Evidence for an angiotensin-(1-7) neuropeptidase expressed in the brain medulla and CSF of sheep

Journal of Neurochemistry

Volumn 130, Issue 2, 2014, Pages 313-323

  Marshall, Allyson C ^a   Pirro, Nancy T ^a   Rose, James C ^a   Diz, Debra I ^a   Chappell, Mark C ^a  

^a WAKE FOREST SCHOOL OF MEDICINE   (United States)

Author keywords

Ang (1 7); metabolism; neuropeptidase; Renin angiotensin system

Indexed keywords

1,10 PHENANTHROLINE; 4 CHLOROMERCURIBENZOIC ACID; ANGIOTENSIN I; ANGIOTENSIN II; ANGIOTENSIN[1-7]; APELIN; BRADYKININ; DIPEPTIDYL CARBOXYPEPTIDASE INHIBITOR; EDETIC ACID; ENZYME INHIBITOR; IODINE 125; JMV 390; MEMBRANE METALLOENDOPEPTIDASE; METALLOPROTEINASE; METALLOPROTEINASE INHIBITOR; NEUROLYSIN; NEUROPEPTIDASE; PEPTIDASE; THIMET OLIGOPEPTIDASE; UNCLASSIFIED DRUG;

ANIMAL TISSUE; ARTICLE; CEREBROSPINAL FLUID; CONTROLLED STUDY; ENZYME PURIFICATION; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HYDROLYSIS; ISOTOPE LABELING; MALE; MEDULLA OBLONGATA; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; SHEEP;

OVIS ARIES;

ANG-(1-7); METABOLISM; NEUROPEPTIDASE; RENIN-ANGIOTENSIN SYSTEM;

ANGIOTENSIN I; ANIMALS; BRADYKININ; CHROMATOGRAPHY, AGAROSE; CHROMATOGRAPHY, DEAE-CELLULOSE; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; ELECTROPHORESIS, POLYACRYLAMIDE GEL; HYDROGEN-ION CONCENTRATION; INTERCELLULAR SIGNALING PEPTIDES AND PROTEINS; KINETICS; MEDULLA OBLONGATA; MERCURY COMPOUNDS; NEUROTENSIN; OLIGOPEPTIDES; PEPTIDE FRAGMENTS; PEPTIDYL-DIPEPTIDASE A; PROTEASE INHIBITORS; SHEEP; SUBSTRATE SPECIFICITY;

EID: 84904039871     PISSN: 00223042     EISSN: 14714159     Source Type: Journal    
DOI: 10.1111/jnc.12720     Document Type: Article

References (42)

1. Acker G. R., Molineaux C., and, Orlowski M., (1987) Synaptosomal membrane-bound form of endopeptidase-24.15 generates Leu-enkephalin from dynorphin1-8, alpha- and beta-neoendorphin, and Met-enkephalin from Met-enkephalin-Arg6-Gly7-Leu8. J. Neurochem. 48, 284-292. (Pubitemid 17031399)
2. Allred A. J., Diz D. I., Ferrario C. M., and, Chappell M. C., (2000) Pathways for angiotensin-(1-7) metabolism in pulmonary and renal tissues. Am. J. Physiol. Renal Physiol. 279, F841-F850.
3. Alzayadneh E. M., and, Chappell M. C., (in press) Nuclear expression of components of renin-angiotensin system in the NRK52E cells. J. Renin Angiotensin Aldosterone Syst., in press.
4. Arnold A. C., Shaltout H. A., Gilliam-Davis S., Kock N. D., and, Diz D. I., (2011) Autonomic control of the heart is altered in Sprague-Dawley rats with spontaneous hydronephrosis. Am. J. Physiol. Heart Circ. Physiol. 300, H2206-H2213.
5. Averill D. B., and, Diz D. I., (2000) Angiotensin peptides and baroreflex control of sympathetic outflow: pathways and mechanisms of the medulla oblongata. Brain Res. Bull. 51, 119-128. (Pubitemid 30069873)
6. Campbell D. J., Anastasopoulos F., Duncan A. M., James G. M., Kladis A., and, Briscoe T. A., (1998) Effects of neutral endopeptidase inhibition and combined angiotensin converting enzyme and neutral endopeptidase inhibition on angiotensin and bradykinin peptides in rats. J. Pharmacol. Exp. Ther. 287, 567-577. (Pubitemid 29133655)
7. Capettini L. S., Montecucco F., Mach F., Stergiopulos N., Santos R. A., and, da Silva R. F., (2012) Role of renin-angiotensin system in inflammation, immunity and aging. Curr. Pharm. Des. 18, 963-970.
8. Chappell M. C., (2007) Emerging evidence for a functional angiotensin-converting enzyme 2-angiotensin-(1-7)-Mas receptor axis: more than regulation of blood pressure? Hypertension 50, 596-599. (Pubitemid 47442717)
9. Chappell M. C., Brosnihan K. B., Diz D. I., and, Ferrario C. M., (1989) Identification of angiotensin-(1-7) in rat brain. Evidence for differential processing of angiotensin peptides. J. Biol. Chem. 264, 16518-16523. (Pubitemid 19243542)
10. Chappell M. C., Pirro N. T., Sykes A., and, Ferrario C. M., (1998) Metabolism of angiotensin-(1-7) by angiotensin-converting enzyme. Hypertension 31, 362-367.
11. Chappell M. C., Marshall A. C., Alzayadneh E. M., Shaltout H. A., and, Diz D. I., (2014) Update on the angiotensin converting enzyme 2-angiotensin (1-7)-Mas receptor axis: fetal programing, sex differences, and intracellular pathways. Front Endocrinol (Lausanne) 4, 1-13.
12. Diz D. I., Garcia-Espinosa M. A., Gallagher P. E., Ganten D., Ferrario C. M., and, Averill D. B., (2008) Angiotensin-(1-7) and baroreflex function in nucleus tractus solitarii of (mRen2)27 transgenic rats. J. Cardiovasc. Pharmacol. 51, 542-548.
13. Diz D. I., Arnold A. C., Nautiyal M., Isa K., Shaltout H. A., and, Tallant E. A., (2011) Angiotensin peptides and central autonomic regulation. Curr. Opin. Pharmacol. 11, 131-137.
14. Doulut S., Dubuc I., Rodriguez M., et al,. (1993) Synthesis and analgesic effects of N-[3-[(hydroxyamino) carbonyl]-1-oxo-2(R)-benzylpropyl]-L-isoleucyl- L-leucine, a new potent inhibitor of multiple neurotensin/neuromedin N degrading enzymes. J. Med. Chem. 36, 1369-1379. (Pubitemid 23164493)
15. Ellis B., Li X. C., Miguel-Qin E., Gu V., and, Zhuo J. L., (2012) Evidence for a functional intracellular angiotensin system in the proximal tubule of the kidney. Am. J. Physiol. Regul. Integr. Comp. Physiol. 302, R494-R509.
16. Ferro E. S., Tullai J. W., Glucksman M. J., and, Roberts J. L., (1999) Secretion of metalloendopeptidase 24.15 (EC 3.4.24.15). DNA Cell Biol. 18, 781-789. (Pubitemid 29504192)
17. Grobe N., Weir N. M., Leiva O., Ong F. S., Bernstein K. E., Schmaier A. H., Morris M., and, Elased K. M., (2013) Identification of prolyl carboxypeptidase as an alternative enzyme for processing of renal angiotensin II using mass spectrometry. Am. J. Physiol.-Cell Physiol. 304, C945-C953.
18. Gwathmey T. M., Alzayadneh E. M., Pendergrass K. D., and, Chappell M. C., (2012) Novel roles of nuclear angiotensin receptors and signaling mechanisms. Am. J. Physiol. Regul. Integr. Comp. Physiol. 302, R518-R530.
19. Healy D. P., and, Orlowski M., (1992) Immunocytochemical localization of endopeptidase 24.15 in rat brain. Brain Res. 571, 121-128.
20. Jeske N. A., Glucksman M. J., and, Roberts J. L., (2003) EP24.15 is associated with lipid rafts. J. Neurosci. Res. 74, 468-473. (Pubitemid 37362823)
21. Jeske N. A., Glucksman M. J., and, Roberts J. L., (2004) Metalloendopeptidase EC 3.4.24.15 is constitutively released from the exofacial leaflet of lipid rafts in GT1-7 cells. J. Neurochem. 90, 819-828. (Pubitemid 39099963)
22. Kar S., Gao L., Belatti D. A., Curry P. L., and, Zucker I. H., (2011) Central angiotensin (1-7) enhances baroreflex gain in conscious rabbits with heart failure. Hypertension 58, 627-634.
23. Krob H. A., Vinsant S. L., Ferrario C. M., and, Friedman D. P., (1998) Angiotensin-(1-7) immunoreactivity in the hypothalamus of the (mRen-2d)27 transgenic rat. Brain Res. 798, 36-45. (Pubitemid 28342018)
24. Marshall A. C., Shaltout H. A., Nautiyal M., Rose J. C., Chappell M. C., and, Diz D. I., (2013a) Fetal betamethasone exposure attenuates angiotensin-(1-7)-Mas receptor expression in the dorsal medulla of adult sheep. Peptides 44, 25-31.
25. Marshall A. C., Shaltout H. A., Pirro N. T., Rose J. C., Diz D. I., and, Chappell M. C., (2013b) Antenatal betamethasone exposure is associated with lower ANG-(1-7) and increased ACE in the CSF of adult sheep. Am. J. Physiol. Regul. Integr. Comp. Physiol. 305, R679-R688.
26. Marshall A. C., Shaltout H. A., Pirro N. T., Rose J. C., Diz D. I., and, Chappell M. C., (2013c) Enhanced activity of an angiotensin-(1-7) neuropeptidase in glucocorticoid-induced fetal programming. Peptides 52C, 74-81.
27. Massarelli E. E., Casatti C. A., Kato A., Camargo A. C., Bauer J. A., Glucksman M. J., Roberts J. L., Hirose S., and, Ferro E. S., (1999) Differential subcellular distribution of neurolysin (EC 3.4.24.16) and thimet oligopeptidase (EC 3.4.24.15) in the rat brain. Brain Res. 851, 261-265. (Pubitemid 30038155)
28. Pereira M. G., Souza L. L., Becari C., et al,. (2013) Angiotensin II-independent angiotensin-(1-7) formation in rat hippocampus: involvement of thimet oligopeptidase. Hypertension 62, 879-885.
29. Rawlings N. D., and, Barrett A. J., (1993) Evolutionary families of peptidases. Biochem. J. 290 (Pt 1), 205-218. (Pubitemid 23081221)
30. Rykl J., Thiemann J., Kurzawski S., Pohl T., Gobom J., Zidek W., and, Schluter H., (2006) Renal cathepsin G and angiotensin II generation. J. Hypertens. 24, 1797-1807. (Pubitemid 44253242)
31. Sadjadi J., Kramer G. L., Yu C. H., Burress Welborn M., 3rd, Chappell M. C., and, Gregory Modrall J., (2005) Angiotensin converting enzyme-independent angiotensin II production by chymase is up-regulated in the ischemic kidney in renovascular hypertension. J. Surg. Res. 127, 65-69. (Pubitemid 41080615)
32. Shaltout H. A., Figueroa J. P., Rose J. C., Diz D. I., and, Chappell M. C., (2009) Alterations in circulatory and renal angiotensin-converting enzyme and angiotensin-converting enzyme 2 in fetal programmed hypertension. Hypertension 53, 404-408.
33. Shrimpton C. N., and, Smith A. I., (2000) Soluble neutral metallopeptidases: physiological regulators of peptide action. J. Pept. Sci. 6, 251-263.
34. Shrimpton C. N., Smith A. I., and, Lew R. A., (2002) Soluble metalloendopeptidases and neuroendocrine signaling. Endocr. Rev. 23, 647-664. (Pubitemid 35191627)
35. Shrimpton C. N., Wolfson A. J., Smith A. I., and, Lew R. A., (2003) Regulators of the neuropeptide-degrading enzyme, EC 3.4.24.15 (thimet oligopeptidase), in cerebrospinal fluid. J. Neurosci. Res. 74, 474-478. (Pubitemid 37362824)
36. Singh V. P., Le B., Bhat V. B., Baker K. M., and, Kumar R., (2007) High-glucose-induced regulation of intracellular ANG II synthesis and nuclear redistribution in cardiac myocytes. Am. J. Physiol. Heart Circ. 293, H939-H948. (Pubitemid 47254192)
37. Thompson A., Huber G., and, Malherbe P., (1995) Cloning and functional expression of a metalloendopeptidase from human brain with the ability to cleave a beta-APP substrate peptide. Biochem. Biophys. Res. Commun. 213, 66-73.
38. Verrilli M. A. L., Pirola C. J., Pascual M. M., Dominici F. P., Turyn D., and, Gironacci M. M., (2009) Angiotensin-(1-7) through AT(2) receptors mediates tyrosine hydroxylase degradation via the ubiquitin-proteasome pathway. J. Neurochem. 109, 326-335.
39. Welches W. R., Santos R. A. S., Chappell M. C., Brosnihan K. B., Greene L. J., and, Ferrario C. M., (1991) Evidence that prolyl endopeptidase participates in the processing of brain angiotensin. J. Hypertens. 9, 631-638.
40. Woulfe J., Checler F., and, Beaudet A., (1992) Light and electron microscopic localization of the neutral metalloendopeptidase EC 3.4.24.16 in the mesencephalon of the rat. Eur. J. Neurosci. 4, 1309-1319. (Pubitemid 23044625)
41. Xu P., Sriramula S., and, Lazartigues E., (2011) ACE2/ANG-(1-7)/Mas pathway in the brain: the axis of good. Am. J. Physiol. Regul. Integr. Comp. Physiol. 300, R804-R817.
42. Yamada K., Iyer S. N., Chappell M. C., Ganten D., and, Ferrario C. M., (1998) Converting enzyme determines plasma clearance of angiotensin-(1-7). Hypertension 32, 496-502. (Pubitemid 28429139)