Can tranexamic acid and hydrogen peroxide reduce blood loss in cemented total knee arthroplasty?

Archives of Orthopaedic and Trauma Surgery

Volumn 134, Issue 7, 2014, Pages 997-1002

  Chen, Jerry Yongqiang ^a   Rikhraj, Inderjeet Singh ^a   Zhou, Zhihong ^a   Tay, Darren Keng Jin ^a   Chin, Pak Lin ^a   Chia, Shi Lu ^a   Lo, Ngai Nung ^a   Yeo, Seng Jin ^a  

^a SINGAPORE GENERAL HOSPITAL   (Singapore)

Author keywords

Blood loss; Hydrogen peroxide; Total knee arthroplasty; Tranexamic acid

Indexed keywords

ENOXAPARIN; HEMOGLOBIN; HYDROGEN PEROXIDE; TRANEXAMIC ACID;

ADULT; AGED; ARTICLE; BLOOD VOLUME; CLINICAL ARTICLE; CONTROLLED STUDY; DEEP VEIN THROMBOSIS; DRUG EFFICACY; FEMALE; HEART ARRHYTHMIA; HEMOGLOBIN BLOOD LEVEL; HUMAN; KNEE IMPLANT; LUNG EMBOLISM; MALE; NON ST SEGMENT ELEVATION MYOCARDIAL INFARCTION; OPERATIVE BLOOD LOSS; PRIORITY JOURNAL; TOTAL KNEE REPLACEMENT; TREATMENT DURATION; VERY ELDERLY; WOUND CLOSURE; WOUND IRRIGATION;

AGED; AGED, 80 AND OVER; ANTIFIBRINOLYTIC AGENTS; ARTHROPLASTY, REPLACEMENT, KNEE; BLOOD LOSS, SURGICAL; BLOOD TRANSFUSION; CASE-CONTROL STUDIES; CEMENTATION; FEMALE; HEMOGLOBINS; HUMANS; HYDROGEN PEROXIDE; INJECTIONS, INTRA-ARTICULAR; MALE; MIDDLE AGED; OSTEOARTHRITIS, KNEE; OXIDANTS; POSTOPERATIVE HEMORRHAGE; TOURNIQUETS; TRANEXAMIC ACID; VENOUS THROMBOSIS;

EID: 84904025287     PISSN: 09368051     EISSN: 14343916     Source Type: Journal    
DOI: 10.1007/s00402-014-1958-z     Document Type: Article

References (41)

1. Abrishami A, Chung F, Wong J (2009) Topical application of antifibrinolytic drugs for on-pump cardiac surgery: a systematic review and meta-analysis. Can J Anaesth 56(3):202-212
2. Good L, Peterson E, Lisander B (2003) Tranexamic acid decreases external blood loss but not hidden blood loss in total knee replacement. Br J Anaesth 90(5):596-599 (Pubitemid 36592332)
3. Hippala S, Strid L, Wennerstrand M, Arvela V, Mantyla S, Ylinen J, Niemelä H (1995) Tranexamic acid (Cyklokapron) reduces perioperative blood loss associated with total knee arthroplasty. Br J Anaesth 74(5):534-537
4. Kalairajah Y, Simpson D, Cossey AJ, Verrall GM, Spriggins AJ (2005) Blood loss after total knee replacement: effects of computer-assisted surgery. J Bone Joint Surg Br 87(11):1480-1482 (Pubitemid 41723088)
5. Fiebig E (1998) Safety of the blood supply. Clin Orthop Relat Res 357:6-18
6. Parvizi J, Chaudhry S, Rasouli MR, Pulido L, Joshi A, Herman JH, Rothman RH (2011) Who needs autologous blood donation in joint replacement? J Knee Surg 24(1):25-31
7. Juelsgaard P, Larsen UT, Sorensen JV, Madsen F, Soballe K (2001) Hypotensive epidural anesthesia in total knee replacement without tourniquet: reduced blood loss and transfusion. Reg Anesth Pain Med 26(2):105-110 (Pubitemid 32230242)
8. Levy O, Martinowitz U, Oran A, Tauber C, Horoszowski H (1999) The use of fibrin tissue adhesive to reduce blood loss and the need for blood transfusion after total knee arthroplasty. A prospective, randomized, multicenter study. J Bone Joint Surg Am 81(11):1580-1588
9. Onodera T, Majima T, Sawaguchi N, Kasahara Y, Ishigaki T, Minami A (2012) Risk of deep venous thrombosis in drain clamping with tranexamic acid and carbazochrome sodium sulfonate hydrate in total knee arthroplasty. J Arthroplast 27(1):105-108
10. Lange DR (1979) The mechanical bonding of methylmethacrylate to cancellous bone: effects of a hemostatic agent. J Bone Joint Surg Am 61(2):254-256
11. Benoni G, Fredin H (1996) Fibrinolytic inhibition with tranexamic acid reduces blood loss and blood transfusion after knee arthroplasty: a prospective, randomised, double-blind study of 86 patients. J Bone Joint Surg Br 78(3):434-440 (Pubitemid 26158834)
12. Camarasa MA, Ollé G, Serra-Prat M, Martín A, Sánchez M, Ricós P, Pérez A, Opisso L (2006) Efficacy of aminocaproic, tranexamic acids in the control of bleeding during total knee replacement: a randomized clinical trial. Br J Anaesth 96(5):576-582
13. Maniar RN, Kumar G, Singhi T, Nayak RM, Maniar PR (2012) Most effective regimen of tranexamic acid in knee arthroplasty: a prospective randomized controlled study in 240 patients. Clin Orthop Relat Res 470(9):2605-2612
14. Sa-Ngasoongsong P, Channoom T, Kawinwonggowit V, Woratanarat P, Chanplakorn P, Wibulpolprasert B, Wongsak S, Udomsubpayakul U, Wechmongkolgorn S, Lekpittaya N (2011) Postoperative blood loss reduction in computer-assisted surgery total knee replacement by low dose intra-articular tranexamic acid injection together with 2-hour clamp drain: a prospective triple-blinded randomized controlled trial. Orthop Rev (Pavia) 3(2):e12
15. Roy SP, Tanki UF, Dutta A, Jain SK, Nagi ON (2012) Efficacy of intra-articular tranexamic acid in blood loss reduction following primary unilateral total knee arthroplasty. Knee Surg Sports Traumatol Arthrosc 20(12):2494-2501
16. Seo JG, Moon YW, Park SH, Kim SM, Ko KR (2013) The comparative efficacies of intra-articular and IV tranexamic acid for reducing blood loss during total knee arthroplasty. Knee Surg Sports Traumatol Arthrosc 21(8):1869-1874
17. Wong J, Abrishami A, El Beheiry H, Mahomed N, Roderick Davey J, Gandhi R, Syed KA, Muhammad Ovais Hasan S, De Silva Y, Chung F (2010) Topical application of tranexamic acid reduces postoperative blood loss in total knee arthroplasty: a randomized, controlled trial. J Bone Joint Surg Am 92(15):2503-2513
18. Mongan PD, Brown RS, Thwaites BK (1998) Tranexamic acid and aprotinin reduce postoperative bleeding and transfusions during primary coronary revascularization. Anaesth Analg 87(2):258-265 (Pubitemid 28369074)
19. Boylan JF, Klinck JR, Sandler AN, Arellano R, Greig PD, Nierenberg H, Roger SL, Glynn MF (1996) Tranexamic acid reduces blood loss, transfusion requirements, and coagulation factor use in primary orthotopic liver transplantation. Anesthesiology 85(5):1043-1048 (Pubitemid 26378289)
20. Wellington K, Wagstaff AJ (2003) Tranexamic acid: a review of its use in the management of menorrhagia. Drugs 63(13):1417-1433 (Pubitemid 36776096)
21. McCormack PL (2012) Tranexamic acid: a review of its use in the treatment of hyperfibrinolysis. Drugs 72(5):585-617
22. Bannister GC, Young SK, Baker AS, Mackinnon JG, Magnusson PA (1990) Control of bleeding in cemented arthroplasty. J Bone Joint Surg Br 72(3):444-446 (Pubitemid 20154155)
23. Hankin FM, Campbell SE, Goldstein SA, Matthews LS (1984) Hydrogen peroxide as a topical hemostatic agent. Clin Orthop Relat Res 186:244-248 (Pubitemid 14079919)
24. Howells RJ, Salmon JM, McCullough KG (1992) The effect of irrigating solutions on the strength of the cement-bone interface. Aust NZ J Surg 62(3):215-218
25. Lisander B, Ivarsson I, Jacobsson SA (1998) Intraoperative autotransfusion is associated with modest reduction of allogeneic transfusion in prosthetic hip surgery. Acta Anaesthesiol Scand 42(6):707-712 (Pubitemid 28298645)
26. Nadler SB, Hidalgo JU, Bloch T (1962) Prediction of blood volume in normal human adults. Surgery 51(4):224-232
27. Fahmy NR, Patel DG (1981) Hemostatic changes and postoperative deep-vein thrombosis associated with use of a pneumatic tourniquet. J Bone Joint Surg Am 63(3):461-465 (Pubitemid 11154154)
28. Langdown AJ, Field J, Grote J, Himayat H (2000) Aprotinin (Trasylol) does not reduce bleeding in primary total hip arthroplasty. J Arthroplast 15(8):1009-1012
29. Ishida K, Tsumura N, Kitagawa A, Hamamura S, Fukuda K, Dogaki Y, Kubo S, Matsumoto T, Matsushita T, Chin T, Iguchi T, Kurosaka M, Kuroda R (2011) Intra-articular injection of tranexamic acid reduces not only blood loss but also knee joint swelling after total knee arthroplasty. Int Orthop 35(11):1639-1645
30. Hiippala ST, Strid LJ, Wennerstrand MI, Arvela JV, Niemela HM, Mantyla SK, Kuisma RP, Ylinen JE (1997) Tranexamic acid radically decreases blood loss and transfusions associated with total knee arthroplasty. Anesth Analg 84(4):839-844 (Pubitemid 27147712)
31. Krohn CD, Sorensen R, Lange JE, Riise R, Bjornsen S, Brosstad F (2003) Tranexamic acid given into the wound reduces postoperative blood loss by half in major orthopaedic surgery. Eur J Surg 588:57-61 (Pubitemid 36918759)
32. Molloy DO, Archbold HA, Ogonda L, McConway J, Wilson RK, Beverland DE (2007) Comparison of topical fibrin spray and tranexamic acid on blood loss after total knee replacement: a prospective, randomised controlled trial. J Bone Joint Surg Br 89(3):306-309 (Pubitemid 46563903)
33. Kagoma YK, Crowther MA, Douketis J, Bhandari M, Eikelboom J, Lim W (2009) Use of antifibrinolytic therapy to reduce transfusion in patients undergoing orthopedic surgery: a systematic review of randomized trials. Thromb Res 123(5):687-696
34. Cid J, Lozano M (2005) Tranexamic acid reduces allogeneic red cell transfusions in patients undergoing total knee arthroplasty: results of a meta-analysis of randomized controlled trials. Transfusion 45(8):1302-1307 (Pubitemid 41647794)
35. Watt BE, Proudfoot AT, Vale JA (2004) Hydrogen peroxide poisoning. Toxicol Rev 23(1):51-57 (Pubitemid 40484572)
36. Ramp WK, Arnold R, Russell JE, Yancey JM (1987) Hydrogen peroxide inhibits glucose metabolism and collagen synthesis in bone. J Periodontol 58(5):340-344
37. Kaysinger KK, Nicholson NC, Ramp WK, Kellam JF (1995) Toxic effects of wound irrigation solutions on cultured tibiae and osteoblasts. J Orthop Trauma 9(4):303-311
38. Nicholson NC, Ramp WK, Kneisl JS, Kaysinger KK (1998) Hydrogen peroxide inhibits giant cell tumor and osteoblast metabolism in vitro. Clin Orthop Relat Res 347:250-260 (Pubitemid 28141462)
39. Shida K, Yasumoto K, Yokoyama T, Maeda T, Ohtsuka N, Hosoyamada A (2002) Oxygen embolism after intraoperative use of hydrogen peroxide. Masui 51(12):1368-1370 (Pubitemid 36077349)
40. Timperley AJ, Bracey DJ (1989) Cardiac arrest following the use of hydrogen peroxide during arthroplasty. J Arthroplast 4(4):369-370 (Pubitemid 20072874)
41. Eipe NP, Ponniah M (2006) Perioperative blood loss assessment - how accurate? Indian J Anaesth 50(1):35-38