Virus-specific peptide dependent NK cell cytotoxicity

Inflammation and Allergy - Drug Targets

Volumn 13, Issue 2, 2014, Pages 128-133

  Tong, Lan ^a   Assenmacher, Mario ^a   Zänker, Kurt S ^b   Jähn, Peter ^a  

^a UNIVERSITY OF WITTEN HERDECKE   (Germany)

^b MILTENYI BIOTEC GMBH   (Germany)

Author keywords

Antigen specific; CMV; Cytotoxicity; EBV; MHC peptide complex; NK cells

Indexed keywords

CD19 ANTIGEN; CD3 ANTIGEN; CD8 ANTIGEN; CYTOMEGALOVIRUS ANTIGEN PP65; EPSTEIN BARR VIRUS ANTIGEN 1; GAMMA INTERFERON; HAPTEN; IMMEDIATE EARLY PROTEIN BZLF1; LYSOSOME ASSOCIATED MEMBRANE PROTEIN 1; MAJOR HISTOCOMPATIBILITY ANTIGEN; VIRUS ANTIGEN; VIRUS PROTEIN; BZLF1 PROTEIN, HERPESVIRUS 4, HUMAN; CYTOMEGALOVIRUS MATRIX PROTEIN 65KDA; MATRIX PROTEIN; PHOSPHOPROTEIN; TRANSACTIVATOR PROTEIN; FAS LIGAND; PEPTIDE; PERFORIN;

ANTIGEN SPECIFICITY; ARTICLE; B LYMPHOCYTE; CELL ACTIVATION; CELL ASSAY; CELL ISOLATION; CELL KILLING; CELL MEDIATED CYTOTOXICITY; CONTROLLED STUDY; CULTURE MEDIUM; CYTOMEGALOVIRUS INFECTION; EPSTEIN BARR VIRUS INFECTION; FLOW CYTOMETRY; HUMAN; HUMAN CELL; IMMUNE RESPONSE; NATURAL KILLER CELL; T LYMPHOCYTE; TARGET CELL; CELL CULTURE; COCULTURE; CYTOMEGALOVIRUS; CYTOTOXICITY; EPSTEIN BARR VIRUS; HOST PATHOGEN INTERACTION; IMMUNOLOGY; PATHOGENICITY; VIROLOGY; CD8+ T LYMPHOCYTE; CELL POPULATION; INNATE IMMUNITY; PERIPHERAL BLOOD MONONUCLEAR CELL; PROTEIN EXPRESSION; VIRUS;

ANTIGENS, VIRAL; B-LYMPHOCYTES; CELLS, CULTURED; COCULTURE TECHNIQUES; CYTOMEGALOVIRUS; CYTOMEGALOVIRUS INFECTIONS; CYTOTOXICITY, IMMUNOLOGIC; EPSTEIN-BARR VIRUS INFECTIONS; HERPESVIRUS 4, HUMAN; HOST-PATHOGEN INTERACTIONS; HUMANS; KILLER CELLS, NATURAL; PHOSPHOPROTEINS; TRANS-ACTIVATORS; VIRAL MATRIX PROTEINS;

EID: 84903696590     PISSN: 18715281     EISSN: None     Source Type: Journal    
DOI: 10.2174/1871528113666140211100616     Document Type: Article

References (15)

1. Bassing, C.H.; Swat, W.; Alt, F.W. The mechanism and regulation of chromosomal V(D)J recombination. Cell, 2002, 109 (Suppl), S45-55.
2. O'Leary, J.G.; Goodarzi, M.; Drayton, D.L.; von Andrian, U.H. T cell- and B cell-independent adaptive immunity mediated by natural killer cells. Nat. Immunol., 2006, 7, 507-516.
3. Paust, S.; Gill, H.S.; Wang, B.Z.; Flynn, M.P.; Moseman, E.A.; Senman, B.; Szczepanik, M.; Telenti, A.; Askenase, P.W.; Compans, R.W.; von Andrian, U.H. Critical role for the chemokine receptor CXCR6 in NK cell-mediated antigen-specific memory of haptens and viruses. Nat. Immunol., 2010, 11, 1127-1135.
4. Cheent, K.; Khakoo, S.I. Natural killer cells: integrating diversity with function. Immunology, 2009, 126, 449-457.
5. Middleton, D.; Gonzelez, F. The extensive polymorphism of KIR genes. Immunology, 2010, 129, 8-19.
6. Wilson, M.J.; Torkar, M.; Haude, A.; Milne, S.; Jones, T.; Sheer, D.; Beck, S.; Trowsdale, J. Plasticity in the organization and sequences of human KIR/ILT gene families. Proc. Natl. Acad. Scie. USA, 2000, 97, 4778-4783.
7. Middleton, D.; Meenagh, A.; Moscoso, J.; Arnaiz-Villena, A. Killer immunoglobulin receptor gene and allele frequencies in Caucasoid, Oriental and Black populations from different continents. Tissue Antigens, 2008, 71, 105-113.
8. Hansasuta, P.; Dong, T.; Thananchai, H.; Weekes, M.; Willberg, C.; Aldemir, H.; Rowland-Jones, S.; Braud, V.M. Recognition of HLA-A3 and HLA-A11 by KIR3DL2 is peptide-specific. Eur. J. Immunol., 2004, 34, 1673-1679.
9. Fadda, L.; Borhis, G.; Ahmed, P.; Cheent, K.; Pageon, S.V.; Cazaly, A.; Stathopoulos, S.; Middleton, D.; Mulder, A.; Claas, F.H.; Elliott, T.; Davis, D.M.; Purbhoo, M.A.; Khakoo, S.I. Peptide antagonism as a mechanism for NK cell activation. Proc. Natl. Acad. Sci. USA, 2010, 107, 10160-10165.
10. Borhis, G.; Ahmed, P.S.; Mbiribindi, B.; Naiyer, M.M.; Davis, D.M.; Purbhoo, M.A.; Khakoo, S.I. A peptide antagonist disrupts NK cell inhibitory synapse formation. J. Immunol., 2013, 190, 2924-2930.
11. Ljunggren, H.G.; Karre, K. In search of the 'missing self': MHC molecules and NK cell recognition. Immunol. Today, 1990, 11, 237-244.
12. Arnon, T.I.; Achdout, H.; Levi, O.; Markel, G.; Saleh, N.; Katz, G.; Gazit, R.; Gonen-Gross, T.; Hanna, J.; Nahari, E.; Porgador, A.; Honigman, A.; Plachter, B.; Mevorach, D.; Wolf, D.G.; Mandelboim, O. Inhibition of the NKp30 activating receptor by pp65 of human cytomegalovirus. Nat. Immunol., 2005, 6, 515-523.
13. Durand-Panteix, S.; Farhat, M.; Youlyouz-Marfak, I.; Rouaud, P.; Ouk-Martin, C.; David, A.; Faumont, N.; Feuillard, J.; Jayat- Vignoles, C. B7-H1, which represses EBV-immortalized B cell killing by autologous T and NK cells, is oppositely regulated by c- Myc and EBV latency III program at both mRNA and secretory lysosome levels. J. Immunol., 2012, 189, 181-190.
14. Brown, D.M.; Kamperschroer, C.; Dilzer, A.M.; Roberts, D.M.; Swain, S.L. IL-2 and antigen dose differentially regulate perforinand FasL-mediated cytolytic activity in antigen specific CD4+ T cells. Cellular Immunol., 2009, 257, 69-79.
15. Gumá, M.; Angulo, A.; Vilches, C.; Gómez-Lozano, N.; Malats, N.; López-Botet, M. Imprint of human cytomegalovirus infection on the NK cell receptor repertoire. Blood, 2004, 104, 3664-3671.