The frequencies of IFNγ+IL2+TNFα+ PPD-specific CD4+CD45RO+ T-cells correlate with the magnitude of the QuantiFERON® gold in-tube response in a prospective study of healthy Indian adolescents

PLoS ONE

Volumn 9, Issue 7, 2014, Pages

  Jenum, Synne ^a   Grewal, Harleen M S ^b,c   Hokey, David A ^d   Kenneth, John ^e   Vaz, Mario ^e   Doherty, Timothy Mark ^f   Jahnsen, Frode Lars ^a   Doherty, T M ^g   Grewal, H M S ^b,c   Lindtjorn B ^b   Hesseling, A C ^h   Jacob, A ⁱ   Jahnsen, F L ^j   Kenneth, J ^e   Kurpad, A V ^e   Macaden, R ^e   Nelson, J ^e   Sumithra, S ^e   Vaz, M ^e   Cardenas V ^d  

^a OSLO UNIVERSITY HOSPITAL   (Norway)

^b UNIVERSITY OF BERGEN   (Norway)

^c HAUKELAND UNIVERSITY HOSPITAL   (Norway)

^d AERAS   (United States)

^e ST JOHN'S NATIONAL ACADEMY OF HEALTH SCIENCES   (India)

^f GLAXOSMITHKLINE   (Denmark)

^g Glaxo SmithKline   (Denmark)

^h Desmond Tutu HIV Centre   (South Africa)

ⁱ Emmaus Swiss Leprosy Project   (India)

^j OSLO UNIVERSITY HOSPITAL   (Norway)

more..

Author keywords

[No Author keywords available]

Indexed keywords

BCG VACCINE; GAMMA INTERFERON; INTERLEUKIN 2; TUMOR NECROSIS FACTOR ALPHA; CD45 ANTIGEN; DIAGNOSTIC KIT; GOLD;

ADOLESCENT; ADULT; ARTICLE; CD4 CD45RO T LYMPHOCYTE; CELLULAR IMMUNITY; CHILD; COHORT ANALYSIS; CONTROLLED STUDY; CYTOKINE PRODUCTION; CYTOKINE RELEASE; FEMALE; FLOW CYTOMETRY; HUMAN; HUMAN CELL; IN VITRO STUDY; INDIAN; INTERFERON GAMMA RELEASE ASSAY; INTERMETHOD COMPARISON; LATENT TUBERCULOSIS; MAJOR CLINICAL STUDY; MALE; MEMORY T LYMPHOCYTE; MYCOBACTERIUM; NONHUMAN; OBSERVATIONAL STUDY; PERIPHERAL BLOOD MONONUCLEAR CELL; PREDICTIVE VALUE; PROSPECTIVE STUDY; QUALITATIVE RESEARCH; QUALITY CONTROL; QUANTITATIVE ANALYSIS; SCHOOL CHILD; SPECIES DIFFERENCE; T LYMPHOCYTE; TREATMENT RESPONSE; TUBERCULIN TEST; TUBERCULOSIS; ASIAN CONTINENTAL ANCESTRY GROUP; CD4+ T LYMPHOCYTE; CHEMISTRY; CYTOLOGY; DIAGNOSTIC KIT; IMMUNOLOGY; INDIA; METABOLISM; MONONUCLEAR CELL;

ADOLESCENT; ANTIGENS, CD45; ASIAN CONTINENTAL ANCESTRY GROUP; CD4-POSITIVE T-LYMPHOCYTES; CHILD; COHORT STUDIES; GOLD; HUMANS; INDIA; INTERFERON-GAMMA; INTERLEUKIN-2; LEUKOCYTES, MONONUCLEAR; PROSPECTIVE STUDIES; REAGENT KITS, DIAGNOSTIC; TUBERCULOSIS; TUMOR NECROSIS FACTOR-ALPHA;

EID: 84903783708     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0101224     Document Type: Article

References (45)

1. WHO (2012) WHO. Global Tuberculosis Report 2012. WHO.
2. Kaufmann SH, Parida SK (2008) Tuberculosis in Africa: learning from pathogenesis for biomarker identification. Cell Host Microbe 4: 219-228.
3. Doherty M, Wallis RS, Zumla A (2009) Biomarkers for tuberculosis disease status and diagnosis. Curr Opin Pulm Med 15: 181-187.
4. Pai M, Denkinger CM, Kik SV, Rangaka MX, Zwerling A, et al. (2014) Gamma interferon release assays for detection of Mycobacterium tuberculosis infection. Clin Microbiol Rev 27: 3-20. 27/1/3 [pii];10.1128/CMR.00034-13 [doi].
5. Radhakrishna S, Frieden TR, Subramani R (2003) Association of initial tuberculin sensitivity, age and sex with the incidence of tuberculosis in south India: a 15-year follow-up. Int J Tuberc Lung Dis 7: 1083-1091.
6. Watkins RE, Brennan R, Plant AJ (2000) Tuberculin reactivity and the risk of tuberculosis: a review. Int J Tuberc Lung Dis 4: 895-903.
7. Lienhardt C, Fielding K, Hane AA, Niang A, Ndao CT, et al. (2010) Evaluation of the prognostic value of IFN-gamma release assay and tuberculin skin test in household contacts of infectious tuberculosis cases in Senegal. PLoS ONE [Electronic Resource] 5: e10508.
8. Hill PC, Jackson-Sillah DJ, Fox A, Brookes RH, de Jong BC, et al. (2008) Incidence of tuberculosis and the predictive value of ELISPOT and Mantoux tests in Gambian case contacts. PLoS One 3: e1379.
9. Andersen P, Doherty TM, Pai M, Weldingh K (2007) The prognosis of latent tuberculosis: can disease be predicted? Trends Mol Med 13: 175-182. (Pubitemid 46687128)
10. Doherty TM, Demissie A, Olobo J, Wolday D, Britton S, et al. (2002) Immune responses to the Mycobacterium tuberculosis-specific antigen ESAT-6 signal subclinical infection among contacts of tuberculosis patients. J Clin Microbiol 40: 704-706. (Pubitemid 34130912)
11. Kim YJ, Kim SI, Kim YR, Wie SH, Park YJ, et al. (2012) Predictive value of interferon-gamma ELISPOT assay in HIV 1-infected patients in an intermediate tuberculosis-endemic area. AIDS Res Hum Retroviruses 28: 1038-1043. 10.1089/AID.2011.0360 [doi].
12. Hinks TS, Dosanjh DP, Innes JA, Pasvol G, Hackforth S, et al. (2009) Frequencies of region of difference 1 antigen-specific but not purified protein derivative-specific gamma interferon-secreting T cells correlate with the presence of tuberculosis disease but do not distinguish recent from remote latent infections. Infect Immun 77: 5486-5495.
13. Vordermeier HM, Chambers MA, Cockle PJ, Whelan AO, Simmons J, et al.(2002) Correlation of ESAT-6-specific gamma interferon production with pathology in cattle following Mycobacterium bovis BCG vaccination against experimental bovine tuberculosis. Infect Immun 70: 3026-3032. (Pubitemid 34564163)
14. Pai M, Joshi R, Dogra S, Mendiratta DK, Narang P, et al. (2006) Serial testing of health care workers for tuberculosis using interferon-gamma assay. Am J Respir Crit Care Med 174: 349-355. (Pubitemid 44156616)
15. Hill PC, Brookes RH, Fox A, Jackson-Sillah D, Jeffries DJ, et al. (2007) Longitudinal assessment of an ELISPOT test for Mycobacterium tuberculosis infection. PLoS Med 4: e192.
16. Ewer K, Millington KA, Deeks JJ, Alvarez L, Bryant G, et al. (2006) Dynamic antigen-specific T-cell responses after point-source exposure to Mycobacterium tuberculosis. Am J Respir Crit Care Med 174: 831-839. (Pubitemid 44511666)
17. Ringshausen FC, Nienhaus A, Schablon A, Schlosser S, Schultze-Werninghaus G, et al. (2010) Predictors of persistently positive Mycobacterium- tuberculosis-specific interferon-gamma responses in the serial testing of health care workers. BMC Infect Dis 10: 220.
18. Pai M, Joshi R, Dogra S, Zwerling AA, Gajalakshmi D, et al. (2009) T-cell assay conversions and reversions among household contacts of tuberculosis patients in rural India. Int J Tuberc Lung Dis 13: 84-92.
19. Pai M, O'Brien R (2007) Serial testing for tuberculosis: can we make sense of T cell assay conversions and reversions? PLoS Med 4: e208.
20. Pantaleo G, Harari A (2006) Functional signatures in antiviral T-cell immunity for monitoring virus-associated diseases. Nat Rev Immunol 6: 417-423.
21. Darrah PA, Patel DT, De Luca PM, Lindsay RW, Davey DF, et al. (2007) Multifunctional TH1 cells define a correlate of vaccine-mediated protection against Leishmania major. Nat Med 13: 843-850. (Pubitemid 47038186)
22. Seder RA, Darrah PA, Roederer M (2008) T-cell quality in memory and protection: implications for vaccine design. Nat Rev Immunol 8: 247-258. (Pubitemid 351432801)
23. Lindenstrom T, Agger EM, Korsholm KS, Darrah PA, Aagaard C, et al. (2009) Tuberculosis subunit vaccination provides long-term protective immunity characterized by multifunctional CD4 memory T cells. J Immunol 182: 8047-8055.
24. Forbes EK, Sander C, Ronan EO, McShane H, Hill AV, et al.(2008) Multifunctional, high-level cytokine-producing Th1 cells in the lung, but not spleen, correlate with protection against Mycobacterium tuberculosis aerosol challenge in mice. J Immunol 181: 4955-4964.
25. Abel B, Tameris M, Mansoor N, Gelderbloem S, Hughes J, et al. (2010) The Novel TB Vaccine, AERAS-402, Induces Robust and Polyfunctional CD4 and CD8 T Cells in Adults. Am J Respir Crit Care Med.
26. Harari A, Rozot V, Enders FB, Perreau M, Stalder JM, et al. (2011) Dominant TNF-alpha+ Mycobacterium tuberculosis-specific CD4 + T cell responses discriminate between latent infection and active disease. Nat Med 17: 372-376.
27. Roederer M, Nozzi JL, Nason MC (2011) SPICE: exploration and analysis of post-cytometric complex multivariate datasets. Cytometry A 79: 167-174. 10.1002/cyto.a.21015 [doi].
28. van Zyl-Smit RN, Pai M, Peprah K, Meldau R, Kieck J, et al. (2009) Within-subject variability and boosting of T-cell interferon-gamma responses after tuberculin skin testing. Am J Respir Crit Care Med 180: 49-58. 200811-1704OC [pii];10.1164/rccm.200811-1704OC [doi].
29. Day CL, Abrahams DA, Lerumo L, Janse van RE, Stone L, et al. (2011) Functional capacity of Mycobacterium tuberculosis-specific T cell responses in humans is associated with mycobacterial load. J Immunol 187: 2222-2232.
30. Sutherland JS, Adetifa IM, Hill PC, Adegbola RA, Ota MO (2009) Pattern and diversity of cytokine production differentiates between Mycobacterium tuberculosis infection and disease. Eur J Immunol 39: 723-729.
31. Young JM, Adetifa IM, Ota MO, Sutherland JS (2010) Expanded polyfunctional T cell response to mycobacterial antigens in TB disease and contraction post-treatment. PLoS One 5: e11237.
32. Mueller H, Detjen AK, Schuck SD, Gutschmidt A, Wahn U, et al. (2008) Mycobacterium tuberculosis-specific CD4+, IFNgamma +, and TNFalpha+ multifunctional memory T cells coexpress GM-CSF. Cytokine 43: 143-148.
33. Streitz M, Fuhrmann S, Thomas D, Cheek E, Nomura L, et al. (2012) The phenotypic distribution and functional profile of tuberculin-specific CD4 T-cells characterizes different stages of TB infection. Cytometry B Clin Cytom 82: 360-368.
34. Caccamo N, Guggino G, Joosten SA, Gelsomino G, Di CP, et al. (2010) Multifunctional CD4(+) T cells correlate with active Mycobacterium tuberculosis infection. Eur J Immunol 40: 2211-2220.
35. Kagina BM, Abel B, Scriba TJ, Hughes EJ, Keyser A, et al. (2010) Specific T cell frequency and cytokine expression profile do not correlate with protection against tuberculosis after bacillus Calmette-Guerin vaccination of newborns. Am J Respir Crit Care Med 182: 1073-1079.
36. Khader SA, Bell GK, Pearl JE, Fountain JJ, Rangel-Moreno J, et al. (2007) IL-23 and IL-17 in the establishment of protective pulmonary CD4+ T cell responses after vaccination and during Mycobacterium tuberculosis challenge. Nat Immunol 8: 369-377. (Pubitemid 46745412)
37. Mittrucker HW, Steinhoff U, Kohler A, Krause M, Lazar D, et al. (2007) Poor correlation between BCG vaccination-induced T cell responses and protection against tuberculosis. Proc Natl Acad Sci U S A 104: 12434-12439. (Pubitemid 47206155)
38. Walzl G, Ronacher K, Hanekom W, Scriba TJ, Zumla A (2011) Immunological biomarkers of tuberculosis. Nat Rev Immunol 11: 343-354.
39. Barry CE III, Boshoff HI, Dartois V, Dick T, Ehrt S, et al. (2009) The spectrum of latent tuberculosis: rethinking the biology and intervention strategies. Nat Rev Microbiol 7: 845-855.
40. Russell DG, Barry CE III, Flynn JL (2010) Tuberculosis: what we don't know can, and does, hurt us. Science 328: 852-856.
41. Turner J, Rhoades ER, Keen M, Belisle JT, Frank AA, et al. (2000) Effective preexposure tuberculosis vaccines fail to protect when they are given in an immunotherapeutic mode. Infect Immun 68: 1706-1709. (Pubitemid 30108577)
42. Saunders BM, Frank AA, Orme IM, Cooper AM (2002) CD4 is required for the development of a protective granulomatous response to pulmonary tuberculosis. Cell Immunol 216: 65-72. (Pubitemid 35193446)
43. Cruz A, Fraga AG, Fountain JJ, Rangel-Moreno J, Torrado E, et al. (2010) Pathological role of interleukin 17 in mice subjected to repeated BCG vaccination after infection with Mycobacterium tuberculosis. J Exp Med 207: 1609-1616.
44. Lin PL, Rodgers M, Smith L, Bigbee M, Myers A, et al. (2009) Quantitative comparison of active and latent tuberculosis in the cynomolgus macaque model. Infect Immun 77: 4631-4642.
45. Franken WP, Arend SM, Thijsen SF, Bouwman JJ, Koster BF, et al. (2008) Interferon-gamma release assays during follow-up of tuberculin skin test-positive contacts. Int J Tuberc Lung Dis 12: 1286-1294.