메뉴 건너뛰기




Volumn 9, Issue 7, 2014, Pages

CTLA4 variants and haplotype contribute genetic susceptibility to myasthenia gravis in Northern Chinese population

Author keywords

[No Author keywords available]

Indexed keywords

CYTOTOXIC T LYMPHOCYTE ANTIGEN 4; CTLA4 PROTEIN, HUMAN;

EID: 84903886501     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0101986     Document Type: Article
Times cited : (29)

References (53)
  • 1
    • 0028779203 scopus 로고
    • Myasthenia gravis
    • Drachman DB (1994) Myasthenia gravis. N Engl J Med 330: 1797-1810.
    • (1994) N Engl J Med , vol.330 , pp. 1797-1810
    • Drachman, D.B.1
  • 3
    • 0032958983 scopus 로고    scopus 로고
    • Late-onset myasthenia gravis: A changing scene
    • Aarli JA (1999) Late-onset myasthenia gravis: a changing scene. Arch Neurol 56: 25-27.
    • (1999) Arch Neurol , vol.56 , pp. 25-27
    • Aarli, J.A.1
  • 4
    • 64349115066 scopus 로고    scopus 로고
    • Autoimmune myasthenia gravis: Emerging clinical and biological heterogeneity
    • Meriggioli MN, Sanders DB (2009) Autoimmune myasthenia gravis: emerging clinical and biological heterogeneity. Lancet Neurol 8: 475-490.
    • (2009) Lancet Neurol , vol.8 , pp. 475-490
    • Meriggioli, M.N.1    Sanders, D.B.2
  • 5
    • 17744416538 scopus 로고
    • Antibody to acetylcholine receptor in myasthenia gravis: Prevalence, clinical correlates, and diagnostic value
    • following
    • Lindstrom JM, Seybold ME, Lennon VA, Whittingham S, Duane DD (1998) Antibody to acetylcholine receptor in myasthenia gravis: prevalence, clinical correlates, and diagnostic value. 1975. Neurology 51: 933 and 936 pages following.
    • (1975) Neurology , vol.51
    • Lindstrom, J.M.1    Seybold, M.E.2    Lennon, V.A.3    Whittingham, S.4    Duane, D.D.5
  • 6
    • 84860727608 scopus 로고    scopus 로고
    • Late onset myasthenia gravis is associated with HLA DRB1*15:01 in the Norwegian population
    • Maniaol AH, Elsais A, Lorentzen AR, Owe JF, Viken MK, et al. (2012) Late onset myasthenia gravis is associated with HLA DRB1*15:01 in the Norwegian population. PLoS One 7: e36603.
    • (2012) PLoS One , vol.7
    • Maniaol, A.H.1    Elsais, A.2    Lorentzen, A.R.3    Owe, J.F.4    Viken, M.K.5
  • 7
    • 0019814626 scopus 로고
    • Myasthenia gravis. A survey
    • Oosterhuis HJ (1981) Myasthenia gravis. A survey. Clin Neurol Neurosurg 83: 105-135.
    • (1981) Clin Neurol Neurosurg , vol.83 , pp. 105-135
    • Oosterhuis, H.J.1
  • 8
    • 0032523840 scopus 로고    scopus 로고
    • A pathogenetic role for the thymoma in myasthenia gravis. Autosensitization of IL-4- producing T cell clones recognizing extracellular acetylcholine receptor epitopes presented by minority class II isotypes
    • Nagvekar N, Moody AM, Moss P, Roxanis I, Curnow J, et al. (1998) A pathogenetic role for the thymoma in myasthenia gravis. Autosensitization of IL-4- producing T cell clones recognizing extracellular acetylcholine receptor epitopes presented by minority class II isotypes. J Clin Invest 101: 2268-2277.
    • (1998) J Clin Invest , vol.101 , pp. 2268-2277
    • Nagvekar, N.1    Moody, A.M.2    Moss, P.3    Roxanis, I.4    Curnow, J.5
  • 9
    • 0033797250 scopus 로고    scopus 로고
    • Normalization of elevated CD4-/CD8- (double-negative) T cells after thymectomy parallels clinical remission in myasthenia gravis associated with thymic hyperplasia but not thymoma
    • Reinhardt C, Melms A (2000) Normalization of elevated CD4-/CD8- (double-negative) T cells after thymectomy parallels clinical remission in myasthenia gravis associated with thymic hyperplasia but not thymoma. Ann Neurol 48: 603-608.
    • (2000) Ann Neurol , vol.48 , pp. 603-608
    • Reinhardt, C.1    Melms, A.2
  • 10
    • 73249122274 scopus 로고    scopus 로고
    • Mapping of multiple susceptibility variants within the MHC region for 7 immune-mediated diseases
    • Rioux JD, Goyette P, Vyse TJ, Hammarstrom L, Fernando MM, et al. (2009) Mapping of multiple susceptibility variants within the MHC region for 7 immune-mediated diseases. Proc Natl Acad Sci U S A 106: 18680-18685.
    • (2009) Proc Natl Acad Sci U S A , vol.106 , pp. 18680-18685
    • Rioux, J.D.1    Goyette, P.2    Vyse, T.J.3    Hammarstrom, L.4    Fernando, M.M.5
  • 11
    • 0034139830 scopus 로고    scopus 로고
    • CTLA-4 in autoimmune diseases - A general susceptibility gene to autoimmunity?
    • Kristiansen OP, Larsen ZM, Pociot F (2000) CTLA-4 in autoimmune diseases-a general susceptibility gene to autoimmunity? Genes Immun 1: 170-184.
    • (2000) Genes Immun , vol.1 , pp. 170-184
    • Kristiansen, O.P.1    Larsen, Z.M.2    Pociot, F.3
  • 12
    • 0037648405 scopus 로고    scopus 로고
    • Association of the T-cell regulatory gene CTLA4 with susceptibility to autoimmune disease
    • Ueda H, Howson JM, Esposito L, Heward J, Snook H, et al. (2003) Association of the T-cell regulatory gene CTLA4 with susceptibility to autoimmune disease. Nature 423: 506-511.
    • (2003) Nature , vol.423 , pp. 506-511
    • Ueda, H.1    Howson, J.M.2    Esposito, L.3    Heward, J.4    Snook, H.5
  • 14
    • 0034254301 scopus 로고    scopus 로고
    • CTLA-4 (CD152) can inhibit T cell activation by two different mechanisms depending on its level of cell surface expression
    • Carreno BM, Bennett F, Chau TA, Ling V, Luxenberg D, et al. (2000) CTLA-4 (CD152) can inhibit T cell activation by two different mechanisms depending on its level of cell surface expression. J Immunol 165: 1352-1356.
    • (2000) J Immunol , vol.165 , pp. 1352-1356
    • Carreno, B.M.1    Bennett, F.2    Chau, T.A.3    Ling, V.4    Luxenberg, D.5
  • 15
    • 0028791059 scopus 로고
    • Lymphoproliferative disorders with early lethality in mice deficient in Ctla-4
    • Waterhouse P, Penninger JM, Timms E, Wakeham A, Shahinian A, et al. (1995) Lymphoproliferative disorders with early lethality in mice deficient in Ctla-4. Science 270: 985-988.
    • (1995) Science , vol.270 , pp. 985-988
    • Waterhouse, P.1    Penninger, J.M.2    Timms, E.3    Wakeham, A.4    Shahinian, A.5
  • 16
    • 17144378972 scopus 로고    scopus 로고
    • CTLA-4 polymorphisms and systemic lupus erythematosus (SLE): A meta-analysis
    • Lee YH, Harley JB, Nath SK (2005) CTLA-4 polymorphisms and systemic lupus erythematosus (SLE): a meta-analysis. Hum Genet 116: 361-367.
    • (2005) Hum Genet , vol.116 , pp. 361-367
    • Lee, Y.H.1    Harley, J.B.2    Nath, S.K.3
  • 17
    • 23044465195 scopus 로고    scopus 로고
    • CTLA-4 gene 49A/G polymorphism in Turkish patients with Behcet's disease
    • Sallakci N, Bacanli A, Coskun M, Yavuzer U, Alpsoy E, et al. (2005) CTLA-4 gene 49A/G polymorphism in Turkish patients with Behcet's disease. Clin Exp Dermatol 30: 546-550.
    • (2005) Clin Exp Dermatol , vol.30 , pp. 546-550
    • Sallakci, N.1    Bacanli, A.2    Coskun, M.3    Yavuzer, U.4    Alpsoy, E.5
  • 18
    • 0036146702 scopus 로고    scopus 로고
    • Polymorphism of the CTLA-4 gene is associated with autoimmune hypothyroidism in the United Kingdom
    • Nithiyananthan R, Heward JM, Allahabadia A, Franklyn JA, Gough SC (2002) Polymorphism of the CTLA-4 gene is associated with autoimmune hypothyroidism in the United Kingdom. Thyroid 12: 3-6.
    • (2002) Thyroid , vol.12 , pp. 3-6
    • Nithiyananthan, R.1    Heward, J.M.2    Allahabadia, A.3    Franklyn, J.A.4    Gough, S.C.5
  • 19
    • 1842455656 scopus 로고    scopus 로고
    • Unravelling the genetic complexity of autoimmune thyroid disease: HLA, CTLA-4 and beyond
    • Simmonds MJ, Gough SC (2004) Unravelling the genetic complexity of autoimmune thyroid disease: HLA, CTLA-4 and beyond. Clin Exp Immunol 136: 1-10.
    • (2004) Clin Exp Immunol , vol.136 , pp. 1-10
    • Simmonds, M.J.1    Gough, S.C.2
  • 20
    • 34548306584 scopus 로고    scopus 로고
    • T-cell regulatory gene CTLA-4 polymorphism/haplotype association with autoimmune pancreatitis
    • Chang MC, Chang YT, Tien YW, Liang PC, Jan IS, et al. (2007) T-cell regulatory gene CTLA-4 polymorphism/haplotype association with autoimmune pancreatitis. Clin Chem 53: 1700-1705.
    • (2007) Clin Chem , vol.53 , pp. 1700-1705
    • Chang, M.C.1    Chang, Y.T.2    Tien, Y.W.3    Liang, P.C.4    Jan, I.S.5
  • 21
    • 74549152607 scopus 로고    scopus 로고
    • Clinical associations of the genetic variants of CTLA-4, Tg, TSHR, PTPN22, PTPN12 and FCRL3 in patients with Graves' disease
    • Gu LQ, Zhu W, Zhao SX, Zhao L, Zhang MJ, et al. (2010) Clinical associations of the genetic variants of CTLA-4, Tg, TSHR, PTPN22, PTPN12 and FCRL3 in patients with Graves' disease. Clin Endocrinol (Oxf) 72: 248-255.
    • (2010) Clin Endocrinol (Oxf) , vol.72 , pp. 248-255
    • Gu, L.Q.1    Zhu, W.2    Zhao, S.X.3    Zhao, L.4    Zhang, M.J.5
  • 22
    • 0035346140 scopus 로고    scopus 로고
    • CTLA-4 gene expression is influenced by promoter and exon 1 polymorphisms
    • Ligers A, Teleshova N, Masterman T, Huang WX, Hillert J (2001) CTLA-4 gene expression is influenced by promoter and exon 1 polymorphisms. Genes Immun 2: 145-152.
    • (2001) Genes Immun , vol.2 , pp. 145-152
    • Ligers, A.1    Teleshova, N.2    Masterman, T.3    Huang, W.X.4    Hillert, J.5
  • 23
    • 36949013882 scopus 로고    scopus 로고
    • Two SNPs in the promoter region of the CTLA-4 gene affect binding of transcription factors and are associated with human myasthenia gravis
    • Wang XB, Pirskanen R, Giscombe R, Lefvert AK (2008) Two SNPs in the promoter region of the CTLA-4 gene affect binding of transcription factors and are associated with human myasthenia gravis. J Intern Med 263: 61-69.
    • (2008) J Intern Med , vol.263 , pp. 61-69
    • Wang, X.B.1    Pirskanen, R.2    Giscombe, R.3    Lefvert, A.K.4
  • 24
    • 25444484922 scopus 로고    scopus 로고
    • A CTLA4high genotype is associated with myasthenia gravis in thymoma patients
    • Chuang WY, Strobel P, Gold R, Nix W, Schalke B, et al. (2005) A CTLA4high genotype is associated with myasthenia gravis in thymoma patients. Ann Neurol 58: 644-648.
    • (2005) Ann Neurol , vol.58 , pp. 644-648
    • Chuang, W.Y.1    Strobel, P.2    Gold, R.3    Nix, W.4    Schalke, B.5
  • 25
    • 33748746572 scopus 로고    scopus 로고
    • The Gly482Ser variant of the PPARGC1 gene is associated with Type 2 diabetes mellitus in northern Chinese, especially men
    • Sun L, Yang Z, Jin F, Zhu XQ, Qu YC, et al. (2006) The Gly482Ser variant of the PPARGC1 gene is associated with Type 2 diabetes mellitus in northern Chinese, especially men. Diabet Med 23: 1085-1092.
    • (2006) Diabet Med , vol.23 , pp. 1085-1092
    • Sun, L.1    Yang, Z.2    Jin, F.3    Zhu, X.Q.4    Qu, Y.C.5
  • 26
    • 33747827929 scopus 로고    scopus 로고
    • SNPStats: A web tool for the analysis of association studies
    • Sole X, Guino E, Valls J, Iniesta R, Moreno V (2006) SNPStats: a web tool for the analysis of association studies. Bioinformatics 22: 1928-1929.
    • (2006) Bioinformatics , vol.22 , pp. 1928-1929
    • Sole, X.1    Guino, E.2    Valls, J.3    Iniesta, R.4    Moreno, V.5
  • 27
    • 12244264435 scopus 로고    scopus 로고
    • Genetic Power Calculator: Design of linkage and association genetic mapping studies of complex traits
    • Purcell S, Cherny SS, Sham PC (2003) Genetic Power Calculator: design of linkage and association genetic mapping studies of complex traits. Bioinformatics 19: 149-150.
    • (2003) Bioinformatics , vol.19 , pp. 149-150
    • Purcell, S.1    Cherny, S.S.2    Sham, P.C.3
  • 30
    • 0030816688 scopus 로고    scopus 로고
    • A CTLA-4 gene polymorphism is associated with both Graves disease and autoimmune hypothyroidism
    • Kotsa K, Watson PF, Weetman AP (1997) A CTLA-4 gene polymorphism is associated with both Graves disease and autoimmune hypothyroidism. Clin Endocrinol (Oxf) 46: 551-554.
    • (1997) Clin Endocrinol (Oxf) , vol.46 , pp. 551-554
    • Kotsa, K.1    Watson, P.F.2    Weetman, A.P.3
  • 31
    • 0031975367 scopus 로고    scopus 로고
    • Association of CTLA-4 gene A-G polymorphism (IDDM12 locus) with acute-onset and insulin-depleted IDDM as well as autoimmune thyroid disease (Graves' disease and Hashimoto's thyroiditis) in the Japanese population
    • Awata T, Kurihara S, Iitaka M, Takei S, Inoue I, et al. (1998) Association of CTLA-4 gene A-G polymorphism (IDDM12 locus) with acute-onset and insulin-depleted IDDM as well as autoimmune thyroid disease (Graves' disease and Hashimoto's thyroiditis) in the Japanese population. Diabetes 47: 128-129.
    • (1998) Diabetes , vol.47 , pp. 128-129
    • Awata, T.1    Kurihara, S.2    Iitaka, M.3    Takei, S.4    Inoue, I.5
  • 32
    • 0031829988 scopus 로고    scopus 로고
    • A study of the association between a polymorphism in the CTLA-4 gene and postpartum thyroiditis
    • Waterman EA, Watson PF, Lazarus JH, Parkes AB, Darke C, et al. (1998) A study of the association between a polymorphism in the CTLA-4 gene and postpartum thyroiditis. Clin Endocrinol (Oxf) 49: 251-255.
    • (1998) Clin Endocrinol (Oxf) , vol.49 , pp. 251-255
    • Waterman, E.A.1    Watson, P.F.2    Lazarus, J.H.3    Parkes, A.B.4    Darke, C.5
  • 33
    • 0031769359 scopus 로고    scopus 로고
    • A cytotoxic T lymphocyte antigen-4 (CTLA-4) gene polymorphism is associated with autoimmune Addison's disease in English patients
    • Kemp EH, Ajjan RA, Husebye ES, Peterson P, Uibo R, et al. (1998) A cytotoxic T lymphocyte antigen-4 (CTLA-4) gene polymorphism is associated with autoimmune Addison's disease in English patients. Clin Endocrinol (Oxf) 49: 609-613.
    • (1998) Clin Endocrinol (Oxf) , vol.49 , pp. 609-613
    • Kemp, E.H.1    Ajjan, R.A.2    Husebye, E.S.3    Peterson, P.4    Uibo, R.5
  • 34
    • 0031750760 scopus 로고    scopus 로고
    • CTLA4 gene haplotypes cannot protect from IDDM in the presence of high-risk HLA DQ8 or DQ2 alleles in German families
    • Donner H, Seidl C, Braun J, Siegmund T, Herwig J, et al. (1998) CTLA4 gene haplotypes cannot protect from IDDM in the presence of high-risk HLA DQ8 or DQ2 alleles in German families. Diabetes 47: 1158-1160.
    • (1998) Diabetes , vol.47 , pp. 1158-1160
    • Donner, H.1    Seidl, C.2    Braun, J.3    Siegmund, T.4    Herwig, J.5
  • 35
    • 8944259914 scopus 로고    scopus 로고
    • The CTLA-4 gene region of chromosome 2q33 is linked to, and associated with, type 1 diabetes
    • Belgian Diabetes Registry
    • Nistico L, Buzzetti R, Pritchard LE, Van der Auwera B, Giovannini C, et al. (1996) The CTLA-4 gene region of chromosome 2q33 is linked to, and associated with, type 1 diabetes. Belgian Diabetes Registry. Hum Mol Genet 5: 1075-1080.
    • (1996) Hum Mol Genet , vol.5 , pp. 1075-1080
    • Nistico, L.1    Buzzetti, R.2    Pritchard, L.E.3    Van Der Auwera, B.4    Giovannini, C.5
  • 37
    • 84904327163 scopus 로고    scopus 로고
    • Late-onset myasthenia gravis - CTLA4 genotype association and low-forage thymic output of naive T cells
    • Chuang WY, Strobel P, Bohlender-Willke AL, Rieckmann P, Nix W, et al. (2013) Late-onset myasthenia gravis - CTLA4 genotype association and low-forage thymic output of naive T cells. J Autoimmun.
    • (2013) J Autoimmun
    • Chuang, W.Y.1    Strobel, P.2    Bohlender-Willke, A.L.3    Rieckmann, P.4    Nix, W.5
  • 38
    • 19944432946 scopus 로고    scopus 로고
    • Genetic structure, self-identified race/ethnicity, and confounding in case-control association studies
    • Tang H, Quertermous T, Rodriguez B, Kardia SL, Zhu X, et al. (2005) Genetic structure, self-identified race/ethnicity, and confounding in case-control association studies. Am J Hum Genet 76: 268-275.
    • (2005) Am J Hum Genet , vol.76 , pp. 268-275
    • Tang, H.1    Quertermous, T.2    Rodriguez, B.3    Kardia, S.L.4    Zhu, X.5
  • 39
    • 0023553503 scopus 로고
    • Myasthenia gravis: Population differences in disease expression and acetylcholine receptor antibody titers between Chinese and Caucasians
    • Chiu HC, Vincent A, Newsom-Davis J, Hsieh KH, Hung T (1987) Myasthenia gravis: population differences in disease expression and acetylcholine receptor antibody titers between Chinese and Caucasians. Neurology 37: 1854-1857.
    • (1987) Neurology , vol.37 , pp. 1854-1857
    • Chiu, H.C.1    Vincent, A.2    Newsom-Davis, J.3    Hsieh, K.H.4    Hung, T.5
  • 40
    • 4644371955 scopus 로고    scopus 로고
    • Treatment and outcome of myasthenia gravis: Retrospective multi-center analysis of 470 Japanese patients, 1999-2000
    • Kawaguchi N, Kuwabara S, Nemoto Y, Fukutake T, Satomura Y, et al. (2004) Treatment and outcome of myasthenia gravis: retrospective multi-center analysis of 470 Japanese patients, 1999-2000. J Neurol Sci 224: 43-47.
    • (2004) J Neurol Sci , vol.224 , pp. 43-47
    • Kawaguchi, N.1    Kuwabara, S.2    Nemoto, Y.3    Fukutake, T.4    Satomura, Y.5
  • 41
    • 1542360725 scopus 로고    scopus 로고
    • A variant of childhood-onset myasthenia gravis: HLA typing and clinical characteristics in Japan
    • Shinomiya N, Nomura Y, Segawa M (2004) A variant of childhood-onset myasthenia gravis: HLA typing and clinical characteristics in Japan. Clin Immunol 110: 154-158.
    • (2004) Clin Immunol , vol.110 , pp. 154-158
    • Shinomiya, N.1    Nomura, Y.2    Segawa, M.3
  • 42
    • 0027520819 scopus 로고
    • Association of HLA-Bw46DR9 combination with juvenile myasthenia gravis in Chinese
    • Chen WH, Chiu HC, Hseih RP (1993) Association of HLA-Bw46DR9 combination with juvenile myasthenia gravis in Chinese. J Neurol Neurosurg Psychiatry 56: 382-385.
    • (1993) J Neurol Neurosurg Psychiatry , vol.56 , pp. 382-385
    • Chen, W.H.1    Chiu, H.C.2    Hseih, R.P.3
  • 44
    • 33947719422 scopus 로고    scopus 로고
    • Clinical and serological study of myasthenia gravis in HuBei Province, China
    • Zhang X, Yang M, Xu J, Zhang M, Lang B, et al. (2007) Clinical and serological study of myasthenia gravis in HuBei Province, China. J Neurol Neurosurg Psychiatry 78: 386-390.
    • (2007) J Neurol Neurosurg Psychiatry , vol.78 , pp. 386-390
    • Zhang, X.1    Yang, M.2    Xu, J.3    Zhang, M.4    Lang, B.5
  • 46
    • 0035915620 scopus 로고    scopus 로고
    • The gender gap in autoimmune disease
    • Poulas K, Tzartos SJ (2001) The gender gap in autoimmune disease. Lancet 357: 234.
    • (2001) Lancet , vol.357 , pp. 234
    • Poulas, K.1    Tzartos, S.J.2
  • 47
    • 0032146465 scopus 로고    scopus 로고
    • Genetic association of Ctla-4 to myasthenia gravis with thymoma
    • Huang D, Liu L, Noren K, Xia SQ, Trifunovic J, et al. (1998) Genetic association of Ctla-4 to myasthenia gravis with thymoma. J Neuroimmunol 88: 192-198.
    • (1998) J Neuroimmunol , vol.88 , pp. 192-198
    • Huang, D.1    Liu, L.2    Noren, K.3    Xia, S.Q.4    Trifunovic, J.5
  • 48
    • 0036483636 scopus 로고    scopus 로고
    • CDS1 and promoter single nucleotide polymorphisms of the CTLA-4 gene in human myasthenia gravis
    • Wang XB, Kakoulidou M, Qiu Q, Giscombe R, Huang D, et al. (2002) CDS1 and promoter single nucleotide polymorphisms of the CTLA-4 gene in human myasthenia gravis. Genes Immun 3: 46-49.
    • (2002) Genes Immun , vol.3 , pp. 46-49
    • Wang, X.B.1    Kakoulidou, M.2    Qiu, Q.3    Giscombe, R.4    Huang, D.5
  • 49
    • 0036718618 scopus 로고    scopus 로고
    • Anti-p110 autoantibodies identify a subtype of "seronegative" myasthenia gravis with prominent oculobulbar involvement
    • Scuderi F, Marino M, Colonna L, Mannella F, Evoli A, et al. (2002) Anti-p110 autoantibodies identify a subtype of "seronegative" myasthenia gravis with prominent oculobulbar involvement. Lab Invest 82: 1139-1146.
    • (2002) Lab Invest , vol.82 , pp. 1139-1146
    • Scuderi, F.1    Marino, M.2    Colonna, L.3    Mannella, F.4    Evoli, A.5
  • 50
    • 2242465734 scopus 로고    scopus 로고
    • A common autoimmunity predisposing signal peptide variant of the cytotoxic Tlymphocyte antigen 4 results in inefficient glycosylation of the susceptibility allele
    • Anjos S, Nguyen A, Ounissi-Benkalha H, Tessier MC, Polychronakos C (2002) A common autoimmunity predisposing signal peptide variant of the cytotoxic Tlymphocyte antigen 4 results in inefficient glycosylation of the susceptibility allele. J Biol Chem 277: 46478-46486.
    • (2002) J Biol Chem , vol.277 , pp. 46478-46486
    • Anjos, S.1    Nguyen, A.2    Ounissi-Benkalha, H.3    Tessier, M.C.4    Polychronakos, C.5
  • 51
    • 0036256007 scopus 로고    scopus 로고
    • A polymorphism in the human cytotoxic T-lymphocyte antigen 4 (CTLA4) gene (exon 1+49) alters T-cell activation
    • Maurer M, Loserth S, Kolb-Maurer A, Ponath A, Wiese S, et al. (2002) A polymorphism in the human cytotoxic T-lymphocyte antigen 4 (CTLA4) gene (exon 1+49) alters T-cell activation. Immunogenetics 54: 1-8.
    • (2002) Immunogenetics , vol.54 , pp. 1-8
    • Maurer, M.1    Loserth, S.2    Kolb-Maurer, A.3    Ponath, A.4    Wiese, S.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.