph ^a   Da Costa, Laura A ^a   Badawi, Alaa ^b   El Sohemy, Ahmed ^a  

^a UNIVERSITY OF TORONTO   (Canada)

^b PUBLIC HEALTH AGENCY OF CANADA   (Canada)

Author keywords

25 Hydroxyvitamin D; Biomarkers; Cardiometabolic disease; Single nucleotide polymorphisms; Vitamin D receptor; Young adults

Indexed keywords

25 HYDROXYVITAMIN D; CHOLESTEROL; HIGH DENSITY LIPOPROTEIN CHOLESTEROL; INSULIN; TRIACYLGLYCEROL; VITAMIN D RECEPTOR; 25-HYDROXYVITAMIN D; BIOLOGICAL MARKER; CALCITRIOL RECEPTOR; DRUG DERIVATIVE; VITAMIN D;

ADULT; ALLELE; ARTICLE; BODY MASS; CARDIOMETABOLIC RISK; CHOLESTEROL BLOOD LEVEL; CONTROLLED STUDY; DIASTOLIC BLOOD PRESSURE; FEMALE; GENETIC ASSOCIATION; GENETIC VARIABILITY; GLUCOSE METABOLISM; HEART DISEASE; HOMOZYGOTE; HUMAN; INSULIN BLOOD LEVEL; INSULIN SENSITIVITY; LIPID METABOLISM; MAJOR CLINICAL STUDY; MALE; METABOLIC DISORDER; PHYSICAL ACTIVITY; PRIORITY JOURNAL; SINGLE NUCLEOTIDE POLYMORPHISM; SYSTOLIC BLOOD PRESSURE; TRIACYLGLYCEROL BLOOD LEVEL; VITAMIN BLOOD LEVEL; WAIST CIRCUMFERENCE; BLOOD; CARDIOVASCULAR DISEASE; CAUCASIAN; ETHNOLOGY; GENETICS; INSULIN RESISTANCE; RISK FACTOR; YOUNG ADULT;

ADULT; BIOLOGICAL MARKERS; CARDIOVASCULAR DISEASES; EUROPEAN CONTINENTAL ANCESTRY GROUP; FEMALE; GENETIC VARIATION; GENOME-WIDE ASSOCIATION STUDY; HUMANS; INSULIN RESISTANCE; MALE; METABOLIC DISEASES; POLYMORPHISM, SINGLE NUCLEOTIDE; RECEPTORS, CALCITRIOL; RISK FACTORS; VITAMIN D; YOUNG ADULT;

EID: 84904057166     PISSN: 16616499     EISSN: 16616758     Source Type: Journal    
DOI: 10.1159/000354729     Document Type: Article

References (49)

1. Rosen CJ, Adams JS, Bikle DD, Black DM, Demay MB, Manson JE, Murad MH, Kovacs CS. The nonskeletal effects of vitamin D. an Endocrine Society scientific statement. Endocr Rev 2012; 33: 456-492
2. VieThR, Bischoff-Ferrari H, Boucher BJ, Dawson-Hughes B, Garland CF, Heaney RP, Holick MF, Hollis BW, Lamberg-Allardt C, McGRath JJ, Norman AW, Scragg R, Whiting SJ, Willett WC, Zittermann A. The urgent need to recommend an intake of vitamin D that is effective. Am J Clin Nutr 2007; 85: 649-650
3. Aschner P. Metabolic syndrome as a risk factor for diabetes. Expert Rev Cardiovasc Ther 2010; 8: 407-412
4. Barzilay JI, Abraham L, Heckbert SR, Cushman M, Kuller LH, Resnick HE, Tracy RP. The relation of markers of inflammation to the development of glucose disorders in theelderly: the Cardiovascular HealThStudy. Diabetes 2001; 50: 2384-2389
5. Hu FB, Meigs JB, Li TY, Rifai N, Manson JE. Inflammatory markers and risk of developing type 2 diabetes in women. Diabetes 2004; 53: 693-700
6. Laaksonen DE, Niskanen L, Nyyssonen K, Punnonen K, Tuomainen TP, Valkonen VP, Salonen R, Salonen JT. C-reactive protein and the development of the metabolic syndrome and diabetes in middle-Aged men. Diabetologia 2004; 47: 1403-1410
7. Jenny NS, Arnold AM, Kuller LH, Tracy RP, Psaty BM. Serum amyloid P and cardiovascular disease in older men and women: results from the Cardiovascular HealThStudy. Arterioscler Thromb Vasc Biol 2007; 27: 352-358
8. Bouillon R, Carmeliet G, Verlinden L, van EE, Verstuyf A, Luderer HF, Lieben L, Mathieu C, Demay M. Vitamin D and human health: lessons from vitamin D receptor null mice. Endocr Rev 2008; 29: 726-776
9. Lagishetty V, Liu NQ, Hewison M. Vitamin D metabolism and innate immunity. Mol Cell Endocrinol 2011; 347: 97-105
10. Maestro B, Campion J, Davila N, Calle C. Stimulation by 1, 25-dihydroxyvitamin D3 of insulin receptor expression and insulin responsiveness for glucose transport in U-937 human promonocytic cells. Endocr J 2000; 47: 383-391
11. Nimitphong H, Holick MF, Fried SK, Lee MJ: 25-Hydroxyvitamin D(3) and 1, 25-dihydroxyvitamin D(3) promote the differentiation of human subcutaneous preadipocytes. PLoS One 2012; 7: e52171
12. Bland R, Markovic D, Hills CE, Hughes SV, Chan SL, Squires PE, Hewison M. Expression of 25-hydroxyvitamin D3-1alpha-hydroxylase in pancreatic islets. J Steroid Biochem Mol Biol 2004; 89-90: 121-125
13. Querfeld U, Hoffmann MM, Klaus G, Eifinger F, Ackerschott M, Michalk D, Kern PA. Antagonistic effects of vitamin D and paRath yroid hormone on lipoprotein lipase in cultured adipocytes. J Am Soc Nephrol 1999; 10: 2158-2164
14. Bellia A, Garcovich C, D'Adamo M, Lombardo M, Tesauro M, Donadel G, Gentileschi P, Lauro D, Federici M, Lauro R, Sbraccia P. Serum 25-hydroxyvitamin D levels are inversely associated with systemic inflammation in severe obese subjects. Intern Emerg Med 2011; 8: 33-40
15. Neyestani TR, Nikooyeh B, Alavi-Majd H, Shariatzadeh N, Kalayi A, Tayebinejad N, Heravifard S, Salekzamani S, Zahedirad M. Improvement of vitamin D status via daily intake of fortified yogurt drink either with or with out extra calcium ameliorates systemic inflammatory biomarkers, including adipokines, in the subjects with type 2 diabetes. J Clin Endocrinol Metab 2012; 97: 2005-2011
16. Kayaniyil S, Retnakaran R, Harris SB, VieThR, Knight JA, Gerstein HC, Perkins BA, Zinman B, Hanley AJ. Prospective associations of vitamin D with beta-cell function and glycemia: the PROspective Metabolism and ISlet cell Evaluation (PROMISE) cohort study. Diabetes 2011; 60: 2947-2953
17. Karhapaa P, Pihlajamaki J, Porsti I, Kastarinen M, Mustonen J, Niemela O, Kuusisto J. Diverse associations of 25-hydroxyvitamin D and 1, 25-dihydroxy-vitamin D with dyslipidaemias. J Intern Med 2010; 268: 604-610
18. Elamin MB, Abu Elnour NO, Elamin KB, Fatourechi MM, Alkatib AA, Almandoz JP, Liu H, Lane MA, Mullan RJ, Hazem A, Erwin PJ, Hensrud DD, Murad MH, Montori VM. Vitamin D and cardiovascular outcomes: a systematic review and meta-Analysis. J Clin Endocrinol Metab 2011; 96: 1931-1942
19. Brondum-Jacobsen P, Benn M, Jensen GB, Nordestgaard BG: 25-Hydroxyvitamin D levels and risk of ischemic heart disease, myocardial infarction, and early death: population-based study and meta-Analyses of 18 and 17 studies. Arterioscler Thromb Vasc Biol 2012; 32: 2794-2802
20. Pittas AG, Chung M, Trikalinos T, Mitri J, Brendel M, Patel K, Lichtenstein AH, Lau J, Balk EM. Systematic review: vitamin D and cardiometabolic outcomes. Ann Intern Med 2010; 152: 307-314
21. Norman AW. From vitamin D to hormone D. fundamentals of the vitamin D endocrine system essential for good health. Am J Clin Nutr 2008; 88: 491S-499S
22. DeLuca HF. Overview of general physiologic features and functions of vitamin D. Am J Clin Nutr 2004; 80: 1689S-1696S
23. Valdivielso JM, Fernandez E. Vitamin D receptor polymorphisms and diseases. Clin Chim Acta 2006; 371: 1-12
24. Reis AF, Hauache OM, Velho G. Vitamin D endocrine system and the genetic susceptibility to diabetes, obesity and vascular disease. A review of evidence. Diabetes Metab 2005; 31: 318-325
25. Levin GP, Robinson-Cohen C, de Boer IH, Houston DK, Lohman K, Liu Y, Kritchevsky SB, Cauley JA, Tanaka T, Ferrucci L, Bandinelli S, Patel KV, Hagström E, Michaëlsson K, Melhus H, Wang T, Wolf M, Psaty BM, Siscovick D, Kestenbaum B. Genetic variants and associations of 25-hydroxyvitamin D concentrations with major clinical outcomes. JAMA 2012; 308: 1898-1905
26. Garcia-Bailo B, Brenner DR, Nielsen D, Lee HJ, Domanski D, Kuzyk M, Borchers CH, Badawi A, Karmali MA, El-Sohemy A. Dietary patterns and ethnicity are associated with distinct plasma proteomic groups. Am J Clin Nutr 2012; 95: 352-361
27. Cahill L, Corey PN, El-Sohemy A. Vitamin C deficiency in a population of young Canadian adults. Am J Epidemiol 2009; 170: 464-471
28. Garcia-Bailo B, Josse AR, Jamnik J, Badawi A, El-Sohemy A. Positive association between 25-hydroxyvitamin D and C-reactive protein is confounded by hormonal contraceptive use. J Womens HealTh(Larchmt) 2013; 22: 417-425
29. Levy JC, Matthews DR, Hermans MP. Correct homeostasis model assessment (HOMA) evaluation uses the computer program. Diabetes Care 1998; 21: 2191-2192
30. Wagner D, Hanwell HE, Schnabl K, Yazdanpanah M, Kimball S, Fu L, Sidhom G, Rousseau D, Cole DE, VieThR. The ratio of serum 24, 25-dihydroxyvitamin D(3) to 25-hydroxyvitamin D(3) is predictive of 25-hydroxyvitamin D(3) response to vitamin D(3) supplementation. J Steroid Biochem Mol Biol 2011; 126: 72-77
31. Josse AR, Da Costa LA, Campos H, El-Sohemy A. Associations between polymorphisms in the AHR and CYP1A1-CYP1A2 gene regions and habitual caffeine consumption. Am J Clin Nutr 2012; 96: 665-671
32. McLaughlin T, Abbasi F, Cheal K, Chu J, Lamendola C, Reaven G. Use of metabolic markers to identify overweight individuals who are insulin resistant. Ann Intern Med 2003; 139: 802-809
33. Wallace TM, Levy JC, Matthews DR. Use and abuse of HOMA modeling. Diabetes Care 2004; 27: 1487-1495
34. Arora P, Garcia-Bailo B, Dastani Z, Brenner D, Villegas A, Malik S, Spector TD, Richards B, El-Sohemy A, Karmali M, Badawi A. Genetic polymorphisms of innate immunity-related inflammatory pathways and their association with factors related to type 2 diabetes. BMC Med Genet 2011; 12: 95
35. Narum SR. Beyond Bonferroni: less conservative analyses for conservation genetics. Cons Genet 2006; 7: 783-787
36. Garcia-Bailo B, Jamnik J, Da Costa LA, Borchers CH, Badawi A, El-Sohemy A. Plasma 25-hydroxyvitamin D, hormonal contraceptive use, and the plasma proteome in Caucasian, East Asian, and SouThAsian young adults. J Proteome Res 2013; 12: 1797-1807
37. Reaven GM. Role of insulin resistance in human disease (syndrome X): an expanded definition. Annu Rev Med 1993; 44: 121-131
38. Alvarez JA, Ashraf AP, Hunter GR, Gower BA. Serum 25-hydroxyvitamin D and paRath yroid hormone are independent determinants of whole-body insulin sensitivity in women and may contribute to lower insulin sensitivity in African Americans. Am J Clin Nutr 2010; 92: 1344-1349
39. von Hurst PR, Stonehouse W, Coad J. Vitamin D supplementation reduces insulin resistance in SouThAsian women living in New Zealand who are insulin resistant and vitamin D deficient-A randomised, placebocontrolled trial. Br J Nutr 2010; 103: 549-555
40. Maestro B, Dávila N, Carranza MC, Calle C. Identification of a vitamin D response element in the human insulin receptor gene promoter. J Steroid Biochem Mol Biol 2003; 84: 223-230
41. Ishida H, Norman AW. Demonstration of a high affinity receptor for 1, 25-dihydroxyvitamin D3 in rat pancreas. Mol Cell Endocrinol 1988; 60: 109-117
42. Ogunkolade BW, Boucher BJ, Prahl JM, Bustin SA, Burrin JM, Noonan K, NorThBV, Mannan N, McDermott MF, DeLuca HF, Hitman GA. Vitamin D receptor (VDR) mRNA and VDR protein levels in relation to vitamin D status, insulin secretory capacity, and VDR genotype in Bangladeshi Asians. Diabetes 2002; 51: 2294-2300
43. Oh JY, Barrett-Connor E. Association between vitamin D receptor polymorphism and type 2 diabetes or metabolic syndrome in community-dwelling older adults: the Rancho Bernardo Study. Metabolism 2002; 51: 356-359
44. Jain R, von Hurst PR, Stonehouse W, Love DR, Higgins CM, Coad J. Association of vitamin D receptor gene polymorphisms with insulin resistance and response to vitamin D. Metabolism 2012; 61: 293-301
45. Kelly JL, Drake MT, Fredericksen ZS, Asmann YW, Liebow M, Shanafelt TD, Feldman AL, Ansell SM, Macon WR, Herr MM, Wang AH, Nowakowski GS, Call TG, Habermann TM, Slager SL, Witzig TE, Cerhan JR. Early life sun exposure, vitamin D-related gene variants, and risk of non-Hodgkin lymphoma. Cancer Causes Control 2012; 23: 1017-1029
46. Mutti DO, Cooper ME, Dragan E, Jones-Jordan LA, Bailey MD, Marazita ML, Murray JC, Zadnik K. Vitamin D receptor (VDR) and group-specific component (GC, vitamin D-binding protein) polymorphisms in myopia. Invest Ophthalmol Vis Sci 2011; 52: 3818-3824
47. Sung CC, Liao MT, Lu KC, Wu CC. Role of vitamin D in insulin resistance. J Biomed Biotechnol 2012; 2012: 634195
48. Ramagopalan SV, Heger A, Berlanga AJ, Maugeri NJ, Lincoln MR, Burrell A, Handunnetthi L, Handel AE, Disanto G, Orton SM, Watson CT, Morahan JM, Giovannoni G, Ponting CP, Ebers GC, Knight JC. A ChIP-seq defined genome-wide map of vitamin D receptor binding: associations with disease and evolution. Genome Res 2010; 20: 1352-1360
49. Heikkinen S, Vaisanen S, Pehkonen P, Seuter S, Benes V, Carlberg C. Nuclear hormone 1alpha, 25-dihydroxyvitamin D3 elicits a genome-wide shift in the locations of VDR chromatin occupancy. Nucleic Acids Res 2011; 39: 9181-9193