Homeobox A7 increases cell proliferation by up-regulation of epidermal growth factor receptor expression in human granulosa cells

Reproductive Biology and Endocrinology

Volumn 8, Issue , 2010, Pages

  Zhang, Yu ^a,b   Huang, Qing ^b   Cheng, Jung Chien ^b   Nishi, Yoshihiro ^c   Yanase, Toshihiko ^d   Huang, He Feng ^a   Leung, Peter C K ^a,b  

^a ZHEJIANG UNIVERSITY SCHOOL OF MEDICINE   (China)

^b UNIVERSITY OF BRITISH COLUMBIA   (Canada)

^c KYUSHU UNIVERSITY   (Japan)

^d FUKUOKA UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

EPIDERMAL GROWTH FACTOR RECEPTOR; HOMEOBOX A7; HOMEODOMAIN PROTEIN; UNCLASSIFIED DRUG; HOXA7 PROTEIN, HUMAN; ONCOPROTEIN; PHOSPHATIDYLINOSITOL 3 KINASE; SMALL INTERFERING RNA;

ARTICLE; CELL PROLIFERATION; CELL VIABILITY; CONTROLLED STUDY; GENE ACTIVATION; GENE EXPRESSION REGULATION; GENE OVEREXPRESSION; GRANULOSA CELL; HUMAN; HUMAN CELL; IMMUNOREACTIVITY; PROTEIN FUNCTION; REAL TIME POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION; UPREGULATION; WESTERN BLOTTING; CELL CULTURE; CELL DIFFERENTIATION; DRUG ANTAGONISM; DRUG EFFECT; ENZYME ACTIVATION; FEMALE; GENETICS; METABOLISM; PHYSIOLOGY;

1-PHOSPHATIDYLINOSITOL 3-KINASE; CELL DIFFERENTIATION; CELL PROLIFERATION; CELLS, CULTURED; ENZYME ACTIVATION; FEMALE; GRANULOSA CELLS; HOMEODOMAIN PROTEINS; HUMANS; MAP KINASE SIGNALING SYSTEM; ONCOGENE PROTEIN V-AKT; RECEPTOR, EPIDERMAL GROWTH FACTOR; RNA, SMALL INTERFERING; UP-REGULATION;

EID: 77953332515     PISSN: None     EISSN: 14777827     Source Type: Journal    
DOI: 10.1186/1477-7827-8-61     Document Type: Article

References (42)

1. Tatone C, Amicarelli F, Carbone MC, Monteleone P, Caserta D, Marci R, Artini PG, Piomboni P, Focarelli R. Cellular and molecular aspects of ovarian follicle ageing. Hum Reprod Update 2008, 14:131-142. 10.1093/humupd/dmm048, 18239135.
2. Colombo N, Parma G, Zanagnolo V, Insinga A. Management of ovarian stromal cell tumors. J Clin Oncol 2007, 25:2944-2951. 10.1200/JCO.2007.11.1005, 17617526.
3. Woods DC, Alvarez C, Johnson AL. Cisplatin-mediated sensitivity to TRAIL-induced cell death in human granulosa tumor cells. Gynecol Oncol 2008, 108:632-640. 10.1016/j.ygyno.2007.11.034, 18191995.
4. Hutt KJ, Albertini DF. An oocentric view of folliculogenesis and embryogenesis. Reprod Biomed Online 2007, 14:758-764. 10.1016/S1472-6483(10)60679-7, 17579993.
5. McGinnis W, Krumlauf R. Homeobox genes and axial patterning. Cell 1992, 68:283-302. 10.1016/0092-8674(92)90471-N, 1346368.
6. Krumlauf R. Hox genes in vertebrate development. Cell 1994, 78:191-201. 10.1016/0092-8674(94)90290-9, 7913880.
7. Gorski DH, Walsh K. The role of homeobox genes in vascular remodeling and angiogenesis. Circ Res 2000, 87:865-872.
8. Vitiello D, Kodaman PH, Taylor HS. HOX genes in implantation. Semin Reprod Med 2007, 25:431-436. 10.1055/s-2007-991040, 17960527.
9. Cheng W, Liu J, Yoshida H, Rosen D, Naora H. Lineage infidelity of epithelial ovarian cancers is controlled by HOX genes that specify regional identity in the reproductive tract. Nat Med 2005, 11:531-537. 10.1038/nm1230, 15821746.
10. Naora H, Montz FJ, Chai CY, Roden RB. Aberrant expression of homeobox gene HOXA7 is associated with mullerian-like differentiation of epithelial ovarian tumors and the generation of a specific autologous antibody response. Proc Natl Acad Sci USA 2001, 98:15209-15214. 10.1073/pnas.011503998, 65008, 11742062.
11. Miao J, Wang Z, Provencher H, Muir B, Dahiya S, Carney E, Leong CO, Sgroi DC, Orsulic S. HOXB13 promotes ovarian cancer progression. Proc Natl Acad Sci USA 2007, 104:17093-17098. 10.1073/pnas.0707938104, 2040435, 17942676.
12. Ota T, Gilks CB, Longacre T, Leung PC, Auersperg N. HOXA7 in epithelial ovarian cancer: interrelationships between differentiation and clinical features. Reprod Sci 2007, 14:605-614. 10.1177/1933719107307781, 17959889.
13. Ota T, Choi KB, Gilks CB, Leung PC, Auersperg N. Cell type- and stage-specific changes in HOXA7 protein expression in human ovarian folliculogenesis: possible role of GDF-9. Differentiation 2006, 74:1-10. 10.1111/j.1432-0436.2006.00053.x, 16466395.
14. Ota T, Asahina H, Park SH, Huang Q, Minegishi T, Auersperg N, Leung PC. HOX cofactors expression and regulation in the human ovary. Reprod Biol Endocrinol 2008, 6:49. 10.1186/1477-7827-6-49, 2585084, 18973687.
15. Yarden Y, Sliwkowski MX. Untangling the ErbB signalling network. Nat Rev Mol Cell Biol 2001, 2:127-137. 10.1038/35052073, 11252954.
16. Jost M, Kari C, Rodeck U. The EGF receptor - an essential regulator of multiple epidermal functions. Eur J Dermatol 2000, 10:505-510.
17. Mondschein JS, Schomberg DW. Growth factors modulate gonadotropin receptor induction in granulosa cell cultures. Science 1981, 211:1179-1180. 10.1126/science.6258228, 6258228.
18. Hsieh M, Zamah AM, Conti M. Epidermal growth factor-like growth factors in the follicular fluid: role in oocyte development and maturation. Semin Reprod Med 2009, 27:52-61. 10.1055/s-0028-1108010, 19197805.
19. Zandi R, Larsen AB, Andersen P, Stockhausen MT, Poulsen HS. Mechanisms for oncogenic activation of the epidermal growth factor receptor. Cell Signal 2007, 19:2013-2023. 10.1016/j.cellsig.2007.06.023, 17681753.
20. Janmaat ML, Giaccone G. The epidermal growth factor receptor pathway and its inhibition as anticancer therapy. Drugs Today (Barc) 2003, 39(Suppl C):61-80.
21. Henderson GS, van Diest PJ, Burger H, Russo J, Raman V. Expression pattern of a homeotic gene, HOXA5, in normal breast and in breast tumors. Cell Oncol 2006, 28:305-313.
22. Whelan JT, Ludwig DL, Bertrand FE. HoxA9 induces insulin-like growth factor-1 receptor expression in B-lineage acute lymphoblastic leukemia. Leukemia 2008, 22:1161-1169. 10.1038/leu.2008.57, 18337761.
23. Bruhl T, Urbich C, Aicher D, Acker-Palmer A, Zeiher AM, Dimmeler S. Homeobox A9 transcriptionally regulates the EphB4 receptor to modulate endothelial cell migration and tube formation. Circ Res 2004, 94:743-751. 10.1161/01.RES.0000120861.27064.09, 14764452.
24. Chen J, Ruley HE. An enhancer element in the EphA2 (Eck) gene sufficient for rhombomere-specific expression is activated by HOXA1 and HOXB1 homeobox proteins. J Biol Chem 1998, 273:24670-24675. 10.1074/jbc.273.38.24670, 9733765.
25. La Celle PT, Polakowska RR. Human homeobox HOXA7 regulates keratinocyte transglutaminase type 1 and inhibits differentiation. J Biol Chem 2001, 276:32844-32853. 10.1074/jbc.M104598200, 11435435.
26. Nishi Y, Yanase T, Mu Y, Oba K, Ichino I, Saito M, Nomura M, Mukasa C, Okabe T, Goto K, Takayanagi R, Kashimura Y, Haji M, Nawata H. Establishment and characterization of a steroidogenic human granulosa-like tumor cell line, KGN, that expresses functional follicle-stimulating hormone receptor. Endocrinology 2001, 142:437-445. 10.1210/en.142.1.437, 11145608.
27. Lie BL, Leung E, Leung PC, Auersperg N. Long-term growth and steroidogenic potential of human granulosa-lutein cells immortalized with SV40 large T antigen. Mol Cell Endocrinol 1996, 120:169-176. 10.1016/0303-7207(96)03835-X, 8832577.
28. Shi FT, Cheung AP, Leung PC. Growth differentiation factor 9 enhances activin a-induced inhibin B production in human granulosa cells. Endocrinology 2009, 150:3540-3546. 10.1210/en.2009-0267, 19423755.
29. Sarno JL, Schatz F, Lockwood CJ, Huang ST, Taylor HS. Thrombin and interleukin-1beta regulate HOXA10 expression in human term decidual cells: implications for preterm labor. J Clin Endocrinol Metab 2006, 91:2366-2372. 10.1210/jc.2005-1807, 16551735.
30. Grier DG, Thompson A, Kwasniewska A, McGonigle GJ, Halliday HL, Lappin TR. The pathophysiology of HOX genes and their role in cancer. J Pathol 2005, 205:154-171. 10.1002/path.1710, 15643670.
31. Taylor HS, Vanden Heuvel GB, Igarashi P. A conserved Hox axis in the mouse and human female reproductive system: late establishment and persistent adult expression of the Hoxa cluster genes. Biol Reprod 1997, 57:1338-1345. 10.1095/biolreprod57.6.1338, 9408238.
32. Nunes FD, de Almeida FC, Tucci R, de Sousa SC. Homeobox genes: a molecular link between development and cancer. Pesqui Odontol Bras 2003, 17:94-98. 10.1590/S1517-74912003000100018, 12908068.
33. Gospodarowicz D, Bialecki H. Fibroblast and epidermal growth factors are mitogenic agents for cultured granulosa cells of rodent, porcine, and human origin. Endocrinology 1979, 104:757-764. 10.1210/endo-104-3-757, 312195.
34. Normanno N, De Luca A, Bianco C, Strizzi L, Mancino M, Maiello MR, Carotenuto A, De Feo G, Caponigro F, Salomon DS. Epidermal growth factor receptor (EGFR) signaling in cancer. Gene 2006, 366:2-16. 10.1016/j.gene.2005.10.018, 16377102.
35. Galizia G, Lieto E, Orditura M, Castellano P, Mura AL, Imperatore V, Pinto M, Zamboli A, De Vita F, Ferraraccio F. Epidermal growth factor receptor (EGFR) expression is associated with a worse prognosis in gastric cancer patients undergoing curative surgery. World J Surg 2007, 31:1458-1468. 10.1007/s00268-007-9016-4, 17516110.
36. Chung CH, Ely K, McGavran L, Varella-Garcia M, Parker J, Parker N, Jarrett C, Carter J, Murphy BA, Netterville J, Burkey BB, Sinard R, Cmelak A, Levy S, Yarbrough WG, Slebos RJ, Hirsch FR. Increased epidermal growth factor receptor gene copy number is associated with poor prognosis in head and neck squamous cell carcinomas. J Clin Oncol 2006, 24:4170-4176. 10.1200/JCO.2006.07.2587, 16943533.
37. Henson ES, Gibson SB. Surviving cell death through epidermal growth factor (EGF) signal transduction pathways: implications for cancer therapy. Cell Signal 2006, 18:2089-2097. 10.1016/j.cellsig.2006.05.015, 16815674.
38. Lafky JM, Wilken JA, Baron AT, Maihle NJ. Clinical implications of the ErbB/epidermal growth factor (EGF) receptor family and its ligands in ovarian cancer. Biochim Biophys Acta 2008, 1785:232-265.
39. Fowler KJ, Walker F, Alexander W, Hibbs ML, Nice EC, Bohmer RM, Mann GB, Thumwood C, Maglitto R, Danks JA, Chetty R, Burgess AW, Dunn AR. A mutation in the epidermal growth factor receptor in waved-2 mice has a profound effect on receptor biochemistry that results in impaired lactation. Proc Natl Acad Sci USA 1995, 92:1465-1469. 10.1073/pnas.92.5.1465, 42540, 7533293.
40. Mitsiades CS, Kotoula V, Poulaki V, Sozopoulos E, Negri J, Charalambous E, Fanourakis G, Voutsinas G, Tseleni-Balafouta S, Mitsiades N. Epidermal growth factor receptor as a therapeutic target in human thyroid carcinoma: mutational and functional analysis. J Clin Endocrinol Metab 2006, 91:3662-3666. 10.1210/jc.2006-0055, 16822827.
41. Adams GP, Weiner LM. Monoclonal antibody therapy of cancer. Nat Biotechnol 2005, 23:1147-1157. 10.1038/nbt1137, 16151408.
42. Amann J, Kalyankrishna S, Massion PP, Ohm JE, Girard L, Shigematsu H, Peyton M, Juroske D, Huang Y, Stuart Salmon J, Kim YH, Pollack JR, Yanagisawa K, Gazdar A, Minna JD, Kurie JM, Carbone DP. Aberrant epidermal growth factor receptor signaling and enhanced sensitivity to EGFR inhibitors in lung cancer. Cancer Res 2005, 65:226-235.