메뉴 건너뛰기




Volumn 281, Issue 13, 2014, Pages 2927-2936

The electrostatic interactions of relaxin-3 with receptor RXFP4 and the influence of its B-chain C-terminal conformation

Author keywords

electrostatic interaction; mutagenesis; relaxin 3; relaxin family peptide; RXFP4

Indexed keywords

HORMONE RECEPTOR; RELAXIN 3; RELAXIN LIKE FAMILY PEPTIDE RECEPTOR 3; RELAXIN LIKE FAMILY PEPTIDE RECEPTOR 4; UNCLASSIFIED DRUG;

EID: 84903766686     PISSN: 1742464X     EISSN: 17424658     Source Type: Journal    
DOI: 10.1111/febs.12830     Document Type: Article
Times cited : (16)

References (28)
  • 1
    • 61349161851 scopus 로고    scopus 로고
    • The human insulin superfamily of polypeptide hormones
    • Shabanpoor F, Separovic F, &, Wade JD, (2009) The human insulin superfamily of polypeptide hormones. Vitam Horm 80, 1-31.
    • (2009) Vitam Horm , vol.80 , pp. 1-31
    • Shabanpoor, F.1    Separovic, F.2    Wade, J.D.3
  • 3
    • 78650012661 scopus 로고    scopus 로고
    • Relaxin-3/insulin-like peptide 7, a neuropeptide involved in the stress response and food intake
    • Tanaka M, (2010) Relaxin-3/insulin-like peptide 7, a neuropeptide involved in the stress response and food intake. FEBS J 277, 4990-4997.
    • (2010) FEBS J , vol.277 , pp. 4990-4997
    • Tanaka, M.1
  • 5
    • 0036734781 scopus 로고    scopus 로고
    • Restricted, but abundant, expression of the novel rat gene-3 (R3) relaxin in the dorsal tegmental region of brain
    • Burazin TC, Bathgate RA, Macris M, Layfield S, Gundlach AL, &, Tregear GW, (2002) Restricted, but abundant, expression of the novel rat gene-3 (R3) relaxin in the dorsal tegmental region of brain. J Neurochem 82, 1553-1557.
    • (2002) J Neurochem , vol.82 , pp. 1553-1557
    • Burazin, T.C.1    Bathgate, R.A.2    Macris, M.3    Layfield, S.4    Gundlach, A.L.5    Tregear, G.W.6
  • 7
    • 70350680168 scopus 로고    scopus 로고
    • Localization of relaxin-3 in brain of Macaca fascicularis: Identification of a nucleus incertus in primate
    • Ma S, Sang Q, Lanciego JL, &, Gundlach AL, (2009) Localization of relaxin-3 in brain of Macaca fascicularis: identification of a nucleus incertus in primate. J Comp Neurol 517, 856-872.
    • (2009) J Comp Neurol , vol.517 , pp. 856-872
    • Ma, S.1    Sang, Q.2    Lanciego, J.L.3    Gundlach, A.L.4
  • 9
    • 79951675001 scopus 로고    scopus 로고
    • Relaxin-3/INSL7 regulates the stress-response system in the rat hypothalamus
    • Watanabe Y, Miyamoto Y, Matsuda T, &, Tanaka M, (2011) Relaxin-3/INSL7 regulates the stress-response system in the rat hypothalamus. J Mol Neurosci 43, 169-174.
    • (2011) J Mol Neurosci , vol.43 , pp. 169-174
    • Watanabe, Y.1    Miyamoto, Y.2    Matsuda, T.3    Tanaka, M.4
  • 10
    • 71549143466 scopus 로고    scopus 로고
    • Swim stress excitation of nucleus incertus and rapid induction of relaxin-3 expression via CRF1 activation
    • Banerjee A, Shen PJ, Ma S, Bathgate RA, &, Gundlach AL, (2010) Swim stress excitation of nucleus incertus and rapid induction of relaxin-3 expression via CRF1 activation. Neuropharmacology 58, 145-155.
    • (2010) Neuropharmacology , vol.58 , pp. 145-155
    • Banerjee, A.1    Shen, P.J.2    Ma, S.3    Bathgate, R.A.4    Gundlach, A.L.5
  • 17
    • 0037424265 scopus 로고    scopus 로고
    • H3 relaxin is a specific ligand for LGR7 and activates the receptor by interacting with both the ectodomain and the exoloop 2
    • Sudo S, Kumagai J, Nishi S, Layfield S, Ferraro T, Bathgate RA, &, Hsueh AJ, (2003) H3 relaxin is a specific ligand for LGR7 and activates the receptor by interacting with both the ectodomain and the exoloop 2. J Biol Chem 278, 7855-7862.
    • (2003) J Biol Chem , vol.278 , pp. 7855-7862
    • Sudo, S.1    Kumagai, J.2    Nishi, S.3    Layfield, S.4    Ferraro, T.5    Bathgate, R.A.6    Hsueh, A.J.7
  • 22
    • 84898872369 scopus 로고    scopus 로고
    • The highly conserved negatively charged Glu141 and Asp145 of the G-protein-coupled receptor RXFP3 interact with the highly conserved positively charged arginine residues of relaxin-3
    • Zhang WJ, Wang XY, Guo YQ, Luo X, Gao XJ, Shao XX, Liu YL, Xu ZG, &, Guo ZY, (2014) The highly conserved negatively charged Glu141 and Asp145 of the G-protein-coupled receptor RXFP3 interact with the highly conserved positively charged arginine residues of relaxin-3. Amino Acids 46, 1393-1402.
    • (2014) Amino Acids , vol.46 , pp. 1393-1402
    • Zhang, W.J.1    Wang, X.Y.2    Guo, Y.Q.3    Luo, X.4    Gao, X.J.5    Shao, X.X.6    Liu, Y.L.7    Xu, Z.G.8    Guo, Z.Y.9
  • 23
    • 33646832952 scopus 로고    scopus 로고
    • Solution structure and novel insights into the determinants of the receptor specificity of human relaxin-3
    • Rosengren KJ, Lin F, Bathgate RA, Tregear GW, Daly NL, Wade JD, &, Craik DJ, (2006) Solution structure and novel insights into the determinants of the receptor specificity of human relaxin-3. J Biol Chem 281, 5845-5851.
    • (2006) J Biol Chem , vol.281 , pp. 5845-5851
    • Rosengren, K.J.1    Lin, F.2    Bathgate, R.A.3    Tregear, G.W.4    Daly, N.L.5    Wade, J.D.6    Craik, D.J.7
  • 24
    • 64849117347 scopus 로고    scopus 로고
    • Structure of human insulin-like peptide 5 and characterization of conserved hydrogen bonds and electrostatic interactions within the relaxin framework
    • Haugaard-Jonsson LM, Hossain MA, Daly NL, Craik DJ, Wade JD, &, Rosengren KJ, (2009) Structure of human insulin-like peptide 5 and characterization of conserved hydrogen bonds and electrostatic interactions within the relaxin framework. Biochem J 419, 619-627.
    • (2009) Biochem J , vol.419 , pp. 619-627
    • Haugaard-Jonsson, L.M.1    Hossain, M.A.2    Daly, N.L.3    Craik, D.J.4    Wade, J.D.5    Rosengren, K.J.6
  • 25
    • 84862783322 scopus 로고    scopus 로고
    • Design, recombinant expression and convenient A-chain N-terminal europium-labelling of a fully active human relaxin-3 analogue
    • Zhang WJ, Luo X, Song G, Wang XY, Shao XX, &, Guo ZY, (2012) Design, recombinant expression and convenient A-chain N-terminal europium-labelling of a fully active human relaxin-3 analogue. FEBS J 279, 1505-1512.
    • (2012) FEBS J , vol.279 , pp. 1505-1512
    • Zhang, W.J.1    Luo, X.2    Song, G.3    Wang, X.Y.4    Shao, X.X.5    Guo, Z.Y.6
  • 27
    • 84862803473 scopus 로고    scopus 로고
    • Site-specific DOTA/europium-labeling of recombinant human relaxin-3 for receptor-ligand interaction studies
    • Zhang WJ, Luo X, Liu YL, Shao XX, Wade JD, Bathgate RA, &, Guo ZY, (2012) Site-specific DOTA/europium-labeling of recombinant human relaxin-3 for receptor-ligand interaction studies. Amino Acids 43, 983-992.
    • (2012) Amino Acids , vol.43 , pp. 983-992
    • Zhang, W.J.1    Luo, X.2    Liu, Y.L.3    Shao, X.X.4    Wade, J.D.5    Bathgate, R.A.6    Guo, Z.Y.7
  • 28
    • 84877711041 scopus 로고    scopus 로고
    • A convenient method for europium-labeling of a recombinant chimeric relaxin family peptide R3/I5 for receptor-binding assays
    • Zhang WJ, Jiang Q, Wang XY, Song G, Shao XX, &, Guo ZY, (2013) A convenient method for europium-labeling of a recombinant chimeric relaxin family peptide R3/I5 for receptor-binding assays. J Pept Sci 19, 350-354.
    • (2013) J Pept Sci , vol.19 , pp. 350-354
    • Zhang, W.J.1    Jiang, Q.2    Wang, X.Y.3    Song, G.4    Shao, X.X.5    Guo, Z.Y.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.