Investigation of the epithelial to mesenchymal transition markers S100A4, vimentin and Snail1 in gastroesophageal junction tumors

Diseases of the Esophagus

Volumn 27, Issue 5, 2014, Pages 485-492

  Mirza, A ^a   Foster, L ^a   Valentine, H ^b   Welch, I ^a   West, C M ^b   Pritchard, S ^a  

^a MANCHESTER UNIVERSITY NHS FOUNDATION TRUST   (United Kingdom)

^b UNIVERSITY OF MANCHESTER   (United Kingdom)

Author keywords

Epithelial mesenchymal transition; Gastroesophageal junction tumor; S100A4; Snail1; Vimentin

Indexed keywords

CALVASCULIN; SNAIL1 PROTEIN; TRANSCRIPTION FACTOR SNAIL; UNCLASSIFIED DRUG; VIMENTIN; PROTEIN S 100; S100A4 PROTEIN, HUMAN; SNAIL FAMILY TRANSCRIPTION FACTORS; TRANSCRIPTION FACTOR; TUMOR MARKER;

AGED; ARTICLE; CANCER PROGNOSIS; CANCER SURGERY; CONTROLLED STUDY; DEMOGRAPHY; EPITHELIAL MESENCHYMAL TRANSITION; ESOPHAGEAL ADENOCARCINOMA; FEMALE; HISTOPATHOLOGY; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; MAJOR CLINICAL STUDY; MALE; OVERALL SURVIVAL; PRIORITY JOURNAL; PROTEIN EXPRESSION; TISSUE MICROARRAY; ADENOCARCINOMA; ESOPHAGUS TUMOR; LOWER ESOPHAGUS SPHINCTER; METABOLISM; MORTALITY; PATHOLOGY; PROGNOSIS; STAINING;

ADENOCARCINOMA; AGED; EPITHELIAL-MESENCHYMAL TRANSITION; ESOPHAGEAL NEOPLASMS; ESOPHAGOGASTRIC JUNCTION; FEMALE; HUMANS; MALE; PROGNOSIS; S100 PROTEINS; STAINING AND LABELING; TRANSCRIPTION FACTORS; TUMOR MARKERS, BIOLOGICAL; VIMENTIN;

EID: 84903881116     PISSN: 11208694     EISSN: 14422050     Source Type: Journal    
DOI: 10.1111/j.1442-2050.2012.01435.x     Document Type: Article

References (37)

1. Pera M, Manterola C, Vidal O, Grande L. Epidemiology of esophageal adenocarcinoma. J Surg Oncol 2005; 92 (3): 151-159.
2. Chang J T, Katzka D A. Gastroesophageal reflux disease, Barrett esophagus, and esophageal adenocarcinoma. Arch Intern Med 2004; 164 (14): 1482-1488.
3. Ryan A M, Duong M, Healy L etal. Obesity, metabolic syndrome and esophageal adenocarcinoma: epidemiology, etiology and new targets. Cancer Epidemiol 2011; 35 (4): 309-319.
4. Griffiths E A, Pritchard S A, Mapstone N P, Welch I M. Emerging aspects of oesophageal and gastro-oesophageal junction cancer histopathology - an update for the surgical oncologist. World J Surg Oncol 2006; 4: 1-16.
5. Kayani B, Zacharakis E, Ahmed K, Hanna G B. Lymph node metastases and prognosis in oesophageal carcinoma - a systematic review. Eur J Surg Oncol 2011; 37 (9): 747-753.
6. Oezcelik A, Kaiser G M, Niebel W etal. Ten-year survival of esophageal cancer after an en-bloc esophagectomy. J Surg Oncol 2012; 105 (3): 284-287.
7. Micalizzi D S, Farabaugh S M, Ford H L. Epithelial-mesenchymal transition in cancer: parallels between normal development and tumor progression. J Mammary Gland Biol Neoplasia 2010; 15 (38): 117-134.
8. Gavert N, Ben-Ze'ev A. Epithelial-mesenchymal transition and the invasive potential of tumors. Trends Mol Med 2008; 14 (5): 199-209.
9. Savagner P. The epithelial-mesenchymal transition (EMT) phenomenon. 2. Ann Oncol 2010; 21 (Suppl 7): vii89-92.
10. Lee J M, Dedhar S, Kalluri R, Thompson E W. The epithelial-mesenchymal transition: new insights in signaling, development, and disease. J Cell Biol 2006; 172 (7): 973-981.
11. Kang Y G, Jung C K, Lee A, Kang W K, Oh S T, Kang C S. Prognostic significance of S100A4 mRNA and protein expression in colorectal cancer. J Surg Oncol 2012; 105 (2): 119-124.
12. Cho Y G, Nam S W, Kim T Y etal. Overexpression of S100A4 is closely related to the aggressiveness of gastric cancer. APMIS 2003; 111 (5): 539-545.
13. Kwon Y W, Chang I H, Kim K D etal. Significance of S100A2 and S100A4 expression in the progression of prostate adenocarcinoma. Korean J Urol 2010; 51 (7): 456-462.
14. Nikitenko L L, Lloyd B H, Rudland P S, Fear S, Barraclough R. Localisation by in situ hybridisation of S100A4 (p9Ka) mRNA in primary human breast tumour specimens. Int J Cancer 2000; 86 (38): 219-228.
15. Sarrio D, Rodriguez-Pinilla S M, Hardisson D, Cano A, Moreno-Bueno G, Palacios J. Epithelial-mesenchymal transition in breast cancer relates to the basal-like phenotype. Cancer Res 2008; 68 (4): 989-997.
16. Otsuki S, Inokuchi M, Enjoji M etal. Vimentin expression is associated with decreased survival in gastric cancer. Oncol Rep 2011; 25 (5): 1235-1242.
17. Al-Saad S, Al-Shibli K, Donnem T, Persson M, Bremnes R M, Busund L T. The prognostic impact of NF-kappaB p105, vimentin, E-cadherin and Par6 expression in epithelial and stromal compartment in non-small-cell lung cancer. Br J Cancer 2008; 99 (9): 1476-1483.
18. de Herreros A G, Peiro S, Nassour M, Savagner P. Snail family regulation and epithelial mesenchymal transitions in breast cancer progression. J Mammary Gland Biol Neoplasia 2010; 15 (38): 135-147.
19. Bolos V, Peinado H, Perez-Moreno M A, Fraga M F, Esteller M, Cano A. The transcription factor Slug represses E-cadherin expression and induces epithelial to mesenchymal transitions: a comparison with Snail and E47 repressors. J Cell Sci 2003; 116 (Pt 3): 499-511.
20. Peinado H, Olmeda D, Snail C A. Zeb and bHLH factors in tumour progression: an alliance against the epithelial phenotype? Nat Rev Cancer 2007; 7 (6): 415-428.
21. Yang M H, Chen C L, Chau G Y etal. Comprehensive analysis of the independent effect of twist and snail in promoting metastasis of hepatocellular carcinoma. Hepatology 2009; 50 (5): 1464-1474.
22. Kim M A, Lee H S, Lee H E, Kim J H, Yang H K, Kim W H. Prognostic importance of epithelial-mesenchymal transition-related protein expression in gastric carcinoma. Histopathology 2009; 54 (4): 442-451.
23. Ismail N, Kaur G, Hashim H, Hassan M. S100A4 overexpression proves to be independent marker for breast cancer progression. Cancer Cell Int 2008; 5 (8): 1-6.
24. Kwak J M, Lee H J, Kim S H etal. Expression of protein S100A4 is a predictor of recurrence in colorectal cancer. World J Gastroenterol 2010; 16 (31): 3897-3904.
25. Jin H, Morohashi S, Sato F etal. Vimentin expression of esophageal squamous cell carcinoma and its aggressive potential for lymph node metastasis. Biomed Res 2010; 31 (38): 105-112.
26. Utsunomiya T, Yao T, Masuda K, Tsuneyoshi M. Vimentin-positive adenocarcinomas of the stomach: co-expression of vimentin and cytokeratin. Histopathology 1996; 29 (6): 507-516.
27. Kuo K T, Chou T Y, Hsu H S, Chen W L, Wang L S. Prognostic significance of NBS1 and Snail expression in esophageal squamous cell carcinoma. Ann Surg Oncol 2012; 19 (Suppl 3): S549-557.
28. Saha A K, Sutton C, Rotimi O, Dexter S, Sue-Ling H, Sarela A I. Neoadjuvant chemotherapy and surgery for esophageal adenocarcinoma: prognostic value of circumferential resection margin and stratification of N1 category. Ann Surg Oncol 2009; 16 (5): 1364-1370.
29. Wang Y Y, Ye Z Y, Zhao Z S, Tao H Q, Chu Y Q. High-level expression of S100A4 correlates with lymph node metastasis and poor prognosis in patients with gastric cancer. Ann Surg Oncol 2010; 17 (1): 89-97.
30. Zhang H Y, Zheng X Z, Xuan X Y, Wang X H, Wang F, Li S S. [Expression of S100A4 in esophageal squamous cell carcinoma and its relation to tumor invasion and metastasis]. Nan Fang Yi Ke Da Xue Xue Bao 2010; 30 (7): 1541-1544.
31. Huang L Y, Xu Y, Cai G X etal. S100A4 over-expression underlies lymph node metastasis and poor prognosis in colorectal cancer. World J Gastroenterol 2011; 17 (1): 69-78.
32. Min H S, Choe G, Kim S W etal. S100A4 expression is associated with lymph node metastasis in papillary microcarcinoma of the thyroid. World J Gastroenterol 2008; 21 (6): 748-755.
33. Fuyuhiro Y, Yashiro M, Noda S etal. Clinical significance of vimentin-positive gastric cancer cells. Anticancer Res 2010; 30 (12): 5239-5243.
34. Liu L K, Jiang X Y, Zhou X X, Wang D M, Song X L, Jiang H B. Upregulation of vimentin and aberrant expression of E-cadherin/beta-catenin complex in oral squamous cell carcinomas: correlation with the clinicopathological features and patient outcome. Mod Pathol 2010; 23 (38): 213-224.
35. Giannelli G, Bergamini C, Marinosci F etal. Clinical role of MMP-2/TIMP-2 imbalance in hepatocellular carcinoma. Int J Cancer Suppl 2002; 97 (4): 425-431.
36. Onogawa S, Kitadai Y, Tanaka S, Kuwai T, Kimura S, Chayama K. Expression of VEGF-C and VEGF-D at the invasive edge correlates with lymph node metastasis and prognosis of patients with colorectal carcinoma. Cancer Sci 2004; 95 (1): 32-39.
37. Becker K F, Rosivatz E, Blechschmidt K, Kremmer E, Sarbia M, Hofler H. Analysis of the E-cadherin repressor Snail in primary human cancers. Cells Tissues Organs 2007; 185 (1-3): 204-212.