Long-term supranutritional supplementation with selenate decreases hyperglycemia and promotes fatty liver degeneration by inducing hyperinsulinemia in diabetic db/db mice

PLoS ONE

Volumn 9, Issue 7, 2014, Pages

  Wang, Chaoqun ^a,b   Yang, Shulin ^b   Zhang, Ningbo ^b   Mu, Yulian ^b   Ren, Hongyan ^b   Wang, Yefu ^a   Li, Kui ^b  

^a WUHAN UNIVERSITY   (China)

^b INSTITUTE OF PLANT PROTECTION   (China)

Author keywords

[No Author keywords available]

Indexed keywords

CATALASE; GLUCOSE; GLUTATHIONE PEROXIDASE; GLYCOGEN; INSULIN; PLACEBO; SELENATE; SUPEROXIDE DISMUTASE; GLUCOSE BLOOD LEVEL; SELENIC ACID;

ALDOB GENE; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIDIABETIC ACTIVITY; ANTIOXIDANT ACTIVITY; APOPTOSIS; ARTICLE; CELL DIFFERENTIATION; CELL PROLIFERATION; CONTROLLED STUDY; DETOXIFICATION; DIABETES MELLITUS; DIET SUPPLEMENTATION; DNA MICROARRAY; DOWN REGULATION; ENDOPLASMIC RETICULUM; FBP2 GENE; GAPDH GENE; GENE; GENE EXPRESSION; GENE LOCATION; GENE SEQUENCE; GLUCOSE BLOOD LEVEL; GLUL GENE; GLYCEMIC CONTROL; GSTA1 GENE; HYPERGLYCEMIA; HYPERINSULINEMIA; INSR GENE; INSULIN BLOOD LEVEL; INSULIN RELEASE; INSULIN SYNTHESIS; LIPID METABOLISM; LIVER FATTY DEGENERATION; LONG TERM CARE; MALE; MASS SPECTROMETRY; MOUSE; MOUSE MODEL; NEUROD1 GENE; NONHUMAN; NUCLEOTIDE SEQUENCE; PANCREAS ISLET; PANCREAS ISLET BETA CELL; PAX6 GENE; PDX1 GENE; PLTP GENE; PROTEIN EXPRESSION; PROTEOMICS; SCD1 GENE; TWO DIMENSIONAL DIFFERENCE GEL ELECTROPHORESIS; UPREGULATION; ANALYSIS; ANIMAL; CHEMICALLY INDUCED; DIABETES MELLITUS, TYPE 2; DRUG EFFECTS; FATTY LIVER; GENETICS; HYPERINSULINISM; LIVER; PANCREAS;

ANIMALS; BLOOD GLUCOSE; DIABETES MELLITUS, TYPE 2; DIETARY SUPPLEMENTS; FATTY LIVER; GENE EXPRESSION; HYPERINSULINISM; INSULIN-SECRETING CELLS; ISLETS OF LANGERHANS; LIVER; MALE; MICE; PANCREAS; SELENIC ACID;

EID: 84903724136     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0101315     Document Type: Article

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