In Vivo visualization of subtle, transient, and local activity of astrocytes using an ultrasensitive Ca2+ indicator

Cell Reports

Volumn 8, Issue 1, 2014, Pages 311-318

  Kanemaru, Kazunori ^a   Sekiya, Hiroshi ^a   Xu, Ming ^b   Satoh, Kaname ^a   Kitajima, Nami ^a   Yoshida, Keitaro ^b   Okubo, Yohei ^a   Sasaki, Takuya ^c   Moritoh, Satoru ^d   Hasuwa, Hidetoshi ^e   Mimura, Masaru ^b   Horikawa, Kazuki ^f   Matsui, Ko ^d   Nagai, Takeharu ^e   Iino, Masamitsu ^a   Tanaka, Kenji F ^b  

^a UNIVERSITY OF TOKYO   (Japan)

^b KEIO UNIVERSITY   (Japan)

^c UNIVERSITY OF CALIFORNIA   (United States)

^d TOHOKU UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

^e OSAKA UNIVERSITY   (Japan)

^f UNIVERSITY OF TOKUSHIMA   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

CALCIUM ION; INDICATOR; UNCLASSIFIED DRUG; YELLOW CAMELEON NANO 50 INDICATOR; CONTRAST MEDIUM; YELLOW CAMELEON NANO 50; CALCIUM BINDING PROTEIN; YELLOW CAMELEON;

AMPLITUDE MODULATION; ANIMAL CELL; ARTICLE; ASTROCYTE; CALCIUM TRANSPORT; CELL ACTIVITY; CONTROLLED STUDY; ELECTROENCEPHALOGRAM; EVOKED CORTICAL RESPONSE; IMAGE ANALYSIS; IN VIVO STUDY; MOLECULAR DYNAMICS; MOLECULAR IMAGING; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; SENSITIVITY ANALYSIS; SENSORY STIMULATION; SIGNAL TRANSDUCTION; ANIMAL EXPERIMENT; ANIMAL TISSUE; ANTIBODY LABELING; CALCIUM SIGNALING; CELL ACTIVATION; CELL FUNCTION; IMMUNOREACTIVITY; OLIGODENDROGLIA; SOMATOSENSORY CORTEX; TRANSGENIC MOUSE; ANIMAL; CYTOLOGY; FLUORESCENCE RESONANCE ENERGY TRANSFER; GENETICS; METABOLISM;

MUS; MUS MUSCULUS;

ANIMALS; ASTROCYTES; CALCIUM SIGNALING; CALCIUM-BINDING PROTEINS; FLUORESCENCE RESONANCE ENERGY TRANSFER; MICE; SOMATOSENSORY CORTEX;

EID: 84904040615     PISSN: None     EISSN: 22111247     Source Type: Journal    
DOI: 10.1016/j.celrep.2014.05.056     Document Type: Article

References (23)

1. 2+ signals insitu and invivo. J.Neurosci. Methods 2009, 181:212-226.
2. 2+ detection and modulation of synaptic release by astrocytes. Nat. Neurosci. 2011, 14:1276-1284.
3. Haydon P.G., Carmignoto G. Astrocyte control of synaptic transmission and neurovascular coupling. Physiol. Rev. 2006, 86:1009-1031.
4. 2+) indicators, yellow Cameleon-Nano. Nat. Methods 2010, 7:729-732.
5. Iadecola C., Nedergaard M. Glial regulation of the cerebral microvasculature. Nat. Neurosci. 2007, 10:1369-1376.
6. Kanemaru K., Kubota J., Sekiya H., Hirose K., Okubo Y., Iino M. Calcium-dependent N-cadherin up-regulation mediates reactive astrogliosis and neuroprotection after brain injury. Proc. Natl. Acad. Sci. USA 2013, 110:11612-11617.
7. 3)-receptor type 2-deficient mice. Circ. Res. 2005, 96:1274-1281.
8. Mank M., Griesbeck O. Genetically encoded calcium indicators. Chem. Rev. 2008, 108:1550-1564.
9. Nimmerjahn A., Kirchhoff F., Kerr J.N., Helmchen F. Sulforhodamine 101 as a specific marker of astroglia in the neocortex invivo. Nat. Methods 2004, 1:31-37.
10. Nimmerjahn A., Mukamel E.A., Schnitzer M.J. Motor behavior activates Bergmann glial networks. Neuron 2009, 62:400-412.
11. Panatier A., Vallée J., Haber M., Murai K.K., Lacaille J.C., Robitaille R. Astrocytes are endogenous regulators of basal transmission at central synapses. Cell 2011, 146:785-798.
12. Perea G., Araque A. Astrocytes potentiate transmitter release atsingle hippocampal synapses. Science 2007, 317:1083-1086.
13. Pérez Koldenkova V., Nagai T. Genetically encoded Ca(2+) indicators: properties and evaluation. Biochim. Biophys. Acta 2013, 1833:1787-1797.
14. 2+ increases in hippocampal astrocytes does not affect baseline CA1 pyramidal neuron synaptic activity. J.Neurosci. 2008, 28:4967-4973.
15. Reeves A.M., Shigetomi E., Khakh B.S. Bulk loading of calcium indicator dyes to study astrocyte physiology: key limitations and improvements using morphological maps. J.Neurosci. 2011, 31:9353-9358.
16. Shigetomi E., Kracun S., Sofroniew M.V., Khakh B.S. A genetically targeted optical sensor to monitor calcium signals in astrocyte processes. Nat. Neurosci. 2010, 13:759-766.
17. Shigetomi E., Tong X., Kwan K.Y., Corey D.P., Khakh B.S. TRPA1 channels regulate astrocyte resting calcium and inhibitory synapse efficacy through GAT-3. Nat. Neurosci. 2012, 15:70-80.
18. Shigetomi E., Bushong E.A., Haustein M.D., Tong X., Jackson-Weaver O., Kracun S., Xu J., Sofroniew M.V., Ellisman M.H., Khakh B.S. Imaging calcium microdomains within entire astrocyte territories and endfeet with GCaMPs expressed using adeno-associated viruses. J.Gen. Physiol. 2013, 141:633-647.
19. Shigetomi E., Jackson-Weaver O., Huckstepp R.T., O'Dell T.J., Khakh B.S. TRPA1 channels are regulators of astrocyte basal calcium levels and long-term potentiation via constitutive D-serine release. J.Neurosci. 2013, 33:10143-10153.
20. Takata N., Mishima T., Hisatsune C., Nagai T., Ebisui E., Mikoshiba K., Hirase H. Astrocyte calcium signaling transforms cholinergic modulation to cortical plasticity invivo. J.Neurosci. 2011, 31:18155-18165.
21. Tanaka K.F., Ahmari S.E., Leonardo E.D., Richardson-Jones J.W., Budreck E.C., Scheiffele P., Sugio S., Inamura N., Ikenaka K., Hen R. Flexible Accelerated STOP Tetracycline Operator-knockin (FAST): a versatile and efficient new gene modulating system. Biol. Psychiatry 2010, 67:770-773.
22. Tanaka K.F., Matsui K., Sasaki T., Sano H., Sugio S., Fan K., Hen R., Nakai J., Yanagawa Y., Hasuwa H., et al. Expanding the repertoire of optogenetically targeted cells with an enhanced gene expression system. Cell Reports 2012, 2:397-406.
23. Thrane A.S., Rangroo Thrane V., Zeppenfeld D., Lou N., Xu Q., Nagelhus E.A., Nedergaard M. General anesthesia selectively disrupts astrocyte calcium signaling in the awake mouse cortex. Proc. Natl. Acad. Sci. USA 2012, 109:18974-18979.