Synthesis of new 2′-deoxy-2′-fluoro-4′-azido nucleoside analogues as potent anti-HIV agents

European Journal of Medicinal Chemistry

Volumn 46, Issue 9, 2011, Pages 4178-4183

  Wang, Qiang ^a   Hu, Weidong ^a   Wang, Shuyang ^a   Pan, Zhenliang ^a   Tao, Le ^b   Guo, Xiaohe ^b   Qian, Keduo ^c   Chen, Chin Ho ^d   Lee, Kuo Hsiung ^c,e   Chang, Junbiao ^a  

^a ZHENGZHOU UNIVERSITY   (China)

^b Hena Key Laboratory of Fine Chemical   (China)

^c UNC Hamner Institute for Drug Safety Sciences   (United States)

^d DUKE UNIVERSITY MEDICAL CENTER   (United States)

^e CHINA MEDICAL UNIVERSITY   (Taiwan)

Author keywords

4 Azido 2 deoxy 2 fluoro nucleosides; Anti HIV activity; Drug resistance; Nucleoside reverse transcriptase inhibitor (NRTI)

Indexed keywords

1 (4 AZIDO 2 DEOXY 2 FLUORO) BETA DEXTRO ARABINOFURANOSYL)CYTOSINE; 1 (4 AZIDO 2 DEOXY 2 FLUORO) BETA DEXTRO ARABINOFURANOSYL)CYTOSINE HYDROCHLORIDE SALT; 1,3,5 O TRIBENZOYL 2 DEOXY 2 FLUORO DEXTRO ARABINOFURANOSIDE; 2' DEOXY 2' FLUORO 4' AZIDO NUCLEOSIDE DERIVATIVE; ANTI HUMAN IMMUNODEFICIENCY VIRUS AGENT; CHLORIDE; NUCLEOSIDE DERIVATIVE; UNCLASSIFIED DRUG;

ARTICLE; CARBON NUCLEAR MAGNETIC RESONANCE; CONTROLLED STUDY; CYTOTOXICITY; DRUG POTENCY; DRUG SCREENING; DRUG STRUCTURE; DRUG SYNTHESIS; FLUORINE NUCLEAR MAGNETIC RESONANCE; HUMAN; HUMAN CELL; INFRARED SPECTROSCOPY; MASS SPECTROMETRY; NONHUMAN; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; PROTON NUCLEAR MAGNETIC RESONANCE; VIRUS MUTATION; VIRUS STRAIN; X RAY CRYSTALLOGRAPHY;

ANTI-HIV AGENTS; CELL LINE; CRYSTALLOGRAPHY, X-RAY; CYTARABINE; HUMANS; INHIBITORY CONCENTRATION 50; MAGNETIC RESONANCE SPECTROSCOPY; MASS SPECTROMETRY; MODELS, MOLECULAR; NUCLEOSIDES; SPECTROPHOTOMETRY, INFRARED;

EID: 80052925838     PISSN: 02235234     EISSN: 17683254     Source Type: Journal    
DOI: 10.1016/j.ejmech.2011.06.020     Document Type: Article

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