Blocking leukotriene synthesis attenuates the pathophysiology of traumatic brain injury and associated cognitive deficits

Experimental Neurology

Volumn 256, Issue , 2014, Pages 7-16

  Corser Jensen, Chelsea E ^a,b   Goodell, Dayton J ^a,b   Freund, Ronald K ^b   Serbedzija, Predrag ^b   Murphy, Robert C ^a,b   Farias, Santiago E ^a,b   Dell'Acqua, Mark L ^a,b   Frey, Lauren C ^b   Serkova, Natalie ^b   Heidenreich, Kim A ^a,b  

^a UNIVERSITY OF COLORADO   (United States)

^b UNIVERSITY OF COLORADO SCHOOL OF MEDICINE   (United States)

Author keywords

Blood brain barrier; Edema; FLAP inhibitor; Hippocampus; Leukotrienes; Long term potentiation; Memory and learning; Neuroinflammation; Traumatic brain injury

Indexed keywords

3 [3 TERT BUTYLTHIO 1 (4 CHLOROBENZYL) 5 ISOPROPYL 2 INDOLYL] 2,2 DIMETHYLPROPIONIC ACID; LEUKOTRIENE; LEUKOTRIENE C4;

ADULT; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIINFLAMMATORY ACTIVITY; ARTICLE; BLOOD BRAIN BARRIER; BRAIN EDEMA; BRAIN SLICE; COGNITIVE DEFECT; CONTROLLED STUDY; DISEASE ASSOCIATION; DRUG EFFICACY; FATTY ACID SYNTHESIS; FEASIBILITY STUDY; HIPPOCAMPAL CA1 REGION; LEARNING DISORDER; LONG TERM POTENTIATION; MALE; MEMORY DISORDER; NONHUMAN; NUCLEAR MAGNETIC RESONANCE IMAGING; PATHOPHYSIOLOGY; PRIORITY JOURNAL; PROTEIN SYNTHESIS INHIBITION; RADIAL ARM MAZE TEST; RAT; REVERSED PHASE LIQUID CHROMATOGRAPHY; SPATIAL LEARNING; SYNAPTIC TRANSMISSION; TANDEM MASS SPECTROMETRY; TRAUMATIC BRAIN INJURY;

BLOOD-BRAIN BARRIER; EDEMA; FLAP INHIBITOR; HIPPOCAMPUS; LEUKOTRIENES; LONG-TERM POTENTIATION; MEMORY AND LEARNING; NEUROINFLAMMATION; TRAUMATIC BRAIN INJURY;

ANIMALS; BRAIN; BRAIN INJURIES; COGNITION DISORDERS; HIPPOCAMPUS; INDOLES; LEUKOTRIENES; LIPOXYGENASE INHIBITORS; LONG-TERM POTENTIATION; MALE; MAZE LEARNING; RATS; RATS, SPRAGUE-DAWLEY; TANDEM MASS SPECTROMETRY;

EID: 84904043156     PISSN: 00144886     EISSN: 10902430     Source Type: Journal    
DOI: 10.1016/j.expneurol.2014.03.008     Document Type: Article

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