Anti-tumor activity of liposomal glucocorticoids: The relevance of liposome-mediated drug delivery, intratumoral localization and systemic activity

Journal of Controlled Release

Volumn 151, Issue 1, 2011, Pages 10-17

  Kluza, Ewelina ^a,c   Yeo, Sin Yuin ^a   Schmid, Sophie ^a   Van Der Schaft, Daisy W J ^a   Boekhoven, Renate W ^a   Schiffelers, Raymond M ^b   Storm, Gert ^b   Strijkers, Gustav J ^a   Nicolay, Klaas ^a  

^a EINDHOVEN UNIVERSITY OF TECHNOLOGY   (Netherlands)

^b UTRECHT UNIVERSITY   (Netherlands)

^c NONE   (Netherlands)

Author keywords

Anti tumor therapy; Magnetic resonance imaging; Monitoring of drug delivery; Multifunctional liposomes; Tumor associated inflammation

Indexed keywords

ANGIOGENESIS; ANTI-CANCER THERAPIES; ANTI-TUMOR ACTIVITIES; ANTI-TUMORS; ANTITUMOR EFFECT; C57BL/6 MICE; DRUG LEAKAGE; GD-DTPA; GLUCOCORTICOIDS; IN-VITRO; LOCAL DELIVERY; LONGITUDINAL RELAXATION; MULTIFUNCTIONAL LIPOSOMES; PREDNISOLONE; SINGLE-DOSE; TUMOR GROWTH; TUMOR SITE; WHITE BLOOD CELLS;

BLOOD; DRUG DELIVERY; ENZYME INHIBITION; FLUORESCENCE; FLUORESCENCE MICROSCOPY; GADOLINIUM; LIPOSOMES; MAGNETIC RESONANCE IMAGING; ONCOLOGY; PARAMAGNETISM; PATHOLOGY; PHOSPHOLIPIDS; RESONANCE;

TUMORS;

GADOLINIUM; GLUCOCORTICOID; LIPID; LIPOSOME; PENTETIC ACID; PREDNISOLONE 21 PHOSPHATE; RHODAMINE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ANTIANGIOGENIC ACTIVITY; ANTINEOPLASTIC ACTIVITY; ARTICLE; BIOACCUMULATION; CANCER INHIBITION; CELL INFILTRATION; CELL POPULATION; CONTROLLED STUDY; DRUG CLEARANCE; DRUG DELIVERY SYSTEM; DRUG DOSAGE FORM COMPARISON; DRUG EFFICACY; DRUG FORMULATION; DRUG MONITORING; DRUG TUMOR LEVEL; ENCAPSULATION; LEUKOCYTE COUNT; MACROPHAGE; MELANOMA B16; MONOCYTE; MOUSE; NONHUMAN; NUCLEAR MAGNETIC RESONANCE IMAGING; PARTICLE SIZE; PRIORITY JOURNAL; TREATMENT OUTCOME; TUMOR VOLUME;

ANIMALS; ANTI-INFLAMMATORY AGENTS; ANTINEOPLASTIC AGENTS; CELL LINE, TUMOR; GLUCOCORTICOIDS; HUMANS; INFLAMMATION; LIPOSOMES; MACROPHAGES; MELANOMA, EXPERIMENTAL; MICE; MICE, INBRED C57BL; NEOPLASMS; PREDNISOLONE;

EID: 79955400601     PISSN: 01683659     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jconrel.2010.11.031     Document Type: Article

References (25)

1. O. Dizdar, and K. Altundag Emerging drugs in metastatic breast cancer Expert Opin. Emerg. Drugs 14 2009 85 98
2. K. Pliarchopoulou, and D. Pectasides Pancreatic cancer: current and future treatment strategies Cancer Treat. Rev. 35 2009 431 436
3. F. Ahmed, J.C. Steele, J.M.J. Herbert, N.M. Steven, and R. Bicknell Tumor stroma as a target in cancer Curr. Cancer Drug Targets 8 2008 447 453
4. J. Folkman Tumor angiogenesis: therapeutic implications N. Engl. J. Med. 285 1971 1182 1186
5. R.S. Kerbel Tumor angiogenesis N. Engl. J. Med. 358 2008 2039 2049 (Pubitemid 351656458)
6. L.M. Coussens, and Z. Werb Inflammation and cancer Nature 420 2002 860 867 (Pubitemid 36019639)
7. A. Mantovani, P. Allavena, A. Sica, and F. Balkwill Cancer-related inflammation Nature 454 2008 436 444
8. N. Ferrara, and R.S. Kerbel Angiogenesis as a therapeutic target Nature 438 2005 967 974 (Pubitemid 43093963)
9. R.M. Schiffelers, J.M. Metselaar, M.H.A.M. Fens, A.P.C.A. Janssen, G. Molema, and G. Storm Liposome-encapsulated prednisolone phosphate inhibits growth of established tumors in mice Neoplasia 7 2005 118 127 (Pubitemid 40315989)
10. M. Banciu, M.H.A.M. Fens, G. Storm, and R.M. Schiffelers Antitumor activity and tumor localization of liposomal glucocorticoids in B16 melanoma-bearing mice J. Control. Release 127 2008 131 136
11. J. Folkman, R. Langer, R.J. Linhardt, C. Haudenschild, and S. Taylor Angiogenesis inhibition and tumor regression caused by heparin or a heparin fragment in the presence of cortisone Science 221 1983 719 725 (Pubitemid 13030626)
12. M. Penhaligon, and R.S. Camplejohn Combination heparin plus cortisone treatment of two transplanted tumors in C3H/He mice J. Natl Cancer Inst. 74 1985 869 873 (Pubitemid 15118244)
13. H. Maeda, J. Wu, Sawa T., Y. Matsumura, and K. Hori Tumor vascular permeability and the EPR effect in macromolecular therapeutics: a review J. Control. Release 65 2000 271 284 (Pubitemid 30122932)
14. M. Banciu, J.M. Metselaar, R.M. Schiffelers, and G. Storm Antitumor activity of liposomal prednisolone phosphate depends on the presence of functional tumor-associated macrophages in tumor tissue Neoplasia 10 2008 108 117 (Pubitemid 351240876)
15. M. Banciu, R.M. Schiffelers, M.H.A.M. Fens, J.M. Metselaar, and G. Storm Anti-angiogenic effects of liposomal prednisolone phosphate on B16 melanoma in mice J. Control. Release 113 2006 1 8 (Pubitemid 43818165)
16. J.M. Metselaar, M.H.M. Wauben, J.P.A. Wagenaar-Hilbers, O.C. Boerman, and G. Storm Complete remission of experimental arthritis by joint targeting of glucocorticoids with long-circulating liposomes Arthritis Rheum. 48 2003 2059 2066 (Pubitemid 36828702)
17. D. Franchimont Overview of the actions of glucocorticoids on the immune response: a good model to characterize new pathways of immunosuppression for new treatment strategies Ann. NY Acad. Sci. 1024 2004 124 137 (Pubitemid 38879597)
18. S.W. Reulen, and M. Merkx Exchange kinetics of protein-functionalized micelles and liposomes studied by Förster resonance energy transfer Bioconjug. Chem. 21 2010 860 866
19. K.K. Jain Personalised medicine for cancer: from drug development into clinical practice Expert Opin. Pharmacother. 6 2005 1463 1476 (Pubitemid 41131687)
20. D.C. Drummond, O. Meyer, K. Hong, D.B. Kirpotin, and D. Papahadjopoulos Optimizing liposomes for delivery of chemotherapeutic agents to solid tumors Pharmacol. Rev. 51 1999 691 743
21. S. Rottey, A. Signore, and C. van de Wiele Radiolabelled chemotherapeutics Q. J. Nucl. Med. Mol. Imaging 51 2007 139 151 (Pubitemid 47071623)
22. W.J.M. Mulder, D.W.J. van der Schaft, P.A.I. Hautvast, G.J. Strijkers, G.A. Koning, G. Storm, K.H. Mayo, A.W. Griffioen, and K. Nicolay Early in vivo assessment of angiostatic therapy efficacy by molecular MRI FASEB J. 21 2007 378 383 (Pubitemid 46213485)
23. N.V. Rooijen, and A. Sanders Liposome mediated depletion of macrophages: mechanism of action, preparation of liposomes and applications J. Immunol. Meth. 174 1994 83 93
24. S.M. Zeisberger, B. Odermatt, C. Marty, A.H.M. Zehnder-Fjällman, K. Ballmer-Hofer, and R.A. Schwendener Clodronate-liposome-mediated depletion of tumour-associated macrophages: a new and highly effective antiangiogenic therapy approach Br. J. Cancer 95 2006 272 281 (Pubitemid 44187587)
25. J. Szebeni Complement activation-related pseudoallergy: a new class of drug-induced acute immune toxicity Toxicology 216 2005 106 121 (Pubitemid 41712000)