Overexpression of Sirt7 exhibits oncogenic property and serves as a prognostic factor in colorectal cancer

Clinical Cancer Research

Volumn 20, Issue 13, 2014, Pages 3434-3445

  Yu, Hongyan ^a   Ye, Wen ^a   Wu, Jiangxue ^a   Meng, Xiangqi ^a   Liu, Ran Yi ^a   Ying, Xiaofang ^a,d   Zhou, Yi ^a   Wang, Hui ^a,e   Pan, Changchuan ^b   Huang, Wenlin ^a,c  

^a SUN YAT SEN UNIVERSITY CANCER CENTER   (China)

^b SICHUAN PROVINCIAL PEOPLE'S HOSPITAL   (China)

^c INSTITUTE OF MICROBIOLOGY   (China)

^d HUBEI CANCER HOSPITAL   (China)

^e School of Medicine   (China)

Author keywords

[No Author keywords available]

Indexed keywords

BETA CATENIN; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; MITOGEN ACTIVATED PROTEIN KINASE KINASE; RAF PROTEIN; SIRTUIN 7; UVOMORULIN; SIRT7 PROTEIN, HUMAN; SIRTUIN;

ADULT; AGED; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CANCER GROWTH; CANCER INHIBITION; CANCER PROGNOSIS; CANCER STAGING; CANCER SURVIVAL; CELL MOTILITY; COHORT ANALYSIS; COLON CARCINOGENESIS; COLONY FORMATION; COLORECTAL CANCER; CONTROLLED STUDY; DISEASE ASSOCIATION; DOWN REGULATION; ENZYME ACTIVITY; EPITHELIAL MESENCHYMAL TRANSITION; FEMALE; GENE SILENCING; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; IN VITRO STUDY; IN VIVO STUDY; LYMPH NODE METASTASIS; MAJOR CLINICAL STUDY; MALE; MOUSE; NONHUMAN; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; QUANTITATIVE ANALYSIS; SIGNAL TRANSDUCTION; TUMOR INVASION; UPREGULATION; WESTERN BLOTTING; ANIMAL; CELL MOTION; CELL PROLIFERATION; COLORECTAL TUMOR; DISEASE MODEL; GENE EXPRESSION; GENETICS; METABOLISM; METASTASIS; MIDDLE AGED; MORTALITY; PATHOLOGY; PHOSPHORYLATION; TUMOR CELL LINE; TUMOR VOLUME; VERY ELDERLY;

ADULT; AGED; AGED, 80 AND OVER; ANIMALS; CELL LINE, TUMOR; CELL MOVEMENT; CELL PROLIFERATION; COLORECTAL NEOPLASMS; DISEASE MODELS, ANIMAL; EPITHELIAL-MESENCHYMAL TRANSITION; FEMALE; GENE EXPRESSION; HUMANS; MALE; MAP KINASE SIGNALING SYSTEM; MIDDLE AGED; NEOPLASM METASTASIS; NEOPLASM STAGING; PHOSPHORYLATION; RAF KINASES; SIRTUINS; TUMOR BURDEN;

EID: 84903823510     PISSN: 10780432     EISSN: 15573265     Source Type: Journal    
DOI: 10.1158/1078-0432.CCR-13-2952     Document Type: Article

References (33)

1. Cunningham D, Atkin W, Lenz HJ, Lynch HT, Minsky B, Nordlinger B, et al. Colorectal cancer. Lancet 2010;375: 1030-47.
2. Wood LD, Parsons DW, Jones S, Lin J, Sjoblom T, Leary RJ, et al. The genomic landscapes of human breast and colorectal cancers. Science 2007;318: 1108-13.
3. Wang H, Wu J, Meng X, Ying X, Zuo Y, Liu R, et al. MicroRNA-342 inhibits colorectal cancer cell proliferation and invasion by directly targeting DNA methyltransferase 1. Carcinogenesis 2011; 32: 1033-42.
4. Haigis MC, Sinclair DA. Mammalian sirtuins: biological insights and disease relevance. Annu Rev Pathol 2010;5: 253-95.
5. Guarente L, Franklin H. Epstein Lecture: Sirtuins, aging, and medicine. N Engl J Med 2011;364: 2235-44.
6. Kaeberlein M, McVey M, Guarente L. The SIR2/3/4 complex and SIR2 alone promote longevity in Saccharomyces cerevisiae by two different mechanisms. Genes Dev 1999;13: 2570-80.
7. Imai S, Armstrong CM, Kaeberlein M, Guarente L. Transcriptional silencing and longevity protein Sir2 is an NAD-dependent histone deacetylase. Nature 2000;403: 795-800.
8. Houtkooper RH, Pirinen E, Auwerx J. Sirtuins as regulators of metabolism and healthspan. Nat Rev Mol Cell Biol 2012;13: 225-38.
9. Bosch-Presegue L, Vaquera A. The dual role of sirtuins in cancer. Genes Cancer 2011; 2: 648-62.
10. North BJ, Verdin E. Sirtuins: Sir2-related NAD-dependent protein deacetylases. Genome Biol 2004;5: 224.
11. Cha EJ, Noh SJ, Kwon KS, Kim CY, Park BH, Park HS, et al. Expression of DBC1 and SIRT1 is associated with poor prognosis of gastric carcinoma. Clin Cancer Res 2009;15: 4453-9.
12. Feige JN, Auwerx J. Transcriptional targets of sirtuins in the coordination of mammalian physiology. Curr Opin Cell Biol 2008;20: 303-9.
13. Blander G, Guarente L. The Sir2 family of protein deacetylases. Annu Rev Biochem 2004;73: 417-35.
14. Grob A, Roussel P, Wright JE, McStay B, Hernandez-Verdun D, Sirri V. Involvement of SIRT7 in resumption of rDNA transcription at the exit from mitosis. J Cell Sei 2009;122: 489-98.
15. Ford E, Voit R, Liszt G, Magin C, Grummt I, Guarente L. Mammalian Sir2 homolog SIRT7 is an activator of RNA polymerase I transcription. Genes Dev 2006;20: 1075-80.
16. de Nigris F, Cerutti J, Morelli C, Califano D, Chiariotti L, Viglietto G, et al. Isolation of a SIR-like gene, SIR-T8, that is overexpressed in thyroid carcinoma cell lines and tissues. Br J Cancer 2002;86: 917-23.
17. Ashraf N, Zino S, Macintyre A, Kingsmore D, Payne AP, George WD, et al. Altered sirtuin expression is associated with node-positive breast cancer. Br J Cancer 2006;95: 1056-61.
18. Voelter-Mahlknecht S, Letzel S, Mahlknecht U. Fluorescence in situ hybridization and chromosomal organization of the human Sirtuin 7 gene. Int J Oncol 2006;28: 899-908.
19. Barber MF, Michishita-Kioi E, Xi Y. Tasselli L, Kioi M, Moqtaderi Z, et al. SIRT7 links H3K18 deacetylation to maintenance of oncogenic transformation. Nature 2012;487: 114-8.
20. Quintana E, Shackleton M, Sabel MS, Fullen DR, Johnson TM, Morrison SJ. Efficient tumour formation by single human melanoma cells. Nature 2008;456: 593-8.
21. Kolch W, Kotwaliwale A, Vass K, Janosch P. The role of Raf kinases in malignant transformation. Expert Rev Mol Med 2002;4: 1-18.
22. Cheng M, Sexl V, Sherr CJ, Roussel MF. Assembly of cyclin D-dependent kinase and titration of p27Kip1 regulated by mitogen-activated protein kinase kinase (MEK1). Proc Natl Acad Sei USA 1998;95: 1091-6.
23. Mansour SJ, Matten WT, Hermann AS, Candia JM, Rong S, Fukasawa K, et al. Transformation of mammalian cells by constitutively active MAP kinase kinase. Science 1994;265: 966-70.
24. Chang L, Karin M. Mammalian MAP kinase signalling cascades. Nature 2001;410: 37-40.
25. Lavoie JN, L'Allemain G, Brunet A, Muller R, Pouyssegur J. Cyclin D1 expression is regulated positively by the p42/p44MAPK and negatively by the p38/HOGMAPK pathway. J Biol Chem 1996;271: 20608-16.
26. Pouyssegur J, Volmat V, Lenormand P. Fidelity and spatio-temporal control in MAP kinase (ERKs) signalling. Biochem Pharmacol 2002;64: 755-63.
27. Roberts PJ, Der CJ. Targeting the Raf-MEK-ERK mitogen-activated protein kinase cascade for the treatment of cancer. Oncogene 2007;26: 3291-310.
28. Ghetie C, Davies M, Cornfeld D, Suh N, Sait MW. Expectoration of a lung metastasis in a patient with colorectal carcinoma. Clin Colorectal Cancer 2008;7: 283-6.
29. Meng X, Wu J, Pan C, Wang H, Ying X, Zhou Y, et al. Genetic and epigenetic down-regulation of microRNA-212 promotes colorectal tumor metastasis via dysregulation of MnSOD. Gastroenterology 2013;145: 426-36 e1-6.
30. Zhu W, Cai MY, Tong ZT, Dong SS, Mai SJ, Liao YJ, et al. Over-expression of EIF5A2 promotes colorectal carcinoma cell aggressiveness by upregulating MTA1 through C-myc to induce epithelial-mesenchymal transition. Gut 2012;61: 562-75.
31. Thiery JP, Acloque H, Huang RY, Nieto MA. Epithelial-mesenchymal transitions in development and disease. Cell 2009;139: 871-90.
32. Thiery JP. Epithelial-mesenchymal transitions in tumour progression. Nat Rev Cancer 2002;2: 442-54.
33. Cano A, Perez-Moreno MA, Rodrigo I, Locascio A, Blanco MJ, del Barrio MG, et al. The transcription factor snail controls epithelial-mesenchymal transitions by repressing E-cadherin expression. Nat Cell Biol 2000;2: 76-83.