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Volumn 108, Issue 1, 2014, Pages 181-191

Update on hepatitis C virus resistance to direct-acting antiviral agents

Author keywords

Direct acting antivirals; Drug resistance; Hepatitis C virus

Indexed keywords

ANTIVIRUS AGENT; BOCEPREVIR; DACLATASVIR; INTERLEUKIN 28B; LEDIPASVIR; MERICITABINE; NONNUCLEOSIDE REVERSE TRANSCRIPTASE INHIBITOR; NONSTRUCTURAL PROTEIN 3; NONSTRUCTURAL PROTEIN 5A; NONSTRUCTURAL PROTEIN 5B; PEGINTERFERON ALPHA; PROTEINASE INHIBITOR; RIBAVIRIN; SOFOSBUVIR; TELAPREVIR; NS-5 PROTEIN, HEPATITIS C VIRUS; NS3 PROTEIN, HEPATITIS C VIRUS; VIRUS PROTEIN;

EID: 84903701056     PISSN: 01663542     EISSN: 18729096     Source Type: Journal    
DOI: 10.1016/j.antiviral.2014.05.015     Document Type: Review
Times cited : (173)

References (89)
  • 2
    • 84898669547 scopus 로고    scopus 로고
    • Ledipasvir and sofosbuvir for previously treated HCV genotype 1 infection
    • N. Afdhal, K. Reddy, and D. Nelson et al. Ledipasvir and sofosbuvir for previously treated HCV genotype 1 infection N. Engl. J. Med. 370 2014 1483 1493
    • (2014) N. Engl. J. Med. , vol.370 , pp. 1483-1493
    • Afdhal, N.1    Reddy, K.2    Nelson, D.3
  • 3
    • 84900339263 scopus 로고    scopus 로고
    • Ledipasvir and sofosbuvir for untreated HCV genotype 1 infection
    • N. Afdhal, S. Zeuzem, and P. Kwo et al. Ledipasvir and sofosbuvir for untreated HCV genotype 1 infection N. Engl. J. Med. 2014
    • (2014) N. Engl. J. Med.
    • Afdhal, N.1    Zeuzem, S.2    Kwo, P.3
  • 4
    • 57049112290 scopus 로고    scopus 로고
    • Selected replicon variants with low-level in vitro resistance to the hepatitis C virus NS5B polymerase inhibitor PSI-6130 lack cross-resistance with R1479
    • S. Ali, V. Leveque, and S. Le Pogam et al. Selected replicon variants with low-level in vitro resistance to the hepatitis C virus NS5B polymerase inhibitor PSI-6130 lack cross-resistance with R1479 Antimicrob. Agents Chemother. 52 2008 4356 4369
    • (2008) Antimicrob. Agents Chemother. , vol.52 , pp. 4356-4369
    • Ali, S.1    Leveque, V.2    Le Pogam, S.3
  • 5
    • 84887994430 scopus 로고    scopus 로고
    • Sofosbuvir-based interferon-free therapy for patients with HCV infection
    • Available from: < >
    • T. Asselah Sofosbuvir-based interferon-free therapy for patients with HCV infection J. Hepatol 2013 Available from: < http://dx.doi.org/10.101016/j. jhep.2013.07.023 >
    • (2013) J. Hepatol
    • Asselah, T.1
  • 6
    • 84872038038 scopus 로고    scopus 로고
    • Interferon free therapy with direct acting antivirals for HCV
    • T. Asselah, and P. Marcelin Interferon free therapy with direct acting antivirals for HCV Liver Int. 33 Suppl. 1 2013 93 104
    • (2013) Liver Int. , vol.33 , Issue.SUPPL. 1 , pp. 93-104
    • Asselah, T.1    Marcelin, P.2
  • 7
    • 79953176289 scopus 로고    scopus 로고
    • Boceprevir for previously treated chronic HCV genotype 1 infection
    • B. Bacon, S. Gordon, and E. Lawitz et al. Boceprevir for previously treated chronic HCV genotype 1 infection N. Engl. J. Med. 364 2011 1207 1217
    • (2011) N. Engl. J. Med. , vol.364 , pp. 1207-1217
    • Bacon, B.1    Gordon, S.2    Lawitz, E.3
  • 8
    • 78649644443 scopus 로고    scopus 로고
    • Susceptibility of treatment-naïve hepatitis C virus (HCV) clinical isolates to HCV protease inhibitors
    • A. Bae, S.C. Sun, and X. Qi et al. Susceptibility of treatment-naïve hepatitis C virus (HCV) clinical isolates to HCV protease inhibitors Antimicrob. Agents Chemother. 54 2010 5288 5297
    • (2010) Antimicrob. Agents Chemother. , vol.54 , pp. 5288-5297
    • Bae, A.1    Sun, S.C.2    Qi, X.3
  • 9
    • 84882876118 scopus 로고    scopus 로고
    • Analysis of boceprevir resistance associated amino acid variants (RAVs) in two phase 3 boceprevir clinical trials
    • R.J. Barnard, J.A. Howe, and R.A. Ogert et al. Analysis of boceprevir resistance associated amino acid variants (RAVs) in two phase 3 boceprevir clinical trials Virology 444 2012 329 336
    • (2012) Virology , vol.444 , pp. 329-336
    • Barnard, R.J.1    Howe, J.A.2    Ogert, R.A.3
  • 10
    • 51749123143 scopus 로고    scopus 로고
    • Natural prevalence of HCV variants with decreased sensitivity to NS3-4A protease inhibitors in treatment-naïve subjects
    • D. Bartels, Y. Zhou, and E. Zhang et al. Natural prevalence of HCV variants with decreased sensitivity to NS3-4A protease inhibitors in treatment-naïve subjects J. Infect. Dis. 198 2008 800 807
    • (2008) J. Infect. Dis. , vol.198 , pp. 800-807
    • Bartels, D.1    Zhou, Y.2    Zhang, E.3
  • 11
    • 84884259683 scopus 로고    scopus 로고
    • Viral resistance in hepatitis C genotype-1 infected patients receiving the NS3 protease inhibitor faldaprevir (BI 2011335) in a phase 1b multiple rising-dose study
    • K.L. Berger, L. Lagacé, and I. Triki et al. Viral resistance in hepatitis C genotype-1 infected patients receiving the NS3 protease inhibitor faldaprevir (BI 2011335) in a phase 1b multiple rising-dose study Antimicrob. Agents Chemother. 57 2013 4928 4936
    • (2013) Antimicrob. Agents Chemother. , vol.57 , pp. 4928-4936
    • Berger, K.L.1    Lagacé, L.2    Triki, I.3
  • 12
    • 0036120573 scopus 로고    scopus 로고
    • Structural analysis of the hepatitis C virus RNA polymerase in complex with ribonucleotides
    • DOI 10.1128/JVI.76.7.3482-3492.2002
    • S. Bressanelli, L. Tomei, and F. Rey et al. Structural analysis of the hepatitis C virus RNA polymerase in complex with ribonucleotides J. Virol. 76 2002 3482 3492 (Pubitemid 34224549)
    • (2002) Journal of Virology , vol.76 , Issue.7 , pp. 3482-3492
    • Bressanelli, S.1    Tomei, L.2    Rey, F.A.3    De Francesco, R.4
  • 13
    • 35748953422 scopus 로고    scopus 로고
    • Advances in the development of new therapeutic agents targeting the NS3-4A serine protease or the NS5B RNA-dependent RNA polymerase of the hepatitis C virus
    • DOI 10.1016/j.addr.2007.04.016, PII S0169409X07001299, Toward Evidence Based Control of Hepatitis C Virus Infection
    • R. De Francesco, and A. Carfi Advances in the development of new therapeutic agents targeting NS3-4A serine protease or the NS5b RNA-dependent RNA polymerase of the hepatitis C virus Adv. Drug Deliv. Rev. 59 2007 1242 1262 (Pubitemid 350047514)
    • (2007) Advanced Drug Delivery Reviews , vol.59 , Issue.12 , pp. 1242-1262
    • De Francesco, R.1    Carfi, A.2
  • 14
    • 84893516367 scopus 로고    scopus 로고
    • Two distinct HCV genotype 1a clades: Geographical distribution and association with natural resistance mutations to HCV NS3/4A inhibitors
    • A. De Luca, S. Di Giambenedetto, and M. Prosperi et al. Two distinct HCV genotype 1a clades: geographical distribution and association with natural resistance mutations to HCV NS3/4A inhibitors Antivir. Ther. 18 Suppl. 1 2013 A47
    • (2013) Antivir. Ther. , vol.18 , Issue.SUPPL. 1 , pp. 47
    • De Luca, A.1    Di Giambenedetto, S.2    Prosperi, M.3
  • 15
    • 84903690431 scopus 로고    scopus 로고
    • Second wave anti-HCV protease inhibitors. Too Little too late?
    • (epub ahead of print)
    • S. De Nicola, and A. Aqhemo Second wave anti-HCV protease inhibitors. Too Little too late? Liver Int. 2014 (epub ahead of print)
    • (2014) Liver Int.
    • De Nicola, S.1    Aqhemo, A.2
  • 16
    • 84903747001 scopus 로고    scopus 로고
    • Daclatasvir combined with peginterferon alfa 2a-ribavirin for 12 or 16 weeks in patients with hepatitis C virus genotype 2 or 3 infection: COMMAND GT 2/3 study
    • 24-28 April 2013, Amsterdam, Belgium. (Abstract 1418)
    • Dore, G.J.; Lawitz, E.; Hezode, C.; et al.; 2013. Daclatasvir combined with peginterferon alfa 2a-ribavirin for 12 or 16 weeks in patients with hepatitis C virus genotype 2 or 3 infection: COMMAND GT 2/3 study. In: 48th Annual Meeting of the European Association for the Study of the Liver, 24-28 April 2013, Amsterdam, Belgium. (Abstract 1418).
    • (2013) 48th Annual Meeting of the European Association for the Study of the Liver
    • Dore . G, J.1    Lawitz, E.2    Hezode, C.3
  • 17
    • 79960453276 scopus 로고    scopus 로고
    • EASL clinical practice guidelines: Management of hepatitis C virus infection
    • Association For The Study Of The Liver E.
    • European Association for the Study of the Liver EASL clinical practice guidelines: management of hepatitis C virus infection J. Hepatol. 55 2011 245 264
    • (2011) J. Hepatol. , vol.55 , pp. 245-264
  • 18
    • 84903705964 scopus 로고    scopus 로고
    • Characterization of HCV NS3 protease variants from patients enrolled in a 28-day phase 2a trial of ACH-1625 daily dosing plus pegIFN-alpha 2a/RBV
    • 18-22 April 2012, Barcelona, Spain. (Abstract 1182)
    • Fabrycki, J.; Patel, D.; Yang, G.; et al.; 2012. Characterization of HCV NS3 protease variants from patients enrolled in a 28-day phase 2a trial of ACH-1625 daily dosing plus pegIFN-alpha 2a/RBV. In: 47th Annual Meeting of the European Association for the Study of the Liver, 18-22 April 2012, Barcelona, Spain. (Abstract 1182).
    • (2012) 47th Annual Meeting of the European Association for the Study of the Liver
    • Fabrycki, J.1    Patel, D.2    Yang, G.3
  • 19
    • 84903711896 scopus 로고    scopus 로고
    • Sofosbuvir-based regimens are associated with high SVR rates across genotypes and among patients with multiple negative predictive factors
    • 9-13 April, 2014, London, UK. (Abstract 066)
    • Foster, G.; et al.; 2014. Sofosbuvir-based regimens are associated with high SVR rates across genotypes and among patients with multiple negative predictive factors. In: 49th Annual Meeting of the European Association for the Study of the Liver, 9-13 April, 2014, London, UK. (Abstract 066).
    • (2014) 49th Annual Meeting of the European Association for the Study of the Liver
    • Foster, G.1
  • 20
    • 77956116880 scopus 로고    scopus 로고
    • Resistance analysis of the hepatitis C virus NS5A inhibitor BMS-790052 in an in vitro replicon system
    • R. Fridell, D. Qiu, C. Wang, L. Valera, and M. Gao Resistance analysis of the hepatitis C virus NS5A inhibitor BMS-790052 in an in vitro replicon system Antimicrob. Agents Chemother. 54 2010 3641 3650
    • (2010) Antimicrob. Agents Chemother. , vol.54 , pp. 3641-3650
    • Fridell, R.1    Qiu, D.2    Wang, C.3    Valera, L.4    Gao, M.5
  • 21
    • 82455192239 scopus 로고    scopus 로고
    • Genotypic and phenotypic analysis of variants resistant to hepatitis C virus nonstructural protein 5A replication complex inhibitor BMS-790052 in humans: In vitro and in vivo correlations
    • R.A. Fridell, C.F. Wang, and J.H. Sun et al. Genotypic and phenotypic analysis of variants resistant to hepatitis C virus nonstructural protein 5A replication complex inhibitor BMS-790052 in humans: in vitro and in vivo correlations Hepatology 54 2011 1924 1935
    • (2011) Hepatology , vol.54 , pp. 1924-1935
    • Fridell, R.A.1    Wang, C.F.2    Sun, J.H.3
  • 22
    • 84866119318 scopus 로고    scopus 로고
    • Interferon-free treatment with a combination of mericitabine and danoprevir/r with or without ribavirin in treatment-naive HCV genotype-1 infected patients
    • E.J. Gane et al. Interferon-free treatment with a combination of mericitabine and danoprevir/r with or without ribavirin in treatment-naive HCV genotype-1 infected patients J. Hepatol 56 Suppl. S2 2012 S555 S556
    • (2012) J. Hepatol , vol.56 , Issue.SUPPL. S2
    • Gane, E.J.1
  • 23
    • 84866119318 scopus 로고    scopus 로고
    • Interferon-free treatment with a combination of mericitabine and danoprevir/r with or without ribavirin in treatment-naïve HCV genotype 1-infected patients
    • E.J. Gane, P. Pockros, and S. Zeuzem et al. Interferon-free treatment with a combination of mericitabine and danoprevir/r with or without ribavirin in treatment-naïve HCV genotype 1-infected patients J. Hepatol. 56 2012 S555 S556
    • (2012) J. Hepatol. , vol.56
    • Gane, E.J.1    Pockros, P.2    Zeuzem, S.3
  • 24
    • 84885949784 scopus 로고    scopus 로고
    • Antiviral activity and resistance of HCV NS5A replication complex inhibitors
    • M. Gao Antiviral activity and resistance of HCV NS5A replication complex inhibitors Curr. Opin. Virol. 3 2013 1 7
    • (2013) Curr. Opin. Virol. , vol.3 , pp. 1-7
    • Gao, M.1
  • 25
    • 77952035218 scopus 로고    scopus 로고
    • Chemical genetics strategy identifies an HCV NS5A inhibitor with a potent clinical effect
    • M. Gao, R. Nettles, and M. Belema et al. Chemical genetics strategy identifies an HCV NS5A inhibitor with a potent clinical effect Nature 465 2010 96 100
    • (2010) Nature , vol.465 , pp. 96-100
    • Gao, M.1    Nettles, R.2    Belema, M.3
  • 26
    • 70349292099 scopus 로고    scopus 로고
    • Genetic variation in IL28B predicts hepatitis C treatment-induced viral clearance
    • D. Ge, J. Fellay, and A. Thompson et al. Genetic variation in IL28B predicts hepatitis C treatment-induced viral clearance Nature 461 2009 399 401
    • (2009) Nature , vol.461 , pp. 399-401
    • Ge, D.1    Fellay, J.2    Thompson, A.3
  • 27
    • 84871814966 scopus 로고    scopus 로고
    • Nucleotide polymerase inhibitor sofosbuvir plus ribavirin for hepatitis C
    • E.J. Gene, C.A. Stedman, and R.H. Hyland et al. Nucleotide polymerase inhibitor sofosbuvir plus ribavirin for hepatitis C N. Engl. J. Med. 368 2013 34 44
    • (2013) N. Engl. J. Med. , vol.368 , pp. 34-44
    • Gene, E.J.1    Stedman, C.A.2    Hyland, R.H.3
  • 28
    • 84872050504 scopus 로고    scopus 로고
    • New therapeutic strategies in HCV: Polymerase inhibitors
    • L. Gerber, T. Welzel, and S. Zeuzem New therapeutic strategies in HCV: polymerase inhibitors Liver Int. 33 Suppl. 1 2013 85 92
    • (2013) Liver Int. , vol.33 , Issue.SUPPL. 1 , pp. 85-92
    • Gerber, L.1    Welzel, T.2    Zeuzem, S.3
  • 29
    • 79958830099 scopus 로고    scopus 로고
    • Hepatitis C virus resistance to protease inhibitors
    • P. Halfon, and S. Locarnini Hepatitis C virus resistance to protease inhibitors J. Hepatol. 55 2011 192 206
    • (2011) J. Hepatol. , vol.55 , pp. 192-206
    • Halfon, P.1    Locarnini, S.2
  • 30
    • 79959438789 scopus 로고    scopus 로고
    • Telaprevir for previously untreated chronic hepatitis C virus infection
    • I. Jacobson, J. McHutchison, and G. Dusheiko et al. Telaprevir for previously untreated chronic hepatitis C virus infection N. Engl. J. Med. 364 2011 2405 2416
    • (2011) N. Engl. J. Med. , vol.364 , pp. 2405-2416
    • Jacobson, I.1    McHutchison, J.2    Dusheiko, G.3
  • 31
    • 84903724866 scopus 로고    scopus 로고
    • Simeprevir (TMC435) with peginterferon/ribavirin for treatment of chronic HCV genotype 1 infection in treatment-naïve patients: Efficacy in difficult-to-treat patient sub-population in the QUEST-1 and 2 Phase III trials
    • 1-5 November, 2013, Washington DC, USA. (Abstract 1122)
    • Jacobson, I.; Dore, G.; Foster, G.; et al.; 2013. Simeprevir (TMC435) with peginterferon/ribavirin for treatment of chronic HCV genotype 1 infection in treatment-naïve patients: efficacy in difficult-to-treat patient sub-population in the QUEST-1 and 2 Phase III trials. In: 64th Annual Meeting of the American Association for the Study of Liver Disease. 1-5 November, 2013, Washington DC, USA. (Abstract 1122).
    • (2013) 64th Annual Meeting of the American Association for the Study of Liver Disease
    • Jacobson, I.1    Dore, G.2    Foster, G.3
  • 32
    • 77950203857 scopus 로고    scopus 로고
    • Viral resistance to specifically targeted antiviral therapies for hepatitis C (STAT-Cs)
    • T.L. Kieffer, A.D. Kwong, and G.R. Picchio Viral resistance to specifically targeted antiviral therapies for hepatitis C (STAT-Cs) J. Antimicrob. Chemother. 65 2010 202 212
    • (2010) J. Antimicrob. Chemother. , vol.65 , pp. 202-212
    • Kieffer, T.L.1    Kwong, A.D.2    Picchio, G.R.3
  • 33
    • 84863550914 scopus 로고    scopus 로고
    • Hepatitis C Viral evolution in genotypes 1 treatment-naïve and treatment-experienced patients receiving telaprevir-based therapy clinical trials
    • T. Kieffer, S. De Meyer, and D. Bartels et al. Hepatitis C Viral evolution in genotypes 1 treatment-naïve and treatment-experienced patients receiving telaprevir-based therapy clinical trials PLoS One 7 2012 e34372
    • (2012) PLoS One , vol.7 , pp. 34372
    • Kieffer, T.1    De Meyer, S.2    Bartels, D.3
  • 34
    • 58149388300 scopus 로고    scopus 로고
    • Naturally occurring dominant resistance mutations to HCV protease and polymerase inhibitors in treatment-naive patients
    • T. Kuntzen, J. Timm, and A. Berical et al. Naturally occurring dominant resistance mutations to HCV protease and polymerase inhibitors in treatment-naive patients Hepatology 48 2008 1769 1778
    • (2008) Hepatology , vol.48 , pp. 1769-1778
    • Kuntzen, T.1    Timm, J.2    Berical, A.3
  • 35
    • 84861109960 scopus 로고    scopus 로고
    • Genotype and subtype profiling of PSI-7977 as a nucleotide inhibitor of hepatitis C virus
    • A.M. Lam, C. Espiritu, and S. Bansal et al. Genotype and subtype profiling of PSI-7977 as a nucleotide inhibitor of hepatitis C virus Antimicrob. Agents Chemother. 56 2012 3359 3368
    • (2012) Antimicrob. Agents Chemother. , vol.56 , pp. 3359-3368
    • Lam, A.M.1    Espiritu, C.2    Bansal, S.3
  • 36
    • 84884245458 scopus 로고    scopus 로고
    • Antiviral effect, safety, and pharmacokinetics of 5 days'oral administration of deleobuvir (BI 207127), and investigational HCV RNA polymerase inhibitor, in patients with chronic hepatitis C
    • D. Larrey, A. Lohse, and C. Trepo et al. Antiviral effect, safety, and pharmacokinetics of 5 days'oral administration of deleobuvir (BI 207127), and investigational HCV RNA polymerase inhibitor, in patients with chronic hepatitis C Antimicrob. Agents Chemother. 57 2013 4727 4735
    • (2013) Antimicrob. Agents Chemother. , vol.57 , pp. 4727-4735
    • Larrey, D.1    Lohse, A.2    Trepo, C.3
  • 37
    • 78751637124 scopus 로고    scopus 로고
    • Safety and antiviral activity of ANA598 in combination with pegylated interferon alpha 2a plus ribavirin in treatment-naïve genotype-1 chronic HCV patients
    • E. Lawitz, M. Rodriguez-Torres, and V.K. Rustgi et al. Safety and antiviral activity of ANA598 in combination with pegylated interferon alpha 2a plus ribavirin in treatment-naïve genotype-1 chronic HCV patients Hepatology 52 2010 334A 335A
    • (2010) Hepatology , vol.52
    • Lawitz, E.1    Rodriguez-Torres, M.2    Rustgi, V.K.3
  • 38
    • 84903728088 scopus 로고    scopus 로고
    • GS-9669, a novel NS5B non-nucleoside thumb site II inhibitor, demonstrates potent antiviral activity, favorable safety profile and potential for once-daily
    • 18-22 April 2012, Barcelona, Spain. (Abstract 1189)
    • Lawitz, E.; Hazan, L.; Gruener, D.; et al.; 2012. GS-9669, a novel NS5B non-nucleoside thumb site II inhibitor, demonstrates potent antiviral activity, favorable safety profile and potential for once-daily. In: 47th Annual Meeting of the European Association for the Study of the Liver, 18-22 April 2012, Barcelona, Spain. (Abstract 1189).
    • (2012) 47th Annual Meeting of the European Association for the Study of the Liver
    • Lawitz, E.1    Hazan, L.2    Gruener, D.3
  • 39
    • 84903692372 scopus 로고    scopus 로고
    • Sofosbuvir + peginterferon + ribavirin for 12 weeks achieves 90% SVR12 in genotype 1, 4, 5, or 6 HCV infected 90% SVR12 in genotype 1, 4, 5, or 6 HCV infected patients: The NEUTRINO study
    • 24-28 April, Amsterdam, Belgium. (Abstract 1411)
    • Lawitz, E.; Wyles, D.; Davis, M.; et al.; 2013a. Sofosbuvir + peginterferon + ribavirin for 12 weeks achieves 90% SVR12 in genotype 1, 4, 5, or 6 HCV infected 90% SVR12 in genotype 1, 4, 5, or 6 HCV infected patients: the NEUTRINO study. In: 48th Annual Meeting of the European Association for the Study of the Liver, 24-28 April, Amsterdam, Belgium. (Abstract 1411).
    • (2013) 48th Annual Meeting of the European Association for the Study of the Liver
    • Lawitz, E.1    Wyles, D.2    Davis, M.3
  • 40
    • 84896710685 scopus 로고    scopus 로고
    • Sofosbuvir in combination with peginterferon and ribavirin for 12 weeks provides high SVR rates in HCV-infected genotype 2 or 3 treatment experienced patients with and without compensated cirrhosis: Results from the LONESTAR-2 study
    • 1-5 November, 2013, Washington DC, USA. (Abstract LB-4)
    • Lawitz, E.; Poordad, F.; Brainard, D.M.; et al.; 2013b. Sofosbuvir in combination with peginterferon and ribavirin for 12 weeks provides high SVR rates in HCV-infected genotype 2 or 3 treatment experienced patients with and without compensated cirrhosis: results from the LONESTAR-2 study. In: 64th Annual Meeting of the American Association for the Study of Liver Disease, 1-5 November, 2013, Washington DC, USA. (Abstract LB-4).
    • (2013) 64th Annual Meeting of the American Association for the Study of Liver Disease
    • Lawitz, E.1    Poordad, F.2    Brainard . D, M.3
  • 41
    • 84894621765 scopus 로고    scopus 로고
    • Sofosbuvir and ledipasvir fixed-dose combination with and without ribavirin in treatment-naïve and previously treated patients with genotype 1 hepatitis C virus infection (LONESTAR): An open-label, randomized, phase 2 trial
    • E. Lawitz, F. Poordad, and P.S. Pang et al. Sofosbuvir and ledipasvir fixed-dose combination with and without ribavirin in treatment-naïve and previously treated patients with genotype 1 hepatitis C virus infection (LONESTAR): an open-label, randomized, phase 2 trial Lancet 383 2014 515 523
    • (2014) Lancet , vol.383 , pp. 515-523
    • Lawitz, E.1    Poordad, F.2    Pang, P.S.3
  • 42
    • 84868028511 scopus 로고    scopus 로고
    • Efficacy of re-treatment with TMC435 as combination therapy in hepatitis C virus-infected patients following TMC435 monotherapy
    • O. Lenz, J. Bruijne, and L. Vijgen et al. Efficacy of re-treatment with TMC435 as combination therapy in hepatitis C virus-infected patients following TMC435 monotherapy Gastroentorology 143 2012 1176 1178
    • (2012) Gastroentorology , vol.143 , pp. 1176-1178
    • Lenz, O.1    Bruijne, J.2    Vijgen, L.3
  • 43
    • 84874105854 scopus 로고    scopus 로고
    • Virologic response and characterization of HCV genotype 2-6 in patients receiving TMC435 (stydy TMC435-C202)
    • O. Lenz, L. Vijgen, and J.M. Berke et al. Virologic response and characterization of HCV genotype 2-6 in patients receiving TMC435 (stydy TMC435-C202) J. Hepatol. 58 2013 445 451
    • (2013) J. Hepatol. , vol.58 , pp. 445-451
    • Lenz, O.1    Vijgen, L.2    Berke, J.M.3
  • 44
    • 84903739791 scopus 로고    scopus 로고
    • Resistance analyses of HCV isolates from patients treated with simeprevir in Phase IIB/III studies
    • 1-5 November, 2013, Washington DC, USA. (Abstract 1101)
    • Lenz, O.; Fevery, B.; Verbinnen, T.; et al.; 2013b. Resistance analyses of HCV isolates from patients treated with simeprevir in Phase IIB/III studies. In: 64th Annual Meeting of the American Association for the Study of Liver Disease. 1-5 November, 2013, Washington DC, USA. (Abstract 1101).
    • (2013) 64th Annual Meeting of the American Association for the Study of Liver Disease
    • Lenz, O.1    Fevery, B.2    Verbinnen, T.3
  • 45
    • 84957045395 scopus 로고    scopus 로고
    • TMC-435 in patients infected with HCV genotype 1 who failed previous pegylated interferon/ribavirin treatment: Virologic analyses of the ASPIRE trial
    • 18-22 April 2013, Barcelona, Spain. (Abstract 1329)
    • Lenz, O.; Fevery, B.; Vijgen, L.; et al.; 2013. TMC-435 in patients infected with HCV genotype 1 who failed previous pegylated interferon/ribavirin treatment: virologic analyses of the ASPIRE trial. In: Presented at 49th Annual Meeting of the European Association for the Study of the Liver, 18-22 April 2013, Barcelona, Spain. (Abstract 1329).
    • (2013) 49th Annual Meeting of the European Association for the Study of the Liver
    • Lenz, O.1    Fevery, B.2    Vijgen, L.3
  • 46
    • 84902663575 scopus 로고    scopus 로고
    • High sustained viral response at 12- and 24-week follow-up of MK-5172 with pegylated interferon alfa-2b and ribavirin in HCV genotype 1 treatment-naïve non-cirrhotic patients
    • 24-28 April, 2013, Amsterdam, Belgium. (Abstract 66)
    • Manns, M.; Vierling, J.M.; Bacon, B.R.; et al.; 2013. High sustained viral response at 12- and 24-week follow-up of MK-5172 with pegylated interferon alfa-2b and ribavirin in HCV genotype 1 treatment-naïve non-cirrhotic patients. In: 48th Annual Meeting of the European Association for the Study of the Liver (EASL 2013), 24-28 April, 2013, Amsterdam, Belgium. (Abstract 66).
    • (2013) 48th Annual Meeting of the European Association for the Study of the Liver (EASL 2013)
    • Manns, M.1    Vierling . J, M.2    Bacon . B, R.3
  • 47
    • 84903702178 scopus 로고    scopus 로고
    • All-oral dual therapy with daclatasvir and asunaprevir in patients with HCV genotype 1b infection: Phase 3 HALLMARK-DUAL study results
    • 9-13 April 2013, London, UK. (Abstract O166)
    • Manss, M.; Pol, S.; Jacobson, I.M.; et al.; 2013. All-oral dual therapy with daclatasvir and asunaprevir in patients with HCV genotype 1b infection: phase 3 HALLMARK-DUAL study results. In: 49th Annual Meeting of the European Association for the Study of the Liver, 9-13 April 2013, London, UK. (Abstract O166).
    • (2013) 49th Annual Meeting of the European Association for the Study of the Liver
    • Manss, M.1    Pol, S.2    Jacobson . I, M.3
  • 48
    • 0026538287 scopus 로고
    • Hepatitis C virus (HCV) circulates as a population of different but closely related genomes: Quasispecies nature of HCV genome distribution
    • M. Martell, J.I. Esteban, J. Quer, J. Genesca, A. Weiner, and R. Esteban et al. Hepatitis C virus (HCV) circulates as a population of different but closely related genomes: quasispecies nature of HCV genome distribution J. Virol. 66 1992 3225 3229
    • (1992) J. Virol. , vol.66 , pp. 3225-3229
    • Martell, M.1    Esteban, J.I.2    Quer, J.3    Genesca, J.4    Weiner, A.5    Esteban, R.6
  • 49
    • 84903741735 scopus 로고    scopus 로고
    • Development of a panel of genotype-specific resistance assays for the detection of amino acid changes in domain 1 of hepatitis C virus (HCV) NS5A associated with drug resistance
    • A.L. McCormick, L. Wang, and A. Garcia et al. Development of a panel of genotype-specific resistance assays for the detection of amino acid changes in domain 1 of hepatitis C virus (HCV) NS5A associated with drug resistance Antivir. Ther. 18 Suppl. 1 2013 A56
    • (2013) Antivir. Ther. , vol.18 , Issue.SUPPL. 1 , pp. 56
    • McCormick, A.L.1    Wang, L.2    Garcia, A.3
  • 50
    • 68249154875 scopus 로고    scopus 로고
    • Peginterferon alfa-2b or alfa-2a with ribavirin for treatment of hepatitis C infection
    • J. McHutchison, E. Lawitz, and M. Shiffman et al. Peginterferon alfa-2b or alfa-2a with ribavirin for treatment of hepatitis C infection N. Engl. J. Med. 361 2009 580 593
    • (2009) N. Engl. J. Med. , vol.361 , pp. 580-593
    • McHutchison, J.1    Lawitz, E.2    Shiffman, M.3
  • 51
    • 84862560600 scopus 로고    scopus 로고
    • Resistance analysis of the hepatitis C virus NS3 protease inhibitor asunaprevir
    • F. Mcphee, J. Friborg, and S. Levine et al. Resistance analysis of the hepatitis C virus NS3 protease inhibitor asunaprevir Antimicrob. Agents Chemother. 56 2012 3670 3681
    • (2012) Antimicrob. Agents Chemother. , vol.56 , pp. 3670-3681
    • McPhee, F.1    Friborg, J.2    Levine, S.3
  • 52
    • 84873054024 scopus 로고    scopus 로고
    • A description of virologic escape in HCV genotype 1-infected patients treated with daclatasvir (BMS-790052) in combination with ribavirin and peginterferon alfa-2a or peinterferon alfa-2b
    • F. McPhee, D. Hernandez, and F. Yu et al. A description of virologic escape in HCV genotype 1-infected patients treated with daclatasvir (BMS-790052) in combination with ribavirin and peginterferon alfa-2a or peinterferon alfa-2b J. Hepatol. 56 2012 S473
    • (2012) J. Hepatol. , vol.56 , pp. 473
    • McPhee, F.1    Hernandez, D.2    Yu, F.3
  • 53
    • 84903732473 scopus 로고    scopus 로고
    • Analysis of HCV resistance variants in a phase 3 trial of daclatasvir combined with asunaprevir for Japanese patients with genotype 1b infection
    • 1-5 November, 2013, Washington DC, USA. (Abstract 1111)
    • McPhee, F.; Toyota, J.; Chayama, D.; et al.; 2013. Analysis of HCV resistance variants in a phase 3 trial of daclatasvir combined with asunaprevir for Japanese patients with genotype 1b infection. In: 64th Annual Meeting of the American Association for the Study of Liver Disease, 1-5 November, 2013, Washington DC, USA. (Abstract 1111).
    • (2013) 64th Annual Meeting of the American Association for the Study of Liver Disease
    • McPhee, F.1    Toyota, J.2    Chayama, D.3
  • 54
    • 0032475822 scopus 로고    scopus 로고
    • Hepatitis C viral dynamics in vivo and the antiviral efficacy of interferon-α therapy
    • DOI 10.1126/science.282.5386.103
    • A.U. Neumann, N.P. Lam, and H. Dahari et al. Hepatitis C viral dynamics in vivo and the antiviral efficacy of interferon-alpha therapy Science 282 1998 103 107 (Pubitemid 28471138)
    • (1998) Science , vol.282 , Issue.5386 , pp. 103-107
    • Neumann, A.U.1    Lam, N.P.2    Dahari, H.3    Gretch, D.R.4    Wiley, T.E.5    Layden, T.J.6    Perelson, A.S.7
  • 55
    • 84878036817 scopus 로고    scopus 로고
    • Resistance-associated amino acid variants associated with boceprevir plus pegylated interferon-2b and ribavirin in patients with chronic hepatitis C in the SPRINT-1 trial
    • R.A. Ogert, J.A. Howe, and J.M. Vierling et al. Resistance-associated amino acid variants associated with boceprevir plus pegylated interferon-2b and ribavirin in patients with chronic hepatitis C in the SPRINT-1 trial Antivir. Ther. 18 2013 387 397
    • (2013) Antivir. Ther. , vol.18 , pp. 387-397
    • Ogert, R.A.1    Howe, J.A.2    Vierling, J.M.3
  • 56
    • 84883089005 scopus 로고    scopus 로고
    • Sofosbuvir and ribavirin for hepatitis C genotype 1 in patients with unfavorable treatment characteristics: A randomized clinical trial
    • A. Osinusi, E.G. Meissner, and Y.-J. Lee et al. Sofosbuvir and ribavirin for hepatitis C genotype 1 in patients with unfavorable treatment characteristics: a randomized clinical trial JAMA 310 2013 804 811
    • (2013) JAMA , vol.310 , pp. 804-811
    • Osinusi, A.1    Meissner, E.G.2    Lee, Y.-J.3
  • 58
    • 84876582239 scopus 로고    scopus 로고
    • Treatment of chronic hepatitis C: Current and future
    • J.M. Pawlotsky Treatment of chronic hepatitis C: current and future Curr. Top. Microbiol. Immunol. 369 2013 321 342
    • (2013) Curr. Top. Microbiol. Immunol. , vol.369 , pp. 321-342
    • Pawlotsky, J.M.1
  • 59
    • 34247895578 scopus 로고    scopus 로고
    • The Hepatitis C Virus Life Cycle as a Target for New Antiviral Therapies
    • DOI 10.1053/j.gastro.2007.03.116, PII S0016508507006427
    • J.M. Pawlotsky, S. Chevaliez, and J. McHutchison The hepatitis C virus life cycle as a target for new antiviral therapies Gastroenterology 132 2007 1979 1998 (Pubitemid 46695724)
    • (2007) Gastroenterology , vol.132 , Issue.5 , pp. 1979-1998
    • Pawlotsky, J.1    Chevaliez, S.2    McHutchison, J.G.3
  • 60
    • 84861655785 scopus 로고    scopus 로고
    • Resistance to mericitabine, a nucleoside analogue inhibitor of HCV RNA-dependent RNA polymerase
    • J.M. Pawlotsky, I. Najera, and I. Jacobson Resistance to mericitabine, a nucleoside analogue inhibitor of HCV RNA-dependent RNA polymerase Antivir. Ther. 17 2012 411 423
    • (2012) Antivir. Ther. , vol.17 , pp. 411-423
    • Pawlotsky, J.M.1    Najera, I.2    Jacobson, I.3
  • 61
    • 79960937707 scopus 로고    scopus 로고
    • Evidence for separation of HCV subtype 1a into two distinct clades
    • B.E. Pickett, R. Striker, and E.J. Lefkowitz Evidence for separation of HCV subtype 1a into two distinct clades J. Viral Hepat. 18 2011 608 618
    • (2011) J. Viral Hepat. , vol.18 , pp. 608-618
    • Pickett, B.E.1    Striker, R.2    Lefkowitz, E.J.3
  • 62
    • 81855199759 scopus 로고    scopus 로고
    • Impact of antiretroviral therapy on the variability of the HCV NS5B polymerase in HIV/HCV co-infected patients
    • Z. Plaza, V. Soriano, and M.M. Gonzales et al. Impact of antiretroviral therapy on the variability of the HCV NS5B polymerase in HIV/HCV co-infected patients J. Antimicrob. Chemother. 66 2011 2838 2842
    • (2011) J. Antimicrob. Chemother. , vol.66 , pp. 2838-2842
    • Plaza, Z.1    Soriano, V.2    Gonzales, M.M.3
  • 63
    • 84858415895 scopus 로고    scopus 로고
    • Prevalence of natural polymorphisms at the HCV NS5A gene associated with resistance to daclatasvir, an NS5A inhibitor
    • Z. Plaza, V. Soriano, and E. Vispo et al. Prevalence of natural polymorphisms at the HCV NS5A gene associated with resistance to daclatasvir, an NS5A inhibitor Antivir. Ther. 17 2012 921 926
    • (2012) Antivir. Ther. , vol.17 , pp. 921-926
    • Plaza, Z.1    Soriano, V.2    Vispo, E.3
  • 64
    • 84870044735 scopus 로고    scopus 로고
    • Nucleoside/nucleotide analogue polymerase inhibitors in development
    • P. Pockros Nucleoside/nucleotide analogue polymerase inhibitors in development Clin. Liver Dis. 17 2013 123 128
    • (2013) Clin. Liver Dis. , vol.17 , pp. 123-128
    • Pockros, P.1
  • 65
    • 84881025292 scopus 로고    scopus 로고
    • JUMP-C: A randomized trial of mericitabine plus pegylated interferón alpha-2a/ribavirin for 24 weeks in treatment-naive HCV genotypes 1/4 patients
    • P.J. Pockros, D. Jensen, and N. Tsai et al. JUMP-C: a randomized trial of mericitabine plus pegylated interferón alpha-2a/ribavirin for 24 weeks in treatment-naive HCV genotypes 1/4 patients Hepatology 58 2013 514 523
    • (2013) Hepatology , vol.58 , pp. 514-523
    • Pockros, P.J.1    Jensen, D.2    Tsai, N.3
  • 66
    • 79953173221 scopus 로고    scopus 로고
    • Boceprevir for untreated chronic HCV genotype 1 infection
    • F. Poordad, J. McCone, and B. Bacon et al. Boceprevir for untreated chronic HCV genotype 1 infection N. Engl. J. Med. 364 2011 1195 1206
    • (2011) N. Engl. J. Med. , vol.364 , pp. 1195-1206
    • Poordad, F.1    McCone, J.2    Bacon, B.3
  • 68
    • 84858421432 scopus 로고    scopus 로고
    • Drug resistance testing in hepatitis C therapy
    • E. Poveda, and V. Soriano Drug resistance testing in hepatitis C therapy Future Virol. 7 2012 1 13
    • (2012) Future Virol. , vol.7 , pp. 1-13
    • Poveda, E.1    Soriano, V.2
  • 69
    • 84856252248 scopus 로고    scopus 로고
    • Predicted challenges using direct acting antivirals in the current HIV-HCV coinfected population in Spain
    • E. Poveda, E. Vispo, and P. Barreiro et al. Predicted challenges using direct acting antivirals in the current HIV-HCV coinfected population in Spain Antivir. Ther. 17 2012 571 575
    • (2012) Antivir. Ther. , vol.17 , pp. 571-575
    • Poveda, E.1    Vispo, E.2    Barreiro, P.3
  • 70
    • 84855494000 scopus 로고    scopus 로고
    • Biochemical activities of the HCV NS5B RNA-dependent RNA polymerase
    • S.L. Tan, 1st ed. Horizon Bioscience Norfolk
    • C.T. Ranjith-Kumar, and C. Cheng Kao Biochemical activities of the HCV NS5B RNA-dependent RNA polymerase S.L. Tan, Hepatitis C Viruses: Genomes and Molecular Biology 1st ed. 2006 Horizon Bioscience Norfolk 293 310
    • (2006) Hepatitis C Viruses: Genomes and Molecular Biology , pp. 293-310
    • Ranjith-Kumar, C.T.1    Cheng Kao, C.2
  • 71
    • 75149151884 scopus 로고    scopus 로고
    • Resistance to direct antiviral agents in patients with hepatitis C virus infection
    • C. Sarrazin, and S. Zeuzem Resistance to direct antiviral agents in patients with hepatitis C virus infection Gastroenterology 138 2010 447 462
    • (2010) Gastroenterology , vol.138 , pp. 447-462
    • Sarrazin, C.1    Zeuzem, S.2
  • 72
    • 84896511970 scopus 로고    scopus 로고
    • Treatment with telaprevir/PEG-IFN/RBV after 14 days telaprevir exposure in phase i studies: Results from the phase IIIB C219 rollover study
    • C. Sarrazin, H. Reesink, and S. Zeuzem et al. Treatment with telaprevir/PEG-IFN/RBV after 14 days telaprevir exposure in phase I studies: results from the phase IIIB C219 rollover study J. Hepatol. 58 2013 S369 S370
    • (2013) J. Hepatol. , vol.58
    • Sarrazin, C.1    Reesink, H.2    Zeuzem, S.3
  • 73
    • 84856903158 scopus 로고    scopus 로고
    • Follow-up of SVR durability and viral resistance in patients with chronic hepatitis C treated with telaprevir-based regimens: Interim analysis of the extend study
    • Sherman, K.; Sulkowski, M.; Zoulim, F.; et al.; 2011. Follow-up of SVR durability and viral resistance in patients with chronic hepatitis C treated with telaprevir-based regimens: interim analysis of the extend study. Hepatology 54, 485A-486A.
    • (2011) Hepatology , vol.54
    • Sherman, K.1    Sulkowski, M.2    Zoulim, F.3
  • 74
    • 45749088957 scopus 로고    scopus 로고
    • Why are there different dynamics in the selection of drug resistance in HIV and hepatitis B and C viruses?
    • DOI 10.1093/jac/dkn175
    • V. Soriano, A. Perelson, and F. Zoulim Why are there different dynamics in the selection of drug resistance in HIV and hepatitis B and C viruses? J. Antimicrob. Chemother. 62 2008 1 4 (Pubitemid 351865869)
    • (2008) Journal of Antimicrobial Chemotherapy , vol.62 , Issue.1 , pp. 1-4
    • Soriano, V.1    Perelson, A.S.2    Zoulim, F.3
  • 75
    • 79960444768 scopus 로고    scopus 로고
    • Directly acting antivirals against hepatitis C virus
    • V. Soriano, E. Vispo, and E. Poveda et al. Directly acting antivirals against hepatitis C virus J. Antimicrob. Chemother. 66 2011 1673 1686
    • (2011) J. Antimicrob. Chemother. , vol.66 , pp. 1673-1686
    • Soriano, V.1    Vispo, E.2    Poveda, E.3
  • 76
    • 84877905656 scopus 로고    scopus 로고
    • Hepatitis C therapy with HCV NS5B polymerase inhibitors
    • V. Soriano, E. Vispo, and C. de Mendoza et al. Hepatitis C therapy with HCV NS5B polymerase inhibitors Expert Opin. Pharmacother. 14 2012 1161 1170
    • (2012) Expert Opin. Pharmacother. , vol.14 , pp. 1161-1170
    • Soriano, V.1    Vispo, E.2    De Mendoza, C.3
  • 77
    • 84892619580 scopus 로고    scopus 로고
    • Daclatasvir plus sofosbuvir for previously treated or untreated chronic HCV infection
    • M. Sulkowski, D. Gardiner, and M. Rodriguez-Torres et al. Daclatasvir plus sofosbuvir for previously treated or untreated chronic HCV infection N. Engl. J. Med. 370 2014 211 221
    • (2014) N. Engl. J. Med. , vol.370 , pp. 211-221
    • Sulkowski, M.1    Gardiner, D.2    Rodriguez-Torres, M.3
  • 78
    • 84864387126 scopus 로고    scopus 로고
    • MK-5172, a selective inhibitor of hepatitis C virus NS3/4A protease with broad activity across genotypes and resistant variants
    • V. Summa, S.W. Ludmerer, and J.A. McCauley et al. MK-5172, a selective inhibitor of hepatitis C virus NS3/4A protease with broad activity across genotypes and resistant variants Antimicrob. Agents Chemother. 56 2012 416 417
    • (2012) Antimicrob. Agents Chemother. , vol.56 , pp. 416-417
    • Summa, V.1    Ludmerer, S.W.2    McCauley, J.A.3
  • 80
    • 84894271490 scopus 로고    scopus 로고
    • In vivo emergence of a novel mutant L159F/L320F in the NS5B polymerase confers low-level resistance to the HCV polymerase inhibitors mericitabine and sofosbuvir
    • X. Tong, S. Le Pogam, L. Li, K. Haines, K. Piso, V. Baronas, J.M. Yan, S.S. So, K. Klumpp, and I. Nájera In vivo emergence of a novel mutant L159F/L320F in the NS5B polymerase confers low-level resistance to the HCV polymerase inhibitors mericitabine and sofosbuvir J. Infect. Dis. 209 2014 668 675
    • (2014) J. Infect. Dis. , vol.209 , pp. 668-675
    • Tong, X.1    Le Pogam, S.2    Li, L.3    Haines, K.4    Piso, K.5    Baronas, V.6    Yan, J.M.7    So, S.S.8    Klumpp, K.9    Nájera, I.10
  • 81
    • 79959401302 scopus 로고    scopus 로고
    • Natural polymorphisms associated with resistance to new antivirals against hepatitis C virus (HCV) in newly diagnosed HIV/HCV-coinfected patients in Spain
    • A. Treviño, C. de Mendoza, and P. Parra et al. Natural polymorphisms associated with resistance to new antivirals against hepatitis C virus (HCV) in newly diagnosed HIV/HCV-coinfected patients in Spain Antivir. Ther. 16 2011 413 416
    • (2011) Antivir. Ther. , vol.16 , pp. 413-416
    • Treviño, A.1    De Mendoza, C.2    Parra, P.3
  • 82
    • 80051599715 scopus 로고    scopus 로고
    • HCV protease variability and anti-HCV protease inhibitor resistance in HIV/HCV-coinfected patients
    • P. Trimoulet, C. Belzunce, and M. Faure et al. HCV protease variability and anti-HCV protease inhibitor resistance in HIV/HCV-coinfected patients HIV Med. 12 2011 506 509
    • (2011) HIV Med. , vol.12 , pp. 506-509
    • Trimoulet, P.1    Belzunce, C.2    Faure, M.3
  • 83
    • 84857186976 scopus 로고    scopus 로고
    • Characterization of resistance to the nonnucleoside NS5B inhibitor filibuvir in hepatitis C virus-infected patients
    • P. Troke, M. Lewis, and P. Simpson et al. Characterization of resistance to the nonnucleoside NS5B inhibitor filibuvir in hepatitis C virus-infected patients Antimicrob. Agents Chemother. 56 2012 1331 1339
    • (2012) Antimicrob. Agents Chemother. , vol.56 , pp. 1331-1339
    • Troke, P.1    Lewis, M.2    Simpson, P.3
  • 85
    • 1642288430 scopus 로고    scopus 로고
    • World Health Organization Updated July
    • World Health Organization. Hepatitis C factsheet No. 164. Updated July 2013. Available from: < http://www.who.int/mediacentre/factsheets/fs164/en/ >.
    • (2013) Hepatitis C Factsheet No. 164
  • 86
    • 84961680766 scopus 로고    scopus 로고
    • Impact of viral sequences beyond HCV NS5A domain i on viral susceptibility to NS5A inhibitors
    • G. Yang, Y. Zhao, and D. Patel et al. Impact of viral sequences beyond HCV NS5A domain I on viral susceptibility to NS5A inhibitors Antivir. Ther. 18 Suppl. 1 2013 A59
    • (2013) Antivir. Ther. , vol.18 , Issue.SUPPL. 1 , pp. 59
    • Yang, G.1    Zhao, Y.2    Patel, D.3
  • 87
    • 79959381354 scopus 로고    scopus 로고
    • Telaprevir for retreatment of HCV infection
    • S. Zeuzem, P. Andreone, and S. Pol et al. Telaprevir for retreatment of HCV infection N. Engl. J. Med. 364 2011 2417 2428
    • (2011) N. Engl. J. Med. , vol.364 , pp. 2417-2428
    • Zeuzem, S.1    Andreone, P.2    Pol, S.3
  • 88
    • 84857415002 scopus 로고    scopus 로고
    • The protease inhibitor, GS-9256, and non-nucleoside polymerase inhibitor tegobuvir alone, with ribavirin or pegylated interferon plus ribavirin in hepatitis C
    • S. Zeuzem, P. Buggisch, and K. Agarwal et al. The protease inhibitor, GS-9256, and non-nucleoside polymerase inhibitor tegobuvir alone, with ribavirin or pegylated interferon plus ribavirin in hepatitis C Hepatology 55 2012 749 758
    • (2012) Hepatology , vol.55 , pp. 749-758
    • Zeuzem, S.1    Buggisch, P.2    Agarwal, K.3
  • 89
    • 84903739022 scopus 로고    scopus 로고
    • Sofosbuvir + ribavirin for 12 or 24 weeks for patients with HCV genotypes 2 or 3: The VALANCE trial
    • 1-5 November, 2013, Washington DC, USA. (Abstract 1085)
    • Zeuzem, S.; Dusheiko, G.M.; Salupere, R.; et al.; 2013. Sofosbuvir + ribavirin for 12 or 24 weeks for patients with HCV genotypes 2 or 3: the VALANCE trial. In: 64th Annual Meeting of the American Association for the Study of Liver Disease, 1-5 November, 2013, Washington DC, USA. (Abstract 1085).
    • (2013) 64th Annual Meeting of the American Association for the Study of Liver Disease
    • Zeuzem, S.1    Dusheiko . G, M.2    Salupere, R.3


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