Traumatic brain injury is not associated with coagulopathy out of proportion to injury in other body regions

Journal of Trauma and Acute Care Surgery

Volumn 77, Issue 1, 2014, Pages 67-72

  Lee, Tim H ^a   Hampton, David A ^a   Diggs, Brian S ^a   McCully, Sean P ^a   Kutcher, Matt ^a   Redick, Britt J ^a   Podbielski, Jeannette ^a   Cotton, Bryan A ^a   Cohen, Mitchell ^a   Schreiber, Martin A ^a  

^a OREGON HEALTH AND SCIENCE UNIVERSITY   (United States)

Author keywords

coagulopathy; Trauma; traumatic brain injury

Indexed keywords

ABDOMINAL INJURY; ADULT; ARTICLE; BLOOD CLOTTING DISORDER; BLOOD CLOTTING TEST; BLUNT TRAUMA; BODY REGION INJURY; DISEASE ASSOCIATION; EMERGENCY HEALTH SERVICE; FACE INJURY; FEMALE; GLASGOW COMA SCALE; HEAD INJURY; HOSPITAL ADMISSION; HUMAN; HYPOCOAGULABILITY; INJURY; INJURY SCALE; INJURY SEVERITY; INTERNATIONAL NORMALIZED RATIO; LIMB INJURY; MAJOR CLINICAL STUDY; MALE; MEAN ARTERIAL PRESSURE; MULTICENTER STUDY; MULTIPLE TRAUMA; OBSERVATIONAL STUDY; PARTIAL THROMBOPLASTIN TIME; PERFUSION; PRIORITY JOURNAL; PROSPECTIVE STUDY; PROTHROMBIN TIME; SHOCK; THORAX INJURY; THROMBOELASTOGRAPHY; TISSUE INJURY; TRAUMATIC BRAIN INJURY;

ABBREVIATED INJURY SCALE; BLOOD COAGULATION DISORDERS; BLOOD COAGULATION TESTS; BRAIN INJURIES; FEMALE; GLASGOW COMA SCALE; HUMANS; INJURY SEVERITY SCORE; MALE; MULTIPLE TRAUMA; PROSPECTIVE STUDIES; RISK FACTORS; SHOCK; THROMBELASTOGRAPHY;

EID: 84903794542     PISSN: 21630755     EISSN: 21630763     Source Type: Journal    
DOI: 10.1097/TA.0000000000000255     Document Type: Article

References (21)

1. Sauaia A, Moore FA, Moore EE, Moser KS, Brennan R, Read RA, Pons PT, et al. Epidemiology of trauma deaths: a reassessment. J Trauma. 1995;38(2):185-193.
2. Maegele M, Spinella PC, Schochl H. The acute coagulopathy of trauma: mechanisms and tools for risk stratification. Shock. 2012;38(5):450-458.
3. Hess JR, Brohi K, Dutton RP, et al. The coagulopathy of trauma: a review of mechanisms. J Trauma. 2008;65(4):748-754.
4. Brohi K, Cohen MJ, Ganter MT, Matthay MA, Mackersie RC, Pittet J. Acute traumatic coagulopathy: initiated by hypoperfusion: modulated through the protein C pathway? Ann Surg. 2007;245(5):812-818. (Pubitemid 46684113)
5. MacLeod JB, Lynn M, McKenney MG, Cohn SM, Murtha M. Early coagulopathy predicts mortality in trauma. J Trauma. 2003;55(1):39-44. (Pubitemid 36919234)
6. Davenport R. Pathogenesis of acute traumatic coagulopathy. Transfusion. 2013;53(Suppl 1):23S-27S.
7. Schreiber MA. Coagulopathy in the trauma patient. Curr Opin Crit Care. 2005;11(6):590-597. (Pubitemid 41697333)
8. Davenport R, Khan S. Management of major trauma haemorrhage: treatment priorities and controversies. Br J Haematol. 2011;155(5): 537-548.
9. Stewart RM, Myers JG, Dent DL, et al. Seven hundred fifty-three consecutive deaths in a level I trauma center: the argument for injury prevention. J Trauma. 2003;54(1):66-70.
10. Mattox KL, Moore EE, Feliciano DV. Trauma. 7th ed. China: McGraw-Hill Professional; 2012.
11. Harhangi BS, Kompanje EJ, Leebeek FW, Maas AI. Coagulation disorders after traumatic brain injury. Acta Neurochir (Wien). 2008;150(2):165-175; discussion 175.
12. Laroche M, Kutcher ME, Huang MC, Cohen MJ, Manley GT. Coagulopathy after traumatic brain injury. Neurosurgery. 2012;70(6): 1334-1345.
13. Zhang J, Jiang R, Liu L, Watkins T, Zhang F, Dong JF. Traumatic brain injury-associated coagulopathy. J Neurotrauma. 2012;29(17):2597-2605.
14. Wafaisade A, Lefering R, Tjardes T, et al. Acute coagulopathy in isolated blunt traumatic brain injury. Neurocrit Care. 2010;12(2):211-219.
15. Talving P, Benfield R, Hadjizacharia P, Inaba K, Chan LS, Demetriades D. Coagulopathy in severe traumatic brain injury: a prospective study. J Trauma. 2009;66(1):55-61; discussion 61-62.
16. Cap AP, Spinella PC. Severityofhead injury is associated with increased risk of coagulopathy incombat casualties.JTrauma. 2011;71(Suppl 1):S78-S81.
17. Genét GF, Johansson PI, Meyer MA, Sølbeck S, Sørensen AM, Larsen CF, Welling KL, Windeløv NA, Rasmussen LS, Ostrowski SR. J Neurotrauma. 2013 Feb 15;30(4):301-6. doi: 10.1089/neu.2012. 2612. Epub 2013 Feb 5. PMID:23134525.
18. Goodnight SH, Kenoyer G, Rapaport SI, Patch MJ, Lee JA, Kurze T. Defibrination after brain-tissue destruction: a serious complication of head injury. N Engl J Med. 1974;290(19):1043-1047.
19. Eddleston M, de la Torre JC, Oldstone MB, Loskutoff DJ, Edgington TS, Mackman N. Astrocytes are the primary source of tissue factor in the murine central nervous system. A role for astrocytes in cerebral hemo-stasis. J Clin Invest. 1993;92(1):349-358. (Pubitemid 23209016)
20. Halpern CH, Reilly PM, Turtz AR, Stein SC. Traumatic coagulopathy: the effect of brain injury. J Neurotrauma. 2008;25(8):997-1001.
21. Cohen MJ1, Brohi K, Ganter MT, Manley GT, Mackersie RC, Pittet JF. Early coagulopathy after traumatic brain injury: the role of hypoperfusion and the protein C pathway. J Trauma. 2007;63(6):1254-1262.