Improved method for the simultaneous determination of aflatoxins, ochratoxin A and Fusarium toxins in cereals and derived products by liquid chromatography-tandem mass spectrometry after multi-toxin immunoaffinity clean up

Journal of Chromatography A

Volumn 1354, Issue , 2014, Pages 139-143

  Lattanzio, Veronica Maria Teresa ^a   Ciasca, Biancamaria ^a   Powers, Stephen ^b   Visconti, Angelo ^a  

^a INSTITUTE OF SCIENCES OF FOOD PRODUCTION   (Italy)

^b VICAM   (United States)

Author keywords

Aflatoxins; Cereals; Fusarium toxins; LC MS MS; Multi mycotoxin immunoaffinity; Ochratoxin A

Indexed keywords

AFLATOXINS; ANTIGEN-ANTIBODY REACTIONS; EXTRACTION; FUNGI; LIQUID CHROMATOGRAPHY; MASS SPECTROMETRY; METABOLITES;

CEREALS; FUSARIUM TOXINS; IMMUNOAFFINITY; LC-MS/MS; OCHRATOXIN A;

TOXICITY;

AFLATOXIN; AFLATOXIN B1; AFLATOXIN B2; AFLATOXIN G1; AFLATOXIN G2; FUMONISIN; FUMONISIN B1; FUMONISIN B2; HT 2 TOXIN; METHANOL; NIVALENOL; OCHRATOXIN; T 2 TOXIN; VOMITOXIN; WATER; ZEARALENONE;

ACCURACY; ARTICLE; CEREAL; CORN FLAKE; FUSARIUM; IMMUNOAFFINITY CHROMATOGRAPHY; LIMIT OF QUANTITATION; LIQUID CHROMATOGRAPHY; MAIZE; MAIZE SNACK; MEASUREMENT REPEATABILITY; MULTI TOXIN IMMUNOAFFINITY COLUMN; PRIORITY JOURNAL; REPRODUCIBILITY; SEPARATION TECHNIQUE; STATISTICAL ANALYSIS; TANDEM MASS SPECTROMETRY; TOXIN ANALYSIS; VALIDATION STUDY; WHEAT; AFFINITY CHROMATOGRAPHY; CHEMISTRY; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; PROCEDURES;

FUSARIUM; TRITICUM AESTIVUM; ZEA MAYS;

AFLATOXINS; CEREALS; CHROMATOGRAPHY, AFFINITY; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; FUSARIUM; OCHRATOXINS; REPRODUCIBILITY OF RESULTS; TANDEM MASS SPECTROMETRY;

EID: 84903715315     PISSN: 00219673     EISSN: 18733778     Source Type: Journal    
DOI: 10.1016/j.chroma.2014.05.069     Document Type: Article

References (17)

1. Miller J.D., Trenholm H.L. Mycotoxins in Grains. Compounds Other than Aflatoxins 1994, Reagan Press, St. Paul, MN, USA.
2. WHO FOOD ADDITIVES SERIES: 47 Safety evaluation of certain mycotoxins in food, prepared by the Fifty-sixth meeting of the Joint FAO/WHO Expert Committee on Food Additives (JECFA). Available at: (accessed 14.03.14). http://www.inchem.org/documents/jecfa/jecmono/v47je01.htm.
3. Commission Regulation (EC) No 1881/2006 of 19 December 2006 setting maximum levels for certain contaminants in foodstuffs, Off. J. Eur. Union, L 364/5.
4. Commission Regulation (EC) No 1126/2007 of 28 September 2007 amending Regulation (EC) No 1881/2006 setting maximum levels for certain contaminants in foodstuffs as regards Fusarium toxins in maize and maize products
5. Commission Recommendation of 27 March 2013 on the presence of T-2 and HT-2 toxin in cereals and cereal products, Off. J. Eur. Union, L 91/12.
6. European Food Safety Authority (EFSA) EFSA J. 2013, 11:3262. Available at: http://www.efsa.europa.eu/en/topics/topic/mycotoxins.htm (accessed 14.03.14).
7. Li P., Zhang Z., Hu X., Zhang Q. Mass Spectrom. Rev. 2013, 32:420. 10.1002/mas.21377.
8. Songsermsakul P., Razzazi-Fazeli E. J. Liq. Chromatogr. Relat. Technol. 2008, 31:1641. 10.1080/10826070802126395.
9. Shephard G.S., Berthiller F., Burdaspal P.A., Crews C., Jonker M.A., Krska R., Lattanzio V.M.T., MacDonald S., Malone R.J., Maragos C., Sabino M., Solfrizzo M., van Egmond H.P., Whitaker T.B. World Mycotoxin J. 2013, 6:3. 10.3920/WMJ2012.1492.
10. Berthiller F., Burdaspal P.A., Crews C., Iha M.H., Krska R., Lattanzio V.M.T., MacDonald S., Malone R.J., Maragos C., Solfrizzo M., Stroka J., Whitaker T.B. World Mycotoxin J. 2014, 7:3. 10.3920/WMJ2013.1637.
11. Commission Regulation (EU) No 401/2006 of 23 February 2006 laying down the methods of sampling and analysis for the official control of the levels of mycotoxins in foodstuffs, Off. J. Eur. Union, L 70/12.
12. CEN Technical Report CEN/TR 16059:2010. Food analysis - performance criteria for single laboratory validated methods of analysis for the determination of mycotoxins.
13. Lattanzio V.M.T., Solfrizzo M., Powers S., Visconti A. Rapid Commun. Mass Spectrom. 2007, 21:3253. 10.1002/rcm.3210.
14. Tang Y.Y., Lin H.Y., Chen Y.C., Su W.T., Wang S.C., Chiueh L.C., Shin Y.C. Food Anal. Methods 2013, 6:727. 10.1007/s12161-012-9473-8.
15. Vaclavikova M., MacMahon S., Zhang K., Begley T.H. Talanta 2013, 117:345. 10.1016/j.talanta.2013.09.007.
16. Commission Decision (EC) No 657/2002 of 12 August 2002 implementing Council Directive 96/23/EC concerning the performance of analytical methods and the interpretation of results, Off. J. Eur. Commun. L 221/8.
17. International Organization for Standardization (ISO) ISO 5725-3:1994(E) 1994, ISO Standards, Geneva, ICS 03:120:30.