Biomimetic microfluidic device for in vitro antihypertensive drug evaluation

Molecular Pharmaceutics

Volumn 11, Issue 7, 2014, Pages 2009-2015

  Li, Lei ^a   Lv, Xiaoqing ^b   Ostrovidov, Serge ^c   Shi, Xuetao ^c   Zhang, Ning ^b   Liu, Jing ^a  

^a TECHNICAL INSTITUTE OF PHYSICS AND CHEMISTRY   (China)

^b TIANJIN MEDICAL UNIVERSITY   (China)

^c TOHOKU UNIVERSITY   (Japan)

Author keywords

antihypertensive drug evaluation; endothelial cells; mechanical pressure; microfluidic chip

Indexed keywords

ANTIHYPERTENSIVE AGENT; DIMETICONE; ENDOTHELIN 1; HYDRALAZINE; PADGEM PROTEIN; BIOMIMETIC MATERIAL; NYLON; POLY(DIMETHYLSILOXANE)-POLYAMIDE COPOLYMER;

ACTIN FILAMENT; ARTICLE; BIOMIMETICS; CELL ADHESION; CELL CULTURE; CHEMICAL STRUCTURE; CONTROLLED STUDY; COST EFFECTIVENESS ANALYSIS; DRUG EFFECT; DRUG SAFETY; DRUG SCREENING; ENDOTHELIAL DYSFUNCTION; ENDOTHELIUM CELL; HUMAN; HUMAN CELL; HYPERTENSION; IN VITRO STUDY; MICROFLUIDIC DEVICE; MICROFLUIDICS; NANOFABRICATION; PRESSURE; PRIORITY JOURNAL; PROTEIN EXPRESSION; SHEAR STRESS; UMBILICAL VEIN ENDOTHELIAL CELL; BLOOD VESSEL; CHEMISTRY; DRUG EFFECTS; LAB ON A CHIP; MECHANICAL STRESS; PROCEDURES; SHEAR STRENGTH;

ANTIHYPERTENSIVE AGENTS; BIOMIMETIC MATERIALS; BIOMIMETICS; BLOOD VESSELS; CELLS, CULTURED; DIMETHYLPOLYSILOXANES; DRUG EVALUATION; ENDOTHELIAL CELLS; HUMAN UMBILICAL VEIN ENDOTHELIAL CELLS; HUMANS; HYDRALAZINE; IN VITRO TECHNIQUES; LAB-ON-A-CHIP DEVICES; MICROFLUIDICS; NYLONS; PRESSURE; SHEAR STRENGTH; STRESS, MECHANICAL;

EID: 84903940578     PISSN: 15438384     EISSN: 15438392     Source Type: Journal    
DOI: 10.1021/mp5000532     Document Type: Article

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