Evaluating the extent of LINE-1 mobility following exposure to heavy metals in HepG2 cells

Biological Trace Element Research

Volumn 160, Issue 1, 2014, Pages 143-151

  Karimi, Abbas ^a   Madjd, Zahra ^a   Habibi, Laleh ^b   Akrami, Seyed Mohammad ^b  

^a IRAN UNIVERSITY OF MEDICAL SCIENCES   (Iran)

^b TEHRAN UNIVERSITY OF MEDICAL SCIENCES   (Iran)

Author keywords

Cytotoxicity; Heavy metals; Human hepatocellular carcinoma cell; LINE 1; Retrotransposition

Indexed keywords

ALUMINUM; COPPER; ENHANCED GREEN FLUORESCENT PROTEIN; LEAD;

ARTICLE; CANCER CELL LINE; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; DOWN REGULATION; EGFP GENE; FLOW CYTOMETRY; GENE EXPRESSION REGULATION; GENE FREQUENCY; GENOME ANALYSIS; GENOMIC INSTABILITY; HEPG2 CELL LINE; HUMAN; HUMAN CELL; L1 RETROTRANSPOSON; MTT ASSAY; QUANTITATIVE ANALYSIS; REAL TIME POLYMERASE CHAIN REACTION; RETROPOSON; UPREGULATION;

EID: 84903985597     PISSN: 01634984     EISSN: 15590720     Source Type: Journal    
DOI: 10.1007/s12011-014-0015-7     Document Type: Article

References (42)

1. Athanikar JN, Morrish TA, Moran JV (2002) Of man in mice. Nat Genet 32(4):562-563 (Pubitemid 35435166)
2. Coufal NG (2008) Evidence for L1 retrotransposition in the human nervous system. University of California, San Diego, Dissertation
3. Cordaux R, Batzer MA (2009) The impact of retrotransposons on human genome evolution. Nat Rev Genet 10(10):691-703
4. Lander ES, Linton LM, Birren B, Nusbaum C, Zody MC, Baldwin J et al (2001) Initial sequencing and analysis of the human genome. Nature 409(6822):860-921 (Pubitemid 32165345)
5. Babushok DV, Kazazian HH Jr (2007) Progress in understanding the biology of the human mutagen LINE-1. Hum Mutat 28(6):527-539 (Pubitemid 46744283)
6. Kazazian HH Jr (2011) Mobile DNA: finding treasure in junk. FT Press Science, New Jersey
7. Deininger PL, Moran JV, Batzer MA, Kazazian HH Jr (2003)Mobile elements and mammalian genome evolution. Curr Opin Genet Dev 13(6):651-658 (Pubitemid 37456885)
8. Hulme A, Kulpa D, Perez J, Moran JV (2006) The impact of LINE-1 retrotransposition on the human genome. In: Lupski J, Stankiewicz P (eds) Genomic Disorders. Humana Press, pp 35-55
9. Konkel MK, Batzer MA (2010) A mobile threat to genome stability: the impact of non-LTR retrotransposons upon the human genome. Semin Cancer Biol 20(4):211-221
10. Symer DE, Connelly C, Szak ST, Caputo EM, Cost GJ, Parmigiani G, Boeke JD (2002) Human L1 retrotransposition is associated with genetic instability in vivo. Cell 110(3):327-338
11. Solyom S, Ewing AD, Rahrmann EP, Doucet T, Nelson HH, Burns MB, Harris RS, Sigmon DF, Casella A, Erlanger B, Wheelan S, Upton KR, Shukla R, Faulkner GJ, Largaespada DA, Kazazian HH Jr (2012) Extensive somatic L1 retrotransposition in colorectal tumors. Genome Res 22(12):2328-2338
12. Shukla R, Upton KR, Munoz-Lopez M, Gerhardt DJ, Fisher ME, Nguyen T, Brennan PM, Baillie JK, Collino A, Ghisletti S, Sinha S, Iannelli F, Radaelli E, Dos Santos A, Rapoud D, Guettier C, Samuel D, Natoli G, Carninci P, Ciccarelli FD, Garcia-Perez JL, Faivre J, Faulkner GJ (2013) Endogenous retrotransposition activates oncogenic pathways in hepatocellular carcinoma. Cell 153(1):101-111
13. McClintock B (1984) The significance of responses of the genome to challenge. Science (New York, NY) 226(4676):792-801
14. Singer T, McConnell MJ, Marchetto MC, Coufal NG, Gage FH (2010) LINE-1 retrotransposons: mediators of somatic variation in neuronal genomes? Trends Neurosci 33(8):345-354
15. Ishizaka Y, Okudaira N, Tamura M, Iijima K, Shimura M, Goto M, Okamura T (2012) Modes of retrotransposition of long interspersed element-1 by environmental factors. Front Microbiol 3:191. doi:10.3389/fmicb.2012.00191
16. Farkash EA, Kao GD, Horman SR, Prak ET (2006) Gamma radiation increases endonuclease-dependent L1 retrotransposition in a cultured cell assay. Nucleic Acids Res 34(4):1196-1204
17. Teneng I,Montoya-Durango DE, Quertermous JL, Lacy ME, Ramos KS (2011) Reactivation of L1 retrotransposon by benzo(a)pyrene involves complex genetic and epigenetic regulation. Epigen Off J DNA Methylation Soc 6(3):355-367
18. Morales JF, Snow ET, Murnane JP (2002) Environmental factors affecting transcription of the human L1 retrotransposon. I. Steroid hormone-like agents. Mutagenesis 17(3):193-200 (Pubitemid 34537747)
19. Okudaira N, Okamura T, Tamura M, Iijma K, Goto M,Matsunaga A, Ochiai M, Nakagama H, Kano S, Fujii-Kuriyama Y, Ishizaka Y (2013) Long interspersed element-1 is differentially regulated by food-borne carcinogens via the aryl hydrocarbon receptor. Oncogene 32(41):4903-4912
20. Del Re B, Marcantonio P, Gavoci E, Bersani F, Giorgi G (2012) Assessing LINE-1 retrotransposition activity in neuroblastoma cells exposed to extremely low-frequency pulsed magnetic fields. Mutat Res 749(1-2):76-81
21. Habibi L, Shokrgozar MA, Motamedi M, Akrami SM (2013) Effect of heavy metals on silencing of engineered long interspersed element-1 retrotransposon in nondividing neuroblastoma cell line. Iran Biomed J 17(4):171-178
22. Habibi L, Shokrgozar MA, Tabrizi M, Modaressi MH, Akrami SM (2013) Mercury specifically induces LINE-1 activity in a human neuroblastoma cell line. Mutat Res. doi:10.1016/j.mrgentox.2013.07.015
23. Baccarelli A, Bollati V (2009) Epigenetics and environmental chemicals. Curr Opin Pediatr 21(2):243-251
24. Jarup L (2003) Hazards of heavy metal contamination. Br Med Bull 68:167-182
25. AK (2008) Mode of action and toxicity of trace elements. In: Trace elements as contaminants and nutrients. John Wiley & Sons, Inc., pp 523-553. doi:10.1002/9780470370124.ch21
26. Brocato J, Costa M (2013) Basicmechanics of DNAmethylation and the unique landscape of the DNA methylome in metal-induced carcinogenesis. Crit Rev Toxicol 43(6):493-514
27. Mosmann T (1983) Rapid colorimetric assay for cellular growth and survival: application to proliferation and cytotosxicity assays. J Immunol Methods 65(1-2):55-63
28. Ostertag EM, Prak ET, DeBerardinis RJ, Moran JV, Kazazian HH Jr (2000) Determination of L1 retrotransposition kinetics in cultured cells. Nucleic Acids Res 28(6):1418-1423 (Pubitemid 30142685)
29. Garcia-Perez JL, Morell M, Scheys JO, Kulpa DA, Morell S, Carter CC, Hammer GD, Collins KL, O'Shea KS, Menendez P, Moran JV (2010) Epigenetic silencing of engineered L1 retrotransposition events in human embryonic carcinoma cells. Nature 466(7307):769-773
30. Garcia-Perez JL, Marchetto MC, Muotri AR, Coufal NG, Gage FH, O'Shea KS, Moran JV (2007) LINE-1 retrotransposition in human embryonic stem cells. Hum Mol Genet 16(13):1569-1577 (Pubitemid 47050670)
31. Baillie JK, Barnett MW, Upton KR, Gerhardt DJ, Richmond TA, De Sapio F, Brennan PM, Rizzu P, Smith S, Fell M, Talbot RT, Gustincich S, Freeman TC, Mattick JS, Hume DA, Heutink P, Carninci P, Jeddeloh JA, Faulkner GJ (2011) Somatic retrotransposition alters the genetic landscape of the human brain. Nature 479(7374):534-537
32. Thomas CA, Paquola AC, Muotri AR (2012) LINE-1 retrotransposition in the nervous system. Annu Rev Cell Dev Biol 28:555-573
33. Carreira PE, Richardson SR, Faulkner GJ (2014) L1 retrotransposons, cancer stem cells and oncogenesis. FEBS J 281(1):63-73
34. Lee E, Iskow R, Yang L, Gokcumen O, Haseley P, Luquette LJ 3rd, Lohr JG, Harris CC, Ding L, Wilson RK, Wheeler DA, Gibbs RA, Kucherlapati R, Lee C, Kharchenko PV, Park PJ (2012) Landscape of somatic retrotransposition in human cancers. Science (New York, NY) 337(6097):967-971
35. Schneider AM, Duffield AS, Symer DE, Burns KH (2009) Roles of retrotransposons in benign and malignant hematologic disease. Cell Sci 6(2):121-145
36. Rangwala SH, Kazazian HH Jr (2009) The L1 retrotransposition assay: a retrospective and toolkit. Methods (San Diego, Calif) 49(3):219-226
37. ATSDR (2008) Toxicological profile for aluminum. US Department of Health and Human Services, Public Health Service Agency for Toxic Substances and Disease Registry
38. ATSDR (2007) Toxicological profile for lead. US Department of Health and Human Services, Public Health Service Agency for Toxic Substances and Disease Registry
39. Wright RO, Schwartz J, Wright RJ, Bollati V, Tarantini L, Park SK, Hu H, Sparrow D, Vokonas P, Baccarelli A (2010) Biomarkers of lead exposure and DNA methylation within retrotransposons. Environ Health Perspect 118(6):790-795
40. Wallace NA, Belancio VP, Deininger PL (2008) L1 mobile element expression causes multiple types of toxicity. Gene 419(1-2):75-81. doi:10.1016/j.gene. 2008.04.013
41. Armendariz AD, Gonzalez M, Loguinov AV, Vulpe CD (2004) Gene expression profiling in chronic copper overload reveals upregulation of Prnp and App. Physiol Genomics 20(1):45-54 (Pubitemid 40388504)
42. ATSDR (2004) Toxicological profile for copper. US Department of Health and Human Services, Public Health Service Agency for Toxic Substances and Disease Registry