Insulin regulates P-glycoprotein in rat brain microvessel endothelial cells via an insulin receptor-mediated PKC/NF-κB pathway but not a PI3K/Akt pathway

European Journal of Pharmacology

Volumn 602, Issue 2-3, 2009, Pages 277-282

  Liu, Haiyan ^a,b   Yang, Huiwen ^c   Wang, Dianlei ^c   Liu, Yuchun ^c   Liu, Xiaodong ^c   Li, Yang ^c   Xie, Lin ^c   Wang, GuangJi ^c  

^a CHINA PHARMACEUTICAL UNIVERSITY   (China)

^b Shanghai Pharmaceutical Group Co Ltd   (China)

^c NONE

Author keywords

Blood brain barrier; Insulin; P glycoprotein; Rat brain microvessel endothelial cell

Indexed keywords

2 MORPHOLINO 8 PHENYLCHROMONE; ALPHA CYANO (3 METHOXY 4 HYDROXY 5 IODO)CINNAMOYL (3',4' DIHYDROXYPHENYL)KETONE; CHELERYTHRINE; GLYCOPROTEIN P; I KAPPA B; I OME AG 538; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INSULIN; INSULIN RECEPTOR; INSULIN RECEPTOR ANTIBODY; INSULIN RECEPTOR KINASE; INSULIN RECEPTOR KINASE INHIBITOR; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN KINASE B; PROTEIN KINASE C; PROTEIN KINASE C INHIBITOR; PYRROLIDINE DITHIOCARBAMATE; RHODAMINE 123; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; BLOOD BRAIN BARRIER; BRAIN MICROCIRCULATION; CONCENTRATION RESPONSE; CONTROLLED STUDY; DIABETES MELLITUS; ENDOTHELIUM CELL; ENZYME MECHANISM; HORMONE PROTEIN COMPLEX; HORMONE RECEPTOR INTERACTION; INSULIN METABOLISM; INSULIN TREATMENT; INTRACELLULAR TRANSPORT; MICROVASCULATURE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; RAT; SIGNAL TRANSDUCTION; WESTERN BLOTTING;

1-PHOSPHATIDYLINOSITOL 3-KINASE; ANIMALS; ANTIBODIES; BLOOD-BRAIN BARRIER; BRAIN; ENDOTHELIAL CELLS; ENZYME INHIBITORS; GENE EXPRESSION REGULATION; INSULIN; MICROVESSELS; NF-KAPPA B; P-GLYCOPROTEIN; PROTEIN KINASE C; PROTEIN-TYROSINE KINASES; PROTO-ONCOGENE PROTEINS C-AKT; RATS; RECEPTOR, INSULIN; SIGNAL TRANSDUCTION;

EID: 58149175658     PISSN: 00142999     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ejphar.2008.11.026     Document Type: Article

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