Apolipoprotein L2 contains a BH3-like domain but it does not behave as a BH3-only protein

Cell Death and Disease

Volumn 5, Issue 6, 2014, Pages

  Galindo Moreno, J ^a   Iurlaro, R ^a   El Mjiyad, N ^a   Diez Perez J ^b,c   Gabaldon T ^b,c,d   Munoz Pinedo C ^a  

^a BELLVITGE BIOMEDICAL RESEARCH INSTITUTE IDIBELL   (Spain)

^b CENTRE FOR GENOMIC REGULATION CRG   (Spain)

^c UNIVERSITAT POMPEU FABRA   (Spain)

^d INSTITUCIÓ CATALANA DE RECERCA I ESTUDIS AVANÇATS ICREA   (Spain)

Author keywords

[No Author keywords available]

Indexed keywords

APOLIPOPROTEIN; APOLIPOPROTEIN L2; BH3 PROTEIN; GAMMA INTERFERON; MESSENGER RNA; PROTEIN BCL 2; PROTEIN BCL XL; PROTEIN P62; SMALL INTERFERING RNA; UNCLASSIFIED DRUG; APOL2 PROTEIN, HUMAN; BMF PROTEIN, HUMAN; C22ORF29 PROTEIN, HUMAN; HIGH DENSITY LIPOPROTEIN; IFNG PROTEIN, HUMAN; PMAIP1 PROTEIN, HUMAN; SIGNAL TRANSDUCING ADAPTOR PROTEIN;

AMINO ACID SEQUENCE; ARTICLE; AUTOPHAGY; CELL DEATH; CELL PROLIFERATION; CONTROLLED STUDY; ENDOPLASMIC RETICULUM; EPITHELIUM CELL; FEMALE; HELA CELL LINE; HUMAN; HUMAN CELL; IMMUNOFLUORESCENCE; IMMUNOPRECIPITATION; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN DOMAIN; PROTEIN EXPRESSION; VIRUS INFECTION; GENE SILENCING; GENETICS; METABOLISM; PHYSIOLOGY; PROTEIN TERTIARY STRUCTURE;

ADAPTOR PROTEINS, SIGNAL TRANSDUCING; APOLIPOPROTEINS; CELL DEATH; GENE KNOCKDOWN TECHNIQUES; HELA CELLS; HUMANS; INTERFERON-GAMMA; LIPOPROTEINS, HDL; PROTEIN STRUCTURE, TERTIARY; PROTO-ONCOGENE PROTEINS C-BCL-2;

EID: 84903786204     PISSN: None     EISSN: 20414889     Source Type: Journal    
DOI: 10.1038/cddis.2014.237     Document Type: Article

References (32)

1. Droin NM, Green DR. Role of Bcl-2 family members in immunity and disease. Biochim Biophys Acta 2004; 1644: 179-188.
2. Frenzel A, Grespi F, Chmelewskij W, Villunger A. Bcl2 family proteins in carcinogenesis and the treatment of cancer. Apoptosis 2009; 14: 584-596.
3. Lomonosova E, Chinnadurai G. BH3-only proteins in apoptosis and beyond: an overview. Oncogene 2008; 27: S2-S19.
4. Youle RJ, Strasser A. The BCL-2 protein family: opposing activities that mediate cell death. Nat Rev Mol Cell Biol 2008; 9: 47-59.
5. Wan G, Zhaorigetu S, Liu Z, Kaini R, Jiang Z, Hu CA. Apolipoprotein L1, a novel Bcl-2 homology domain 3-only lipid-binding protein, induces autophagic cell death. J Biol Chem 2008; 283: 21540-21549.
6. Zhaorigetu S, Wan G, Kaini R, Jiang Z, Hu CA. ApoL1, a BH3-only lipid-binding protein, induces autophagic cell death. Autophagy 2008; 4: 1079-1082.
7. Liu Z, Lu H, Jiang Z, Pastuszyn A, Hu CA. Apolipoprotein l6, a novel proapoptotic Bcl-2 homology 3-only protein, induces mitochondria-mediated apoptosis in cancer cells. Mol Cancer Res 2005; 3: 21-31.
8. Perez-Morga D, Vanhollebeke B, Paturiaux-Hanocq F, Nolan DP, Lins L, Homble F et al. Apolipoprotein L-I promotes trypanosome lysis by forming pores in lysosomal membranes. Science 2005; 309: 469-472.
9. Vanhollebeke B, Pays E. The function of apolipoproteins L. Cell Mol Life Sci 2006; 63: 1937-1944.
10. Sigrist CJA, de Castro E, Cerutti L, Cuche BA, Hulo N, Bridge A et al. New and continuing developments at PROSITE. Nucleic Acids Res 2013; 41: D344-D347.
11. Finn RD, Bateman A, Clements J, Coggill P, Eberhardt RY, Eddy SR et al. Pfam: the protein families database. Nucleic Acids Res 2014; 42: D222-D230.
12. Coultas L, Pellegrini M, Visvader JE, Lindeman GJ, Chen L, Adams JM et al. Bfk: a novel weakly proapoptotic member of the Bcl-2 protein family with a BH3 and a BH2 region. Cell Death Differ 2003; 10: 185-192.
13. Kaczmarek K, Studencka M, Meinhardt A, Wieczerzak K, Thoms S, Engel W et al. Overexpression of peroxisomal testis specific 1 protein induces germ cell apoptosis and leads to infertility in male mice. Mol Biol Cell 2011; 22: 1766-1779.
14. Liao W, Goh FY, Betts RJ, Kemeny DM, Tam J, Bay BH et al. A novel anti-apoptotic role for apolipoprotein L2 in IFN-gamma-induced cytotoxicity in human bronchial epithelial cells. J Cell Physiol 2011; 226: 397-406.
15. Ahn WS, Bae SM, Lee JM, Namkoong SE, Han S-J, Cho YL et al. Searching for pathogenic gene functions to cervical cancer. Gynecol Oncol 2004; 93: 41-48.
16. Page NM, Butlin DJ, Lomthaisong K, Lowry PJ. The human apolipoprotein L gene cluster: identification, classification, and sites of distribution. Genomics 2001; 74: 71-78.
17. Zhaorigetu S, Yang Z, Toma I, McCaffrey TA, Hu CA. Apolipoprotein L6, induced in atherosclerotic lesions, promotes apoptosis and blocks Beclin 1-dependent autophagy in atherosclerotic cells. J Biol Chem 2011; 286: 27389-27398.
18. Llambi F, Moldoveanu T, Tait SW, Bouchier-Hayes L, Temirov J, McCormick LL et al. A unified model of mammalian BCL-2 protein family interactions at the mitochondria. Mol Cell 2011; 44: 517-531.
19. Aouacheria A, Brunet F, Gouy M. Phylogenomics of life-or-death switches in multicellular animals: Bcl-2, BH3-only, and BNip families of apoptotic regulators. Mol Biol Evol 2005; 22: 2395-2416.
20. Duchateau PN, Pullinger CR, Orellana RE, Kunitake ST, Naya-Vigne J, O'Connor PM et al. Apolipoprotein L, a new human high density lipoprotein apolipoprotein expressed by the pancreas. Identification, cloning, characterization, and plasma distribution of apolipoprotein L. J Biol Chem 1997; 272: 25576-25582.
21. Monajemi H, Fontijn RD, Pannekoek H, Horrevoets AJ. The apolipoprotein L gene cluster has emerged recently in evolution and is expressed in human vascular tissue. Genomics 2002; 79: 539-546.
22. Kuwana T, Mackey MR, Perkins G, Ellisman MH, Latterich M, Schneiter R et al. Bid, Bax, and lipids cooperate to form supramolecular openings in the outer mitochondrial membrane. Cell 2002; 111: 331-342.
23. Wu X, Wang H, Bai L, Yu Y, Sun Z, Yan Y et al. Mitochondrial proteomic analysis of human host cells infected with H3N2 swine influenza virus. J Proteomics 2013; 91: 136-150.
24. Tischner D, Villunger A. Bcl-G acquitted of murder! Cell Death Dis 2012; 3: e405.
25. Giam M, Okamoto T, Mintern JD, Strasser A, Bouillet P. Bcl-2 family member Bcl-G is not a proapoptotic protein. Cell Death Dis 2012; 3: e404.
26. Hetz C, Glimcher L. The daily job of night killers: alternative roles of the BCL-2 family in organelle physiology. Trends Cell Biol 2008; 18: 38-44.
27. Laulier C, Lopez BS. The secret life of Bcl-2: apoptosis-independent inhibition of DNA repair by Bcl-2 family members. Mutat Res 2012; 751: 247-257.
28. Russell DJ, Katoh K, Standley D. MAFFT: iterative refinement and additional methods. In: Multiple Sequence Alignment Methods. Humana Press: Suita, Japan, 2014, pp 131-146.
29. Capella-Gutiérrez S, Silla-Martínez JM, Gabaldón T. trimAl: a tool for automated alignment trimming in large-scale phylogenetic analyses. Bioinformatics 2009; 25: 1972-1973.
30. Eddy SR. Accelerated profile HMM searches. PLoS Comput Biol 2011; 7: e1002195.
31. Flicek P, Amode MR, Barrell D, Beal K, Billis K, Brent S et al. Ensembl 2014. Nucleic Acids Res 2014; 42: D749-D755.
32. Slater GS, Birney E. Automated generation of heuristics for biological sequence comparison. BMC Bioinformatics 2005; 6: 31.