Simultaneous determination of three glucuronide conjugates of scutellarein in rat plasma by LC-MS/MS for pharmacokinetic study of breviscapine

Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences

Volumn 965, Issue , 2014, Pages 79-84

  Wang, Xin ^a   Xia, Hongjun ^a   Liu, Youping ^a   Qiu, Feng ^a   Di, Xin ^a  

^a SHENYANG PHARMACEUTICAL UNIVERSITY   (China)

Author keywords

Breviscapine; LC MS MS; Metabolite; Pharmacokinetics; Rat; Scutellarin

Indexed keywords

ELECTROSPRAY IONIZATION; FLAVONOIDS; MASS SPECTROMETRY; METABOLITES; PHARMACOKINETICS; RATING;

BREVISCAPINE; INTRAGASTRIC ADMINISTRATION; LC-MS/MS; MASS SPECTROMETRIC DETECTION; METHANOL-WATER-FORMIC ACID; SCUTELLARIN; SELECTED REACTION MONITORING; SIMULTANEOUS DETERMINATIONS;

BODY FLUIDS;

ACETONITRILE; BAICALIN; BREVISCAPINE; FORMIC ACID; GLUCURONIDE; METHANOL; SCUTELLAREIN; SCUTELLAREIN 6 O BETA DEXTRO GLUCURONIDE; SCUTELLAREIN 6,7 DI O BETA DEXTRO GLUCURONIDE; UNCLASSIFIED DRUG; WATER; APIGENIN; FLAVONOID;

ANALYTICAL ERROR; ANIMAL EXPERIMENT; ARTICLE; BLOOD SAMPLING; COLUMN CHROMATOGRAPHY; DRUG BLOOD LEVEL; DRUG DETERMINATION; ELECTROSPRAY; IONIZATION; LIQUID CHROMATOGRAPHY; MEASUREMENT ACCURACY; NONHUMAN; PRECIPITATION; PRIORITY JOURNAL; RAT; TANDEM MASS SPECTROMETRY; ANIMAL; BLOOD; CHEMISTRY; DRUG STABILITY; MALE; PROCEDURES; REPRODUCIBILITY; SENSITIVITY AND SPECIFICITY; STATISTICAL MODEL; WISTAR RAT;

ANIMALS; APIGENIN; CHROMATOGRAPHY, LIQUID; DRUG STABILITY; FLAVONOIDS; GLUCURONIDES; LINEAR MODELS; MALE; RATS; RATS, WISTAR; REPRODUCIBILITY OF RESULTS; SENSITIVITY AND SPECIFICITY; TANDEM MASS SPECTROMETRY;

EID: 84903747446     PISSN: 15700232     EISSN: 1873376X     Source Type: Journal    
DOI: 10.1016/j.jchromb.2014.06.013     Document Type: Article

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