Exploring cross-talk between oxidative damage and excitotoxicity and the effects of riluzole in the rat cortex after exposure to methylmercury

Neurotoxicity Research

Volumn 26, Issue 1, 2014, Pages 40-51

  Deng, Yu ^a   Xu, Zhaofa ^a   Xu, Bin ^a   Liu, Wei ^a   Wei, Yangang ^a   Li, Yuehui ^a   Feng, Shu ^a   Yang, Tianyao ^a  

^a CHINA MEDICAL UNIVERSITY   (China)

Author keywords

Cortex; Cross talk; Excitotoxicity; Methylmercury; Oxidative damage; Riluzole

Indexed keywords

CALCIUM; EOSIN; GLUTAMATE TRANSPORTER; GLUTAMIC ACID; GLUTAMINE; GLUTATHIONE; HEMATOXYLIN; METHYLMERCURY; N METHYL DEXTRO ASPARTIC ACID RECEPTOR; REACTIVE OXYGEN METABOLITE; RILUZOLE; TRANSCRIPTION FACTOR NRF2; MERCURY; METHYLMERCURY DERIVATIVE; NEUROPROTECTIVE AGENT; NEUROTOXIN; NFE2L2 PROTEIN, RAT;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIOXIDANT ACTIVITY; ARTICLE; BIOACCUMULATION; BRAIN CORTEX; DOWN REGULATION; ENZYME ACTIVITY; ENZYME INHIBITION; EXCITOTOXICITY; EXPOSURE; FLOW CYTOMETRY; FLUORESCENCE ANALYSIS; FLUORESCENCE SPECTROSCOPY; MALE; MOLECULAR INTERACTION; NEUROPROTECTION; NEUROTOXICITY; NONHUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; RAT MODEL; REAL TIME POLYMERASE CHAIN REACTION; SPECTROFLUOROMETRY; WESTERN BLOTTING; ANIMAL; DRUG EFFECTS; METABOLISM; PATHOLOGY; PATHOPHYSIOLOGY; PHYSIOLOGY; TOXICITY; WISTAR RAT;

RATTUS;

ANIMALS; CALCIUM; CEREBRAL CORTEX; GLUTAMATE PLASMA MEMBRANE TRANSPORT PROTEINS; GLUTAMIC ACID; GLUTAMINE; GLUTATHIONE; MALE; MERCURY; METHYLMERCURY COMPOUNDS; NEUROPROTECTIVE AGENTS; NEUROTOXINS; NF-E2-RELATED FACTOR 2; OXIDATIVE STRESS; RATS, WISTAR; REACTIVE OXYGEN SPECIES; RECEPTORS, N-METHYL-D-ASPARTATE; RILUZOLE;

EID: 84903783977     PISSN: 10298428     EISSN: 14763524     Source Type: Journal    
DOI: 10.1007/s12640-013-9448-6     Document Type: Article

References (44)

1. Ahamed M, Akhtar MJ, Siddiqui MA et al (2011) Oxidative stress mediated apoptosis induced by nickel ferrite nanoparticles in cultured A549 cells. Toxicology 283(2-3):101-108
2. Allgaier C (2002) Ethanol sensitivity of NMDA receptors. Neuroche Int 41(6):377-382
3. Aschner M, Clarkson TW (1987) Mercury 203 distribution in pregnant and nonpregnant rats following systemic infusions with thiol-containing amino acids. Teratology 36(3):321-328 (Pubitemid 18016556)
4. Bensimon G, Lacomblez L, Meininger V (1994) A controlled trial of riluzole in amyotrophic lateral sclerosis. ALS/riluzole study group. N Engl J Med 330(9):585-591 (Pubitemid 24065791)
5. Castoldi AF, Coccini T, Ceccatelli S et al (2001) Neurotoxicity and molecular effects of methylmercury. Brain Res Bull 55(2):197-203 (Pubitemid 32722159)
6. + concentrations in intact Merkel cells of an isolated, functioning rat sinus hair preparation. Exp Brain Res 108(3):357-366
7. Curi TC, De Melo MP, De Azevedo RB et al (1997) Glutamine utilization by rat neutrophils: presence of phosphate-dependent glutaminase. Am J Physiol 273(4 Pt 1):1124-1129
8. Deng Y, Xu Z, Xu B et al (2009) The protective effect of riluzole on manganese caused disruption of glutamate-glutamine cycle in rats. Brain Res 1289:106-117
9. Distelmaier F, Valsecchi F, Forkink M et al (2012) Trolox-sensitive reactive oxygen species regulate mitochondrial morphology, oxidative phosphorylation and cytosolic calcium handling in healthy cells. Antioxid Redox Signal 17(12):1657-1669
10. Farina M, Aschner M, Rocha JB (2011) Oxidative stress in MeHg-induced neurotoxicity. Toxicol Appl Pharmacol 256(3):405-417
11. Franco R, Cidlowski JA (2012) Glutathione efflux and cell death. Antioxid Redox Signal 17(12):1694-1713
12. Fumagalli E, Funicello M, Rauen T (2008) Riluzole enhances the activity of glutamate transporters GLAST, GLT1 and EAAC1. Eur J Pharmacol 578(2-3):171-176 (Pubitemid 350309596)
13. Gabryel B, Małecki A (2006) Ebselen attenuates oxidative stress in ischemic astrocytes depleted of glutathione. Comparison with glutathione precursors. Pharmacol Rep 58(3):381-392 (Pubitemid 44111073)
14. Gyengesi E, Paxinos G, Andrews ZB (2012) Oxidative stress in the hypothalamus: the importance of calcium signaling and mitochondrial ROS in body weight regulation. Curr Neuropharmacol 10(4):344-353
15. Had-Aissouni L (2012) Toward a new role for plasma membrane sodium-dependent glutamate transporters of astrocytes: maintenance of antioxidant defenses beyond extracellular glutamate clearance. Amino Acids 42(1):181-197
16. He Y, Cui J, Lee JC et al (2011) Prolonged exposure of cortical neurons to oligomeric amyloid-b impairs NMDA receptor function via NADPH oxidase-mediated ROS production: protective effect of green tea (-)-epigallocatechin-3-gallate. ASN Neuro 3(1):e00050
17. Hong YS, Kim YM, Lee KE (2012) Methylmercury exposure and health effects. J Prev Med Public Health 45(6):353-363
18. Itoh K, Tong KI, YamamotoM(2004) Molecular mechanism activating Nrf2-Keap1 pathway in regulation of adaptive response to electrophiles. Free Radic Biol Med 36(10):1208-1213 (Pubitemid 38526314)
19. Jaekel B, Mühlberg K, Garcia de Arriba S et al (2006) Neuroprotection associated with alternative splicing of NMDA receptors in rat cortical neurons. Br J Pharmacol 147(6):622-633
20. 2+ superoxide dismutase 1 G93A mice: glutamate-mediated excitotoxicity. J Pharmacol Exp Ther 338(2):518-527
21. Jyrkkänen HK, Kuosmanen S, Heinäniemi M et al (2011) Novel insights into the regulation of antioxidant-response-element-mediated gene expression by electrophiles: induction of the transcriptional repressor BACH1 by Nrf2. Biochem J 440(2):67-174
22. Kolls JK (2006) Oxidative stress in sepsis: a redox redux. J Clin Invest 116(4):860-863
23. Liu Y, Wong TP, Aarts M et al (2007) NMDA receptor subunits have differential roles in mediating excitotoxic neuronal death both in vitro and in vivo. J Neurosci 27(11):2846-2857 (Pubitemid 46438991)
24. Liu CH, Jiao H, Guo ZH et al (2013) Up-regulated GLT-1 resists glutamate toxicity and attenuates glutamate-induced calcium loading in cultured neurocytes. Basic Clin Pharmacol Toxicol 112(1):19-24
25. Lowry OH, Rosebrough NJ, Farr AL et al (1951) Protein measurement with the Folin phenol reagent. J Biol Chem 193(1):265-275
26. Mehta A, Prabhakar M, Kumar P et al (2013) Excitotoxicity: bridge to various triggers in neurodegenerative disorders. Eur J Pharmacol 698(1-3):6-18
27. Meldrum BS (2000) Glutamate as a neurotransmitter in the brain: review of physiology and pathology. J Nutr 130(4S Suppl):1007S-1015S
28. Muller A, Maurin L, Bonne C (1998) Free radicals and glutamate uptake in the retina. Gen Pharmacol 30(3):315-318 (Pubitemid 28046500)
29. Murali G, Panneerselvam KS, Panneerselvam C (2008) Age-associated alterations of lipofuscin, membrane-bound ATPases and intracellular calcium in cortex, striatum and hippocampus of rat brain: protective role of glutathione monoester. Int J Dev Neurosci 26(2):211-215
30. Ni M, Li X, Yin Z et al (2010) Methylmercury induces acute oxidative stress, altering Nrf2 protein level in primary microglial cells. Toxicol Sci 116(2):590-603
31. Polunas M, Halladay A, Tjalkens RB et al (2011) Role of oxidative stress and the mitochondrial permeability transition in methyl-mercury cytotoxicity. Neurotoxicology 32(5):526-534
32. Rastogi RP, Singh SP, Häder DP et al (2010) Detection of reactive oxygen species (ROS) by the oxidant-sensing probe 2′,7′- dichlorodihydrofluorescein diacetate in the cyanobacterium Anabaena variabilis PCC 7937. Biochem Biophys Res Commun 397(3):603-607
33. Renis M, Cardile V, Russo A et al (1998) Glutamine synthetase activity and HSP70 levels in cultured rat astrocytes: effect of 1-octadecyl-2-methyl-rac- glycero-3-phosphocholine. Brain Res 783(1):143-150 (Pubitemid 28131432)
34. Rinwa P, Jaggi AS, Singh N (2012) Pharmacological investigation of memory restorative effect of riluzole in mice. Indian J Pharmacol 44(3):366-371
35. Roos D, Seeger R, Puntel R et al (2012) Role of calcium and mitochondria in MeHg-mediated cytotoxicity. J Biomed Biotechnol 2012:248764
36. Shen J (2013) Modeling the glutamate-glutamine neurotransmitter cycle. Front Neuroenergetics 5:1
37. Stockwell PB, Corns WT (1993) The role of atomic fluorescence spectrometry in the automatic environmental monitoring of trace element analysis. J Automatic Chem 15(3):79-84 (Pubitemid 23299144)
38. Storch A, Burkhardt K, Ludolph AC et al (2000) Protective effects of riluzole on dopamine neurons: involvement of oxidative stress and cellular energy metabolism. J Neurochem 75(6):2259-2269
39. Thörn I, Olsson-Strömberg U, Ohlsen C et al (2005) The impact of RNA stabilization on minimal residual disease assessment in chronic myeloid leukemia. Haematologica 90(11):1471-1476 (Pubitemid 41658759)
40. Toyama T, Sumi D, Shinkai Y et al (2007) Cytoprotective role of Nrf2/Keap1 system in methylmercury toxicity. Biochem Biophys Res Commun 363(3):645-650 (Pubitemid 47513679)
41. Trotti D, Rossi D, Gjesdal O et al (1996) Peroxynitrite inhibits glutamate transporter subtypes. J Biol Chem 271(11):5976-5979 (Pubitemid 26095396)
42. Vahter ME, Mottet NK, Friberg LT et al (1995) Demethylation of methyl mercury in different brain sites of Macaca fascicularis monkeys during long-term subclinical methyl mercury exposure. Toxicol Appl Pharmacol 134(2):273-284
43. 2+ uptake in acutely dissociated brain cells derived from adult rats. Brain Res 570(1-2):347-353
44. Zarate CA, Manji HK (2008) Riluzole in psychiatry: a systematic review of the literature. Expert Opin Drug Metab Toxicol 4(9):1223-1234