메뉴 건너뛰기




Volumn 20, Issue 11, 2014, Pages 1647-1654

Transcription factor WT1 and promoter CpG hypomethylation coactivate HOXA10 expression in ovarian cancer

Author keywords

5 AZA dC; Bisulfite DNA sequencing and methylation specific PCR; HOXA10; Hypomethylation; Ovarian cancer; SiRNA; WT1

Indexed keywords

MESSENGER RNA; SMALL INTERFERING RNA; TRANSCRIPTION FACTOR HOXA10; WT1 PROTEIN; AZACITIDINE; HOMEODOMAIN PROTEIN; HOXA10 PROTEIN, HUMAN;

EID: 84903690748     PISSN: 13816128     EISSN: 18734286     Source Type: Journal    
DOI: 10.2174/13816128113199990545     Document Type: Article
Times cited : (13)

References (28)
  • 1
    • 0024157206 scopus 로고
    • Homeobox proteins as sequence-specific transcription factors
    • Levine M, Hoey T. Homeobox proteins as sequence-specific transcription factors. Cell 1988; 55: 537-40.
    • (1988) Cell , vol.55 , pp. 537-540
    • Levine, M.1    Hoey, T.2
  • 2
    • 0036782277 scopus 로고    scopus 로고
    • Deregulated homeobox gene expression in cancer: Cause or consequence?
    • Abate-Shen C. Deregulated homeobox gene expression in cancer: cause or consequence? Nat Rev Cancer 2002; 2: 777-85.
    • (2002) Nat Rev Cancer , vol.2 , pp. 777-785
    • Abate-Shen, C.1
  • 3
    • 0042306256 scopus 로고    scopus 로고
    • The study of HOX gene function in hematopoietic, breast and lung carcinogenesis
    • Maroulakou IG, Spyropoulos DD. The study of HOX gene function in hematopoietic, breast and lung carcinogenesis. Anticancer Res 2003; 23: 2101-10.
    • (2003) Anticancer Res , vol.23 , pp. 2101-2110
    • Maroulakou, I.G.1    Spyropoulos, D.D.2
  • 4
    • 13644265950 scopus 로고    scopus 로고
    • The pathophysiology of HOX genes and their role in cancer
    • Grier DG, Thompson A, Kwasniewska A, et al. The pathophysiology of HOX genes and their role in cancer. J Pathol 2005; 205: 154-71.
    • (2005) J Pathol , vol.205 , pp. 154-171
    • Grier, D.G.1    Thompson, A.2    Kwasniewska, A.3
  • 5
    • 77953332515 scopus 로고    scopus 로고
    • Homeobox A7 increases cell proliferation by up-regulation of epidermal growth factor receptor expression in human granulosa cells
    • Zhang Y, Huang Q, Cheng JC, et al. Homeobox A7 increases cell proliferation by up-regulation of epidermal growth factor receptor expression in human granulosa cells. Reprod Biol Endocrinol 2010; 8: 61.
    • (2010) Reprod Biol Endocrinol , vol.8 , pp. 61
    • Zhang, Y.1    Huang, Q.2    Cheng, J.C.3
  • 6
    • 18344373769 scopus 로고    scopus 로고
    • Lineage infidelity of epithelial ovarian cancers is controlled by HOX genes that specify regional identity in the reproductive tract
    • Cheng W, Liu J, Yoshida H, et al. Lineage infidelity of epithelial ovarian cancers is controlled by HOX genes that specify regional identity in the reproductive tract. Nat Med 2005; 11: 531-7.
    • (2005) Nat Med , vol.11 , pp. 531-537
    • Cheng, W.1    Liu, J.2    Yoshida, H.3
  • 7
    • 79952116756 scopus 로고    scopus 로고
    • Distinct DNA methylation profile in ovarian serous neoplasms and their implication in ovarian carcinogenesis
    • Shih Ie M, Chen L, Wang CC, et al. Distinct DNA methylation profile in ovarian serous neoplasms and their implication in ovarian carcinogenesis, Am J Obstet Gynecol 2010; 203: 584-22.
    • (2010) Am J Obstet Gynecol , vol.203 , pp. 522-584
    • Shih, I.M.1    Chen, L.2    Wang, C.C.3
  • 8
    • 0037413703 scopus 로고    scopus 로고
    • Methylation of HoxA5 and HoxB5 and its relevance to expression during mouse development
    • Hershko AY, Kafri T, Fainsod A, et al. Methylation of HoxA5 and HoxB5 and its relevance to expression during mouse development. Gene 2003; 302: 65-72.
    • (2003) Gene , vol.302 , pp. 65-72
    • Hershko, A.Y.1    Kafri, T.2    Fainsod, A.3
  • 9
    • 0037068353 scopus 로고    scopus 로고
    • DNA methylation in cancer: Too much, but also too little
    • Ehrlich M. DNA methylation in cancer: too much, but also too little. Oncogene 2002; 21: 5400-13.
    • (2002) Oncogene , vol.21 , pp. 5400-5413
    • Ehrlich, M.1
  • 10
    • 34248361968 scopus 로고    scopus 로고
    • Homeobox gene methylation in lung cancer studied by genome-wide analysis with a microarraybased methylated CpG island recovery assay
    • Rauch T, Wang Z, Zhang X, et al. Homeobox gene methylation in lung cancer studied by genome-wide analysis with a microarraybased methylated CpG island recovery assay. Proc Natl Acad Sci USA 2007; 104: 5527-32.
    • (2007) Proc Natl Acad Sci USA , vol.104 , pp. 5527-5532
    • Rauch, T.1    Wang, Z.2    Zhang, X.3
  • 11
    • 77954608135 scopus 로고    scopus 로고
    • Identification of aberrant promoter hypomethylation of HOXA10 in ovarian cancer
    • Wenjun Cheng, Yi Jiang, Cuixia Liu, et al. Identification of aberrant promoter hypomethylation of HOXA10 in ovarian cancer. J Cancer Res Clin Oncol 2010; 136: 1221-7.
    • (2010) J Cancer Res Clin Oncol , vol.136 , pp. 1221-1227
    • Cheng, W.1    Yi, J.2    Liu, C.3
  • 12
    • 77951188429 scopus 로고    scopus 로고
    • WT1 represses HOX gene expression in the regulation of gynecologic tumor histologic type
    • Vaagn Andikyan, Taylor HS. WT1 represses HOX gene expression in the regulation of gynecologic tumor histologic type. J Cell Mol Med 2009; 13: 4522-31.
    • (2009) J Cell Mol Med , vol.13 , pp. 4522-4531
    • Andikyan, V.1    Taylor, H.S.2
  • 13
    • 0033616205 scopus 로고    scopus 로고
    • Genetics of the female reproductive ducts
    • Simpson, JL. Genetics of the female reproductive ducts. Am J Med Genet 1999; 89: 224-23913.
    • (1999) Am J Med Genet , vol.89 , pp. 224-23913
    • Simpson, J.L.1
  • 14
    • 12244276678 scopus 로고    scopus 로고
    • HOXA10 regulates p53 expression and matrigel invasion in human breast cancer cells
    • Chu MC, Selam FB, Taylor HS. HOXA10 regulates p53 expression and matrigel invasion in human breast cancer cells. Cancer Biol Ther 2004; 3: 568-72.
    • (2004) Cancer Biol Ther , vol.3 , pp. 568-572
    • Chu, M.C.1    Selam, F.B.2    Taylor, H.S.3
  • 15
    • 77349123961 scopus 로고    scopus 로고
    • Aberrant expressions of HOX genes in colorectal and hepatocellalar carcinomas
    • Kanai M, Hamada J, Takada M, et al. Aberrant expressions of HOX genes in colorectal and hepatocellalar carcinomas. Oncol Rep 2010; 23: 843-51.
    • (2010) Oncol Rep , vol.23 , pp. 843-851
    • Kanai, M.1    Hamada, J.2    Takada, M.3
  • 16
    • 23844520882 scopus 로고    scopus 로고
    • Aberrant methylation at HOXA10 may be responsible for its aberrant expression in the endometrium of patients with endometriosis
    • Wu Y, Halverson G, Basir Z, Strawn E, Yan P, Guo SW. Aberrant methylation at HOXA10 may be responsible for its aberrant expression in the endometrium of patients with endometriosis. Am J Obstet Gynecol 2005; 193: 371-80.
    • (2005) Am J Obstet Gynecol , vol.193 , pp. 371-380
    • Wu, Y.1    Halverson, G.2    Basir, Z.3    Strawn, E.4    Yan, P.5    Guo, S.W.6
  • 17
    • 0028587166 scopus 로고
    • The genetics of Wilms'tumor-a case of disrupted development
    • Hastie ND. The genetics of Wilms'tumor-a case of disrupted development. Annu Rev Genet 1994; 28: 523-8.
    • (1994) Annu Rev Genet , vol.28 , pp. 523-528
    • Hastie, N.D.1
  • 18
    • 0025099787 scopus 로고
    • Isolation and characterization of a zinc finger polypeptide gene at the human chromosome 11 Wilms'tumor locus
    • Call KM, Glaser T, Ito CY, et al. Isolation and characterization of a zinc finger polypeptide gene at the human chromosome 11 Wilms'tumor locus. Cell 1990; 60: 509-20.
    • (1990) Cell , vol.60 , pp. 509-520
    • Call, K.M.1    Glaser, T.2    Ito, C.Y.3
  • 20
    • 0033565656 scopus 로고    scopus 로고
    • WT1 modulates apoptosis by transcriptionally upregulating the bcl-2 proto-oncogene
    • Mayo MW, Wang CY, Drouin SS, et al. WT1 modulates apoptosis by transcriptionally upregulating the bcl-2 proto-oncogene. EMBO J 1999; 18: 3990-4003.
    • (1999) EMBO J , vol.18 , pp. 3990-4003
    • Mayo, M.W.1    Wang, C.Y.2    Drouin, S.S.3
  • 21
    • 0029164446 scopus 로고
    • The WT1 gene product stabilizes p53 and inhibits p53-mediated apoptosis
    • Maheswaran S, Englert C, Bennett P, Heinrich G, Haber DA. The WT1 gene product stabilizes p53 and inhibits p53-mediated apoptosis. Genes Dev 1995; 9: 2143-56.
    • (1995) Genes Dev , vol.9 , pp. 2143-2156
    • Maheswaran, S.1    Englert, C.2    Bennett, P.3    Heinrich, G.4    Haber, D.A.5
  • 22
    • 0027161785 scopus 로고
    • Physical and functional interaction between WT1 and p53 proteins
    • Maheswaran S, Park S, Bernard A, et al. Physical and functional interaction between WT1 and p53 proteins. Proc Natl Acad Sci USA 1993; 90: 5100-4.
    • (1993) Proc Natl Acad Sci USA , vol.90 , pp. 5100-5104
    • Maheswaran, S.1    Park, S.2    Bernard, A.3
  • 23
    • 0034004365 scopus 로고    scopus 로고
    • Immunohistochemical detection of theWilms tumor gene (WT1) in epithelial ovarian tumors
    • Shimizu M, Toki T, Takagi Y, Konishi I, Fujii S. Immunohistochemical detection of theWilms tumor gene (WT1) in epithelial ovarian tumors. Int J Gynecol Pathol. 2000; 19: 158-63.
    • (2000) Int J Gynecol Pathol , vol.19 , pp. 158-163
    • Shimizu, M.1    Toki, T.2    Takagi, Y.3    Konishi, I.4    Fujii, S.5
  • 24
    • 33750328319 scopus 로고    scopus 로고
    • HOXB7, a homeodomain protein, is overexpressed in breast cancer and confers epithelialomesenchymal transition
    • Wu, X, Chen H, Parker B, et al. HOXB7, a homeodomain protein, is overexpressed in breast cancer and confers epithelialomesenchymal transition. Cancer Res 2006; 66: 9527-34.
    • (2006) Cancer Res , vol.66 , pp. 9527-9534
    • Wu, X.1    Chen, H.2    Parker, B.3
  • 25
    • 38349125704 scopus 로고    scopus 로고
    • The trithorax group and Pc group proteins are differentially involved in heterochromatin formation in Drosophila
    • Fanti L, Perrini B, Piacentini L, et al. The trithorax group and Pc group proteins are differentially involved in heterochromatin formation in Drosophila. Chromosoma 2008; 117: 25-39.
    • (2008) Chromosoma , vol.117 , pp. 25-39
    • Fanti, L.1    Perrini, B.2    Piacentini, L.3
  • 26
    • 12944332088 scopus 로고    scopus 로고
    • Mammalian Trithorax and polycomb-group homolegues are antagonisic regulators of homeotic development
    • Hanson RD, Hess JL, Yu BD, et al. Mammalian Trithorax and polycomb-group homolegues are antagonisic regulators of homeotic development. Proc Natl Acad Sci USA 1999; 96: 14372-7.
    • (1999) Proc Natl Acad Sci USA , vol.96 , pp. 14372-14377
    • Hanson, R.D.1    Hess, J.L.2    Yu, B.D.3
  • 27
    • 0038240453 scopus 로고    scopus 로고
    • Gene expression signatures in MLL-rearranged T-lineage and B-precursor acute leukemias: Dominance of HOX dysregulation
    • Ferrando AA, Armstrong SA, Neuberg DS, et al. Gene expression signatures in MLL-rearranged T-lineage and B-precursor acute leukemias: dominance of HOX dysregulation. Blood 2003; 102: 262-8.
    • (2003) Blood , vol.102 , pp. 262-268
    • Ferrando, A.A.1    Armstrong, S.A.2    Neuberg, D.S.3
  • 28
    • 0142062911 scopus 로고    scopus 로고
    • MLL-rearranged leukemias: Insights from gene expression profiling
    • Armstrong SA, Golub TR, Korsmeyer SJ. MLL-rearranged leukemias: insights from gene expression profiling. Semin Hematol 2003; 40: 268-73.
    • (2003) Semin Hematol , vol.40 , pp. 268-273
    • Armstrong, S.A.1    Golub, T.R.2    Korsmeyer, S.J.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.