Nanomechanical basis of selective gating by the nuclear pore complex

Science

Volumn 318, Issue 5850, 2007, Pages 640-643

  Lim, Roderick Y H ^a   Fahrenkrog, Birthe ^a   Köser, Joachim ^a,c   Schwarz Herion, Kyrill ^a   Deng, Jie ^b   Aebi, Ueli ^a  

^a UNIVERSITY OF BASEL   (Switzerland)

^b INSTITUTE OF MATERIALS RESEARCH AND ENGINEERING   (Singapore)

^c Concentris GmbH ^*  (Switzerland)

Author keywords

[No Author keywords available]

Indexed keywords

GUANOSINE TRIPHOSPHATE; KARYOPHERIN BETA; NUCLEIC ACID; NUCLEOPORIN; PHENYLALANYLGLYCINE; POLYMER; RAN PROTEIN;

AMINO ACID; CELL ORGANELLE; CYTOPLASM; FROG; MOLECULAR ANALYSIS;

ARTICLE; CHANNEL GATING; CHEMICAL ANALYSIS; CONFORMATION; HUMAN; MOLECULAR MECHANICS; NUCLEAR PORE COMPLEX; NUCLEOCYTOPLASMIC TRANSPORT; OOCYTE; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN DOMAIN; PROTEIN TRANSPORT; XENOPUS;

ACTIVE TRANSPORT, CELL NUCLEUS; AMINO ACID MOTIFS; ANIMALS; BETA KARYOPHERINS; GLYCINE; GUANOSINE DIPHOSPHATE; GUANOSINE TRIPHOSPHATE; HUMANS; MICROSCOPY, IMMUNOELECTRON; NUCLEAR PORE; NUCLEAR PORE COMPLEX PROTEINS; PHENYLALANINE; PROTEIN BINDING; PROTEIN CONFORMATION; PROTEIN STRUCTURE, TERTIARY; RAN GTP-BINDING PROTEIN; XENOPUS LAEVIS;

EID: 35548946277     PISSN: 00368075     EISSN: 10959203     Source Type: Journal    
DOI: 10.1126/science.1145980     Document Type: Article

References (30)

1. K. Weis, Cell 112, 441 (2003).
2. M. Suntharalingam, S. R. Wente, Dev. Cell 4, 775 (2003).
3. B. Fahrenkrog, U. Aebi, Nat. Rev. Mol. Cell Biol. 4, 757 (2003).
4. M. Beck et al., Science 306, 1387 (2004); published online 28 October 2004 (10.1126/science.1104808).
5. M. P. Rout et al., J. Cell Biol. 148, 635 (2000).
6. D. P. Denning, S. S. Patel, V. Uversky, A. L. Fink, M. Rexach, Proc. Natl. Acad. Sci. U.S.A. 100, 2450 (2003).
7. L. A. Strawn, T. X. Shen, N. Shulga, D. S. Goldfarb, S. R. Wente, Nat. Cell Biol. 6, 197 (2004).
8. M. Stewart, Nat. Rev. Mol. Cell Biol. 8, 195 (2007).
9. N. Pante, M. Kann, Mol. Biol. Cell 13, 425 (2002).
10. K. Ribbeck, D. Gorlich, EMBO J. 21, 2664 (2002).
11. M. Rexach, G. Blobel, Cell 83, 683 (1995).
12. I. G. Macara, Microbiol. Mol. Biol. Rev. 65, 570 (2001).
13. R. Peters, Traffic 6, 421 (2005).
14. S. Frey, R. P. Richter, D. Görlich, Science 314, 815 (2006).
15. R. Y. H. Lim et al., Proc. Natl. Acad. Sci. U.S.A. 103, 9512 (2006).
16. R. Y. H. Lim, J. Köser, N. P. Huang, K. Schwarz-Herion, U. Aebi, J. Struct. Biol. 159, 277 (2007).
17. D. Gorlich, N. Pante, U. Kutay, U. Aebi, F. R. Bischoff, EMBO J. 15, 5584 (1996).
18. B. Fahrenkrog et al., J. Struct. Biol. 140, 254 (2002).
19. S. S. Patel, B. J. Belmont, J. M. Sante, M. F. Rexach, Cell 129, 83 (2007).
20. K. Chattopadhyay, E. L. Elson, C. Frieden, Proc. Natl. Acad. Sci. U.S.A. 102, 2385 (2005).
21. W. Yang, S. M. Musser, J. Cell Biol. 174, 951 (2006).
22. N. Shulga, D. S. Goldfarb, Mol. Cell. Biol. 23, 534 (2003).
23. T. A. Isgro, K. Schulten, Structure 13, 1869 (2005).
24. B. A. Shoemaker, J. J. Portman, P. G. Wolynes, Proc. Natl. Acad. Sci. U.S.A. 97, 8868 (2000).
25. S. M. Paulillo et al., J. Mol. Biol. 351, 784 (2005).
26. A. K. Dunker, Z. Obradovic, Nat. Biotechnol. 19, 805 (2001).
27. B. L. Timney et al., J. Cell Biol. 175, 579 (2006).
28. A. Paradise, M. K. Levin, G. Korza, J. H. Carson, J. Mol. Biol. 365, 50 (2007).
29. J. C. T. Eijkel, A. van den Berg, Microfluid. Nanofluid. 1, 249 (2005).
30. We thank K. S. Ullman for providing antibodies to C2-Nup153. Supported by the National Center of Competence in Research in Nanoscale Science, the Swiss National Science Foundation, the M. E. Müller Foundation of Switzerland, and the Canton Basel-Stadt.