메뉴 건너뛰기




Volumn 99, Issue 7, 2014, Pages 2575-2583

Bacterial DNA translocation holds increased insulin resistance and systemic inflammatory levels in morbid obese patients

Author keywords

[No Author keywords available]

Indexed keywords

BACTERIAL DNA; ENDOTOXIN;

EID: 84904052550     PISSN: 0021972X     EISSN: 19457197     Source Type: Journal    
DOI: 10.1210/jc.2013-4483     Document Type: Article
Times cited : (28)

References (30)
  • 1
    • 33845881411 scopus 로고    scopus 로고
    • Mechanisms linking obesity to insulin resistance and type 2 diabetes
    • DOI 10.1038/nature05482, PII NATURE05482
    • Kahn SE, Hull RL, Utzschneider KM. Mechanisms linking obesity to insulin resistance and type 2 diabetes. Nature. 2006;444(7121):840-846. (Pubitemid 46024990)
    • (2006) Nature , vol.444 , Issue.7121 , pp. 840-846
    • Kahn, S.E.1    Hull, R.L.2    Utzschneider, K.M.3
  • 2
    • 46949102499 scopus 로고    scopus 로고
    • Systemic inflammation and cardiovascular risk factors: Are morbidly obese subjects different?
    • Faintuch J, Marques PC, Bortolotto LA, Faintuch JJ, Cecconello I. Systemic inflammation and cardiovascular risk factors: are morbidly obese subjects different? Obes Surg. 2008;18(7):854-862.
    • (2008) Obes Surg , vol.18 , Issue.7 , pp. 854-862
    • Faintuch, J.1    Marques, P.C.2    Bortolotto, L.A.3    Faintuch, J.J.4    Cecconello, I.5
  • 3
    • 2642539496 scopus 로고    scopus 로고
    • The chronic inflammatory hypothesis for the morbidity associated with morbid obesity: Implications and effect of weight loss
    • DOI 10.1381/096089204323093345
    • Cottam DR, Mattar SG, Barinas-Mitchell E, et al. The chronic inflammatory hypothesis for the morbidity associated with morbid obesity: implications and effects of weight loss. Obes Surg. 2004;14(5):589-600. (Pubitemid 38716577)
    • (2004) Obesity Surgery , vol.14 , Issue.5 , pp. 589-600
    • Cottam, D.R.1    Mattar, S.G.2    Barinas-Mitchell, E.3    Eid, G.4    Kuller, L.5    Kelley, D.E.6    Schauer, P.R.7
  • 4
    • 84934434968 scopus 로고    scopus 로고
    • Overview of adipose tissue and its role in obesity and metabolic disorders
    • Frühbeck G. Overview of adipose tissue and its role in obesity and metabolic disorders. Methods Mol Biol. 2008;456:1-22.
    • (2008) Methods Mol Biol , vol.456 , pp. 1-22
    • Frühbeck, G.1
  • 5
    • 79952451443 scopus 로고    scopus 로고
    • Obesity, insulin resistance and free fatty acids
    • Boden G. Obesity, insulin resistance and free fatty acids. Curr Opin Endocrinol Diabetes Obes. 2011;18(2):139-143.
    • (2011) Curr Opin Endocrinol Diabetes Obes , vol.18 , Issue.2 , pp. 139-143
    • Boden, G.1
  • 7
    • 84876179073 scopus 로고    scopus 로고
    • Dyslipidemia in obesity: Mechanisms and potential targets
    • Klop B, Elte JW, Cabezas MC. Dyslipidemia in obesity: mechanisms and potential targets. Nutrients. 2013;5(4):1218-1240.
    • (2013) Nutrients , vol.5 , Issue.4 , pp. 1218-1240
    • Klop, B.1    Elte, J.W.2    Cabezas, M.C.3
  • 8
    • 61549135793 scopus 로고    scopus 로고
    • Obesity and inflammation: The effects of weight loss
    • Forsythe LK, Wallace JM, Livingstone MB. Obesity and inflammation: the effects of weight loss. Nutr Res Rev. 2008;21(2):117-133.
    • (2008) Nutr Res Rev , vol.21 , Issue.2 , pp. 117-133
    • Forsythe, L.K.1    Wallace, J.M.2    Livingstone, M.B.3
  • 10
    • 51649088497 scopus 로고    scopus 로고
    • Adipose macrophage infiltration is associated with insulin resistance and vascular endothelial dysfunction in obese subjects
    • Apovian CM, Bigornia S, Mott M, et al. Adipose macrophage infiltration is associated with insulin resistance and vascular endothelial dysfunction in obese subjects. Arterioscler Thromb Vasc Biol. 2008;28(9):1654-1659.
    • (2008) Arterioscler Thromb Vasc Biol , vol.28 , Issue.9 , pp. 1654-1659
    • Apovian, C.M.1    Bigornia, S.2    Mott, M.3
  • 11
    • 33845866857 scopus 로고    scopus 로고
    • Inflammation and metabolic disorders
    • DOI 10.1038/nature05485, PII NATURE05485
    • Hotamisligil GS. Inflammation and metabolic disorders. Nature. 2006;444(7121):860-867. (Pubitemid 46024993)
    • (2006) Nature , vol.444 , Issue.7121 , pp. 860-867
    • Hotamisligil, G.S.1
  • 13
    • 0036264984 scopus 로고    scopus 로고
    • Markers of chronic inflammation and obesity: A prospective study on the reversibility of this association in middle-aged women undergoing weight loss by surgical intervention
    • DOI 10.1038/sj.ijo.0801970
    • Laimer M, Ebenbichler CF, Kaser S, et al. Markers of chronic inflammation and obesity: a prospective study on the reversibility of this association in middle-aged women undergoing weight loss by surgical intervention. Int J Obes Relat Metab Disord. 2002;26(5):659-662. (Pubitemid 34499286)
    • (2002) International Journal of Obesity , vol.26 , Issue.5 , pp. 659-662
    • Laimer, M.1    Ebenbichler, C.F.2    Kaser, S.3    Sandhofer, A.4    Weiss, H.5    Nehoda, H.6    Aigner, F.7    Patsch, J.R.8
  • 15
    • 84865297442 scopus 로고    scopus 로고
    • The inflammation highway: Metabolism accelerates inflammatory traffic in obesity
    • Johnson AR, Milner JJ, Makowski L. The inflammation highway: metabolism accelerates inflammatory traffic in obesity. Immunol Rev. 2012;249(1):218-238.
    • (2012) Immunol Rev , vol.249 , Issue.1 , pp. 218-238
    • Johnson, A.R.1    Milner, J.J.2    Makowski, L.3
  • 16
    • 84860852477 scopus 로고    scopus 로고
    • The impact of obesity on the immune response to infection
    • Milner JJ, Beck MA. The impact of obesity on the immune response to infection. Proc Nutr Soc. 2012;71(2):298-306.
    • (2012) Proc Nutr Soc , vol.71 , Issue.2 , pp. 298-306
    • Milner, J.J.1    Beck, M.A.2
  • 17
    • 33845901507 scopus 로고    scopus 로고
    • Microbial ecology: Human gut microbes associated with obesity
    • DOI 10.1038/4441022a, PII 4441022A
    • Ley RE, Turnbaugh PJ, Klein S, Gordon JI. Microbial ecology: human gut microbes associated with obesity. Nature. 2006;444(7122):1022-1023. (Pubitemid 46018512)
    • (2006) Nature , vol.444 , Issue.7122 , pp. 1022-1023
    • Ley, R.E.1    Turnbaugh, P.J.2    Klein, S.3    Gordon, J.I.4
  • 18
    • 33845874101 scopus 로고    scopus 로고
    • An obesity-associated gut microbiome with increased capacity for energy harvest
    • DOI 10.1038/nature05414, PII NATURE05414
    • Turnbaugh PJ, Ley RE, Mahowald MA, Magrini V, Mardis ER, Gordon JI. An obesity-associated gut microbiome with increased capacity for energy harvest. Nature. 2006;444(7122):1027-1031. (Pubitemid 46018515)
    • (2006) Nature , vol.444 , Issue.7122 , pp. 1027-1031
    • Turnbaugh, P.J.1    Ley, R.E.2    Mahowald, M.A.3    Magrini, V.4    Mardis, E.R.5    Gordon, J.I.6
  • 19
    • 43349107591 scopus 로고    scopus 로고
    • High prevalence of small intestinal bacterial overgrowth in patients with morbid obesity: A contributor to severe hepatic steatosis
    • Sabaté JM, Jouët P, Harnois F, et al. High prevalence of small intestinal bacterial overgrowth in patients with morbid obesity: a contributor to severe hepatic steatosis. Obes Surg. 2008;18(4):371-377.
    • (2008) Obes Surg , vol.18 , Issue.4 , pp. 371-377
    • Sabaté, J.M.1    Jouët, P.2    Harnois, F.3
  • 20
    • 79952451549 scopus 로고    scopus 로고
    • Small intestinal bacterial overgrowth in patients with morbid obesity
    • Jouet P, Coffin B, Sabate JM. Small intestinal bacterial overgrowth in patients with morbid obesity. Dig Dis Sci. 2011;56(2):615.
    • (2011) Dig Dis Sci , vol.56 , Issue.2 , pp. 615
    • Jouet, P.1    Coffin, B.2    Sabate, J.M.3
  • 21
    • 0031737373 scopus 로고    scopus 로고
    • Correct homeostasis model assessment (HOMA) evaluation uses the computer program [3]
    • Levy JC, Matthews DR, Hermans MP. Correct homeostasis model assessment (HOMA) evaluation uses the computer program. Diabetes Care. 1998;21(12):2191- 2192. (Pubitemid 28549174)
    • (1998) Diabetes Care , vol.21 , Issue.12 , pp. 2191-2192
    • Levy, J.C.1    Matthews, D.R.2    Hermans, M.P.3
  • 24
    • 0024999256 scopus 로고
    • Optimization of detection of bacterial endotoxin in plasma with the Limulus test
    • Roth RI, Levin FC, Levin J. Optimization of detection of bacterial endotoxin in plasma with the Limulus test. J Lab Clin Med. 1990;116(2):153-161. (Pubitemid 20269808)
    • (1990) Journal of Laboratory and Clinical Medicine , vol.116 , Issue.2 , pp. 153-161
    • Roth, R.I.1    Levin, F.C.2    Levin, J.3
  • 26
    • 40949083014 scopus 로고    scopus 로고
    • Bacterial DNA in patients with cirrhosis and noninfected ascites mimics the soluble immune response established in patients with spontaneous bacterial peritonitis
    • DOI 10.1002/hep.22083
    • Francés R, Zapater P, González-Navajas JM, et al. Bacterial DNA in patients with cirrhosis and noninfected ascites mimics the soluble immune response established in patients with spontaneous bacterial peritonitis. Hepatology. 2008;47(3):978-985. (Pubitemid 351449689)
    • (2008) Hepatology , vol.47 , Issue.3 , pp. 978-985
    • Frances, R.1    Zapater, P.2    Gonzalez-Navajas, J.M.3    Munoz, C.4    Cano, R.5    Moreu, R.6    Pascual, S.7    Bellot, P.8    Perez-Mateo, M.9    Such, J.10
  • 28
    • 0028256436 scopus 로고
    • Mechanisms of insulin resistance during acute endotoxemia
    • DOI 10.1210/en.134.5.2072
    • Virkamäki A, Yki-Järvinen H. Mechanisms of insulin resistance during acute endotoxemia. Endocrinology. 1994;134(5):2072-2078. (Pubitemid 24142945)
    • (1994) Endocrinology , vol.134 , Issue.5 , pp. 2072-2078
    • Virkamaki, A.1    Yki-Jarvinen, H.2
  • 29
    • 0027459878 scopus 로고
    • Adipose expression of tumor necrosis factor-α: Direct role in obesity-linked insulin resistance
    • Hotamisligil GS, Shargill NS, Spiegelman BM. Adipose expression of tumor necrosis factor-α: direct role in obesity-linked insulin resistance. Science. 1993;259(5091):87-91. (Pubitemid 23036092)
    • (1993) Science , vol.259 , Issue.5091 , pp. 87-91
    • Hotamisligil, G.S.1    Shargill, N.S.2    Spiegelman, B.M.3
  • 30
    • 0030061922 scopus 로고    scopus 로고
    • IRS-1-mediated inhibition of insulin receptor tyrosine kinase activity in TNF-α- and obesity-induced insulin resistance
    • Hotamisligil GS, Peraldi P, Budavari A, Ellis R, White MF, Spiegelman BM. IRS-1-mediated inhibition of insulin receptor tyrosine kinase activity in TNF-α- and obesity-induced insulin resistance. Science. 1996;271(5249):665-668. (Pubitemid 26052915)
    • (1996) Science , vol.271 , Issue.5249 , pp. 665-668
    • Hotamisligil, G.S.1    Peraldi, P.2    Budavari, A.3    Ellis, R.4    White, M.F.5    Spiegelman, B.M.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.