Mechanism of 2-hydropropyl-beta-cyclodextrin in the stabilization of frozen formulations

European Journal of Pharmaceutical Sciences

Volumn 62, Issue , 2014, Pages 281-292

  Wong, Joseph ^a   Kipp, James E ^a   Miller, Reagan L ^a   Nair, Lakshmy M ^a   Joseph Ray, G ^a  

^a BAXTER HEALTHCARE CORPORATION   (United States)

Author keywords

2 Hydroxypropyl cyclodextrin; Frozen stability; Glass transition temperature (Tg ); Meropenem; Vitrification

Indexed keywords

2 HYDROPROPYL BETA CYCLODEXTRIN; BETA CYCLODEXTRIN SULFOBUTYL ETHER; CYCLODEXTRIN DERIVATIVE; DEXTRAN 40; HETASTARCH; MEROPENEM; UNCLASSIFIED DRUG; 2-HYDROXYPROPYL-BETA-CYCLODEXTRIN; ANTIINFECTIVE AGENT; BETA CYCLODEXTRIN DERIVATIVE; DEXTRAN; DEXTRAN 1; THIENAMYCIN DERIVATIVE;

ARTICLE; COMPLEX FORMATION; CONTROLLED STUDY; DRUG FORMULATION; DRUG MECHANISM; DRUG POTENCY; DRUG STABILITY; DRUG STORAGE; FREEZING; GLASS TRANSITION TEMPERATURE; IONIC STRENGTH; NUCLEAR MAGNETIC RESONANCE; PH; PRIORITY JOURNAL; SHELF LIFE; TEMPERATURE; THAWING; VITRIFICATION; CHEMISTRY; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; TRANSITION TEMPERATURE;

ANTI-BACTERIAL AGENTS; BETA-CYCLODEXTRINS; DEXTRANS; DRUG STABILITY; DRUG STORAGE; FREEZING; MAGNETIC RESONANCE SPECTROSCOPY; THIENAMYCINS; TRANSITION TEMPERATURE; VITRIFICATION;

EID: 84903948967     PISSN: 09280987     EISSN: 18790720     Source Type: Journal    
DOI: 10.1016/j.ejps.2014.05.024     Document Type: Article

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