Androgens alter T-cell immunity by inhibiting T-helper 1 differentiation

Proceedings of the National Academy of Sciences of the United States of America

Volumn 111, Issue 27, 2014, Pages 9887-9892

  Kissick, Haydn T ^a   Sanda, Martin G ^b   Dunn, Laura K ^a   Pellegrini, Kathryn L ^c   On, Seung T ^a   Noel, Jonathan K ^a   Arredouani, Mohamed S ^a  

^a HARVARD MEDICAL SCHOOL   (United States)

^b EMORY UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c BRIGHAM AND WOMEN S HOSPITAL   (United States)

Author keywords

Cancer immunotherapy; Immunomodulation; Prostate neoplasm

Indexed keywords

CHEMOKINE RECEPTOR CCR5; CHEMOKINE RECEPTOR CXCR3; GAMMA INTERFERON; INTERFERON REGULATORY FACTOR 1; INTERFERON REGULATORY FACTOR 3; INTERFERON REGULATORY FACTOR 7; INTERLEUKIN 12; INTERLEUKIN 12 RECEPTOR BETA2; JANUS KINASE 2; PROTEIN KINASE TYK2; PROTEIN TYROSINE PHOSPHATASE; PROTEIN TYROSINE PHOSPHATASE NONRECEPTOR 1; RETINOID RELATED ORPHAN RECEPTOR GAMMA; SOMATOMEDIN C RECEPTOR; STAT1 PROTEIN; STAT4 PROTEIN; TESTOSTERONE; TRANSCRIPTION FACTOR FOXP3; TRANSCRIPTION FACTOR GATA 3; TRANSCRIPTION FACTOR T BET; UNCLASSIFIED DRUG;

ANDROGEN DEPRIVATION THERAPY; ANIMAL CELL; ARTICLE; AUTOIMMUNITY; CD4+ T LYMPHOCYTE; CELLULAR IMMUNITY; CYTOKINE PRODUCTION; DOWN REGULATION; GENE EXPRESSION; GENE EXPRESSION PROFILING; HUMAN; HUMAN CELL; IN VITRO STUDY; IN VIVO STUDY; LYMPHOCYTE DIFFERENTIATION; LYMPHOCYTIC INFILTRATION; MALE; MOUSE; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN DEPHOSPHORYLATION; PROTEIN PHOSPHORYLATION; SEX DIFFERENCE; SIGNAL TRANSDUCTION; TH1 CELL; UPREGULATION;

CANCER IMMUNOTHERAPY; IMMUNOMODULATION; PROSTATE NEOPLASM;

ANIMALS; CELL DIFFERENTIATION; INTERLEUKIN-12; INTESTINES; INTRONS; LUNG; MALE; MICE; ORCHIECTOMY; PHOSPHORYLATION; PROSTATE; PROTEIN TYROSINE PHOSPHATASE, NON-RECEPTOR TYPE 1; STAT4 TRANSCRIPTION FACTOR; T-LYMPHOCYTES; TESTOSTERONE; TH1 CELLS; TYK2 KINASE; UP-REGULATION;

EID: 84903977462     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1402468111     Document Type: Article

References (31)

1. Klein SL, Jedlicka A, Pekosz A (2010) The Xs and Y of immune responses to viral vaccines. Lancet Infect Dis 10(5):338-349.
2. Engler RJ, et al.; Walter Reed Health Care System Influenza Vaccine Consortium (2008) Half- vs full-dose trivalent inactivated influenza vaccine (2004-2005): Age, dose, and sex effects on immune responses. Arch Intern Med 168(22):2405-2414.
3. Bonds RS, Midoro-Horiuti T (2013) Estrogen effects in allergy and asthma. Curr Opin Allergy Clin Immunol 13(1):92-99.
4. Cooper GS, Stroehla BC (2003) The epidemiology of autoimmune diseases. Autoimmun Rev 2(3):119-125. (Pubitemid 37443848)
5. Furman D, et al. (2014) Systems analysis of sex differences reveals an immunosuppressive role for testosterone in the response to influenza vaccination. Proc Natl Acad Sci USA 111(2):869-874.
6. Muehlenbein MP, Cogswell FB, James MA, Koterski J, Ludwig GV (2006) Testosterone correlates with Venezuelan equine encephalitis virus infection in macaques. Virol J 3:19.
7. Markle JG, et al. (2013) Sex differences in the gut microbiome drive hormone-dependent regulation of autoimmunity. Science 339(6123):1084-1088.
8. Drake CG, et al. (2005) Androgen ablation mitigates tolerance to a prostate/prostate cancer-restricted antigen. Cancer Cell 7(3):239-249. (Pubitemid 40568683)
9. Arredouani MS, et al. (2010) Androgen ablation augments human HLA2.1-restricted T cell responses to PSA self-antigen in transgenic mice. Prostate 70(9):1002-1011.
10. Roden AC, et al. (2004) Augmentation of T cell levels and responses induced by androgen deprivation. J Immunol 173(10):6098-6108. (Pubitemid 39487766)
11. Mercader M, et al. (2001) T cell infiltration of the prostate induced by androgen withdrawal in patients with prostate cancer. Proc Natl Acad Sci USA 98(25):14565-14570. (Pubitemid 33121432)
12. National Library of Medicine and the National Institute of Health (2000) ClinicalTrials. gov. Available at www.clinicaltrials.gov. Accessed October, 2013.
13. Wan YY, Flavell RA (2009) How diverse - CD4 effector T cells and their functions. J Mol Cell Biol 1(1):20-36.
14. O'Malley JT, et al. (2009) Signal transducer and activator of transcription 4 limits the development of adaptive regulatory T cells. Immunology 127(4):587-595.
15. Myers MP, et al. (2001) TYK2 and JAK2 are substrates of protein-tyrosine phosphatase 1B. J Biol Chem 276(51):47771-47774.
16. Chernoff J, Schievella AR, Jost CA, Erikson RL, Neel BG (1990) Cloning of a cDNA for a major human protein-tyrosine-phosphatase. Proc Natl Acad Sci USA 87(7): 2735-2739.
17. Yu WM, Wang S, Keegan AD, Williams MS, Qu CK (2005) Abnormal Th1 cell differentiation and IFN-gamma production in T lymphocytes from motheaten viable mice mutant for Src homology 2 domain-containing protein tyrosine phosphatase-1. J Immunol 174(2):1013-1019. (Pubitemid 40094297)
18. Yu CL, Jin YJ, Burakoff SJ (2000) Cytosolic tyrosine dephosphorylation of STAT5. Potential role of SHP-2 in STAT5 regulation. J Biol Chem 275(1):599-604.
19. Lundin Brockdorff J, et al. (2002) SHP2 regulates IL-2 induced MAPK activation, but not Stat3 or Stat5 tyrosine phosphorylation, in cutaneous T cell lymphoma cells. Cytokine 20(4):141-147.
20. Aoki N, Matsuda T (2000) A cytosolic protein-tyrosine phosphatase PTP1B specifically dephosphorylates and deactivates prolactin-activated STAT5a and STAT5b. J Biol Chem 275(50):39718-39726. (Pubitemid 32059000)
21. Lu X, et al. (2008) PTP1B is a negative regulator of interleukin 4-induced STAT6 signaling. Blood 112(10):4098-4108.
22. Berdnikovs S, et al. (2012) PTP1B deficiency exacerbates inflammation and accelerates leukocyte trafficking in vivo. J Immunol 188(2):874-884.
23. Frangioni JV, Beahm PH, Shifrin V, Jost CA, Neel BG (1992) The nontransmembrane tyrosine phosphatase PTP-1B localizes to the endoplasmic reticulum via its 35 amino acid C-terminal sequence. Cell 68(3):545-560.
24. Cicirelli MF, et al. (1990) Microinjection of a protein-tyrosine- phosphatase inhibits insulin action in Xenopus oocytes. Proc Natl Acad Sci USA 87(14):5514-5518.
25. Olivier M, et al. (2004) Single nucleotide polymorphisms in protein tyrosine phosphatase 1beta (PTPN1) are associated with essential hypertension and obesity. Hum Mol Genet 13(17):1885-1892. (Pubitemid 39214336)
26. Benten WP, et al. (1999) Functional testosterone receptors in plasma membranes of T cells. FASEB J 13(1):123-133. (Pubitemid 29038282)
27. Benten WP, Becker A, Schmitt-Wrede HP, Wunderlich F (2002) Developmental regulation of intracellular and surface androgen receptors in T cells. Steroids 67(11): 925-931. (Pubitemid 35286749)
28. Grosse A, Bartsch S, Baniahmad A (2012) Androgen receptor-mediated gene repression. Mol Cell Endocrinol 352(1-2):46-56.
29. Tewari AK, et al. (2012) Chromatin accessibility reveals insights into androgen receptor activation and transcriptional specificity. Genome Biol 13(10):R88.
30. Lessard L, et al. (2012) PTP1B is an androgen receptor-regulated phosphatase that promotes the progression of prostate cancer. Cancer Res 72(6):1529-1537.
31. Elchebly M, et al. (1999) Increased insulin sensitivity and obesity resistance in mice lacking the protein tyrosine phosphatase-1B gene. Science 283(5407):1544-1548.