Multigenerational exposure to dietary zearalenone (ZEA), an estrogenic mycotoxin, affects puberty and reproduction in female mice

Reproductive Toxicology

Volumn 47, Issue , 2014, Pages 81-88

  Zhao, Fei ^a   Li, Rong ^a   Xiao, Shuo ^a,b   Diao, Honglu ^a,c   El Zowalaty, Ahmed E ^a   Ye, Xiaoqin ^a  

^a UNIVERSITY OF GEORGIA   (United States)

^b NORTHWESTERN UNIVERSITY   (United States)

^c HUBEI UNIVERSITY OF MEDICINE   (China)

Author keywords

Embryo implantation; Female reproduction; Litter size; Multigeneration; Multipregnancy; Vaginal opening; Zearalenone

Indexed keywords

ZEARALENONE; ESTROGEN; MYCOTOXIN;

ADVERSE OUTCOME; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BODY WEIGHT; CONTROLLED STUDY; FEMALE; FEMALE INFERTILITY; FLUID INTAKE; FOOD INTAKE; GESTATION PERIOD; LITTER SIZE; MATING; MOUSE; MULTIPLE PREGNANCY; NIDATION; NONHUMAN; PREGNANCY RATE; PUBERTY; REPRODUCTION; REPRODUCTIVE SUCCESS; REPRODUCTIVE TOXICITY; ANIMAL; C57BL MOUSE; DIET; DRUG EFFECTS; FERTILITY; PREGNANCY; SEXUAL MATURATION; ENVIRONMENTAL EXPOSURE; FOOD CONTAMINATION; MALE; PROGENY; SUBFERTILITY; WEANING;

ANIMALS; DIET; ESTROGENS; FEMALE; FERTILITY; LITTER SIZE; MICE, INBRED C57BL; PREGNANCY; REPRODUCTION; SEXUAL MATURATION; ZEARALENONE;

MUS;

EID: 84903756098     PISSN: 08906238     EISSN: 18731708     Source Type: Journal    
DOI: 10.1016/j.reprotox.2014.06.005     Document Type: Article

References (26)

1. Zinedine A., Soriano J.M., Molto J.C., Manes J. Review on the toxicity, occurrence, metabolism, detoxification, regulations and intake of zearalenone: an oestrogenic mycotoxin. Food Chem Toxicol 2007, 45:1-18.
2. EFSA Scientific opinion on the risks for public health related to the presence of zearalenone in food. EFSA J 2011, 9:2197.
3. Bandera E.V., Chandran U., Buckley B., Lin Y., Isukapalli S., Marshall I., et al. Urinary mycoestrogens, body size and breast development in New Jersey girls. Sci Total Environ 2011, 409:5221-5227.
4. Massart F., Saggese G. Oestrogenic mycotoxin exposures and precocious pubertal development. Int J Androl 2010, 33:369-376.
5. Deng F., Tao F.B., Liu D.Y., Xu Y.Y., Hao J.H., Sun Y., et al. Effects of growth environments and two environmental endocrine disruptors on children with idiopathic precocious puberty. Eur J Endocrinol 2012, 166:803-809.
6. Delemarre E.M., Felius B., Delemarre-van de Waal H.A. Inducing puberty. Eur J Endocrinol 2008, 159(Suppl. 1):S9-S15.
7. Mayer C., Acosta-Martinez M., Dubois S.L., Wolfe A., Radovick S., Boehm U., et al. Timing and completion of puberty in female mice depend on estrogen receptor alpha-signaling in kisspeptin neurons. Proc Natl Acad Sci U S A 2010, 107:22693-22698.
8. Findlay J.K., Liew S.H., Simpson E.R., Korach K.S. Estrogen signaling in the regulation of female reproductive functions. Handb Exp Pharmacol 2010, 198:29-35.
9. Zhao F., Li R., Xiao S., Diao H., Viveiros M.M., Song X., et al. Postweaning exposure to dietary zearalenone, a mycotoxin, promotes premature onset of puberty and disrupts early pregnancy events in female mice. Toxicol Sci 2013, 132:431-442.
10. FDA Guidance for Industry and Other Stakeholders Toxicological Principles for the Safety Assessment of Food Ingredients 2000.
11. Martin M.T., Mendez E., Corum D.G., Judson R.S., Kavlock R.J., Rotroff D.M., et al. Profiling the reproductive toxicity of chemicals from multigeneration studies in the toxicity reference database. Toxicol Sci 2009, 110:181-190.
12. Chung B.Y., Kyung M., Lim S.K., Choi S.M., Lim D.S., Kwack S.J., et al. Uterotrophic and Hershberger assays for endocrine disruption properties of plastic food contact materials polypropylene (PP) and polyethylene terephthalate (PET). J Toxicol Environ Health A 2013, 76:624-634.
13. Waldemarson A.H., Hedenqvist P., Salomonsson A.C., Haggblom P. Mycotoxins in laboratory rodent feed. Lab Anim 2005, 39:230-235.
14. Boettger-Tong H., Murthy L., Chiappetta C., Kirkland J.L., Goodwin B., Adlercreutz H., et al. A case of a laboratory animal feed with high estrogenic activity and its impact on in vivo responses to exogenously administered estrogens. Environ Health Perspect 1998, 106:369-373.
15. Rasier G., Toppari J., Parent A.S., Bourguignon J.P. Female sexual maturation and reproduction after prepubertal exposure to estrogens and endocrine disrupting chemicals: a review of rodent and human data. Mol Cell Endocrinol 2006, 254-255:187-201.
16. Maranghi F., Mantovani A. Targeted toxicological testing to investigate the role of endocrine disrupters in puberty disorders. Reprod Toxicol 2012, 33:290-296.
17. Ye X., Hama K., Contos J.J., Anliker B., Inoue A., Skinner M.K., et al. LPA3-mediated lysophosphatidic acid signalling in embryo implantation and spacing. Nature 2005, 435:104-108.
18. Diao H., Paria B.C., Xiao S., Ye X. Temporal expression pattern of progesterone receptor in the uterine luminal epithelium suggests its requirement during early events of implantation. Fertil Steril 2011, 95:2087-2093.
19. Delclos K.B., Weis C.C., Bucci T.J., Olson G., Mellick P., Sadovova N., et al. Overlapping but distinct effects of genistein and ethinyl estradiol (EE(2)) in female Sprague-Dawley rats in multigenerational reproductive and chronic toxicity studies. Reprod Toxicol 2009, 27:117-132.
20. Nikaido Y., Danbara N., Tsujita-Kyutoku M., Yuri T., Uehara N., Tsubura A. Effects of prepubertal exposure to xenoestrogen on development of estrogen target organs in female CD-1 mice. In Vivo 2005, 19:487-494.
21. Malekinejad H., Schoevers E.J., Daemen I.J., Zijlstra C., Colenbrander B., Fink-Gremmels J., et al. Exposure of oocytes to the Fusarium toxins zearalenone and deoxynivalenol causes aneuploidy and abnormal embryo development in pigs. Biol Reprod 2007, 77:840-847.
22. Becci P.J., Johnson W.D., Hess F.G., Gallo M.A., Parent R.A., Taylor J.M. Combined two-generation reproduction-teratogenesis study of zearalenone in the rat. J Appl Toxicol 1982, 2:201-206.
23. NTP Multigenerational reproductive study of genistein (Cas No 446-72-0) in Sprague-Dawley rats (feed study). Natl Toxicol Program Tech Rep Ser 2008, 1-266.
24. Zeybel M., Hardy T., Wong Y.K., Mathers J.C., Fox C.R., Gackowska A., et al. Multigenerational epigenetic adaptation of the hepatic wound-healing response. Nat Med 2012, 18:1369-1377.
25. Hollingsworth J.W., Maruoka S., Boon K., Garantziotis S., Li Z., Tomfohr J., et al. In utero supplementation with methyl donors enhances allergic airway disease in mice. J Clin Invest 2008, 118:3462-3469.
26. Yang J.Y., Wang G.X., Liu J.L., Fan J.J., Cui S. Toxic effects of zearalenone and its derivatives alpha-zearalenol on male reproductive system in mice. Reprod Toxicol 2007, 24:381-387.