Antibiotics and antiseptics for venous leg ulcers

Cochrane Database of Systematic Reviews

Volumn 2014, Issue 1, 2014, Pages

  O'Meara, Susan ^a   Al Kurdi, Deyaa ^b   Ologun, Yemisi ^c   Ovington, Liza G ^d   Martyn St James, Marrissa ^e   Richardson, Rachel ^b  

^a UNIVERSITY OF LEEDS   (United Kingdom)

^b UNIVERSITY OF YORK   (United Kingdom)

^c CHESTERFIELD ROYAL HOSPITAL   (United Kingdom)

^d ETHICON INC   (United States)

^e UNIVERSITY OF SHEFFIELD   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

AMOXICILLIN; ANTIBIOTIC AGENT; ANTIINFECTIVE AGENT; CADEXOMER IODINE; CHLORAMPHENICOL; CHLORHEXIDINE; CIPROFLOXACIN; ETHACRIDINE; ETHACRIDINE LACTATE; FRAMYCETIN; LEVAMISOLE; PLACEBO; POVIDONE IODINE; PSEUDOMONIC ACID; TRIMETHOPRIM; TOPICAL ANTIINFECTIVE AGENT;

ANTIBIOTIC RESISTANCE; BACKACHE; BACTERIAL FLORA; CLINICAL EFFECTIVENESS; DRUG EFFICACY; DRUG SAFETY; DRUG WITHDRAWAL; HEADACHE; HUMAN; LEG ULCER; MIGRAINE; NAUSEA; PATIENT SATISFACTION; PRIORITY JOURNAL; PRURITUS; QUALITY OF LIFE; RANDOMIZED CONTROLLED TRIAL (TOPIC); REVIEW; SYSTEMATIC REVIEW; TREATMENT DURATION; TREATMENT RESPONSE; UNSPECIFIED SIDE EFFECT; WOUND HEALING; ADULT; META ANALYSIS; MICROBIOLOGY; OCCLUSIVE DRESSING; VARICOSIS;

ADULT; ANTI-BACTERIAL AGENTS; ANTI-INFECTIVE AGENTS, LOCAL; HUMANS; OCCLUSIVE DRESSINGS; RANDOMIZED CONTROLLED TRIALS AS TOPIC; VARICOSE ULCER; WOUND HEALING;

EID: 84903821251     PISSN: 14651858     EISSN: None     Source Type: Journal    
DOI: 10.1002/14651858.CD003557.pub5     Document Type: Review

References (244)

1. Alinovi A, Bassissi P, Pini M. Systemic administration of antibiotics in the management of venous ulcers: a randomized clinical trial. Journal of the American Academy of Dermatology 1986;15(2):186-91.
2. Alinovi A, Bassissi P, Pini M, Talignani G. Systemic administration of antibiotics in the management of chronic venous ulcers. 14th World Congress International Union of Angiology, 6-11 July 1986, Munich, West Germany. 1986.
3. Beitner H. Treatment of chronic leg ulcers with topical application of benzoyl peroxide lotion. Current Therapeutic Research 1985;38(4):657-60.
4. Beitner H. Treatment of chronic leg ulcers with topical application of benzoyl peroxide lotion. Current Therapeutic Research 1985;38(4):657-60.
5. Belcaro G, Cesarone MR, Nicolaides AN, Geroulakos G, Di Renzo A, Milani M, et al.Improvement of microcirculation and healing of venous hypertension and ulcers with Crystacide Evaluation of free radicals, laser Doppler flux and PO2: a prospective-randomized-controlled study. Angiology 2003;54(4):325-30.
6. Belcaro G, Cesarone MR, Errichi BM, Di Renzo A, Errichi S, Ricci A, et al.Improvement of microcirculation and healing of venous hypertension and ulcers with Crystacide: evaluation with a microcirculatory model, including free radicals, laser Doppler flux and PO2/PCO2 measurement. Angiology 2007;58(3):323-7.
7. Binić I, Janković A, Janković D, Janković I, Vrucinić Z. Evaluation of healing and antimicrobiological effects of herbal therapy on venous leg ulcer: pilot study. Phytotherapy Research 2010;24(2):277-82.
8. Bishop JB, Phillips LG, Mustoe TA, VanderZee AJ, Wiersema L, Roach DE, et al.A prospective randomized evaluator-blinded trial of two potential wound healing agents for the treatment of venous stasis ulcers. Journal of Vascular Surgery 1992;16(2):251-7.
9. Blair SD, Backhouse CM, Wright DDI, Riddle E, McCollum CN. Do dressings influence the healing of chronic venous ulcers?. Phlebology 1988;3:129-34.
10. Cameron J, Cherry GW, Poewll S, Ryan TJ. The efficacy of mupirocin (pseudomonic acid) in the management of venous leg ulcers (poster presentation). American Academy of Dermatology 50th Annual Meeting, 7-12 December 1991, Dallas, Texas, USA. 1991.
11. Cherry GW, Powell SM, Ryan T. The efficacy of mupirocin in the management of venous leg ulcers. 2nd European Conference on Advances in Wound Management, 20-23 October 1992, Harrogate. 1992.
12. Casoni P. Randomized trial using new topical colloids and bandages. 16th Annual Congress of the American College of Phlebology, 7-10 November 2002, Fort Lauderdale, Florida. 2002.
13. Chaloner D. A comparative study of two silver containing dressings, Acticoat 7 and Avance in the treatment of chronic venous ulcers. 2nd World Union of Wound Healing Societies Meeting, 8-13 July 2004, Paris. 2004.
14. Chaloner D. A prospective, multi-centre, randomised, comparative study to compare the effects of Acticoat 7 antimicrobial barrier dressing to Avance silver impregnated foam film dressing in the treatment of chronic venous leg ulcers. Unpublished report.
15. Daroczy J. Quality control in chronic wound management: the role of local povidone-iodine (Betadine) therapy. Dermatology 2006;212:82-7.
16. Dimakakos E, Katsenis K, Kalemikerakis J, Arkadopoulos N, Mylonas S, Arapoglou V, et al.Infected venous leg ulcers: management with silver-releasing foam dressing. Wounds: A Compendium of Clinical Research and Practice 2009;21(1):4-8.
17. Fischer H, Gilliet F, Hornemann M, Leyh F, Lindemayr H, Stegmann W, et al.Enzymatic debridement in venous ulcus cruris. Report of a multicenter clinical comparative study with various enzyme preparations [Enzymatische wundreinigung beim venösen ulcus cruris. Beritch uber eine multizentrische klinische vergleichsstudie mit verschiedenen enzympräparaten]. Fortschritte der Medizin 1984;102(10):281-3.
18. Fumal I, Braham C, Paquet P, Piérard-Franchimont C, Piérard GE. The beneficial toxicity paradox of antimicrobials in leg ulcer healing impaired by a polymicrobial flora: a proof-of-concept study. Dermatology 2002;204(Suppl 1):70-4.
19. Fumal I, Braham C, Paquet P, Piérard-Franchimont C, Piérard GE. The beneficial toxicity paradox of antimicrobials in leg ulcer healing impaired by a polymicrobial flora: a proof-of-concept study. Dermatology 2002;204(Suppl 1):70-4.
20. Fumal I, Braham C, Paquet P, Piérard-Franchimont C, Piérard GE. The beneficial toxicity paradox of antimicrobials in leg ulcer healing impaired by a polymicrobial flora: a proof-of-concept study. Dermatology 2002;204(Suppl 1):70-4.
21. Geske T, Hachmann E, Effendy I. Wound treatment with ethacridine lactate in venous leg ulcers: a prospective, randomized, placebo-controlled, single-blind study. Vasomed 2005;17(3):99-103.
22. Gethin G, Cowman S. Bacteriological changes in sloughy venous leg ulcers treated with manuka honey or hydrogel: an RCT. Journal of Wound Care 2008;17(6):241-7.
23. Gethin G, Cowman S. Manuka honey versus hydrogel to deslough venous leg ulcers: a randomised controlled trial. 17th Conference of the European Wound Management Association, 2007 May 2-4, Glasgow. 2007.
24. Gethin G, Cowman S. Manuka honey versus hydrogel to deslough venous ulcers - a randomised controlled trial. 3rd Congress of the World Union of Wound Healing Societies Meeting, 2008 June 4-8, Toronto. 2008.
25. Gethin G, Cowman S. Manuka honey vs. hydrogel - a prospective, open label, multicentre, randomised controlled trial to compare desloughing efficacy and healing outcomes in venous ulcers. Journal of Clinical Nursing 2008;18(3):466-74.
26. Groenewald JH. An evaluation of dextranomer as a cleansing agent in the treatment of the post-phlebitic stasis ulcer. South African Medical Journal 1980;57(20):809-15.
27. Groenewald JH. The treatment of varicose stasis ulcers: a controlled trail. Schweizerische Rundschau fur Medizin Praxis 1981;70(28):1273-8.
28. Hansson C. The effects of cadexomer iodine paste in the treatment of venous leg ulcers compared with hydrocolloid dressing and paraffin gauze dressing. Cadexomer Iodine Study Group. International Journal of Dermatology 1998;37(5):390-6.
29. Månsson T. Effect of Iodosorb dressing, Duoderm E and Jelonet on symptomatic parameters in exudative venous leg ulcers. 5th European Conference on Advances in Wound Management, November 1995. 1996.
30. Harcup JW, Saul PA. A study of the effect of Cadexomer iodine in the treatment of venous leg ulcers. British Journal of Clinical Practice 1986;40(9):360-4.
31. Holloway GA, Johansen KH, Barnes RW, Pierce GE. Multicenter trial of cadexomer iodine to treat venous stasis ulcer. Western Journal of Medicine 1989;151(1):35-8.
32. Huovinen S, Kotilainen P, Jarvinen H, Malanin K, Sarna S, Helander I, et al.Comparison of ciprofloxacin or trimethoprim therapy for venous leg ulcers: results of a pilot study. Journal of the American Academy of Dermatology 1994;31(2):279-81.
33. Ishibashi Y, Soeda S, Oura T, Nishikawa T, Niimura M, Nakajima H, et al.Clinical effects of KCB-1, a solution of recombinant human basic fibroblast growth factor, on skin ulcers: a phase III study comparing with sugar and povidone iodine ointment. Rinsho Iyaku 1996;12(10):2159-87.
34. Jull A. Honey and venous leg ulceration: a systematic review & randomised controlled trial. PhD thesis. University of Aukland, New Zealand, 2007.
35. Jull A, Walker N, Parag V, Molan P, Arroll B, Waters J, et al.Honey as adjuvant therapy for leg ulcers (HALT) trial: a randomized controlled trial (ISRCTN 06161544). 16th Conference of the European Wound Management Association, 2006 May 18-20, Prague, Czech Republic. 2006.
36. Jull A, Walker N, Parag V, Molan P, Rodgers A on behalf of the Honey as Adjuvant Leg Ulcer Therapy trial collaborators. Randomized clinical trial of honey-impregnated dressings for venous leg ulcers. British Journal of Surgery 2008;95(2):175-82.
37. Jull A, Walker N, Rodgers A, Bennett D, Molan P, Arroll B, et al.Honey for leg ulcers - The HALT trial. 2nd World Union of Wound Healing Societies Meeting, 2004 July 8-13, Paris. 2004.
38. Ivins N, Harding KG, Price P, Jurgensen B, Lohmann M, Gottrup F, et al.Safety and efficacy in long-term use of a sustained silver-releasing foam dressing: a randomized, controlled trial on venous leg ulcers. Symposium on Advanced Wound Care (SAWC) & Medical Research Forum on Wound Repair, 2006 April 30 - May 3, San Antonio, Texas. 2006.
39. Ivins N, Jørgensen B, Lohmann M, Harding KG, Price P, Gottrup F, et al.Safety and efficacy in long term use of a sustained silver-releasing foam dressing: a randomised, controlled trial on venous leg ulcers. 15th Conference of the European Wound Management Association, 2005 September 15-17, Stuttgart, Germany. 2005:Poster abstracts P180 284.
40. Jørgensen B, Price P, Andersen KE, Gottrup F, Bech-Thomsen N, Scanlon E, et al.The silver-releasing foam dressing, Contreet Foam, promotes faster healing of critically colonised venous leg ulcers: a randomised, controlled trial. International Wound Journal 2005;2(1):64-73.
41. Price P, CONTREET Study Group. Health-related quality of life aspects after treatment with a foam dressing and a silver containing foam dressing in chronic leg ulcers. 2nd World Union of Wound Healing Societies Meeting, 2004 July 8-13, Paris. 2004:161.
42. Sibbald RG, CONTREET Study Group. Wound bed preparation properties of a foam dressing and a silver containing foam dressing. 2nd World Union of Wound Healing Societies Meeting, 2004 July 8-13, Paris. 2004:35.
43. Kerihuel JC. Effect of activated charcoal dressings on healing outcomes of chronic wounds. Journal of Wound Care 2010;19(5):208-15.
44. Kero M, Tarvainen K, Hollmen A, Pekanmaki K. A comparison of cadexomer iodine with dextranomer in the treatment of venous leg ulcers. Current Therapeutic Research 1987;42(5):761-7.
45. Tarvainen K. Cadexomer iodine (Iodosorb) compared with dextranomer (Debrisan) in the treatment of chronic leg ulcers. Acta Chirurgica Scandinavica (Supplementum) 1988;544:57-9.
46. Kuznetsov NA, Rodoman GV, Nikitin VG, Karev MA, Shalayeva TI. The use of current bandages in the treatment of patients with venous trophic ulcers of the skin: clinical and economic aspects. Khirurgiia 2009;11:63-9.
47. Laudanska H, Gustavson B. In-patient treatment of chronic varicose venous ulcers: a randomized trial of cadexomer iodine versus standard dressings. Journal of International Medical Research 1988;16(6):428-35.
48. Lazareth I, Meaume S, Sigal-Grinberg ML, Combemale P, Le Guyadec T, Zagnoli A, et al.The role of a silver releasing lipido-colloid contact layer in venous leg ulcers presenting inflammatory signs suggesting heavy bacterial colonization: results of a randomized controlled study. Wounds: A Compendium of Clinical Research and Practice 2008;20(6):158-66.
49. Sigal-Grinberg M, Senet P, Lazareth I, Sauvadet A, Bohbot S. Evaluation of a new contact layer impregnated with silver salts in the management of critically colonized venous leg ulcers. Results of a randomized clinical trial. 17th Conference of the European Wound Management Association, 2007 May 2-4, Glasgow, Scotland. 2007:31.
50. Lindsay G, Latta D, Lyons KGB, Livingstone ED, Thomson W. A study in general practice of the efficacy of cadexomer iodine in venous leg ulcers treated on alternate days. Acta Therapeutica 1986;12:141-7.
51. Meaume S, Vallet D, Morere MN, Téot L. Evaluation of a silver-releasing hydroalginate dressing in chronic wounds with signs of local infection. Journal of Wound Care 2005;14(9):411-19.
52. Meaume S, Vallet D, Morere MN, Téot L. Evaluation of a silver-releasing hydroalginate dressing in chronic wounds with signs of local infection [Evaluation einer silberionen-freisetzenden hydroalinat-wundauflage bei chronischen wunden mit anzeichen einer lokalen infektion]. Zeitschrift fur Wundheilung 2006;11(5):236-45.
53. Michaels JA, Campbell B, King B, Palfreyman SJ, Shackley P, Stevenson M. Randomized controlled trial and cost-effectiveness analysis of silver-donating antimicrobial dressings for venous leg ulcers (VULCAN trial). British Journal of Surgery 2009;96(10):1147-56.
54. Michaels JA, Campbell WB, King BM, MacIntyre J, Palfreyman SJ, Shackley P, et al.A prospective randomised controlled trial and economic modelling of antimicrobial silver dressings versus non-adherent control dressings for venous leg ulcers: the VULCAN trial. Health Technology Assessment 2009;13(56):1-138.
55. Palfreyman S, King B, Turner B, Sears N, Carmody SE, Michaels J. An update on the progress of the VULCAN trial. Wounds UK 2006;2(2):35-44.
56. Palfreyman S, Walker N. Venous leg ulcers and the VULCAN trial. British Journal of Nursing 2007;16(8):442-3.
57. Carville K, Kapp S, Newall N, Saflekas S, Lewin G, Gliddon T, et al.Predicting covert and overt infection in venous leg ulcers: a randomised controlled trial. Australian Wound Management Association 7th National Conference: Dreams, Diversity, Disasters, 2008 May 7-10, Darwin, Australia. 2008.
58. Kapp S, Carville K, Saflekas S, Newall N, Lewin G, Flowers C, et al.The Angior initiative: results of a randomised controlled trial comparing the effectiveness of two antimicrobials. 3rd Congress of the World Union of Wound Healing Societies Meeting, 2008 June 4-8, Toronto, Canada. 2008.
59. Kapp S, Carville K, Saflekas S, Newall N, Lewin G, Flowers C, et al.The Angior Initiative: results of a randomised controlled trial comparing the effectiveness of two antimicrobials. Australian Wound Management Association 7th National Conference: Dreams, Diversity, Disasters, 2008 May 7-10, Darwin, Australia. 2008.
60. Miller C, Kapp S, Newall N, Lewin G, Karimi L, Carville K, et al.Predicting concordance with multilayer compression bandaging. Journal of Wound Care 2011;20(2):101-12.
61. Miller C, Karimi L, Kapp S, Newall N, Lewin G, Carville K, et al.Client perceptions of two types of antimicrobial dressings and compression bandaging. Wound Practice and Research 2010;18(3):124-32.
62. Miller CN, Carville K, Newall N, Kapp S, Lewin G, Karimi L, et al.Assessing bacterial burden in wounds: comparing clinical observation and wound swabs. International Wound Journal 2011;8(1):45-55.
63. Miller CN, Newall N, Kapp SE, Lewin G, Karimi L, Carville K, et al.A randomized-controlled trial comparing cadexomer iodine and nanocrystalline silver on the healing of leg ulcers. Wound Repair and Regeneration 2010;18(4):359-67.
64. Morias J, Peremans W, Campaert H, Mertens RL. Levamisole treatment in ulcus cruris. A double-blind placebo-controlled. Arzneimittel-Forschung 1979;29(7):1050-2.
65. Moss C, Taylor A, Shuster S. Controlled trial of Iodosorb in chronic venous ulcers. BMJ 1985;297(6499):902.
66. Moss C, Taylor AEM, Shuster S. Comparison of cadexomer iodine and dextranomer for chronic venous ulcers. Clinical and Experimental Dermatology 1987;12(6):413-8.
67. Moss C, Taylow A, Shuster S. Comparative study of cadexomer iodine and dextranomer in chronic leg ulcers. Scottish Medical Journal 1984;25:54.
68. Münter K-C, Beele H, Russell L, Basse PB, Groechenig E, Crespi A, et al.The CONTOP Study: a large-scale, comparative, randomised study in patients treated with a sustained silver-releasing foam dressing. European Wound Management Association Conference, 2005 September 15-17, Stuttgart, Germany. 2005:Poster abstracts P193 292.
69. Münter KC, Beele H, Russell L, Basse PB, Groechenig E, Crespi A, et al.The CONTOP Study: a large-scale, comparative, randomized study in patients treated with a sustained silver-releasing foam dressing. Symposium on Advanced Wound Care & Medical Research Forum on Wound Repair, 2006 April 30 - May 3, San Antonio, Texas. 2006:Poster 11.
70. Münter KC, Beele H, Russell L, Basse PB, Gröchenig E, Crespi A, et al.The CONTOP Study: improved healing of delayed healing ulcers with sustained silver-releasing foam dressing versus other silver dressings. 16th Conference of the European Wound Management Association, 2006 May 18-20, Prague, Czech Republic. 2006:210, Abstract No.P068.
71. Münter KC, Beele H, Russell L, Crespi A, Gröchenig E, Basse P, et al.Effect of a sustained silver-releasing dressing on ulcers with delayed healing: the CONTOP study. Journal of Wound Care 2005;15(5):199-206.
72. Russell L (on behalf of the UK investigators). The CONTOP multinational study: preliminary data from the UK arm. Wounds UK 2005;1(1):44-54.
73. Russell L, Nebbioso G, Münter KC, Beele H, Basse PB, Dienst H. The CONTOP Study: a hydro-activated silver containing foam dressing versus standard care. 2nd World Union of Wound Healing Societies Meeting, 2004 July 8-13, Paris, France. 2004.
74. Scalise A, Forma O, Happe M, Hahn TW. The CONTOP study: real life experiences from an international study comparing a silver containing hydro-activated foam dressing with standard wound care. 13th Conference of the European Wound Management Association, 2003 May 22-24, Pisa, Italy. 2003.
75. Ormiston MC, Seymour MT, Venn GE, Cohen RI, Fox JA. A randomised comparison of cadexomer iodine and a standard treatment in out-patients with chronic venous ulcers. Cadexomer Iodine. Stuttgart: Schattauer Verlag, 1983:63-9.
76. Ormiston MC, Seymour MT, Venn GE, Cohen RI, Fox JA. Controlled trial of Iodosorb in chronic venous ulcers. BMJ 1985;291(6491):308-10.
77. Hillstrom L. Iodosorb compared to standard treatment in chronic venous leg ulcers--a multicenter study. Acta Chirurgica Scandinavica - Supplementum 1988;544:53-6.
78. Skog E, Arnesjö B, Troëng T, Gjöres JE, Bergljung L, Gundersen J, et al.A randomized trial comparing cadexomer iodine and standard treatment in the out-patient management of chronic venous ulcers. British Journal of Dermatology 1983;109(1):77-83.
79. Troëng T, Skog E, Arnesjö B, Gjöres JE, Bergljung L, Gundersen J, et al.A randomised multicentre trial to compare the efficacy of cadexomer iodine and standard treatment in the management of chronic venous ulcers in out-patients. Unpublished report 43-50.
80. Smith JM, Dore CJ, Charlett A, Lewis JD. A randomized trial of biofilm dressing for venous leg ulcers. Phlebology 1992;7(3):108-13.
81. Steele K, Irwin G, Dowds N. Cadexomer iodine in the management of venous leg ulcers in general practice. The Practitioner 1986;230(1411):63-8.
82. Valtonen V, Karppinen L, Kariniemi AL. A comparative study of Ciprofloxacin and conventional therapy in the treatment of patients with chronic lower leg ulcers infected with Pseudomonas aeruginosa or other gram-negative rods. Scandinavian Journal of Infectious Diseases Supplement 1989;60:79-83.
83. Wunderlich U, Orfanos CE. Treatment of venous ulcera cruris with dry wound dressings. Phase overlapping use of silver impregnated activated charcoal xero-dressing [Bedhandlung der ulcera cruris venosa mit trockenen wundauflagen. Phasenübergreifende anwendung eines silber-imprägnierten aktivkohle-xerodressings]. Der Hautarzt 1991;42(7):446-50.
84. Allen S, Cooper J. The effect of an antibacterial on pain ulcerated legs. British Journal of Clinical Practice 1980;10:284-5.
85. Allen RB, Kerstein M, Klassen H, Friedmann PS, Pryce DW, Lawrence JC, et al.Prospective study of clinical infections in wounds dressed with occlusive versus conventional dressings. 9th Annual Symposium on Advanced Wound Care and 6th Annual Medical Research Forum on Wound Repair, 20-24 April 1996, Atlanta, Georgia, USA. 1996.
86. Hermans M. A prospective clinical trial of wound dressings to investigate the rate of infection under occlusion. First World Wound Healing Congress, 10-13 September 2000, Melbourne, Australia. 2000.
87. Altman MA, Richter IH, Kaplan LH. Use of an aqueous triple iodine solution in the treatment of chronic leg ulcers and gangrene. Angiology 1976;76(27):181-7.
88. Anonymous . Does metronidazole help leg ulcers and pressure sores?. Drug and Therapeutics Bulletin 1982;20(3):9-10.
89. Bazzigaluppi F, Biraghi MG, Fano M, Moschin AM, Toscani P, Cervone C, et al.Cadexomer iodine in the treatment of cutaneous ulcers: open, multicentric trial. Gazetta Medica Italiana - Archivo per le Scienze Mediche 1991;150(11):471-80.
90. Beele H, Meuleneire F, Nahuys M, Percival SL. A prospective randomised open label study to evaluate the potential of a new silver alginate/carboxymethylcellulose antimicrobial wound dressing to promote wound healing. International Wound Journal 2010;7(4):262-70.
91. Beitner H. Treatment of chronic leg ulcers with topical application of benzoyl peroxide lotion. Current Therapeutic Research 1985;38(4):657-60.
92. Bender E. Local treatment of leg ulcers with silver sulfadiazine in ambulatory practice [Die lokale behandlung von unterschenkelgeschwüren mit sulfadiazin-silber in der ambulanten praxis]. Fortschritte der Medizin 1982;100(29):1372-3.
93. Bourgeois P. Clinical trials of Kitasamycin. Gazette Medicale de France 1963;70:22-5.
94. Braumann C, Pirlich M, Menenakos C, Lochs H, Mueller JM. Implementation of the clean and close concept for treatment of surgical and chronic wounds in three university centres in Berlin - Germany. Abstract number 44. EWMA Journal 2008;8(2 Suppl):41.
95. Brzezińska-Wcisło L, Krauze E, Suwała-Jurczyk B. Levamisole in the treatment of crural ulcers [Levamisol w leczeniu owrzodzen podudzi]. Przeglad Dermatologiczny 1990;77(1):51-5.
96. Castellano JJ, Shafii SM, Ko F, Donate G, Wright TE, Mannari RJ, et al.Comparative evaluation of silver-containing antimicrobial dressings and drugs. International Wound Journal 2007;4(2):114-22.
97. Chaparro M, Alvarez de los Heros F, Novo E, Rodriguez-Alvarez J, Stolle D, Losada A. Effectiveness of topical treatment of chronic varicose ulcers with sterile single-dose ciprofloxacin ampoules versus physiologic serum. Revista Espanola de Geriatria y Gerontologia 2003;38(3):145-52.
98. Chaudhary M, Kumar Dwivedi V, Naithani V. Clinical trial survey report of ampucare done on patients with different wounds. Journal of Ecophysiology and Occupational Health 2008;8(1-2):89-97.
99. Cherry GW. Comparison of Syerilox with tap water in the treatment of chronic venous ulcers of the leg. National Research Register 2003.
100. Chirwa Z, Bhengu T, Litiane K. The cost effectiveness of using calcium alginate silver matrix in the treatment of wounds. EWMA Journal 2010;10(2):257.
101. Colombo P. Topical chloroxidating solution in wounds treatment: a controlled trial. Acta Toxicologica Therapeutica 1993;24:65-71.
102. Colonna MR, Amadeo G, Giofre C, Strano A, Stagno D'Alcontres F. Are nanocristalline silver dressings effective in reducing both secretions and bacterial colonization in necrotic infected wounds. 2nd World Union of Wound Healing Societies Meeting, 8-13 July 2004, Paris. 2004:91.
103. Contretas-Ruiz J, Fuentes-Suarez S, Arroyo-Escalante S, Sosa-De-Martinez C, Maravilla-Franco E, Dominguez-Cherit J. Larval debridement therapy to control infection in venous leg ulcers. A comparative study. 2nd World Union of Wound Healing Societies Meeting, 8-13 July 2004, Paris. 2004:103.
104. ® dressing on superficial wound bed and bacterial balance of chronic wounds. International Wound Journal 2005;2(4):348-56.
105. Daltrey DC, Cunliffe WJ. A double-blind study of the effects of benzoyl peroxide 20% and eusol and liquid paraffin on the microbial flora of leg ulcers. Acta Dermatologica Venereologica 1981;61(6):575-7.
106. Danielsen L, Cherry GW, Harding K, Rollman O. Cadexomer iodine in ulcers colonised by Pseudomonas aeruginosa. Journal of Wound Care 1997;6(4):169-72.
107. Dharap SB, Ghag GS, Kulkarni KP, Venkatesh V. Efficacy and safety of oxum in treatment of the venous ulcer. Journal of the Indian Medical Association 2008;106(5):326-9.
108. Ferrara F, Meli F, Raimondi F, Amato C, Bonura F, Mulè G. The treatment of venous leg ulcers, a new therapeutic use of iloprost. Annals of Surgery 2007;246(5):860-4.
109. Fox DB. Trial of betamethasone 17-valerate with neomycin tulle in the treatment of gravitational eczema and ulceration of the leg. British Journal of Clinical Practice 1966;20:183-9.
110. Friedman SJ, Su WP. Management of leg ulcers with hydrocolloid occlusive dressing. Archives of Dermatology 1984;120(10):1329-36.
111. Garcia HGG, Cobian RR, Martin JR, Konaizeh S, Rahola JG. The effect on the reparation process of dextranomer (Debrisan) in perimalleolar ulcers due to chronic venous insufficiency. Clinical Trials Journal 1984;21(3):121-34.
112. Gottrup F, Aabenhus A, Holt R and the Contreet Study Group. Evaluation of clinical results from 4 studies on two new antibacterial silver containing dressings. 13th Conference of the European Wound Management Association, 22-24 May 2003, Pisa, Italy. 2003.
113. Haler D. Polynoxylin: a new antiseptic. British Journal of Clinical Practice 1964;May 18:267-9.
114. Hanft J, Serena T, Snyder R. Evaluation of the clinical effectiveness of a collagen-orc antimicrobial matrix in venous leg ulcers. 16th Conference of the European Wound Management Association, 18-20 May 2006, Prague, Czech Republic. 2006.
115. Hanft JR, Serena T, Snyder R. A study to evaluate the clinical effectiveness of a Collagen-ORC Antimicrobial Matrix in venous leg ulcers. Wound Repair and Regeneration 2006;14(2):A64.
116. Heggers JP. Assessing and controlling wound infection. Clinics in Plastic Surgery 2003;30(1):25-35.
117. Howell Jones RS, Wilson MJ, Hill KE, Howard AJ, Price PE, Thomas DW. A review of the microbiology, antibiotic usage and resistance in chronic skin wounds. Journal of Antimicrobial Chemotherapy 2005;55(2):143-9.
118. Hutchinson JJ. A prospective clinical trial of wound dressings to investigate the rate of infection under occlusion. 3rd European Conference on Advances in Wound Management, 19-22 October 1993, Harrogate, UK. 1993.
119. Hutchinson JJ. Influence of occlusive dressings on wound microbiology - interim results of a multi-centre clinical trial of an occlusive hydrocolloid dressing. 1st European Conference on Advances in Wound Management, 4-6 September 1991, Cardiff, UK. 1991.
120. Ivins N, Harding KG, Price P, Jørgensen B, Lohmann M, Gottrup F, et al.Safety and efficacy in long-term use of a sustained silver-releasing foam dressing: a randomized, controlled trial on venous leg ulcers. SAWC 2006, April 30 - May 3, 2006, San Antonio, Texas. 2006.
121. Ivins N, Jørgensen B, Lohmann M. Safety and efficacy in long term use of a sustained silver-releasing foam dressing: a randomised, controlled trial on venous leg ulcers. European Wound Management Association Conference, 15-17 September 2005, Stuttgart, Germany. 2005.
122. Karap Z. Significant difference in pain levels of delayed-healing wounds during applying an ionic silver hydrofibre dressing. Poster 281. EWMA Journal. Proceedings of the 18th Conference of the European Wound Management Association, 2008, Lisbon, Portugal. 2008.
123. Karas Z, Zabel J, Erenski P. Treatment of chronic crural ulcers with Pseudomonilia. Przeglad Dermatologiczny 1984;71(1):78-9.
124. Katelaris PM, Fletcher JP, Little JM, McEntyre RJ, Jeffcoate KW. Electrical stimulation in the treatment of chronic venous ulceration. Australian and New Zealand Journal of Surgery 1987;57(9):605-7.
125. Kordestani S, Shahrezaee M, Tahmasebi MN, Hajimahmodi H, Haji Ghasemali D, Abyaneh MS. A randomised control trial on the effectiveness of an advanced wound dressing used in Iran. Journal of wound care July 2008;17(7):323-7.
126. Kosicek M, Planinsek Rucigaj T. A comparative clinical trial: microbial colonisation of venous leg ulcers treated with hydrofibre dressings or with ointments. 2nd World Union of Wound Healing Societies Meeting, 8-13 July 2004, Paris. 2004.
127. Lanzara S, Tacconi G, Gianesini S, Menegatti E, Federici F, Liboni A, et al.A pilot randomized trial to determine the effects of a new active dressing on wound healing of venous leg ulcers. EWMA Journal 2008;8(2 Suppl):76.
128. Lischka G, Wolff HH. Benzoyl peroxide for the treatment of badly healing leg ulcers: a double-blind study. Munchener Medizinische Wochenschrift 1980;122(49):1781-4.
129. Locati F, Rozzoni M, Reseghetti A, Sena P. Evaluation of the efficacy and tolerability of a new cutaneous antiseptic combination. Giornale Italiano di Dermatologia e Venereologia 1994;129(5):XXVII-XXX.
130. Magana Lozano M. Ulcer leg complex: double blind study of bromelins alone or associated to tetracyclines. Compendium de Investigaciones Clinicas Latinoamericanas 1980;1(2):6-12.
131. Maiques Nadal V, Zambrano Zambrano A. Trial of an enzymatic preparation in the treatment of various ulcerative processes. Revista Clinica Espanola 1976;141(1):67-72.
132. Mancuso G, Staffa M, Errani A. Acetic acid in the treatment of superficial dermic burns and venous leg ulcers infected by Pseudomonas aeruginosa. Chronica Dermatologica 1994;4(3):473-8.
133. Markoishvili K, Tsitlanadze G, Katsarava R, Morris JG Jr, Sulakvelidze A. A novel sustained-release matrix based on biodegradable poly(ester amide)s and impregnated with bacteriophages and an antibiotic shows promise in management of infected venous stasis ulcers and other poorly healing wounds. International Journal of Dermatology 2002;41(7):453-8.
134. Marzin L, Rouveix B. An evaluation of collagen gel in chronic leg ulcers. Schweizerische Rundschau fur Medizin Praxis 1982;71(36):1373-8.
135. McKnight AG. A clinical trial of povidone-iodine in the treatment of chronic leg ulcers. Practitioner 1965;195:230-4.
136. Mehtar S, Fox D. A double-blind comparative study with Mupirocin vs placebo base in the treatment of chronic leg ulcers. British Journal of Clinical Practice 1988;42(8):324-8.
137. Mogabgab WJ. Treatment of skin and soft-tissue infections with cefsulodin. Reviews of Infectious Diseases 1984;6(Suppl 3):S721-7.
138. Morely de Benzaquen S, Cirelli N, Halmai O, Sanjuan E, Piquero Martín J, Arbona J, et al.Argentic sulfadiazine in lower limbs ulcers: double-blinded study. Archivos Venezolanos de Farmacología y Terapéutica 1990;9(2):116-9.
139. Motta GJ, Milne CT, Corbett LQ. Impact of antimicrobial gauze on bacterial colonies in wounds that require packing. Ostomy/Wound Management 2004;50(8):48-62.
140. Nakagawa K, Kobayashi H, Kono T, Hayashi A, Tsuruta D, Ishii M. Evaluation of the effects of cadexomer iodine ointment (Decrat(TM) ointment) in the treatment of skin Ulcer. Skin Research 1997;39(3):364-78.
141. Ouvry PA. A trial of silver sulfadiazine in the local treatment of venous ulcer [Essai de la sulfadiazine argentique dans le traitement local de l'ulc re veineux]. Phlebologie 1989;42(4):673-9.
142. Pardes JB, Carson PA, Eaglstein WH, Falanga V. Mupirocin treatment of exudative venous ulcers. Journal of the American Academy of Dermatology 1993;29(3):497-8.
143. Paul E. Wound healing with Iruxol. Results of a multicenter study. Fortschritte der Medizin 1990;108(35):679-81.
144. Pegum JM, Fegan WG. Polynoxylin in the treatment of varicose ulcers. Irish Journal of Medical Science 1968;7(7):299-302.
145. Pereira M, Baudrier T, Cotta F, Mota A, Fonseca C. Influence of 0.5% sodium hypochlorite solution on bacterial countings in leg ulcers. 2nd World Union of Wound Healing Societies Meeting, 8-13 July 2004, Paris. 2004.
146. Pierard-Franchimont C, Paquet P, Arrese JE, Pierard GE. Healing rate and bacterial necrotizing vasculitis in venous leg ulcers. Dermatology 1997;194(4):383-7.
147. Planinsek TR. Treatment of venous leg ulcers with different alginate dressings: their effects on healing rate and pain. 16th Conference of the European Wound Management Association, 18-20 May 2006, Prague, Czech Republic. 2006:154.
148. Pollice F, D'Agostino D, Mirizzi F. Treatment of varicose ulcer with iodine cadexomere in powder form. Phlebologie 1989:1184-7.
149. Privat Y. Clinical trial of Pulvo 47 Neomycin in the treatment of leg ulcer. Semaine des Hopitaux 1979;55(13-14):711-3.
150. TM) with standard therapy in wound care: randomized clinical trial. Journal of Advanced Nursing 2009;65(3):565-75 doi: 10.1111/j.1365-2648.2008.04923.x.
151. Rogers RR, Alvarez OM, Patel M. Effect of a silver ion-containing wound dressing on the bacterial burden of chronic venous ulcers. 13th Annual Symposium on Advanced Wound Care and 10th Annual Medical Research Forum on Wound Repair, 1-4 April 2000, Dallas, Texas. 2000:D35-D36.
152. Romanelli M, Dini V, Barbanera S, Bertone MS. Evaluation of the efficacy and tolerability of a solution containing propyl betaine and polihexanide for wound irrigation. Skin Pharmacology and Physiology 2010;23(Suppl 1):41-4.
153. Romanelli M, Dini V, Bertone MS. Evaluation of the efficacy and tolerability of a cleansing solution with propil betaine and polyhexanide in reducing the bacterial load of venous wounds in lower limbs (poster presentation). 17th Conference of the European Wound Management Association, 2-4 May 2007, Glasgow, Scotland. 2007.
154. Rubisz-Brzezińska J, Szarmach H, Filipiuk J, Brzezińska-Wcisło L, Wilkowska A. Benzoyl peroxide in the treatment of crural ulcerations [Nadtlenek benzoilu w leczeniu owrzodzeń podudzi]. Przeglad Dermatologiczny 1987;74(4-5):363-9.
155. Rucigaj TP. Comparative effects of honey based and silver/charcoal based dressings on the healing of venous leg ulcers: a randomized clinical study. 17th Conference of the European Wound Management Association, 2-4 May 2007, Glasgow, Scotland. 2007.
156. Rucigaj TP. Effectiveness of non alcohol film forming skin protector on skins isles inside the ulcers and the healing rate of venous leg ulcers. EWMA Journal 2007;7(1):23-5.
157. Salim AS. The role of oxygen-derived free radicals in the management of venous (varicose) ulceration: a new approach. World Journal of Surgery 1991;15(2):264-9.
158. Sánchez-Vázquez R, Briseño-Rodríguez G, Cardona-Muñoz EG, Gálvez-Gastélum FJ, Totsuka-Sutto SE, Garcia-Benavides L. Isosorbide dinitrate spray as therapeutic strategy for treatment of chronic venous ulcers. Angiology 2008;59(1):64-71.
159. Serra N, Torres OG, Romo MI, Llovera JM, Vigil-Escalera LJ, Soto MA, et al.Hydro-colloidal dressings which liberate hydro-active silver [Apósitos hidrocoloides liberadores de plata hidroactiva: estudio clínico comparativo en el tratamiento de úlceras crónicas]. Revista de Enfermeria 2005;28(2):13-8.
160. Sibbald RG, Coutts P, Fierheller M, Woo K. A pilot (real-life) randomised clinical evaluation of a pain-relieving foam dressing: (Ibuprofen-foam versus local best practice). International Wound Journal 2007;4(Suppl 1):16-23.
161. Sibbald RG, Coutts P, Woo KY. Reduction of bacterial burden and pain in chronic wounds using a new polyhexamethylene biguanide antimicrobial foam dressing-clinical trial results. Advances in Skin and Wound Care 2011;24(2):78-84.
162. Woo K, Sibbald G, Coutts P. Reduction of infection and pain in chronic wounds using a new antimicrobial foam dressing. EWMA Journal 2010;10(2):59, Abstract 78.
163. Steenvoorde P, van Doorn LP, Jacobi CE, Oskam J. An unexpected effect of Dermacyn on infected leg ulcers. Journal of Wound Care 2007;16(2):60-1.
164. Subrahmanyam M. Honey as a surgical dressing for burns and ulcers. Indian Journal of Surgery 1993;55(9):468-73.
165. Thebbe B, Orfanos CE. Therapy of leg ulcers and decubitus ulcers with a xerodressing: modern wound dressing with anti-bacterial activity. Zeitschrift fur Hautkrankheiten 1996;71(9):697-702.
166. Thorne N, Fox D. A trial of povidone-iodine ointment in the treatment of leg ulcers. The Practitioner 1965;Feb:250-3.
167. Wuite J, van der Meer BJ. Local silver nitrate therapy in leg ulcer associated with aPseudomonas aeruginosa super infection [Silbernitrat-lokaltherapie bei ulcus cruris mit pseudomonas aeruginosa-superinfektion]. Der Hautarzt 1974;25(8):388-91.
168. Association for the Advancement of Wound Care (AAWC). Association for the Advancement of Wound Care (AAWC) venous ulcer guideline. Malvern (PA) 2010:Available from http://www.guideline.gov/content.aspx?id=36081.
169. Altman DG, Bland JM. Statistics notes: units of analysis. BMJ 1997;314(7098):1874.
170. Augustin M, Brocatti LK, Rustenbach SJ, Schäfer I, Herberger K. Cost-of-illness of leg ulcers in the community. International Wound Journal 2012;9:doi: 10.1111/j.1742-481X.2012.01089.x.
171. Ayton M. Wounds that won't heal. Nursing Times 1985;81(46):386-8.
172. Aziz Z, Cullum N, Flemming K. Electromagnetic therapy for treating venous leg ulcers. Cochrane Database of Systematic Reviews 2013, Issue 2. [DOI: 10.1002/14651858.CD002933.pub5]
173. Bisht R, Katiyar A, Singh R, Mittal P. Antibiotic resistance - a global issue of concern. Asian Journal of Pharmaceutical and Clinical Research 2009;2(2):34-9.
174. British National Formulary, British Medical Association, British Royal Pharmaceutical Society of Great Britain. British National Formulary November 2013. London: British Medical Association, 2013.
175. Boucher HW, Talbot GH, Bradley JS, Edwards JE, Gilbert D, Rice LB, et al.Bad bugs, no drugs: no ESKAPE! An update from the Infectious Diseases Society of America. Clinical Infectious Diseases 2009;48(1):1-12. doi: 10.1086/595011.
176. Bowler PG. The 105 bacterial growth guideline: reassessing its clinical relevance in wound healing. Ostomy/Wound Management 2003;49(1):44-53.
177. Brook I, Frazier EH. Aerobic and anaerobic microbiology of chronic venous ulcers. International Journal of Dermatology 1998;37:426-8.
178. Cardinal M, Eisenbud DE, Armstrong DG, Zelen C, Driver V, Attinger C, et al.Serial surgical debridement: a retrospective study on clinical outcomes in chronic lower extremity wounds. Wound Repair and Regeneration 2009;17:306-11.
179. Carter MJ, Tingley-Kelley K, Warriner RA. Silver treatments and silver-impregnated dressings for the healing of leg wounds and ulcers: a systematic review and meta-analysis. Journal of the American Adademy of Dermatology 2010;63(4):668-79.
180. Chambers H, Dumville JC, Cullum N. Silver treatments for leg ulcers: a systematic review. Wound Repair and Regeneration 2007;15(2):165-73.
181. Chang A, Osterloh J, Thomas J. Levamisole: a dangerous new cocaine adulterant. Clinical Pharmacology and Therapeutics 2010;88(3):408-11 doi:10.1038/clpt.2010.156.
182. Cullum N, Al-Kurdi D, Bell-Syer SEM. Therapeutic ultrasound for venous leg ulcers. Cochrane Database of Systematic Reviews 2010, Issue 6. [DOI: 10.1002/14651858.CD001180.pub3]
183. Cutting KF, White R. Defined and refined: criteria for identifying wound infection revisited. British Journal of Community Nursing 2004;9(3):S6-S15.
184. Davies CE, Turton G, Woolfrey G, Elley R, Taylor M. Exploring debridement options for chronic venous leg ulcers. British Journal of Nursing 2005;14(7):393-7.
185. Davies CE, Hill KE, Newcombe RG, Stephens P, Wilson MJ, Harding KG, et al.A prospective study of the microbiology of chronic venous leg ulcers to reevaluate the clinical predictive value of tissue biopsies and swabs. Wound Repair and Regeneration 2007;15(1):17-22.
186. Deeks JJ, Higgins JPT, Altman DG on behalf of the Cochrane Statistical Methods Group. Chapter 9: Analysing data and undertaking meta-analyses. Higgins JPT, Green S (editors). Cochrane Handbook for Systematic Reviews of Interventions Version 5.1.0 [updated March 2011]. The Cochrane Collaboration, 2011. www.cochrane-handbook.org.
187. Doughty DB, Sparks-DeFriese B. Wound healing physiology. In: Bryant RA, Nix DP editor(s). Acute and chronic wounds: current management concepts. 3rd Edition. St Louis, Missouri, USA: Mosby, 2007.
188. Dow G, Browne A, Sibbald RG. Infection in chronic wounds: controversies in diagnosis and treatment. Ostomy/Wound Management 1999;45(8):23-40.
189. Farid KJ, Kelly K, Roshlin S. Gentian violet 1% solution in the treatment of wounds in the geriatric patient: a retrospective study. Geriatric Nursing 2011;32(2):85-95.
190. Flemming K, Cullum NA. Laser therapy for venous leg ulcers. Cochrane Database of Systematic Reviews 1999, Issue 1. [DOI: 10.1002/14651858.CD001182]
191. Gardner SE, Frantz RA, Doebbeling BN. The validity of the clinical signs and symptoms used to identify localized chronic wound infection. Wound Repair and Regeneration 2001;9(3):178-86.
192. Gohel MS, Taylor M, Earnshaw JJ, Heather BP, Poskitt KR, Whyman MR. Risk factors for delayed healing and recurrence of chronic venous leg ulcers - an analysis of 1324 legs. European Journal of Vascular and Endovascular Surgery 2005;29(1):74-7.
193. Graham ID, Harrison MB, Nelson EA, Lorimer K, Fisher A. Prevalence of lower-limb ulceration: a systematic review of prevalence studies. Advances in Skin and Wound Care 2003;16(6):305-16.
194. Halbert AR, Stacey MC, Rohr JB, Jopp-McKay A. The effect of bacterial colonization on venous ulcer healing. Australasian Journal of Dermatology 1992;33:75-80.
195. Hansson C, Hoborn J, Moller A, Swanbeck G. The microbial flora in venous leg ulcers without clinical signs of infection. Acta Dermato-venereologica 1995;75(1):24-30.
196. Harker J. The effect of bacteria on leg ulcer healing. British Journal of Community Nursing 2001;6(3):126-34.
197. Herber OR, Schnepp W, Rieger MA. A systematic review on the impact of leg ulceration on patients' quality of life. Health and Quality of Life Outcomes 2007;5(44):DOI:10.1186/1477-7525-5-44. Available from http://www.hqlo.com/content/5/1/44.
198. Higgins JPT, Thompson SG. Quantifying heterogeneity in a meta-analysis. Statistics in Medicine 2002;21:1539-58.
199. Higgins JPT, Thompson SG, Deeks JJ, Altman DG. Measuring inconsistency in meta-analyses. BMJ 2003;327(7414):557-60.
200. Higgins JPT, Altman DG, Sterne JAC on behalf of the Cochrane Statistical Methods Group and the Cochrane Bias Methods Group. Chapter 8: Assessing risk of bias in included studies. Higgins JPT, Green S (editors). Cochrane Handbook for Systematic Reviews of Interventions Version 5.1.0 [updated March 2011]. The Cochrane Collaboration, 2011. www.cochrane-handbook.org.
201. Higgins JPT, Deeks JJ. Chapter 7: Selecting studies and collecting data. Higgins JPT, Green S (editors). Cochrane Handbook for Systematic Reviews of Interventions Version 5.1.0 [updated March 2011]. The Cochrane Collaboration, 2011. www.cochrane-handbook.org.
202. Iglesias C, Nelson EA, Cullum NA, Torgerson DJ on behalf of the VenUS Team. VenUS I: a randomised controlled trial of two types of bandage for treating venous leg ulcers. Health Technology Assessment 2004;8(29):1-120.
203. Jull AB, Walker N, Deshpande S. Honey as a topical treatment for wounds. Cochrane Database of Systematic Reviews 2013, Issue 2. [DOI: 10.1002/14651858.CD005083.pub2]
204. Kontiainen S, Rinne E. Bacteria in ulcera crurum. Acta Dermato-Venereologica 1988;68(3):240-4.
205. Lansdown ABG. Silver I: its antibacterial properties and mechanism of action. Journal of Wound Care 2002;11(4):125-30.
206. Lazarus GS, Zenilman JM. Wound microbiology: tabula rosa, a blank slate. Wound Repair and Regeneration 2011;19:531.
207. Lefebvre C, Manheimer E, Glanville J, on behalf of the Cochrane Information Retrieval Methods Group. Chapter 6: Searching for studies. In: Higgins JPT, Green S (editors). Cochrane Handbook for Systematic Reviews of Interventions Version 5.1.0 [updated March 2011]. The Cochrane Collaboration, 2011. www.cochrane-handbook.org.
208. Liberati A, Altman DG, Tetzlaff J, Mulrow C, Gøtzsche PC, Ioannidis JPA, et al.The PRISMA Statement for reporting systematic reviews and meta-analyses of studies that evaluate health care interventions: explanation and elaboration. PLoS Medicine 2009;6(7):e1000100. doi:10.1371/journal.pmed.1000100.
209. Lo S-F, Chang C-J, Hu W-Y, Hayter M, Chang Y-T. The effectiveness of silver-releasing dressings in the management of non-healing chronic wounds: a meta-analysis. Journal of Clinical Nursing 2009;18(5):716-28.
210. Lorimer K, Harrison MB, Graham ID, Friedberg E, Davies B. Assessing venous ulcer population characteristics and practices in a home care community. Ostomy/Wound Management 2003;49(5):32-43.
211. Lorimer KR, Harrison MB, Graham ID, Friedberg E, Davies B. Venous leg ulcer care: how evidence-based is nursing practice?. Journal of Wound Ostomy and Continence Nursing 2003;30:132-42.
212. Macpherson G (ed). Black's Student Medical Dictionary. London: A & C Black Publishers Limited, 2004.
213. Madsen SM, Westh H, Danielsen L, Rosdahl VT. Bacterial colonisation and healing of venous leg ulcers. APMIS 1996;104(12):895-9.
214. 2+ in rat experimental wounds. Journal of Clinical Investigation 1993;92:2368-76.
215. Margolis DJ, Berlin JA, Strom BL. Which venous leg ulcers will heal with limb compression bandages?. American Journal of Medicine 2000;109:15-9.
216. Margolis DJ, Bilker W, Santanna J, Baumgarten M. Venous leg ulcer: the incidence and prevalence in the elderly. Journal of the American Academy of Dermatology 2002;46(3):381-9.
217. Margolis DJ, Allen-Taylor L, Hoffstad O, Berlin JA. The accuracy of venous leg ulcer prognostic models in a wound care system. Wound Repair and Regeneration 2004;12:163-8.
218. Moffatt CJ, Dorman MC. Recurrence of leg ulcers within a community ulcer service. Journal of Wound Care 1995;4(2):57-61.
219. Moffatt CJ, Franks PJ, Doherty DC, Martin R, Blewett R, Ross F. Prevalence of leg ulceration in a London population. QJM: monthly journal of the Association of Physicians 2004;97(7):431-7.
220. Moffatt C. Compression therapy in practice. Aberdeen: Wounds UK Publishing, 2007.
221. Moore K, Hall V, Paull A, Morris T, Brown S, McCulloch D, et al.Surface bacteriology of venous leg ulcers and healing outcome. Journal of Clinical Pathology 2010;63:830-4.
222. Nelzen O. Prevalence of venous leg ulcer: the importance of the data collection method. Phlebolymphology 2008;15(4):143-50.
223. O'Meara SM, Cullum NA, Majid M, Sheldon TA. Systematic review of antimicrobial agents used for chronic wounds. British Journal of Surgery 2001;88(1):4-21.
224. O'Meara S, Cullum N, Nelson EA, Dumville JC. Compression for venous leg ulcers. Cochrane Database of Systematic Reviews 2012, Issue 11. [DOI: 10.1002/14651858.CD000265.pub2]
225. Parmar MKB, Torri V, Stewart L. Extracting summary statistics to perform meta-analyses of the published literature for survival endpoints. Statistics in Medicine 1998;17(24):2815-34.
226. Persoon A, Heinen MA, van der Vleuten CJM, de Rooij MG, van de Kerkhof PCM, van Achterberg T. Leg ulcers: a review of their impact on daily life. Journal of Clinical Nursing 2004;13(3):341-54.
227. Ragnarson Tennvall G, Hjelmgren J. Annual costs of treatment for venous leg ulcers in Sweden and the United Kingdom. Wound Repair and Regeneration 2005;13(1):13-8.
228. Royal College of Nursing. Clinical practice guidelines. The nursing management of patients with venous leg ulcers, 2006. http://www.rcn.org.uk/development/practice/clinicalguidelines/venous_leg_ulcers (accessed 14 June 2013). Royal College of Nursing, 2006.
229. The Nordic Cochrane Centre, The Cochrane Collaboration. Review Manager (RevMan). 5.2. Copenhagen: The Nordic Cochrane Centre, The Cochrane Collaboration, 2012.
230. Robson MC, Cooper DM, Aslam R, Gould LJ, Harding KG, Margolis DJ, et al.Guidelines for the treatment of venous ulcers. Wound Repair and Regeneration 2006;14(6):649-62.
231. Ruckley CV. Caring for patients with chronic leg ulcer. BMJ 1998;316(7129):407-8.
232. Siah CJ, Yatim J. Efficacy of a total occlusive ionic silver-containing dressing combination in decreasing risk of surgical site infection: an RCT. Journal of Wound Care 2011;20(12):561-8.
233. Scottish Intercollegiate Guidelines Network (SIGN). SIGN Guildeline 120. Management of chronic venous leg ulcers. http://www.sign.ac.uk/guidelines/fulltext/120/index.html 2010 (accessed 29 November 2013).
234. Scottish Intercollegiate Guidelines Network (SIGN). Search filters. http://www.sign.ac.uk/methodology/filters.html (accessed 17 May 2013).
235. Srinivasaiah N, Dugdall H, Barrett S, Drew PJ. A point prevalence survey of wounds in north-east England. Journal of Wound Care 2007;16(10):413-9.
236. Sterne JAC, Egger M, Moher D on behalf of the Cochrane Bias Methods Group. Chapter 10: Addressing reporting biases. Higgins JPT, Green S (editors). Cochrane Handbook for Systematic Reviews of Interventions Version 5.1.0 [updated March 2011]. The Cochrane Collaboration www.cochrane-handbook.org.
237. Trengove NJ, Stacey MC, McGechie DF, Stingemore NF, Mata S. Qualitative bacteriology and leg ulcer healing. Journal of Wound Care 1996;5:277-80.
238. Vermeulen H, van Hattem JM, Storm-Versloot MN, Ubbink DT, Westerbos SJ. Topical silver for treating infected wounds. Cochrane Database of Systematic Reviews 2007, Issue 1. [DOI: 10.1002/14651858.CD005486.pub2]
239. Vowden KR, Vowden P. The prevalence, management and outcome for patients with lower limb ulceration identified in a wound care survey within one English health care district. Journal of Tissue Viability 2009;18(1):13-9.
240. Vowden KR, Vowden P. A survey of wound care provision within one English health care district. Journal of Tissue Viability 2009;18(1):2-6.
241. Vowden K, Vowden P. The resource costs of wound care in Bradford and Airedale primary care trust in the UK. Journal of Wound Care 2009;18(3):93-102.
242. White RJ, Cooper R, Kingsley A. Wound colonization and infection: the role of topical antimicrobials. British Journal of Nursing 2001;10(9):563-78.
243. Wilton JMA. Levamisole in chronic inflammatory diseases. Journal of Rheumatology. Supplement 1978;4:101-1.
244. Öien RF, Forssell HW. Ulcer healing time and antibiotic treatment before and after the introduction of the Registry of Ulcer Treatment: an improvement project in a national quality registry in Sweden. BMJ Open 2013;3:e003091. doi:10.1136/bmjopen-2013-003091.