-
1
-
-
77349104615
-
Graves' ophthalmopathy
-
Bahn RS. Graves' ophthalmopathy. N Engl J Med. 2010;362:726-738.
-
(2010)
N Engl J Med
, vol.362
, pp. 726-738
-
-
Bahn, R.S.1
-
2
-
-
68149156416
-
Current insights into the pathogenesis of Graves' orbitopathy
-
Eckstein AK, Johnson KT, Thanos M, Esser J, Ludgate M. Current insights into the pathogenesis of Graves' orbitopathy. Horm Metab Res. 2009;41:456-464.
-
(2009)
Horm Metab Res
, vol.41
, pp. 456-464
-
-
Eckstein, A.K.1
Johnson, K.T.2
Thanos, M.3
Esser, J.4
Ludgate, M.5
-
3
-
-
0036129562
-
Unlocking the immunological mechanisms of orbital inflammation in thyroid eye disease
-
DOI 10.1046/j.1365-2249.2002.01792.x
-
Ludgate M, Baker G. Unlocking the immunological mechanisms of orbital inflammation in thyroid eye disease. Clin Exp Immunol. 2002;127:193-198. (Pubitemid 34233922)
-
(2002)
Clinical and Experimental Immunology
, vol.127
, Issue.2
, pp. 193-198
-
-
Ludgate, M.1
Baker, G.2
-
4
-
-
0031764515
-
Thyrotropin receptor expression in Graves' orbital adipose/connective tissues: Potential autoantigen in Graves' ophthalmopathy
-
DOI 10.1210/jc.83.3.998
-
Bahn RS, Dutton CM, Natt N, Joba W, Spitzweg C, Heufelder AE. Thyrotropin receptor expression in Graves' orbital adipose/connective tissues: potential autoantigen in Graves' ophthalmopathy. J Clin Endocrinol Metab. 1998;83:998-1002. (Pubitemid 28496482)
-
(1998)
Journal of Clinical Endocrinology and Metabolism
, vol.83
, Issue.3
, pp. 998-1002
-
-
Bahn, R.S.1
Dutton, C.M.2
Natt, N.3
Joba, W.4
Spitzweg, C.5
Heufelder, A.E.6
-
5
-
-
0031159748
-
Thyrotropin receptor transcripts in human adipose tissue
-
Crisp MS, Lane C, Halliwell M, Wynford-Thomas D, Ludgate M. Thyrotropin receptor transcripts in human adipose tissue. J Clin Endocrinol Metab. 1997;82:2003-2005. (Pubitemid 127495225)
-
(1997)
Journal of Clinical Endocrinology and Metabolism
, vol.82
, Issue.6
, pp. 2003-2005
-
-
Crisp, M.S.1
Lane, C.2
Halliwell, M.3
Wynford-Thomas, D.4
Ludgate, M.5
-
6
-
-
0027280209
-
Expression of thyrotropin-receptor mRNA in healthy and Graves' disease retro-orbital tissue
-
DOI 10.1016/0140-6736(93)91475-2
-
Feliciello A, Porcellini A, Ciullo I, Bonavolonta G, Avvedimento EV, Fenzi G. Expression of thyrotropin-receptor mRNA in healthy and Graves' disease retro-orbital tissue. Lancet. 1993;342:337-338. (Pubitemid 23227563)
-
(1993)
Lancet
, vol.342
, Issue.8867
, pp. 337-338
-
-
Feliciello, A.1
Porcellini, A.2
Ciullo, I.3
Bonavolonta, G.4
Avvedimento, E.V.5
Fenzi, G.6
-
7
-
-
0033386948
-
The combination of absent thyroid peroxidase antibodies and high thyroid-stimulating immunoglobulin levels in Graves disease identifies a group at markedly increased risk of ophthalmopathy
-
Khoo DH, Ho SC, Seah LL, et al. The combination of absent thyroid peroxidase antibodies and high thyroid-stimulating immunoglobulin levels in Graves' disease identifies a group at markedly increased risk of ophthalmopathy. Thyroid. 1999;9:1175-1180. (Pubitemid 30038925)
-
(1999)
Thyroid
, vol.9
, Issue.12
, pp. 1175-1180
-
-
Khoo, D.H.C.1
Ho, S.C.2
Seah, L.L.3
Fong, K.S.4
Tai, E.S.5
Chee, S.P.6
Eng, P.H.K.7
Aw, S.E.8
Fok, A.C.K.9
-
8
-
-
84860752351
-
A stimulatory thyrotropin receptor antibody enhances hyaluronic acid synthesis in graves' orbital fibroblasts: Inhibition by an IGF-I receptor blocking antibody
-
Kumar S, Iyer S, Bauer H, Coenen M, Bahn RS. A stimulatory thyrotropin receptor antibody enhances hyaluronic acid synthesis in graves' orbital fibroblasts: inhibition by an IGF-I receptor blocking antibody. J Clin Endocrinol Metab. 2012;97:1681-1687.
-
(2012)
J Clin Endocrinol Metab
, vol.97
, pp. 1681-1687
-
-
Kumar, S.1
Iyer, S.2
Bauer, H.3
Coenen, M.4
Bahn, R.S.5
-
9
-
-
79959508641
-
A stimulatory TSH receptor antibody enhances adipogenesis via phosphoinositide 3-kinase activation in orbital preadipocytes from patients with Graves' ophthalmopathy
-
Kumar S, Nadeem S, Stan MN, Coenen M, Bahn RS. A stimulatory TSH receptor antibody enhances adipogenesis via phosphoinositide 3-kinase activation in orbital preadipocytes from patients with Graves' ophthalmopathy. J Mol Endocrinol. 2011;46:155-163.
-
(2011)
J Mol Endocrinol
, vol.46
, pp. 155-163
-
-
Kumar, S.1
Nadeem, S.2
Stan, M.N.3
Coenen, M.4
Bahn, R.S.5
-
10
-
-
70350366898
-
Thyrotropin receptor activation increases hyaluronan production in preadipocyte fibroblasts: Contributory role in hyaluronan accumulation in thyroid dysfunction
-
Zhang L, Bowen T, Grennan-Jones F, et al. Thyrotropin receptor activation increases hyaluronan production in preadipocyte fibroblasts: contributory role in hyaluronan accumulation in thyroid dysfunction. J Biol Chem. 2009a;284:26447-26455.
-
(2009)
J Biol Chem
, vol.284
, pp. 26447-26455
-
-
Zhang, L.1
Bowen, T.2
Grennan-Jones, F.3
-
11
-
-
84863011719
-
Adipose tissue depot-specific differences in the regulation of hyaluronan production of relevance to Graves' orbitopathy
-
Zhang L, Grennan-Jones F, Lane C, Rees DA, Dayan CM, Ludgate M. Adipose tissue depot-specific differences in the regulation of hyaluronan production of relevance to Graves' orbitopathy. J Clin Endocrinol Metab. 2012;97:653-662.
-
(2012)
J Clin Endocrinol Metab
, vol.97
, pp. 653-662
-
-
Zhang, L.1
Grennan-Jones, F.2
Lane, C.3
Rees, D.A.4
Dayan, C.M.5
Ludgate, M.6
-
12
-
-
33645512229
-
Immunoglobulin G from patients with Graves' disease induces interleukin-16 and RANTES expression in cultured human thyrocytes: A putative mechanism for T-cell infiltration of the thyroid in autoimmune disease
-
Gianoukakis AG, Douglas RS, King CS, Cruikshank WW, Smith TJ. Immunoglobulin G from patients with Graves' disease induces interleukin-16 and RANTES expression in cultured human thyrocytes: a putative mechanism for T-cell infiltration of the thyroid in autoimmune disease. Endocrinology. 2006;147:1941-1949.
-
(2006)
Endocrinology
, vol.147
, pp. 1941-1949
-
-
Gianoukakis, A.G.1
Douglas, R.S.2
King, C.S.3
Cruikshank, W.W.4
Smith, T.J.5
-
13
-
-
84873639591
-
Autoantibodies to the IGF1 receptor in Graves' orbitopathy
-
Minich WB, Dehina N, Welsink T, et al. Autoantibodies to the IGF1 receptor in Graves' orbitopathy. J Clin Endocrinol Metab. 2013;98:752-760.
-
(2013)
J Clin Endocrinol Metab
, vol.98
, pp. 752-760
-
-
Minich, W.B.1
Dehina, N.2
Welsink, T.3
-
14
-
-
0027818199
-
Autoantibodies to IGF-1 binding sites in thyroid associated ophthalmopathy
-
Weightman DR, Perros P, Sherif IH, Kendall-Taylor P. Autoantibodies to IGF-1 binding sites in thyroid associated ophthalmopathy. Autoimmunity. 1993;16:251-257. (Pubitemid 24111622)
-
(1993)
Autoimmunity
, vol.16
, Issue.4
, pp. 251-257
-
-
Weightman, D.R.1
Perros, P.2
Sherif, I.H.3
Kendall-Taylor, P.4
-
15
-
-
84873682522
-
Circulating IgGs may modulate IGF-I receptor stimulating activity in a subset of patients with Graves' ophthalmopathy
-
Varewijck AJ, Boelen A, Lamberts SW, et al. Circulating IgGs may modulate IGF-I receptor stimulating activity in a subset of patients with Graves' ophthalmopathy. J Clin Endocrinol Metab. 2013;98:769-776.
-
(2013)
J Clin Endocrinol Metab
, vol.98
, pp. 769-776
-
-
Varewijck, A.J.1
Boelen, A.2
Lamberts, S.W.3
-
16
-
-
0022627396
-
Somatomedin C in pathogenesis of malignant exophthalmos of endocrine origin
-
Hansson HA, Petruson B, Skottner A. Somatomedin C in pathogenesis of malignant exophthalmos of endocrine origin. Lancet. 1986;1:218-219. (Pubitemid 16135552)
-
(1986)
Lancet
, vol.1
, Issue.8474
, pp. 218-219
-
-
Hansson, H.A.1
Petruson, B.2
Skottner, A.3
-
17
-
-
0037241331
-
Free and total insulin-like growth factor (IGF)-I, -II, and IGF binding protein-1, -2, and -3 serum levels in patients with active thyroid eye disease
-
DOI 10.1210/jc.2002-021349
-
Krassas GE, Pontikides N, Kaltsas T, et al. Free and total insulin-like growth factor (IGF)-I, -II, and IGF binding protein-1, -2, and -3 serum levels in patients with active thyroid eye disease. J Clin Endocrinol Metab. 2003;88:132-135. (Pubitemid 36115154)
-
(2003)
Journal of Clinical Endocrinology and Metabolism
, vol.88
, Issue.1
, pp. 132-135
-
-
Krassas, G.E.1
Pontikides, N.2
Kaltsas, T.3
Dumas, A.4
Frystyk, J.5
Chen, J.W.6
Flyvbjerg, A.7
-
18
-
-
79961243732
-
Autoimmunity in Graves' ophthalmopathy: The result of an unfortunate marriage between TSH receptors and IGF-1 receptors?
-
Wiersinga WM. Autoimmunity in Graves' ophthalmopathy: the result of an unfortunate marriage between TSH receptors and IGF-1 receptors? J Clin Endocrinol Metab. 2011;96(8):2386-2394.
-
(2011)
J Clin Endocrinol Metab
, vol.96
, Issue.8
, pp. 2386-2394
-
-
Wiersinga, W.M.1
-
19
-
-
34248211130
-
Biological effects of thyrotropin receptor activation on human orbital preadipocytes
-
DOI 10.1167/iovs.06-0596
-
Zhang L, Baker G, Janus D, Paddon CA, Fuhrer D, Ludgate M. Biological effects of thyrotropin receptor activation on human orbital preadipocytes. Invest Ophthalmol Vis Sci. 2006;47:5197-5203. (Pubitemid 46723765)
-
(2006)
Investigative Ophthalmology and Visual Science
, vol.47
, Issue.12
, pp. 5197-5203
-
-
Zhang, L.1
Baker, G.2
Janus, D.3
Paddon, C.A.4
Fuhrer, D.5
Ludgate, M.6
-
20
-
-
84861232365
-
Thyroid eye disease: Towards an evidence base for treatment in the 21st century
-
Gillespie EF, Smith TJ, Douglas RS. Thyroid eye disease: towards an evidence base for treatment in the 21st century. Curr Neurol Neurosci Rep. 2012;12:318-324.
-
(2012)
Curr Neurol Neurosci Rep
, vol.12
, pp. 318-324
-
-
Gillespie, E.F.1
Smith, T.J.2
Douglas, R.S.3
-
21
-
-
33847727902
-
Treatment of graves' disease and associated opthalmopathy with the anti-CD20 monoclonal antibody rituximab: An open study
-
DOI 10.1530/eje.1.02325
-
Salvi M, Vannucchi G, Campi I, et al. Treatment of Graves' disease and associated ophthalmopathy with the anti-CD20 monoclonal antibody rituximab: an open study. Eur J Endocrinol. 2007;156:33-40. (Pubitemid 46553901)
-
(2007)
European Journal of Endocrinology
, vol.156
, Issue.1
, pp. 33-40
-
-
Salvi, M.1
Vannucchi, G.2
Campi, I.3
Curro, N.4
Dazzi, D.5
Simonetta, S.6
Bonara, P.7
Rossi, S.8
Sina, C.9
Guastella, C.10
Ratiglia, R.11
Beck-Peccoz, P.12
-
22
-
-
0037205048
-
The phosphoinositide 3-kinase pathway
-
DOI 10.1126/science.296.5573.1655
-
Cantley LC. The phosphoinositide 3-kinase pathway. Science. 2002;296:1655-1657. (Pubitemid 34579158)
-
(2002)
Science
, vol.296
, Issue.5573
, pp. 1655-1657
-
-
Cantley, L.C.1
-
23
-
-
0034181368
-
Rapamycin inhibits human adipocyte differentiation in primary culture
-
Bell A, Grunder L, Sorisky A. Rapamycin inhibits human adipocyte differentiation in primary culture. Obes Res. 2000;8:249-254.
-
(2000)
Obes Res
, vol.8
, pp. 249-254
-
-
Bell, A.1
Grunder, L.2
Sorisky, A.3
-
25
-
-
0028170210
-
A specific inhibitor of phosphatidylinositol 3-kinase, 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one (LY294002)
-
Vlahos CJ, Matter WF, Hui KY, Brown RF. A specific inhibitor of phosphatidylinositol 3-kinase, 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one (LY294002). J Biol Chem. 1994;269:5241-5248.
-
(1994)
J Biol Chem
, vol.269
, pp. 5241-5248
-
-
Vlahos, C.J.1
Matter, W.F.2
Hui, K.Y.3
Brown, R.F.4
-
26
-
-
3242686718
-
Insulin-like growth factor-I stimulates both cell growth and lipogenesis during differentiation of human mesenchymal stem cells into adipocytes
-
DOI 10.1210/jc.2003-031682
-
Scavo LM, Karas M, Murray M, Leroith D. Insulin-like growth factor-I stimulates both cell growth and lipogenesis during differentiation of human mesenchymal stem cells into adipocytes. J Clin Endocrinol Metab. 2004;89:3543-3553. (Pubitemid 38951933)
-
(2004)
Journal of Clinical Endocrinology and Metabolism
, vol.89
, Issue.7
, pp. 3543-3553
-
-
Scavo, L.M.1
Karas, M.2
Murray, M.3
Leroith, D.4
-
27
-
-
6344235084
-
Immunoglobulins from patients with graves' disease induce hyaluronan synthesis in their orbital fibroblasts through the self-antigen, insulin-like growth factor-I receptor
-
DOI 10.1210/jc.2004-0716
-
Smith TJ, Hoa N. Immunoglobulins from patients with Graves' disease induce hyaluronan synthesis in their orbital fibroblasts through the self-antigen, insulin-like growth factor-I receptor. J Clin Endocrinol Metab. 2004;89:5076-5080. (Pubitemid 39391451)
-
(2004)
Journal of Clinical Endocrinology and Metabolism
, vol.89
, Issue.10
, pp. 5076-5080
-
-
Smith, T.J.1
Hoa, N.2
-
28
-
-
56149127454
-
Evidence for an association between thyroid-stimulating hormone and insulin-like growth factor 1 receptors: A tale of two antigens implicated in Graves' disease
-
Tsui S, Naik V, Hoa N, et al. Evidence for an association between thyroid-stimulating hormone and insulin-like growth factor 1 receptors: a tale of two antigens implicated in Graves' disease. J Immunol. 2008;181:4397-4405.
-
(2008)
J Immunol
, vol.181
, pp. 4397-4405
-
-
Tsui, S.1
Naik, V.2
Hoa, N.3
-
29
-
-
58149471219
-
Characterization of thyrotropin receptor antibody-induced signaling cascades
-
Morshed SA, Latif R, Davies TF. Characterization of thyrotropin receptor antibody-induced signaling cascades. Endocrinology. 2009;150:519-529.
-
(2009)
Endocrinology
, vol.150
, pp. 519-529
-
-
Morshed, S.A.1
Latif, R.2
Davies, T.F.3
-
30
-
-
0026673198
-
Thyroid stimulating immunoglobulins, like thyrotropin activate both the cyclic AMP and the PIP2 cascades in CHO cells expressing the TSH receptor
-
Van Sande J, Lejeune C, Ludgate M, et al. Thyroid stimulating immunoglobulins, like thyrotropin activate both the cyclic AMP and the PIP2 cascades in CHO cells expressing the TSH receptor. Mol Cell Endocrinol. 1992;88:R1-R5.
-
(1992)
Mol Cell Endocrinol
, vol.88
-
-
Van Sande, J.1
Lejeune, C.2
Ludgate, M.3
-
31
-
-
70349257892
-
Gsalpha signalling suppresses PPARγ2 generation and inhibits 3T3-L1 adipogenesis
-
Zhang L, Paddon C, Lewis MD, Grennan-Jones F, Ludgate M. Gsalpha signalling suppresses PPARγ2 generation and inhibits 3T3-L1 adipogenesis. J Endocrinol. 2009b;202:207-215.
-
(2009)
J Endocrinol
, vol.202
, pp. 207-215
-
-
Zhang, L.1
Paddon, C.2
Lewis, M.D.3
Grennan-Jones, F.4
Ludgate, M.5
-
32
-
-
0032582522
-
Posttranscriptional control of adipocyte differentiation through activation of phosphoinositide 3-kinase
-
DOI 10.1074/jbc.273.44.28945
-
Sakaue H, Ogawa W, Matsumoto M, et al. Posttranscriptional control of adipocyte differentiation through activation of phosphoinositide 3-kinase. J Biol Chem. 1998;273:28945-28952. (Pubitemid 28507588)
-
(1998)
Journal of Biological Chemistry
, vol.273
, Issue.44
, pp. 28945-28952
-
-
Sakaue, H.1
Ogawa, W.2
Matsumoto, M.3
Kuroda, S.4
Takata, M.5
Sugimoto, T.6
Spiegelman, B.M.7
Kasuga, M.8
-
33
-
-
39949084497
-
Critical role of phosphoinositide 3-kinase cascade in adipogenesis of human mesenchymal stem cells
-
Yu W, Chen Z, Zhang J, et al. Critical role of phosphoinositide 3-kinase cascade in adipogenesis of human mesenchymal stem cells. Mol Cell Biochem. 2008;310:11-18.
-
(2008)
Mol Cell Biochem
, vol.310
, pp. 11-18
-
-
Yu, W.1
Chen, Z.2
Zhang, J.3
-
34
-
-
33845764280
-
H-89 potentiates adipogenesis in 3T3-L1 cells by activating insulin signaling independently of protein kinase A
-
DOI 10.1016/j.lfs.2006.09.029, PII S0024320506007594
-
Kato Y, Ozaki N, Yamada T, Miura Y, Oiso Y. H-89 potentiates adipogenesis in 3T3-L1 cells by activating insulin signaling independently of protein kinase A. Life Sci. 2007;80:476-483. (Pubitemid 46013907)
-
(2007)
Life Sciences
, vol.80
, Issue.5
, pp. 476-483
-
-
Kato, Y.1
Ozaki, N.2
Yamada, T.3
Miura, Y.4
Oiso, Y.5
-
35
-
-
38849206392
-
Protein kinase A suppresses the differentiation of 3T3-L1 preadipocytes
-
DOI 10.1038/cr.2008.12, PII CR200812
-
Li F, Wang D, Zhou Y, et al. Protein kinase A suppresses the differentiation of 3T3-L1 preadipocytes. Cell Research. 2008;18:311-323. (Pubitemid 351206167)
-
(2008)
Cell Research
, vol.18
, Issue.2
, pp. 311-323
-
-
Li, F.1
Wang, D.2
Zhou, Y.3
Zhou, B.4
Yang, Y.5
Chen, H.6
Song, J.7
-
36
-
-
84877709693
-
A small molecule antagonist inhibits thyrotropin receptor antibody-induced orbital fibroblast functions involved in the pathogenesis of Graves ophthalmopathy
-
Turcu AF, Kumar S, Neumann S, et al. A small molecule antagonist inhibits thyrotropin receptor antibody-induced orbital fibroblast functions involved in the pathogenesis of Graves ophthalmopathy. J Clin Endocrinol Metab. 2013;98:2153-2159.
-
(2013)
J Clin Endocrinol Metab
, vol.98
, pp. 2153-2159
-
-
Turcu, A.F.1
Kumar, S.2
Neumann, S.3
-
37
-
-
0038683276
-
Adipose thyrotrophin receptor expression is elevated in Grave's thyroid eye diseases ex vivo and indicates adipogenesis in progress in vivo
-
DOI 10.1677/jme.0.0300369
-
Starkey KJ, Janezic A, Jones G, Jordan N, Baker G, Ludgate M. Adipose thyrotrophin receptor expression is elevated in Graves' and thyroid eye diseases ex vivo and indicates adipogenesis in progress in vivo. J Mol Endocrinol. 2003;30:369-380. (Pubitemid 36722625)
-
(2003)
Journal of Molecular Endocrinology
, vol.30
, Issue.3
, pp. 369-380
-
-
Starkey, K.J.1
Janezic, A.2
Jones, G.3
Jordan, N.4
Baker, G.5
Ludgate, M.6
-
38
-
-
0033158423
-
Differentiation of human orbital preadipocyte fibroblasts induces expression of functional thyrotropin receptor
-
Valyasevi RW, Erickson DZ, Harteneck DA, et al. Differentiation of human orbital preadipocyte fibroblasts induces expression of functional thyrotropin receptor. J Clin Endocrinol Metab. 1999;84:2557-2562.
-
(1999)
J Clin Endocrinol Metab
, vol.84
, pp. 2557-2562
-
-
Valyasevi, R.W.1
Erickson, D.Z.2
Harteneck, D.A.3
-
39
-
-
84856388619
-
The past, present, and future of exudative age-related macular degeneration treatment
-
Barak Y, Heroman WJ, Tezel TH. The past, present, and future of exudative age-related macular degeneration treatment. Middle East Afr J Ophthalmol. 2012;19:43-51.
-
(2012)
Middle East Afr J Ophthalmol
, vol.19
, pp. 43-51
-
-
Barak, Y.1
Heroman, W.J.2
Tezel, T.H.3
-
40
-
-
56449087509
-
Palomid 529, a novel small-molecule drug, is a TORC1/TORC2 inhibitor that reduces tumor growth, tumor angiogenesis, and vascular permeability
-
Xue Q, Hopkins B, Perruzzi C, Udayakumar D, Sherris D, Benjamin LE. Palomid 529, a novel small-molecule drug, is a TORC1/TORC2 inhibitor that reduces tumor growth, tumor angiogenesis, and vascular permeability. Cancer Res. 2008;68:9551-9557.
-
(2008)
Cancer Res
, vol.68
, pp. 9551-9557
-
-
Xue, Q.1
Hopkins, B.2
Perruzzi, C.3
Udayakumar, D.4
Sherris, D.5
Benjamin, L.E.6
|