Selective transport control on molecular velcro made from intrinsically disordered proteins

Nature Nanotechnology

Volumn 9, Issue 7, 2014, Pages 525-530

  Schleicher, Kai D ^a   Dettmer, Simon L ^b   Kapinos, Larisa E ^a   Pagliara, Stefano ^b   Keyser, Ulrich F ^b   Jeney, Sylvia ^a   Lim, Roderick Y H ^a  

^a UNIVERSITY OF BASEL   (Switzerland)

^b UNIVERSITY OF CAMBRIDGE   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

AMINO ACIDS; BINDING SITES; BIOMIMETICS; DIFFUSION; PROTEINS; SOLS;

ARTIFICIAL ENVIRONMENTS; INTRINSICALLY DISORDERED PROTEINS; MOLECULAR BRUSH SURFACES; NUCLEAR PORE COMPLEXES; PARTICLE DIFFUSIVITY; PHOTONIC FORCE MICROSCOPE; REDUCTION OF DIMENSIONALITY; TWO DIMENSIONAL DIFFUSION;

PHOTONS;

INTRINSICALLY DISORDERED PROTEIN; KARYOPHERIN; NANOMATERIAL; NUCLEOPORIN;

ARTICLE; ATOMIC FORCE MICROSCOPY; BACTERIAL CELL; BINDING AFFINITY; BINDING SITE; COLLOID; DIFFUSION; DIFFUSION COEFFICIENT; EUKARYOTIC CELL; LIPID BILAYER; MOLECULAR DYNAMICS; NANOPORE; NONHUMAN; NUCLEAR PORE COMPLEX; OPTICAL TWEEZERS; POLYMERIZATION; PRIORITY JOURNAL; PROTEIN TRANSPORT; SURFACE PLASMON RESONANCE; SURFACE PROPERTY; TEMPERATURE; VIDEO MICROSCOPY; VISCOSITY; MOLECULAR BIOLOGY; TRANSPORT AT THE CELLULAR LEVEL;

ACTIVE TRANSPORT, CELL NUCLEUS; COLLOIDS; HUMANS; MODELS, BIOLOGICAL; NUCLEAR PORE; NUCLEAR PORE COMPLEX PROTEINS;

EID: 84903935479     PISSN: 17483387     EISSN: 17483395     Source Type: Journal    
DOI: 10.1038/nnano.2014.103     Document Type: Article

References (32)

1. Alberts, B., Johnson, A., Lewis, J., Raff, M., Roberts, K & Walter, P. Molecular Biology of the Cell 4th edn (Garland, 2002). Adam, G. & Delbrück, M. in Structural Chemistry and Molecular Biology (eds Rich, A. & Davidson, N.) 198-215 (W.H. Freeman, 1968).
2. Berg, O. G. & Vonhippel, P. H. Diffusion-controlled macromolecular interactions. Annu. Rev. Biophys. Biophys. Chem. 14, 131-160 (1985).
3. Santer, S. & Ruhe, J. Motion of nano-objects on polymer brushes. Polymer 45, 8279-8297 (2004).
4. Denning, D. P., Patel, S. S., Uversky, V., Fink, A. L. & Rexach, M. Disorder in the nuclear pore complex: The FG repeat regions of nucleoporins are natively unfolded. Proc. Natl Acad. Sci. USA 100, 2450-2455 (2003).
5. Grunwald, D., Singer, R. H. & Rout, M. Nuclear export dynamics of RNA-protein complexes. Nature 475, 333-341 (2011).
6. Jeney, S., Mor, F., Koszali, R., Forro, L. & Moy, V. T. Monitoring ligand-receptor interactions by photonic force microscopy. Nanotechnology 21, 255102 (2010).
7. Dettmer, S. L., Keyser, U. F. & Pagliara, S. Local characterization of hindered Brownian motion by using digital video microscopy and 3D particle tracking. Rev. Sci. Instrum. 85, 23708 (2014).
8. Chook, Y. M. & Sueel, K. E. Nuclear import by karyopherin-betas: Recognition and inhibition. Biochim. Biophys. Acta 1813, 1593-1606 (2011).
9. Kapinos, L. E., Schoch, R. L., Wagner, R. S., Schleicher, K. D. & Lim, R. Y. H. Karyopherin-centric control of nuclear pores based on molecular occupancy and kinetic analysis of multivalent binding with FG-nucleoporins. Biophys. J. 106, 1751-1762 (2014).
10. Stuart, M. A. C. et al. Emerging applications of stimuli-responsive polymer materials. Nature Mater. 9, 101-113 (2010).
11. Whitesides, G. M. The origins and the future of microfluidics. Nature 442, 368-373 (2006).
12. Van den Heuvel, M. G. L. & Dekker, C. Motor proteins at work for nanotechnology. Science 317, 333-336 (2007).
13. Peters, R. Translocation through the nuclear pore complex: Selectivity and speed by reduction-of-dimensionality. Traffic 6, 421-427 (2005).
14. Elbaum, M. Polymers in the pore. Science 314, 766-767 (2006).
15. Jovanovic-Talisman, T. et al. Artificial nanopores that mimic the transport selectivity of the nuclear pore complex. Nature 457, 1023-1027 (2009).
16. Kowalczyk, S. W. et al. Single-molecule transport across an individual biomimetic nuclear pore complex. Nature Nanotech. 6, 433-438 (2011).
17. Lim, R. Y. H. et al. Nanomechanical basis of selective gating by the nuclear pore complex. Science 318, 640-643 (2007).
18. Patel, S. S., Belmont, B. J., Sante, J. M. & Rexach, M. F. Natively unfolded nucleoporins gate protein diffusion across the nuclear pore complex. Cell 129, 83-96 (2007).
19. Mammen, M., Choi, S. K. & Whitesides, G. M. Polyvalent interactions in biological systems: Implications for design and use of multivalent ligands and inhibitors. Angew. Chem. Int. Ed. 37, 2755-2794 (1998).
20. Isgro, T. A. & Schulten, K. Binding dynamics of isolated nucleoporin repeat regions to importin-beta. Structure 13, 1869-1879 (2005).
21. Paradise, A., Levin, M. K., Korza, G. & Carson, J. H. Significant proportions of nuclear transport proteins with reduced intracellular mobilities resolved by fluorescence correlation spectroscopy. J. Mol. Biol. 365, 50-65 (2007).
22. Happel, J. & Brenner, H. Low Reynolds Number Hydrodynamics (Martinus Nijhoff, 1983).
23. Perl, A. et al. Gradient-driven motion of multivalent ligand molecules along a surface functionalized with multiple receptors. Nature Chem. 3, 317-322 (2011).
24. Martinez-Veracoechea, F. J. & Frenkel, D. Designing super selectivity in multivalent nano-particle binding. Proc. Natl Acad. Sci. USA 108, 10963-10968 (2011).
25. Bormuth, V., Varga, V., Howard, J. & Schaffer, E. Protein friction limits diffusive and directed movements of kinesin motors on microtubules. Science 325, 870-873 (2009).
26. Yang, W. D. & Musser, S. M. Nuclear import time and transport efficiency depend on importin beta concentration. J. Cell Biol. 174, 951-961 (2006).
27. Tu, L. C., Fu, G., Zilman, A. & Musser, S. M. Large cargo transport by nuclear pores: Implications for the spatial organization of FG-nucleoporins. EMBO J. 32, 3220-3230 (2013).
28. Jacobson, K., Ishihara, A. & Inman, R. Lateral diffusion of proteins in membranes. Annu. Rev. Physiol. 49, 163-175 (1987).
29. Eichmann, S. L., Meric, G., Swavola, J. C. & Bevan, M. A. Diffusing colloidal probes of protein-carbohydrate interactions. Langmuir 29, 2299-2310 (2013).
30. Uversky, V. N. Intrinsically disordered proteins from A to Z. Int. J. Biochem. Cell Biol. 43, 1090-1103 (2011).
31. Pierres, A., Benoliel, A. M. & Bongrand, P. Measuring the lifetime of bonds made between surface-linked molecules. J. Biol. Chem. 270, 26586-26592 (1995).
32. Srinivasan, N. & Kumar, S. Ordered and disordered proteins as nanomaterial building blocks. Nanomed. Nanobiotechnol. 4, 204-218 (2012).