-
2
-
-
84898669547
-
Ledipasvir and sofosbuvir for previously treated HCV genotype 1 infection
-
N. Afdhal, K. Reddy, and D. Nelson et al. Ledipasvir and sofosbuvir for previously treated HCV genotype 1 infection N. Engl. J. Med. 370 2014 1483 1493
-
(2014)
N. Engl. J. Med.
, vol.370
, pp. 1483-1493
-
-
Afdhal, N.1
Reddy, K.2
Nelson, D.3
-
3
-
-
84900339263
-
Ledipasvir and sofosbuvir for untreated HCV genotype 1 infection
-
N. Afdhal, S. Zeuzem, and P. Kwo et al. Ledipasvir and sofosbuvir for untreated HCV genotype 1 infection N. Engl. J. Med. 2014
-
(2014)
N. Engl. J. Med.
-
-
Afdhal, N.1
Zeuzem, S.2
Kwo, P.3
-
4
-
-
57049112290
-
Selected replicon variants with low-level in vitro resistance to the hepatitis C virus NS5B polymerase inhibitor PSI-6130 lack cross-resistance with R1479
-
S. Ali, V. Leveque, and S. Le Pogam et al. Selected replicon variants with low-level in vitro resistance to the hepatitis C virus NS5B polymerase inhibitor PSI-6130 lack cross-resistance with R1479 Antimicrob. Agents Chemother. 52 2008 4356 4369
-
(2008)
Antimicrob. Agents Chemother.
, vol.52
, pp. 4356-4369
-
-
Ali, S.1
Leveque, V.2
Le Pogam, S.3
-
5
-
-
84887994430
-
Sofosbuvir-based interferon-free therapy for patients with HCV infection
-
Available from: < >
-
T. Asselah Sofosbuvir-based interferon-free therapy for patients with HCV infection J. Hepatol 2013 Available from: < http://dx.doi.org/10.101016/j. jhep.2013.07.023 >
-
(2013)
J. Hepatol
-
-
Asselah, T.1
-
6
-
-
84872038038
-
Interferon free therapy with direct acting antivirals for HCV
-
T. Asselah, and P. Marcelin Interferon free therapy with direct acting antivirals for HCV Liver Int. 33 Suppl. 1 2013 93 104
-
(2013)
Liver Int.
, vol.33
, Issue.SUPPL. 1
, pp. 93-104
-
-
Asselah, T.1
Marcelin, P.2
-
7
-
-
79953176289
-
Boceprevir for previously treated chronic HCV genotype 1 infection
-
B. Bacon, S. Gordon, and E. Lawitz et al. Boceprevir for previously treated chronic HCV genotype 1 infection N. Engl. J. Med. 364 2011 1207 1217
-
(2011)
N. Engl. J. Med.
, vol.364
, pp. 1207-1217
-
-
Bacon, B.1
Gordon, S.2
Lawitz, E.3
-
8
-
-
78649644443
-
Susceptibility of treatment-naïve hepatitis C virus (HCV) clinical isolates to HCV protease inhibitors
-
A. Bae, S.C. Sun, and X. Qi et al. Susceptibility of treatment-naïve hepatitis C virus (HCV) clinical isolates to HCV protease inhibitors Antimicrob. Agents Chemother. 54 2010 5288 5297
-
(2010)
Antimicrob. Agents Chemother.
, vol.54
, pp. 5288-5297
-
-
Bae, A.1
Sun, S.C.2
Qi, X.3
-
9
-
-
84882876118
-
Analysis of boceprevir resistance associated amino acid variants (RAVs) in two phase 3 boceprevir clinical trials
-
R.J. Barnard, J.A. Howe, and R.A. Ogert et al. Analysis of boceprevir resistance associated amino acid variants (RAVs) in two phase 3 boceprevir clinical trials Virology 444 2012 329 336
-
(2012)
Virology
, vol.444
, pp. 329-336
-
-
Barnard, R.J.1
Howe, J.A.2
Ogert, R.A.3
-
10
-
-
51749123143
-
Natural prevalence of HCV variants with decreased sensitivity to NS3-4A protease inhibitors in treatment-naïve subjects
-
D. Bartels, Y. Zhou, and E. Zhang et al. Natural prevalence of HCV variants with decreased sensitivity to NS3-4A protease inhibitors in treatment-naïve subjects J. Infect. Dis. 198 2008 800 807
-
(2008)
J. Infect. Dis.
, vol.198
, pp. 800-807
-
-
Bartels, D.1
Zhou, Y.2
Zhang, E.3
-
11
-
-
84884259683
-
Viral resistance in hepatitis C genotype-1 infected patients receiving the NS3 protease inhibitor faldaprevir (BI 2011335) in a phase 1b multiple rising-dose study
-
K.L. Berger, L. Lagacé, and I. Triki et al. Viral resistance in hepatitis C genotype-1 infected patients receiving the NS3 protease inhibitor faldaprevir (BI 2011335) in a phase 1b multiple rising-dose study Antimicrob. Agents Chemother. 57 2013 4928 4936
-
(2013)
Antimicrob. Agents Chemother.
, vol.57
, pp. 4928-4936
-
-
Berger, K.L.1
Lagacé, L.2
Triki, I.3
-
12
-
-
0036120573
-
Structural analysis of the hepatitis C virus RNA polymerase in complex with ribonucleotides
-
DOI 10.1128/JVI.76.7.3482-3492.2002
-
S. Bressanelli, L. Tomei, and F. Rey et al. Structural analysis of the hepatitis C virus RNA polymerase in complex with ribonucleotides J. Virol. 76 2002 3482 3492 (Pubitemid 34224549)
-
(2002)
Journal of Virology
, vol.76
, Issue.7
, pp. 3482-3492
-
-
Bressanelli, S.1
Tomei, L.2
Rey, F.A.3
De Francesco, R.4
-
13
-
-
35748953422
-
Advances in the development of new therapeutic agents targeting the NS3-4A serine protease or the NS5B RNA-dependent RNA polymerase of the hepatitis C virus
-
DOI 10.1016/j.addr.2007.04.016, PII S0169409X07001299, Toward Evidence Based Control of Hepatitis C Virus Infection
-
R. De Francesco, and A. Carfi Advances in the development of new therapeutic agents targeting NS3-4A serine protease or the NS5b RNA-dependent RNA polymerase of the hepatitis C virus Adv. Drug Deliv. Rev. 59 2007 1242 1262 (Pubitemid 350047514)
-
(2007)
Advanced Drug Delivery Reviews
, vol.59
, Issue.12
, pp. 1242-1262
-
-
De Francesco, R.1
Carfi, A.2
-
14
-
-
84893516367
-
Two distinct HCV genotype 1a clades: Geographical distribution and association with natural resistance mutations to HCV NS3/4A inhibitors
-
A. De Luca, S. Di Giambenedetto, and M. Prosperi et al. Two distinct HCV genotype 1a clades: geographical distribution and association with natural resistance mutations to HCV NS3/4A inhibitors Antivir. Ther. 18 Suppl. 1 2013 A47
-
(2013)
Antivir. Ther.
, vol.18
, Issue.SUPPL. 1
, pp. 47
-
-
De Luca, A.1
Di Giambenedetto, S.2
Prosperi, M.3
-
15
-
-
84903690431
-
Second wave anti-HCV protease inhibitors. Too Little too late?
-
(epub ahead of print)
-
S. De Nicola, and A. Aqhemo Second wave anti-HCV protease inhibitors. Too Little too late? Liver Int. 2014 (epub ahead of print)
-
(2014)
Liver Int.
-
-
De Nicola, S.1
Aqhemo, A.2
-
16
-
-
84903747001
-
Daclatasvir combined with peginterferon alfa 2a-ribavirin for 12 or 16 weeks in patients with hepatitis C virus genotype 2 or 3 infection: COMMAND GT 2/3 study
-
24-28 April 2013, Amsterdam, Belgium. (Abstract 1418)
-
Dore, G.J.; Lawitz, E.; Hezode, C.; et al.; 2013. Daclatasvir combined with peginterferon alfa 2a-ribavirin for 12 or 16 weeks in patients with hepatitis C virus genotype 2 or 3 infection: COMMAND GT 2/3 study. In: 48th Annual Meeting of the European Association for the Study of the Liver, 24-28 April 2013, Amsterdam, Belgium. (Abstract 1418).
-
(2013)
48th Annual Meeting of the European Association for the Study of the Liver
-
-
Dore . G, J.1
Lawitz, E.2
Hezode, C.3
-
17
-
-
79960453276
-
EASL clinical practice guidelines: Management of hepatitis C virus infection
-
Association For The Study Of The Liver E.
-
European Association for the Study of the Liver EASL clinical practice guidelines: management of hepatitis C virus infection J. Hepatol. 55 2011 245 264
-
(2011)
J. Hepatol.
, vol.55
, pp. 245-264
-
-
-
18
-
-
84903705964
-
Characterization of HCV NS3 protease variants from patients enrolled in a 28-day phase 2a trial of ACH-1625 daily dosing plus pegIFN-alpha 2a/RBV
-
18-22 April 2012, Barcelona, Spain. (Abstract 1182)
-
Fabrycki, J.; Patel, D.; Yang, G.; et al.; 2012. Characterization of HCV NS3 protease variants from patients enrolled in a 28-day phase 2a trial of ACH-1625 daily dosing plus pegIFN-alpha 2a/RBV. In: 47th Annual Meeting of the European Association for the Study of the Liver, 18-22 April 2012, Barcelona, Spain. (Abstract 1182).
-
(2012)
47th Annual Meeting of the European Association for the Study of the Liver
-
-
Fabrycki, J.1
Patel, D.2
Yang, G.3
-
19
-
-
84903711896
-
Sofosbuvir-based regimens are associated with high SVR rates across genotypes and among patients with multiple negative predictive factors
-
9-13 April, 2014, London, UK. (Abstract 066)
-
Foster, G.; et al.; 2014. Sofosbuvir-based regimens are associated with high SVR rates across genotypes and among patients with multiple negative predictive factors. In: 49th Annual Meeting of the European Association for the Study of the Liver, 9-13 April, 2014, London, UK. (Abstract 066).
-
(2014)
49th Annual Meeting of the European Association for the Study of the Liver
-
-
Foster, G.1
-
20
-
-
77956116880
-
Resistance analysis of the hepatitis C virus NS5A inhibitor BMS-790052 in an in vitro replicon system
-
R. Fridell, D. Qiu, C. Wang, L. Valera, and M. Gao Resistance analysis of the hepatitis C virus NS5A inhibitor BMS-790052 in an in vitro replicon system Antimicrob. Agents Chemother. 54 2010 3641 3650
-
(2010)
Antimicrob. Agents Chemother.
, vol.54
, pp. 3641-3650
-
-
Fridell, R.1
Qiu, D.2
Wang, C.3
Valera, L.4
Gao, M.5
-
21
-
-
82455192239
-
Genotypic and phenotypic analysis of variants resistant to hepatitis C virus nonstructural protein 5A replication complex inhibitor BMS-790052 in humans: In vitro and in vivo correlations
-
R.A. Fridell, C.F. Wang, and J.H. Sun et al. Genotypic and phenotypic analysis of variants resistant to hepatitis C virus nonstructural protein 5A replication complex inhibitor BMS-790052 in humans: in vitro and in vivo correlations Hepatology 54 2011 1924 1935
-
(2011)
Hepatology
, vol.54
, pp. 1924-1935
-
-
Fridell, R.A.1
Wang, C.F.2
Sun, J.H.3
-
22
-
-
84866119318
-
Interferon-free treatment with a combination of mericitabine and danoprevir/r with or without ribavirin in treatment-naive HCV genotype-1 infected patients
-
E.J. Gane et al. Interferon-free treatment with a combination of mericitabine and danoprevir/r with or without ribavirin in treatment-naive HCV genotype-1 infected patients J. Hepatol 56 Suppl. S2 2012 S555 S556
-
(2012)
J. Hepatol
, vol.56
, Issue.SUPPL. S2
-
-
Gane, E.J.1
-
23
-
-
84866119318
-
Interferon-free treatment with a combination of mericitabine and danoprevir/r with or without ribavirin in treatment-naïve HCV genotype 1-infected patients
-
E.J. Gane, P. Pockros, and S. Zeuzem et al. Interferon-free treatment with a combination of mericitabine and danoprevir/r with or without ribavirin in treatment-naïve HCV genotype 1-infected patients J. Hepatol. 56 2012 S555 S556
-
(2012)
J. Hepatol.
, vol.56
-
-
Gane, E.J.1
Pockros, P.2
Zeuzem, S.3
-
24
-
-
84885949784
-
Antiviral activity and resistance of HCV NS5A replication complex inhibitors
-
M. Gao Antiviral activity and resistance of HCV NS5A replication complex inhibitors Curr. Opin. Virol. 3 2013 1 7
-
(2013)
Curr. Opin. Virol.
, vol.3
, pp. 1-7
-
-
Gao, M.1
-
25
-
-
77952035218
-
Chemical genetics strategy identifies an HCV NS5A inhibitor with a potent clinical effect
-
M. Gao, R. Nettles, and M. Belema et al. Chemical genetics strategy identifies an HCV NS5A inhibitor with a potent clinical effect Nature 465 2010 96 100
-
(2010)
Nature
, vol.465
, pp. 96-100
-
-
Gao, M.1
Nettles, R.2
Belema, M.3
-
26
-
-
70349292099
-
Genetic variation in IL28B predicts hepatitis C treatment-induced viral clearance
-
D. Ge, J. Fellay, and A. Thompson et al. Genetic variation in IL28B predicts hepatitis C treatment-induced viral clearance Nature 461 2009 399 401
-
(2009)
Nature
, vol.461
, pp. 399-401
-
-
Ge, D.1
Fellay, J.2
Thompson, A.3
-
27
-
-
84871814966
-
Nucleotide polymerase inhibitor sofosbuvir plus ribavirin for hepatitis C
-
E.J. Gene, C.A. Stedman, and R.H. Hyland et al. Nucleotide polymerase inhibitor sofosbuvir plus ribavirin for hepatitis C N. Engl. J. Med. 368 2013 34 44
-
(2013)
N. Engl. J. Med.
, vol.368
, pp. 34-44
-
-
Gene, E.J.1
Stedman, C.A.2
Hyland, R.H.3
-
28
-
-
84872050504
-
New therapeutic strategies in HCV: Polymerase inhibitors
-
L. Gerber, T. Welzel, and S. Zeuzem New therapeutic strategies in HCV: polymerase inhibitors Liver Int. 33 Suppl. 1 2013 85 92
-
(2013)
Liver Int.
, vol.33
, Issue.SUPPL. 1
, pp. 85-92
-
-
Gerber, L.1
Welzel, T.2
Zeuzem, S.3
-
29
-
-
79958830099
-
Hepatitis C virus resistance to protease inhibitors
-
P. Halfon, and S. Locarnini Hepatitis C virus resistance to protease inhibitors J. Hepatol. 55 2011 192 206
-
(2011)
J. Hepatol.
, vol.55
, pp. 192-206
-
-
Halfon, P.1
Locarnini, S.2
-
30
-
-
79959438789
-
Telaprevir for previously untreated chronic hepatitis C virus infection
-
I. Jacobson, J. McHutchison, and G. Dusheiko et al. Telaprevir for previously untreated chronic hepatitis C virus infection N. Engl. J. Med. 364 2011 2405 2416
-
(2011)
N. Engl. J. Med.
, vol.364
, pp. 2405-2416
-
-
Jacobson, I.1
McHutchison, J.2
Dusheiko, G.3
-
31
-
-
84903724866
-
Simeprevir (TMC435) with peginterferon/ribavirin for treatment of chronic HCV genotype 1 infection in treatment-naïve patients: Efficacy in difficult-to-treat patient sub-population in the QUEST-1 and 2 Phase III trials
-
1-5 November, 2013, Washington DC, USA. (Abstract 1122)
-
Jacobson, I.; Dore, G.; Foster, G.; et al.; 2013. Simeprevir (TMC435) with peginterferon/ribavirin for treatment of chronic HCV genotype 1 infection in treatment-naïve patients: efficacy in difficult-to-treat patient sub-population in the QUEST-1 and 2 Phase III trials. In: 64th Annual Meeting of the American Association for the Study of Liver Disease. 1-5 November, 2013, Washington DC, USA. (Abstract 1122).
-
(2013)
64th Annual Meeting of the American Association for the Study of Liver Disease
-
-
Jacobson, I.1
Dore, G.2
Foster, G.3
-
32
-
-
77950203857
-
Viral resistance to specifically targeted antiviral therapies for hepatitis C (STAT-Cs)
-
T.L. Kieffer, A.D. Kwong, and G.R. Picchio Viral resistance to specifically targeted antiviral therapies for hepatitis C (STAT-Cs) J. Antimicrob. Chemother. 65 2010 202 212
-
(2010)
J. Antimicrob. Chemother.
, vol.65
, pp. 202-212
-
-
Kieffer, T.L.1
Kwong, A.D.2
Picchio, G.R.3
-
33
-
-
84863550914
-
Hepatitis C Viral evolution in genotypes 1 treatment-naïve and treatment-experienced patients receiving telaprevir-based therapy clinical trials
-
T. Kieffer, S. De Meyer, and D. Bartels et al. Hepatitis C Viral evolution in genotypes 1 treatment-naïve and treatment-experienced patients receiving telaprevir-based therapy clinical trials PLoS One 7 2012 e34372
-
(2012)
PLoS One
, vol.7
, pp. 34372
-
-
Kieffer, T.1
De Meyer, S.2
Bartels, D.3
-
34
-
-
58149388300
-
Naturally occurring dominant resistance mutations to HCV protease and polymerase inhibitors in treatment-naive patients
-
T. Kuntzen, J. Timm, and A. Berical et al. Naturally occurring dominant resistance mutations to HCV protease and polymerase inhibitors in treatment-naive patients Hepatology 48 2008 1769 1778
-
(2008)
Hepatology
, vol.48
, pp. 1769-1778
-
-
Kuntzen, T.1
Timm, J.2
Berical, A.3
-
35
-
-
84861109960
-
Genotype and subtype profiling of PSI-7977 as a nucleotide inhibitor of hepatitis C virus
-
A.M. Lam, C. Espiritu, and S. Bansal et al. Genotype and subtype profiling of PSI-7977 as a nucleotide inhibitor of hepatitis C virus Antimicrob. Agents Chemother. 56 2012 3359 3368
-
(2012)
Antimicrob. Agents Chemother.
, vol.56
, pp. 3359-3368
-
-
Lam, A.M.1
Espiritu, C.2
Bansal, S.3
-
36
-
-
84884245458
-
Antiviral effect, safety, and pharmacokinetics of 5 days'oral administration of deleobuvir (BI 207127), and investigational HCV RNA polymerase inhibitor, in patients with chronic hepatitis C
-
D. Larrey, A. Lohse, and C. Trepo et al. Antiviral effect, safety, and pharmacokinetics of 5 days'oral administration of deleobuvir (BI 207127), and investigational HCV RNA polymerase inhibitor, in patients with chronic hepatitis C Antimicrob. Agents Chemother. 57 2013 4727 4735
-
(2013)
Antimicrob. Agents Chemother.
, vol.57
, pp. 4727-4735
-
-
Larrey, D.1
Lohse, A.2
Trepo, C.3
-
37
-
-
78751637124
-
Safety and antiviral activity of ANA598 in combination with pegylated interferon alpha 2a plus ribavirin in treatment-naïve genotype-1 chronic HCV patients
-
E. Lawitz, M. Rodriguez-Torres, and V.K. Rustgi et al. Safety and antiviral activity of ANA598 in combination with pegylated interferon alpha 2a plus ribavirin in treatment-naïve genotype-1 chronic HCV patients Hepatology 52 2010 334A 335A
-
(2010)
Hepatology
, vol.52
-
-
Lawitz, E.1
Rodriguez-Torres, M.2
Rustgi, V.K.3
-
38
-
-
84903728088
-
GS-9669, a novel NS5B non-nucleoside thumb site II inhibitor, demonstrates potent antiviral activity, favorable safety profile and potential for once-daily
-
18-22 April 2012, Barcelona, Spain. (Abstract 1189)
-
Lawitz, E.; Hazan, L.; Gruener, D.; et al.; 2012. GS-9669, a novel NS5B non-nucleoside thumb site II inhibitor, demonstrates potent antiviral activity, favorable safety profile and potential for once-daily. In: 47th Annual Meeting of the European Association for the Study of the Liver, 18-22 April 2012, Barcelona, Spain. (Abstract 1189).
-
(2012)
47th Annual Meeting of the European Association for the Study of the Liver
-
-
Lawitz, E.1
Hazan, L.2
Gruener, D.3
-
39
-
-
84903692372
-
Sofosbuvir + peginterferon + ribavirin for 12 weeks achieves 90% SVR12 in genotype 1, 4, 5, or 6 HCV infected 90% SVR12 in genotype 1, 4, 5, or 6 HCV infected patients: The NEUTRINO study
-
24-28 April, Amsterdam, Belgium. (Abstract 1411)
-
Lawitz, E.; Wyles, D.; Davis, M.; et al.; 2013a. Sofosbuvir + peginterferon + ribavirin for 12 weeks achieves 90% SVR12 in genotype 1, 4, 5, or 6 HCV infected 90% SVR12 in genotype 1, 4, 5, or 6 HCV infected patients: the NEUTRINO study. In: 48th Annual Meeting of the European Association for the Study of the Liver, 24-28 April, Amsterdam, Belgium. (Abstract 1411).
-
(2013)
48th Annual Meeting of the European Association for the Study of the Liver
-
-
Lawitz, E.1
Wyles, D.2
Davis, M.3
-
40
-
-
84896710685
-
Sofosbuvir in combination with peginterferon and ribavirin for 12 weeks provides high SVR rates in HCV-infected genotype 2 or 3 treatment experienced patients with and without compensated cirrhosis: Results from the LONESTAR-2 study
-
1-5 November, 2013, Washington DC, USA. (Abstract LB-4)
-
Lawitz, E.; Poordad, F.; Brainard, D.M.; et al.; 2013b. Sofosbuvir in combination with peginterferon and ribavirin for 12 weeks provides high SVR rates in HCV-infected genotype 2 or 3 treatment experienced patients with and without compensated cirrhosis: results from the LONESTAR-2 study. In: 64th Annual Meeting of the American Association for the Study of Liver Disease, 1-5 November, 2013, Washington DC, USA. (Abstract LB-4).
-
(2013)
64th Annual Meeting of the American Association for the Study of Liver Disease
-
-
Lawitz, E.1
Poordad, F.2
Brainard . D, M.3
-
41
-
-
84894621765
-
Sofosbuvir and ledipasvir fixed-dose combination with and without ribavirin in treatment-naïve and previously treated patients with genotype 1 hepatitis C virus infection (LONESTAR): An open-label, randomized, phase 2 trial
-
E. Lawitz, F. Poordad, and P.S. Pang et al. Sofosbuvir and ledipasvir fixed-dose combination with and without ribavirin in treatment-naïve and previously treated patients with genotype 1 hepatitis C virus infection (LONESTAR): an open-label, randomized, phase 2 trial Lancet 383 2014 515 523
-
(2014)
Lancet
, vol.383
, pp. 515-523
-
-
Lawitz, E.1
Poordad, F.2
Pang, P.S.3
-
42
-
-
84868028511
-
Efficacy of re-treatment with TMC435 as combination therapy in hepatitis C virus-infected patients following TMC435 monotherapy
-
O. Lenz, J. Bruijne, and L. Vijgen et al. Efficacy of re-treatment with TMC435 as combination therapy in hepatitis C virus-infected patients following TMC435 monotherapy Gastroentorology 143 2012 1176 1178
-
(2012)
Gastroentorology
, vol.143
, pp. 1176-1178
-
-
Lenz, O.1
Bruijne, J.2
Vijgen, L.3
-
43
-
-
84874105854
-
Virologic response and characterization of HCV genotype 2-6 in patients receiving TMC435 (stydy TMC435-C202)
-
O. Lenz, L. Vijgen, and J.M. Berke et al. Virologic response and characterization of HCV genotype 2-6 in patients receiving TMC435 (stydy TMC435-C202) J. Hepatol. 58 2013 445 451
-
(2013)
J. Hepatol.
, vol.58
, pp. 445-451
-
-
Lenz, O.1
Vijgen, L.2
Berke, J.M.3
-
44
-
-
84903739791
-
Resistance analyses of HCV isolates from patients treated with simeprevir in Phase IIB/III studies
-
1-5 November, 2013, Washington DC, USA. (Abstract 1101)
-
Lenz, O.; Fevery, B.; Verbinnen, T.; et al.; 2013b. Resistance analyses of HCV isolates from patients treated with simeprevir in Phase IIB/III studies. In: 64th Annual Meeting of the American Association for the Study of Liver Disease. 1-5 November, 2013, Washington DC, USA. (Abstract 1101).
-
(2013)
64th Annual Meeting of the American Association for the Study of Liver Disease
-
-
Lenz, O.1
Fevery, B.2
Verbinnen, T.3
-
45
-
-
84957045395
-
TMC-435 in patients infected with HCV genotype 1 who failed previous pegylated interferon/ribavirin treatment: Virologic analyses of the ASPIRE trial
-
18-22 April 2013, Barcelona, Spain. (Abstract 1329)
-
Lenz, O.; Fevery, B.; Vijgen, L.; et al.; 2013. TMC-435 in patients infected with HCV genotype 1 who failed previous pegylated interferon/ribavirin treatment: virologic analyses of the ASPIRE trial. In: Presented at 49th Annual Meeting of the European Association for the Study of the Liver, 18-22 April 2013, Barcelona, Spain. (Abstract 1329).
-
(2013)
49th Annual Meeting of the European Association for the Study of the Liver
-
-
Lenz, O.1
Fevery, B.2
Vijgen, L.3
-
46
-
-
84902663575
-
High sustained viral response at 12- and 24-week follow-up of MK-5172 with pegylated interferon alfa-2b and ribavirin in HCV genotype 1 treatment-naïve non-cirrhotic patients
-
24-28 April, 2013, Amsterdam, Belgium. (Abstract 66)
-
Manns, M.; Vierling, J.M.; Bacon, B.R.; et al.; 2013. High sustained viral response at 12- and 24-week follow-up of MK-5172 with pegylated interferon alfa-2b and ribavirin in HCV genotype 1 treatment-naïve non-cirrhotic patients. In: 48th Annual Meeting of the European Association for the Study of the Liver (EASL 2013), 24-28 April, 2013, Amsterdam, Belgium. (Abstract 66).
-
(2013)
48th Annual Meeting of the European Association for the Study of the Liver (EASL 2013)
-
-
Manns, M.1
Vierling . J, M.2
Bacon . B, R.3
-
47
-
-
84903702178
-
All-oral dual therapy with daclatasvir and asunaprevir in patients with HCV genotype 1b infection: Phase 3 HALLMARK-DUAL study results
-
9-13 April 2013, London, UK. (Abstract O166)
-
Manss, M.; Pol, S.; Jacobson, I.M.; et al.; 2013. All-oral dual therapy with daclatasvir and asunaprevir in patients with HCV genotype 1b infection: phase 3 HALLMARK-DUAL study results. In: 49th Annual Meeting of the European Association for the Study of the Liver, 9-13 April 2013, London, UK. (Abstract O166).
-
(2013)
49th Annual Meeting of the European Association for the Study of the Liver
-
-
Manss, M.1
Pol, S.2
Jacobson . I, M.3
-
48
-
-
0026538287
-
Hepatitis C virus (HCV) circulates as a population of different but closely related genomes: Quasispecies nature of HCV genome distribution
-
M. Martell, J.I. Esteban, J. Quer, J. Genesca, A. Weiner, and R. Esteban et al. Hepatitis C virus (HCV) circulates as a population of different but closely related genomes: quasispecies nature of HCV genome distribution J. Virol. 66 1992 3225 3229
-
(1992)
J. Virol.
, vol.66
, pp. 3225-3229
-
-
Martell, M.1
Esteban, J.I.2
Quer, J.3
Genesca, J.4
Weiner, A.5
Esteban, R.6
-
49
-
-
84903741735
-
Development of a panel of genotype-specific resistance assays for the detection of amino acid changes in domain 1 of hepatitis C virus (HCV) NS5A associated with drug resistance
-
A.L. McCormick, L. Wang, and A. Garcia et al. Development of a panel of genotype-specific resistance assays for the detection of amino acid changes in domain 1 of hepatitis C virus (HCV) NS5A associated with drug resistance Antivir. Ther. 18 Suppl. 1 2013 A56
-
(2013)
Antivir. Ther.
, vol.18
, Issue.SUPPL. 1
, pp. 56
-
-
McCormick, A.L.1
Wang, L.2
Garcia, A.3
-
50
-
-
68249154875
-
Peginterferon alfa-2b or alfa-2a with ribavirin for treatment of hepatitis C infection
-
J. McHutchison, E. Lawitz, and M. Shiffman et al. Peginterferon alfa-2b or alfa-2a with ribavirin for treatment of hepatitis C infection N. Engl. J. Med. 361 2009 580 593
-
(2009)
N. Engl. J. Med.
, vol.361
, pp. 580-593
-
-
McHutchison, J.1
Lawitz, E.2
Shiffman, M.3
-
51
-
-
84862560600
-
Resistance analysis of the hepatitis C virus NS3 protease inhibitor asunaprevir
-
F. Mcphee, J. Friborg, and S. Levine et al. Resistance analysis of the hepatitis C virus NS3 protease inhibitor asunaprevir Antimicrob. Agents Chemother. 56 2012 3670 3681
-
(2012)
Antimicrob. Agents Chemother.
, vol.56
, pp. 3670-3681
-
-
McPhee, F.1
Friborg, J.2
Levine, S.3
-
52
-
-
84873054024
-
A description of virologic escape in HCV genotype 1-infected patients treated with daclatasvir (BMS-790052) in combination with ribavirin and peginterferon alfa-2a or peinterferon alfa-2b
-
F. McPhee, D. Hernandez, and F. Yu et al. A description of virologic escape in HCV genotype 1-infected patients treated with daclatasvir (BMS-790052) in combination with ribavirin and peginterferon alfa-2a or peinterferon alfa-2b J. Hepatol. 56 2012 S473
-
(2012)
J. Hepatol.
, vol.56
, pp. 473
-
-
McPhee, F.1
Hernandez, D.2
Yu, F.3
-
53
-
-
84903732473
-
Analysis of HCV resistance variants in a phase 3 trial of daclatasvir combined with asunaprevir for Japanese patients with genotype 1b infection
-
1-5 November, 2013, Washington DC, USA. (Abstract 1111)
-
McPhee, F.; Toyota, J.; Chayama, D.; et al.; 2013. Analysis of HCV resistance variants in a phase 3 trial of daclatasvir combined with asunaprevir for Japanese patients with genotype 1b infection. In: 64th Annual Meeting of the American Association for the Study of Liver Disease, 1-5 November, 2013, Washington DC, USA. (Abstract 1111).
-
(2013)
64th Annual Meeting of the American Association for the Study of Liver Disease
-
-
McPhee, F.1
Toyota, J.2
Chayama, D.3
-
54
-
-
0032475822
-
Hepatitis C viral dynamics in vivo and the antiviral efficacy of interferon-α therapy
-
DOI 10.1126/science.282.5386.103
-
A.U. Neumann, N.P. Lam, and H. Dahari et al. Hepatitis C viral dynamics in vivo and the antiviral efficacy of interferon-alpha therapy Science 282 1998 103 107 (Pubitemid 28471138)
-
(1998)
Science
, vol.282
, Issue.5386
, pp. 103-107
-
-
Neumann, A.U.1
Lam, N.P.2
Dahari, H.3
Gretch, D.R.4
Wiley, T.E.5
Layden, T.J.6
Perelson, A.S.7
-
55
-
-
84878036817
-
Resistance-associated amino acid variants associated with boceprevir plus pegylated interferon-2b and ribavirin in patients with chronic hepatitis C in the SPRINT-1 trial
-
R.A. Ogert, J.A. Howe, and J.M. Vierling et al. Resistance-associated amino acid variants associated with boceprevir plus pegylated interferon-2b and ribavirin in patients with chronic hepatitis C in the SPRINT-1 trial Antivir. Ther. 18 2013 387 397
-
(2013)
Antivir. Ther.
, vol.18
, pp. 387-397
-
-
Ogert, R.A.1
Howe, J.A.2
Vierling, J.M.3
-
56
-
-
84883089005
-
Sofosbuvir and ribavirin for hepatitis C genotype 1 in patients with unfavorable treatment characteristics: A randomized clinical trial
-
A. Osinusi, E.G. Meissner, and Y.-J. Lee et al. Sofosbuvir and ribavirin for hepatitis C genotype 1 in patients with unfavorable treatment characteristics: a randomized clinical trial JAMA 310 2013 804 811
-
(2013)
JAMA
, vol.310
, pp. 804-811
-
-
Osinusi, A.1
Meissner, E.G.2
Lee, Y.-J.3
-
57
-
-
34250803753
-
Binding-site identification and genotypic profiling of hepatitis C virus polymerase inhibitors
-
DOI 10.1128/JVI.01543-06
-
F. Pauwels, W. Mostmans, and L. Quirymen et al. Binding-site identification and genotypic profiling of hepatitis C virus polymerase inhibitors J. Virol. 81 2007 6909 6919 (Pubitemid 46986627)
-
(2007)
Journal of Virology
, vol.81
, Issue.13
, pp. 6909-6919
-
-
Pauwels, F.1
Mostmans, W.2
Quirynen, L.M.M.3
Van Der Helm, L.4
Boutton, C.W.5
Rueff, A.-S.6
Cleiren, E.7
Raboisson, P.8
Surleraux, D.9
Nyanguile, O.10
Simmen, K.A.11
-
58
-
-
84876582239
-
Treatment of chronic hepatitis C: Current and future
-
J.M. Pawlotsky Treatment of chronic hepatitis C: current and future Curr. Top. Microbiol. Immunol. 369 2013 321 342
-
(2013)
Curr. Top. Microbiol. Immunol.
, vol.369
, pp. 321-342
-
-
Pawlotsky, J.M.1
-
59
-
-
34247895578
-
The Hepatitis C Virus Life Cycle as a Target for New Antiviral Therapies
-
DOI 10.1053/j.gastro.2007.03.116, PII S0016508507006427
-
J.M. Pawlotsky, S. Chevaliez, and J. McHutchison The hepatitis C virus life cycle as a target for new antiviral therapies Gastroenterology 132 2007 1979 1998 (Pubitemid 46695724)
-
(2007)
Gastroenterology
, vol.132
, Issue.5
, pp. 1979-1998
-
-
Pawlotsky, J.1
Chevaliez, S.2
McHutchison, J.G.3
-
60
-
-
84861655785
-
Resistance to mericitabine, a nucleoside analogue inhibitor of HCV RNA-dependent RNA polymerase
-
J.M. Pawlotsky, I. Najera, and I. Jacobson Resistance to mericitabine, a nucleoside analogue inhibitor of HCV RNA-dependent RNA polymerase Antivir. Ther. 17 2012 411 423
-
(2012)
Antivir. Ther.
, vol.17
, pp. 411-423
-
-
Pawlotsky, J.M.1
Najera, I.2
Jacobson, I.3
-
61
-
-
79960937707
-
Evidence for separation of HCV subtype 1a into two distinct clades
-
B.E. Pickett, R. Striker, and E.J. Lefkowitz Evidence for separation of HCV subtype 1a into two distinct clades J. Viral Hepat. 18 2011 608 618
-
(2011)
J. Viral Hepat.
, vol.18
, pp. 608-618
-
-
Pickett, B.E.1
Striker, R.2
Lefkowitz, E.J.3
-
62
-
-
81855199759
-
Impact of antiretroviral therapy on the variability of the HCV NS5B polymerase in HIV/HCV co-infected patients
-
Z. Plaza, V. Soriano, and M.M. Gonzales et al. Impact of antiretroviral therapy on the variability of the HCV NS5B polymerase in HIV/HCV co-infected patients J. Antimicrob. Chemother. 66 2011 2838 2842
-
(2011)
J. Antimicrob. Chemother.
, vol.66
, pp. 2838-2842
-
-
Plaza, Z.1
Soriano, V.2
Gonzales, M.M.3
-
63
-
-
84858415895
-
Prevalence of natural polymorphisms at the HCV NS5A gene associated with resistance to daclatasvir, an NS5A inhibitor
-
Z. Plaza, V. Soriano, and E. Vispo et al. Prevalence of natural polymorphisms at the HCV NS5A gene associated with resistance to daclatasvir, an NS5A inhibitor Antivir. Ther. 17 2012 921 926
-
(2012)
Antivir. Ther.
, vol.17
, pp. 921-926
-
-
Plaza, Z.1
Soriano, V.2
Vispo, E.3
-
64
-
-
84870044735
-
Nucleoside/nucleotide analogue polymerase inhibitors in development
-
P. Pockros Nucleoside/nucleotide analogue polymerase inhibitors in development Clin. Liver Dis. 17 2013 123 128
-
(2013)
Clin. Liver Dis.
, vol.17
, pp. 123-128
-
-
Pockros, P.1
-
65
-
-
84881025292
-
JUMP-C: A randomized trial of mericitabine plus pegylated interferón alpha-2a/ribavirin for 24 weeks in treatment-naive HCV genotypes 1/4 patients
-
P.J. Pockros, D. Jensen, and N. Tsai et al. JUMP-C: a randomized trial of mericitabine plus pegylated interferón alpha-2a/ribavirin for 24 weeks in treatment-naive HCV genotypes 1/4 patients Hepatology 58 2013 514 523
-
(2013)
Hepatology
, vol.58
, pp. 514-523
-
-
Pockros, P.J.1
Jensen, D.2
Tsai, N.3
-
66
-
-
79953173221
-
Boceprevir for untreated chronic HCV genotype 1 infection
-
F. Poordad, J. McCone, and B. Bacon et al. Boceprevir for untreated chronic HCV genotype 1 infection N. Engl. J. Med. 364 2011 1195 1206
-
(2011)
N. Engl. J. Med.
, vol.364
, pp. 1195-1206
-
-
Poordad, F.1
McCone, J.2
Bacon, B.3
-
68
-
-
84858421432
-
Drug resistance testing in hepatitis C therapy
-
E. Poveda, and V. Soriano Drug resistance testing in hepatitis C therapy Future Virol. 7 2012 1 13
-
(2012)
Future Virol.
, vol.7
, pp. 1-13
-
-
Poveda, E.1
Soriano, V.2
-
69
-
-
84856252248
-
Predicted challenges using direct acting antivirals in the current HIV-HCV coinfected population in Spain
-
E. Poveda, E. Vispo, and P. Barreiro et al. Predicted challenges using direct acting antivirals in the current HIV-HCV coinfected population in Spain Antivir. Ther. 17 2012 571 575
-
(2012)
Antivir. Ther.
, vol.17
, pp. 571-575
-
-
Poveda, E.1
Vispo, E.2
Barreiro, P.3
-
70
-
-
84855494000
-
Biochemical activities of the HCV NS5B RNA-dependent RNA polymerase
-
S.L. Tan, 1st ed. Horizon Bioscience Norfolk
-
C.T. Ranjith-Kumar, and C. Cheng Kao Biochemical activities of the HCV NS5B RNA-dependent RNA polymerase S.L. Tan, Hepatitis C Viruses: Genomes and Molecular Biology 1st ed. 2006 Horizon Bioscience Norfolk 293 310
-
(2006)
Hepatitis C Viruses: Genomes and Molecular Biology
, pp. 293-310
-
-
Ranjith-Kumar, C.T.1
Cheng Kao, C.2
-
71
-
-
75149151884
-
Resistance to direct antiviral agents in patients with hepatitis C virus infection
-
C. Sarrazin, and S. Zeuzem Resistance to direct antiviral agents in patients with hepatitis C virus infection Gastroenterology 138 2010 447 462
-
(2010)
Gastroenterology
, vol.138
, pp. 447-462
-
-
Sarrazin, C.1
Zeuzem, S.2
-
72
-
-
84896511970
-
Treatment with telaprevir/PEG-IFN/RBV after 14 days telaprevir exposure in phase i studies: Results from the phase IIIB C219 rollover study
-
C. Sarrazin, H. Reesink, and S. Zeuzem et al. Treatment with telaprevir/PEG-IFN/RBV after 14 days telaprevir exposure in phase I studies: results from the phase IIIB C219 rollover study J. Hepatol. 58 2013 S369 S370
-
(2013)
J. Hepatol.
, vol.58
-
-
Sarrazin, C.1
Reesink, H.2
Zeuzem, S.3
-
73
-
-
84856903158
-
Follow-up of SVR durability and viral resistance in patients with chronic hepatitis C treated with telaprevir-based regimens: Interim analysis of the extend study
-
Sherman, K.; Sulkowski, M.; Zoulim, F.; et al.; 2011. Follow-up of SVR durability and viral resistance in patients with chronic hepatitis C treated with telaprevir-based regimens: interim analysis of the extend study. Hepatology 54, 485A-486A.
-
(2011)
Hepatology
, vol.54
-
-
Sherman, K.1
Sulkowski, M.2
Zoulim, F.3
-
74
-
-
45749088957
-
Why are there different dynamics in the selection of drug resistance in HIV and hepatitis B and C viruses?
-
DOI 10.1093/jac/dkn175
-
V. Soriano, A. Perelson, and F. Zoulim Why are there different dynamics in the selection of drug resistance in HIV and hepatitis B and C viruses? J. Antimicrob. Chemother. 62 2008 1 4 (Pubitemid 351865869)
-
(2008)
Journal of Antimicrobial Chemotherapy
, vol.62
, Issue.1
, pp. 1-4
-
-
Soriano, V.1
Perelson, A.S.2
Zoulim, F.3
-
75
-
-
79960444768
-
Directly acting antivirals against hepatitis C virus
-
V. Soriano, E. Vispo, and E. Poveda et al. Directly acting antivirals against hepatitis C virus J. Antimicrob. Chemother. 66 2011 1673 1686
-
(2011)
J. Antimicrob. Chemother.
, vol.66
, pp. 1673-1686
-
-
Soriano, V.1
Vispo, E.2
Poveda, E.3
-
77
-
-
84892619580
-
Daclatasvir plus sofosbuvir for previously treated or untreated chronic HCV infection
-
M. Sulkowski, D. Gardiner, and M. Rodriguez-Torres et al. Daclatasvir plus sofosbuvir for previously treated or untreated chronic HCV infection N. Engl. J. Med. 370 2014 211 221
-
(2014)
N. Engl. J. Med.
, vol.370
, pp. 211-221
-
-
Sulkowski, M.1
Gardiner, D.2
Rodriguez-Torres, M.3
-
78
-
-
84864387126
-
MK-5172, a selective inhibitor of hepatitis C virus NS3/4A protease with broad activity across genotypes and resistant variants
-
V. Summa, S.W. Ludmerer, and J.A. McCauley et al. MK-5172, a selective inhibitor of hepatitis C virus NS3/4A protease with broad activity across genotypes and resistant variants Antimicrob. Agents Chemother. 56 2012 416 417
-
(2012)
Antimicrob. Agents Chemother.
, vol.56
, pp. 416-417
-
-
Summa, V.1
Ludmerer, S.W.2
McCauley, J.A.3
-
80
-
-
84894271490
-
In vivo emergence of a novel mutant L159F/L320F in the NS5B polymerase confers low-level resistance to the HCV polymerase inhibitors mericitabine and sofosbuvir
-
X. Tong, S. Le Pogam, L. Li, K. Haines, K. Piso, V. Baronas, J.M. Yan, S.S. So, K. Klumpp, and I. Nájera In vivo emergence of a novel mutant L159F/L320F in the NS5B polymerase confers low-level resistance to the HCV polymerase inhibitors mericitabine and sofosbuvir J. Infect. Dis. 209 2014 668 675
-
(2014)
J. Infect. Dis.
, vol.209
, pp. 668-675
-
-
Tong, X.1
Le Pogam, S.2
Li, L.3
Haines, K.4
Piso, K.5
Baronas, V.6
Yan, J.M.7
So, S.S.8
Klumpp, K.9
Nájera, I.10
-
81
-
-
79959401302
-
Natural polymorphisms associated with resistance to new antivirals against hepatitis C virus (HCV) in newly diagnosed HIV/HCV-coinfected patients in Spain
-
A. Treviño, C. de Mendoza, and P. Parra et al. Natural polymorphisms associated with resistance to new antivirals against hepatitis C virus (HCV) in newly diagnosed HIV/HCV-coinfected patients in Spain Antivir. Ther. 16 2011 413 416
-
(2011)
Antivir. Ther.
, vol.16
, pp. 413-416
-
-
Treviño, A.1
De Mendoza, C.2
Parra, P.3
-
82
-
-
80051599715
-
HCV protease variability and anti-HCV protease inhibitor resistance in HIV/HCV-coinfected patients
-
P. Trimoulet, C. Belzunce, and M. Faure et al. HCV protease variability and anti-HCV protease inhibitor resistance in HIV/HCV-coinfected patients HIV Med. 12 2011 506 509
-
(2011)
HIV Med.
, vol.12
, pp. 506-509
-
-
Trimoulet, P.1
Belzunce, C.2
Faure, M.3
-
83
-
-
84857186976
-
Characterization of resistance to the nonnucleoside NS5B inhibitor filibuvir in hepatitis C virus-infected patients
-
P. Troke, M. Lewis, and P. Simpson et al. Characterization of resistance to the nonnucleoside NS5B inhibitor filibuvir in hepatitis C virus-infected patients Antimicrob. Agents Chemother. 56 2012 1331 1339
-
(2012)
Antimicrob. Agents Chemother.
, vol.56
, pp. 1331-1339
-
-
Troke, P.1
Lewis, M.2
Simpson, P.3
-
85
-
-
1642288430
-
-
World Health Organization Updated July
-
World Health Organization. Hepatitis C factsheet No. 164. Updated July 2013. Available from: < http://www.who.int/mediacentre/factsheets/fs164/en/ >.
-
(2013)
Hepatitis C Factsheet No. 164
-
-
-
86
-
-
84961680766
-
Impact of viral sequences beyond HCV NS5A domain i on viral susceptibility to NS5A inhibitors
-
G. Yang, Y. Zhao, and D. Patel et al. Impact of viral sequences beyond HCV NS5A domain I on viral susceptibility to NS5A inhibitors Antivir. Ther. 18 Suppl. 1 2013 A59
-
(2013)
Antivir. Ther.
, vol.18
, Issue.SUPPL. 1
, pp. 59
-
-
Yang, G.1
Zhao, Y.2
Patel, D.3
-
87
-
-
79959381354
-
Telaprevir for retreatment of HCV infection
-
S. Zeuzem, P. Andreone, and S. Pol et al. Telaprevir for retreatment of HCV infection N. Engl. J. Med. 364 2011 2417 2428
-
(2011)
N. Engl. J. Med.
, vol.364
, pp. 2417-2428
-
-
Zeuzem, S.1
Andreone, P.2
Pol, S.3
-
88
-
-
84857415002
-
The protease inhibitor, GS-9256, and non-nucleoside polymerase inhibitor tegobuvir alone, with ribavirin or pegylated interferon plus ribavirin in hepatitis C
-
S. Zeuzem, P. Buggisch, and K. Agarwal et al. The protease inhibitor, GS-9256, and non-nucleoside polymerase inhibitor tegobuvir alone, with ribavirin or pegylated interferon plus ribavirin in hepatitis C Hepatology 55 2012 749 758
-
(2012)
Hepatology
, vol.55
, pp. 749-758
-
-
Zeuzem, S.1
Buggisch, P.2
Agarwal, K.3
-
89
-
-
84903739022
-
Sofosbuvir + ribavirin for 12 or 24 weeks for patients with HCV genotypes 2 or 3: The VALANCE trial
-
1-5 November, 2013, Washington DC, USA. (Abstract 1085)
-
Zeuzem, S.; Dusheiko, G.M.; Salupere, R.; et al.; 2013. Sofosbuvir + ribavirin for 12 or 24 weeks for patients with HCV genotypes 2 or 3: the VALANCE trial. In: 64th Annual Meeting of the American Association for the Study of Liver Disease, 1-5 November, 2013, Washington DC, USA. (Abstract 1085).
-
(2013)
64th Annual Meeting of the American Association for the Study of Liver Disease
-
-
Zeuzem, S.1
Dusheiko . G, M.2
Salupere, R.3
|