Quantification of 2'-deoxy-2'-β-fluoro-4'-azidocytidine in rat and dog plasma using liquid chromatography-quadrupole time-of-flight and liquid chromatography-triple quadrupole mass spectrometry: Application to bioavailability and pharmacokinetic studies

Journal of Pharmaceutical and Biomedical Analysis

Volumn 98, Issue , 2014, Pages 379-386

  Peng, Youmei ^a   Cheng, Tiefeng ^b   Dong, Lihong ^c   Zhang, Yuhai ^a   Chen, Xiaojing ^a   Jiang, Jinhua ^a   Zhang, Jingmin ^a   Guo, Xiaohe ^c   Guo, Mintong ^a   Chang, Junbiao ^a   Wang, Qingduan ^a  

^a ZHENGZHOU UNIVERSITY   (China)

^b HENAN UNIVERSITY   (China)

^c Henan Key Laboratory of Fine Chemicals   (China)

Author keywords

2' Deoxy 2' fluoro 4' azidocytidine; Bioavailability; High performance liquid chromatography quadrupole time of flight mass spectrometry; High performance liquid chromatography triple quadrupole mass spectrometry; Pharmacokinetics

Indexed keywords

2' DEOXY 2' BETA FLUORO 4' AZIDOCYTIDINE; 4' AZIDOCYTIDINE; AMMONIUM ACETATE; FORMIC ACID; LAMIVUDINE; METHANOL; UNCLASSIFIED DRUG; 2'-DEOXY-2'-FLUORO-4'-AZIDOCYTIDINE; 4'-AZIDOCYTIDINE; CYTIDINE; DEOXYCYTIDINE;

ANIMAL EXPERIMENT; AREA UNDER THE CURVE; ARTICLE; CONTROLLED STUDY; DRUG ABSORPTION; DRUG BIOAVAILABILITY; DRUG BLOOD LEVEL; DRUG CLEARANCE; DRUG ELIMINATION; DRUG HALF LIFE; EXPERIMENTAL DOG; EXPERIMENTAL RAT; FEMALE; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY TANDEM QUADRUPOLE TIME OF FLIGHT MASS SPECTROMETRY; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY TANDEM TRIPLE QUADRUPOLE MASS SPECTROMETRY; LIMIT OF DETECTION; LIMIT OF QUANTITATION; MALE; MAXIMUM PLASMA CONCENTRATION; NONHUMAN; PHARMACOKINETICS; PLASMA CONCENTRATION-TIME CURVE; PRIORITY JOURNAL; QUADRUPOLE MASS SPECTROMETRY; RAT; SINGLE DRUG DOSE; STEADY STATE; STORAGE; TANDEM MASS SPECTROMETRY; TIME OF FLIGHT MASS SPECTROMETRY; TIME TO MAXIMUM PLASMA CONCENTRATION; ANALOGS AND DERIVATIVES; ANIMAL; BIOAVAILABILITY; BLOOD; CHEMISTRY; DOG; MASS SPECTROMETRY; PLASMA; PROCEDURES; SPRAGUE DAWLEY RAT; STANDARD;

ANIMALS; BIOLOGICAL AVAILABILITY; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; CYTIDINE; DEOXYCYTIDINE; DOGS; FEMALE; LAMIVUDINE; MALE; MASS SPECTROMETRY; PLASMA; RATS; RATS, SPRAGUE-DAWLEY; REFERENCE STANDARDS;

EID: 84903829560     PISSN: 07317085     EISSN: 1873264X     Source Type: Journal    
DOI: 10.1016/j.jpba.2014.06.019     Document Type: Article

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